Mitochondrial DNA (mtDNA) Haplogroups Influence the Progression of Knee Osteoarthritis. Data from the Osteoarthritis Initiative (OAI)
Publication Date
November 12, 2014
Journal
PLOS ONE
Authors
Angel Soto Hermida, Mercedes Fernández Moreno, Natividad Oreiro, Carlos Fernández López, et al
Volume
9
Issue
11
Pages
e112735
DOI
https://dx.plos.org/10.1371/journal.pone.0112735
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0112735
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25390621
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229258
Europe PMC
http://europepmc.org/abstract/MED/25390621
Web of Science
000349144400122
Scopus
84911483452
Mendeley
http://www.mendeley.com/research/mitochondrial-dna-mtdna-haplogroups-influence-progression-knee-osteoarthritisdata-osteoarthritis-ini
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Mendeley | Further Information

{"title"=>"Mitochondrial DNA (mtDNA) haplogroups influence the progression of knee osteoarthritis.Data from the osteoarthritis initiative (OAI)", "type"=>"journal", "authors"=>[{"first_name"=>"Angel", "last_name"=>"Soto-Hermida", "scopus_author_id"=>"54398075300"}, {"first_name"=>"Mercedes", "last_name"=>"Fernández-Moreno", "scopus_author_id"=>"25624680000"}, {"first_name"=>"Natividad", "last_name"=>"Oreiro", "scopus_author_id"=>"35784923700"}, {"first_name"=>"Carlos", "last_name"=>"Fernández-López", "scopus_author_id"=>"6507647303"}, {"first_name"=>"Sonia", "last_name"=>"Pértega", "scopus_author_id"=>"6506895327"}, {"first_name"=>"Estefania", "last_name"=>"Cortés-Pereira", "scopus_author_id"=>"56056883700"}, {"first_name"=>"Ignacio", "last_name"=>"Rego-Pérez", "scopus_author_id"=>"24554214500"}, {"first_name"=>"Francisco J.", "last_name"=>"Blanco", "scopus_author_id"=>"7102243071"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"600489270", "sgr"=>"84911483452", "issn"=>"19326203", "pmid"=>"25390621", "scopus"=>"2-s2.0-84911483452", "doi"=>"10.1371/journal.pone.0112735", "isbn"=>"1932-6203"}, "id"=>"c1efb15b-ff81-3c60-b2a8-84351c1fe4d0", "abstract"=>"Objective: To evaluate the influence of the mtDNA haplogroups on knee osteoarthritis progression in Osteoarthritis Initiative (OAI) participants through longitudinal data from radiographs and magnetic resonance imaging (MRI). [[ampi]]copy;2014 Soto-Hermida et al.Methods: Four-year knee osteoarthritis progression was analyzed as increase in Kellgren and Lawrence (KL) grade, in addition to increase in OARSI atlas grade for joint space narrowing (JSN), osteophytes and subchondral sclerosis in the tibia medial compartment of 891 Caucasian individuals from the progression subcohort. The influence of the haplogroups on the rate of structural progression was also assessed as the four-year change in minimum joint space width (mJSW in millimetres) in both knees of (n = 216) patients with baseline unilateral medial-tibiofemoral JSN. Quantitative cartilage measures from longitudinal MRI data were those related to cartilage thickness and volume with a 24 month follow-up period (n = 381).Results: During the four-year follow-up period, knee OA patients with the haplogroup T showed the lowest increase in KL grade (Hazard Risk [HR] = 0.499; 95% Confidence Interval [CI]: 0.261-0.819; p,0.05) as well as the lowest cumulative probability of progression for JSN (HR = 0.547; 95% CI: 0.280-0.900; p,0.05), osteophytes (HR = 0.573; 95% CI: 0.304-0.893; p,0.05) and subchondral sclerosis (HR = 0.549; 95% CI: 0.295-0.884; p, 0.05). They also showed the lowest decline in mJSW (standardized response means (SRM) = 20.39; p = 0.037) in those knees without baseline medial JSN (no-JSN knees). Normalized cartilage volume loss was significantly lower in patients carrying the haplogroup T at medial tibia femoral (SRM = 20.33; p = 0.023) and central medial femoral (SRM = 20.27; p = 0.031) compartments. Cartilage thickness loss was significantly lower in carriers of haplogroup T at central medial tibia-femoral (SRM = 20.42; p = 0.011), medial tibia femoral (SRM = 20.32; p = 0.018), medial tibia anterior (SRM = +0.31; p = 0.013) and central medial femoral (SRM = 20.19; p = 0.013) compartments.Conclusions: Mitochondrial genome seems to play a role in the progression of knee osteoarthritis. mtDNA variation could improve identification of patients predisposed to faster or severe progression of the disease.", "link"=>"http://www.mendeley.com/research/mitochondrial-dna-mtdna-haplogroups-influence-progression-knee-osteoarthritisdata-osteoarthritis-ini", "reader_count"=>13, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>6}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1789884"], "description"=>"<p>KL: Kellgren and Lawrence; JSN: joint space narrowing; BMI: body mass index; bl: baseline; (<b><sup>¥</sup></b>): cumulative osteoarthritis progression rate after 48 months of follow-up; HR: hazard ratio; CI: confidence interval; (#): confidence intervals for the hazard ratios obtained using the bootstrap methodology by the percentile method; (±): the worst knee at baseline refers to the radiological status of the knee attending to (highest) KL grade, JSN grade, osteophytes grade or sclerosis grade, as appropriate on each case; (*): statistical significance declared at p≤0.05.</p><p>Cumulative probability of osteoarthritis progression according to mitochondrial DNA (mtDNA) haplogroups and results of the extended Cox proportional hazard model.</p>", "links"=>[], "tags"=>["oai", "baseline medial JSN", "Quantitative cartilage measures", "mri", "subchondral sclerosis", "hr", "Osteoarthritis Initiative", "kl", "medial tibia femoral", "OARSI atlas grade", "medial femoral", "knee OA patients", "tibia medial compartment", "haplogroup T", "Cartilage thickness loss", "ci", "dna", "srm", "891 Caucasian individuals", "knee osteoarthritis progression", "Normalized cartilage volume loss", "mtdna", "data"], "article_id"=>1237952, "categories"=>["Biological Sciences"], "users"=>["Angel Soto-Hermida", "Mercedes Fernández-Moreno", "Natividad Oreiro", "Carlos Fernández-López", "Sonia Pértega", "Estefania Cortés-Pereira", "Ignacio Rego-Pérez", "Francisco J. Blanco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112735.t002", "stats"=>{"downloads"=>7, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cumulative_probability_of_osteoarthritis_progression_according_to_mitochondrial_DNA_mtDNA_haplogroups_and_results_of_the_extended_Cox_proportional_hazard_model_/1237952", "title"=>"Cumulative probability of osteoarthritis progression according to mitochondrial DNA (mtDNA) haplogroups and results of the extended Cox proportional hazard model.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-12 02:55:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1789885"], "description"=>"<p>Data are mean±standard deviation, in millimetres (mm); mJSW: medial joint space width; JSN: joint space narrowing; SD: standard deviation; SRM: standardized response means (mean divided by SD); (#) multivariate (ANCOVA) analysis, adjusting for gender, age and body mass index (BMI) at baseline; (*) indicates statistical significance at p≤0.05.</p><p>Mean differences in mJSW change over 4 years at minimum mJSW among the mitochondrial DNA (mtDNA) haplogroups in 216 OA patients.</p>", "links"=>[], "tags"=>["oai", "baseline medial JSN", "Quantitative cartilage measures", "mri", "subchondral sclerosis", "hr", "Osteoarthritis Initiative", "kl", "medial tibia femoral", "OARSI atlas grade", "medial femoral", "knee OA patients", "tibia medial compartment", "haplogroup T", "Cartilage thickness loss", "ci", "dna", "srm", "891 Caucasian individuals", "knee osteoarthritis progression", "Normalized cartilage volume loss", "mtdna", "data"], "article_id"=>1237953, "categories"=>["Biological Sciences"], "users"=>["Angel Soto-Hermida", "Mercedes Fernández-Moreno", "Natividad Oreiro", "Carlos Fernández-López", "Sonia Pértega", "Estefania Cortés-Pereira", "Ignacio Rego-Pérez", "Francisco J. Blanco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112735.t003", "stats"=>{"downloads"=>5, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_differences_in_mJSW_change_over_4_years_at_minimum_mJSW_among_the_mitochondrial_DNA_mtDNA_haplogroups_in_216_OA_patients_/1237953", "title"=>"Mean differences in mJSW change over 4 years at minimum mJSW among the mitochondrial DNA (mtDNA) haplogroups in 216 OA patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-12 02:55:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1789886"], "description"=>"<p>BMI: body mass index; B: regression coefficient; SE: standard error; (†) the coefficient of each haplogroup represents the mean difference between a particular haplogroup and the reference haplogroup H at baseline; (<b>¥</b>) shows the interaction between the mtDNA haplogroups and the loss rate of cartilage volume and thickness over time; (#) linear mixed-effects random-intercept and random-slope repeated measures analysis adjusting for gender, age and BMI at baseline and considering the most common mtDNA haplogroup, H, as the reference group; (*): indicates statistical significance at p≤0.05.</p><p>Random-coefficients linear mixed model to analyze the influence of mtDNA haplogroups on change in cartilage volume (upper) and thickness (lower) over time in 381 knee OA patients in the progression subcohort of the OAI.</p>", "links"=>[], "tags"=>["oai", "baseline medial JSN", "Quantitative cartilage measures", "mri", "subchondral sclerosis", "hr", "Osteoarthritis Initiative", "kl", "medial tibia femoral", "OARSI atlas grade", "medial femoral", "knee OA patients", "tibia medial compartment", "haplogroup T", "Cartilage thickness loss", "ci", "dna", "srm", "891 Caucasian individuals", "knee osteoarthritis progression", "Normalized cartilage volume loss", "mtdna", "data"], "article_id"=>1237954, "categories"=>["Biological Sciences"], "users"=>["Angel Soto-Hermida", "Mercedes Fernández-Moreno", "Natividad Oreiro", "Carlos Fernández-López", "Sonia Pértega", "Estefania Cortés-Pereira", "Ignacio Rego-Pérez", "Francisco J. Blanco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112735.t004", "stats"=>{"downloads"=>6, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Random_coefficients_linear_mixed_model_to_analyze_the_influence_of_mtDNA_haplogroups_on_change_in_cartilage_volume_upper_and_thickness_lower_over_time_in_381_knee_OA_patients_in_the_progression_subcohort_of_the_OAI_/1237954", "title"=>"Random-coefficients linear mixed model to analyze the influence of mtDNA haplogroups on change in cartilage volume (upper) and thickness (lower) over time in 381 knee OA patients in the progression subcohort of the OAI.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-12 02:55:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1789887", "https://ndownloader.figshare.com/files/1789888", "https://ndownloader.figshare.com/files/1789889", "https://ndownloader.figshare.com/files/1789890"], "description"=>"<div><p>Objective</p><p>To evaluate the influence of the mtDNA haplogroups on knee osteoarthritis progression in Osteoarthritis Initiative (OAI) participants through longitudinal data from radiographs and magnetic resonance imaging (MRI).</p><p>Methods</p><p>Four-year knee osteoarthritis progression was analyzed as increase in Kellgren and Lawrence (KL) grade, in addition to increase in OARSI atlas grade for joint space narrowing (JSN), osteophytes and subchondral sclerosis in the tibia medial compartment of 891 Caucasian individuals from the progression subcohort. The influence of the haplogroups on the rate of structural progression was also assessed as the four-year change in minimum joint space width (mJSW in millimetres) in both knees of (n = 216) patients with baseline unilateral medial-tibiofemoral JSN. Quantitative cartilage measures from longitudinal MRI data were those related to cartilage thickness and volume with a 24 month follow-up period (n = 381).</p><p>Results</p><p>During the four-year follow-up period, knee OA patients with the haplogroup T showed the lowest increase in KL grade (Hazard Risk [HR] = 0.499; 95% Confidence Interval [CI]: 0.261–0.819; p<0.05) as well as the lowest cumulative probability of progression for JSN (HR = 0.547; 95% CI: 0.280–0.900; p<0.05), osteophytes (HR = 0.573; 95% CI: 0.304–0.893; p<0.05) and subchondral sclerosis (HR = 0.549; 95% CI: 0.295–0.884; p<0.05). They also showed the lowest decline in mJSW (standardized response means (SRM) = −0.39; p = 0.037) in those knees without baseline medial JSN (no-JSN knees). Normalized cartilage volume loss was significantly lower in patients carrying the haplogroup T at medial tibia femoral (SRM = −0.33; p = 0.023) and central medial femoral (SRM = −0.27; p = 0.031) compartments. Cartilage thickness loss was significantly lower in carriers of haplogroup T at central medial tibia-femoral (SRM = −0.42; p = 0.011), medial tibia femoral (SRM = −0.32; p = 0.018), medial tibia anterior (SRM = +0.31; p = 0.013) and central medial femoral (SRM = −0.19; p = 0.013) compartments.</p><p>Conclusions</p><p>Mitochondrial genome seems to play a role in the progression of knee osteoarthritis. mtDNA variation could improve identification of patients predisposed to faster or severe progression of the disease.</p></div>", "links"=>[], "tags"=>["oai", "baseline medial JSN", "Quantitative cartilage measures", "mri", "subchondral sclerosis", "hr", "Osteoarthritis Initiative", "kl", "medial tibia femoral", "OARSI atlas grade", "medial femoral", "knee OA patients", "tibia medial compartment", "haplogroup T", "Cartilage thickness loss", "ci", "dna", "srm", "891 Caucasian individuals", "knee osteoarthritis progression", "Normalized cartilage volume loss", "mtdna", "data"], "article_id"=>1237955, "categories"=>["Biological Sciences"], "users"=>["Angel Soto-Hermida", "Mercedes Fernández-Moreno", "Natividad Oreiro", "Carlos Fernández-López", "Sonia Pértega", "Estefania Cortés-Pereira", "Ignacio Rego-Pérez", "Francisco J. Blanco"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0112735.s001", "https://dx.doi.org/10.1371/journal.pone.0112735.s002", "https://dx.doi.org/10.1371/journal.pone.0112735.s003", "https://dx.doi.org/10.1371/journal.pone.0112735.s004"], "stats"=>{"downloads"=>13, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mitochondrial_DNA_mtDNA_Haplogroups_Influence_the_Progression_of_Knee_Osteoarthritis_Data_from_the_Osteoarthritis_Initiative_OAI_/1237955", "title"=>"Mitochondrial DNA (mtDNA) Haplogroups Influence the Progression of Knee Osteoarthritis. Data from the Osteoarthritis Initiative (OAI)", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-11-12 02:55:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1789882"], "description"=>"<p>MFTC.VCtAB: normalized cartilage volume in medial tibia femoral compartment; cMF.VCtAB: normalized cartilage volume in central medial femoral; MFTC.VC: cartilage volume in medial tibia femoral compartment; cMF.VC: volume of cartilage in central medial femoral. MFTC.VC and cMF.VC that are shown in cubic millimeters (mm3) and MFTC.VCtAB and cMF.VCtAB are shown in square centimeters (cm2); (*) indicates statistical significance (p<0.05). Values are mean change+SE (standard error). <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112735#pone-0112735-g001\" target=\"_blank\"><b>Figure 1b</b></a>. Longitudinal change between baseline and 24 months in cartilage thickness grouped by mitochondrial DNA (mtDNA) haplogroups. cMFTC.ThCtAB: mean cartilage thickness in central medial tibia femoral compartment (weight-bearing); MFTC.ThCtAB: mean cartilage thickness in medial tibia femoral compartment; aMT.ThCtAB: mean cartilage thickness in medial tibia (anterior); ccMF.ThCtAB: mean cartilage thickness in central medial femoral (center). All of them represented in millimeters (mm); (*) indicates statistical significance (p<0.05). Values are mean change+SE (standard error).</p>", "links"=>[], "tags"=>["oai", "baseline medial JSN", "Quantitative cartilage measures", "mri", "subchondral sclerosis", "hr", "Osteoarthritis Initiative", "kl", "medial tibia femoral", "OARSI atlas grade", "medial femoral", "knee OA patients", "tibia medial compartment", "haplogroup T", "Cartilage thickness loss", "ci", "dna", "srm", "891 Caucasian individuals", "knee osteoarthritis progression", "Normalized cartilage volume loss", "mtdna", "data"], "article_id"=>1237950, "categories"=>["Biological Sciences"], "users"=>["Angel Soto-Hermida", "Mercedes Fernández-Moreno", "Natividad Oreiro", "Carlos Fernández-López", "Sonia Pértega", "Estefania Cortés-Pereira", "Ignacio Rego-Pérez", "Francisco J. Blanco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112735.g001", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Figure_1a_Longitudinal_change_between_baseline_and_24_months_in_cartilage_volume_grouped_by_mitochondrial_DNA_mtDNA_haplogroups_/1237950", "title"=>"Figure 1a. Longitudinal change between baseline and 24 months in cartilage volume grouped by mitochondrial DNA (mtDNA) haplogroups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-12 02:55:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1789883"], "description"=>"<p>Values are mean±standard deviation or number of patients with percentage in parentheses; OAI: osteoarthritis initiative; (*) Kruskal-Wallis non-parametric test for comparison between mtDNA haplogroups; (#) Chi-square test; BMI: body mass index; KL: Kellgren and Lawrence; mJSN: Joint space narrowing in medial compartment; (**) The worst knee and the less severe knee at baseline were designated, respectively, as the knee with the highest and lowest KL (Kellgren andLawrence) grade, OARSI JSN (joint space narrowing) grade, OARSI osteophytes grade or OARSI sclerosis grade, as appropriate on each case; significant p-values are in bold.</p><p>Demographic characteristics of the study population at baseline grouped by mitochondrial DNA (mtDNA) haplogroups in the progression subcohort of the OAI.</p>", "links"=>[], "tags"=>["oai", "baseline medial JSN", "Quantitative cartilage measures", "mri", "subchondral sclerosis", "hr", "Osteoarthritis Initiative", "kl", "medial tibia femoral", "OARSI atlas grade", "medial femoral", "knee OA patients", "tibia medial compartment", "haplogroup T", "Cartilage thickness loss", "ci", "dna", "srm", "891 Caucasian individuals", "knee osteoarthritis progression", "Normalized cartilage volume loss", "mtdna", "data"], "article_id"=>1237951, "categories"=>["Biological Sciences"], "users"=>["Angel Soto-Hermida", "Mercedes Fernández-Moreno", "Natividad Oreiro", "Carlos Fernández-López", "Sonia Pértega", "Estefania Cortés-Pereira", "Ignacio Rego-Pérez", "Francisco J. Blanco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112735.t001", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_characteristics_of_the_study_population_at_baseline_grouped_by_mitochondrial_DNA_mtDNA_haplogroups_in_the_progression_subcohort_of_the_OAI_/1237951", "title"=>"Demographic characteristics of the study population at baseline grouped by mitochondrial DNA (mtDNA) haplogroups in the progression subcohort of the OAI.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-12 02:55:49"}

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  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
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  • {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"19", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
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  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"64", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[267]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[282]}, {"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[333]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 482]}, {"subject_area"=>"/Biology and life sciences/Population biology", "average_usage"=>[312, 475]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[266]}, {"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[257]}, {"subject_area"=>"/Medicine and health sciences/Radiology and imaging", "average_usage"=>[246]}, {"subject_area"=>"/Medicine and health sciences/Rheumatology", "average_usage"=>[300, 469]}]}
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Net::HTTPInternalServerError

Source
Counter
Time
2019-04-06 02:38:42 UTC
Target URL
http://counter-101.soma.plos.org/api/v1.0/stats/doi/10.1371%2Fjournal.pone.0112735
Trace

/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'