Baseline MxA mRNA Expression Predicts Interferon Beta Response in Multiple Sclerosis Patients
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{"title"=>"Baseline MxA mRNA expression predicts interferon beta response in multiple sclerosis patients", "type"=>"journal", "authors"=>[{"first_name"=>"Elisabet", "last_name"=>"Matas", "scopus_author_id"=>"36022629400"}, {"first_name"=>"Laura", "last_name"=>"Bau", "scopus_author_id"=>"25824620700"}, {"first_name"=>"María", "last_name"=>"Martínez-Iniesta", "scopus_author_id"=>"12806584200"}, {"first_name"=>"Lucía", "last_name"=>"Romero-Pinel", "scopus_author_id"=>"6506024443"}, {"first_name"=>"M.", "last_name"=>"Alba Mañé", "scopus_author_id"=>"56426402100"}, {"first_name"=>"Älvaro", "last_name"=>"Cobo-Calvo", "scopus_author_id"=>"36605922700"}, {"first_name"=>"Sergio", "last_name"=>"Martínez-Yélamos", "scopus_author_id"=>"6603084662"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84911936808", "pui"=>"600506623", "sgr"=>"84911936808", "issn"=>"19326203", "pmid"=>"25396411", "doi"=>"10.1371/journal.pone.0112758"}, "id"=>"8101e255-ca50-3972-b036-ba658a4a540e", "abstract"=>"BACKGROUND:Myxovirus resistance protein A (MxA) is a molecule induced after interferon-beta injection, mostly used to evaluate its bioactivity. There is little available data on clinical utility of baseline MxA mRNA status. The objective of the study is to investigate whether baseline MxA mRNA expression can predict relapse and disease progression in multiple sclerosis patients treated with interferon-beta.\\n\\nMETHODS:Baseline blood samples were obtained before the first interferon-beta dose was administered to evaluate MxA mRNA expression using real-time polymerase chain reaction (PCR). Demographic and clinical variables were prospectively recorded to define treatment responder and non responder groups.\\n\\nRESULTS:104 patients were included in the study. Baseline MxA mRNA expression was significantly lower in the group of patients who met the definition of responders (1.07 vs 1.95, Student t test, p<0.0001). A threshold of 1.096 was established using Receiver Operating Characteristic analysis to differentiate between responders and non-responders (sensitivity 73.9%, specificity 69.0%). Survival analysis using this threshold showed that time to next relapse (p<0.0001) and to EDSS progression (p = 0.01) were significantly higher in patients with lower MxA titers.\\n\\nCONCLUSION:The results suggest that baseline MxA mRNA levels may be useful for predicting whether multiple sclerosis patients will respond or not to interferon-beta treatment.", "link"=>"http://www.mendeley.com/research/baseline-mxa-mrna-expression-predicts-interferon-beta-response-multiple-sclerosis-patients-2", "reader_count"=>5, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>2, "Neuroscience"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>1}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1795727"], "description"=>"<p>Patients belonging to the low-MxA group (MxA <1.096) showed a significantly longer time to increase by one point on the EDSS scale (p = 0.01).</p>", "links"=>[], "tags"=>["baseline MxA mRNA expression", "MxA titers.ConclusionThe results", "edss", "pcr", "baseline MxA mRNA status", "sclerosis patients", "Multiple Sclerosis Patients BackgroundMyxovirus resistance protein", "MxA mRNA expression", "polymerase chain reaction", "baseline MxA mRNA levels", "responder groups.Results 104 patients", "Receiver Operating Characteristic analysis", "Baseline MxA mRNA Expression Predicts Interferon Beta Response"], "article_id"=>1242622, "categories"=>["Biological Sciences"], "users"=>["Elisabet Matas", "Laura Bau", "María Martínez-Iniesta", "Lucía Romero-Pinel", "M. Alba Mañé", "Álvaro Cobo-Calvo", "Sergio Martínez-Yélamos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112758.g002", "stats"=>{"downloads"=>4, "page_views"=>50, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_curve_for_the_time_to_EDSS_progression_using_the_1_096_threshold_/1242622", "title"=>"Survival curve for the time to EDSS progression using the 1.096 threshold.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-14 03:19:05"}
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