Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAM) 1, 5 and 6 as Biomarkers in Pancreatic Cancer
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{"title"=>"Carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 1, 5 and 6 as biomarkers in pancreatic cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Florian", "last_name"=>"Gebauer", "scopus_author_id"=>"23466630900"}, {"first_name"=>"Daniel", "last_name"=>"Wicklein", "scopus_author_id"=>"54978454800"}, {"first_name"=>"Jennifer", "last_name"=>"Horst", "scopus_author_id"=>"56432389200"}, {"first_name"=>"Philipp", "last_name"=>"Sundermann", "scopus_author_id"=>"56433661600"}, {"first_name"=>"Hanna", "last_name"=>"Maar", "scopus_author_id"=>"56118441500"}, {"first_name"=>"Thomas", "last_name"=>"Streichert", "scopus_author_id"=>"6506880491"}, {"first_name"=>"Michael", "last_name"=>"Tachezy", "scopus_author_id"=>"25640190500"}, {"first_name"=>"Jakob R.", "last_name"=>"Izbicki", "scopus_author_id"=>"54417289400"}, {"first_name"=>"Maximilian", "last_name"=>"Bockhorn", "scopus_author_id"=>"8431544700"}, {"first_name"=>"Udo", "last_name"=>"Schumacher", "scopus_author_id"=>"7102933228"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"600550301", "doi"=>"10.1371/journal.pone.0113023", "sgr"=>"84913528609", "scopus"=>"2-s2.0-84913528609", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "pmid"=>"25409014"}, "id"=>"c14d6c0d-ae00-3635-86a9-d25379bf04b2", "abstract"=>"<sec> <title>Background</title> <p>Aim of this study was to assess the biological function in tumor progression and metastatic process carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 1, 5 and 6 in pancreatic adenocarcinoma (PDAC).</p> </sec><sec> <title>Experimental Design</title> <p>CEACAM knock down cells were established and assessed in vitro and in a subcutaneous and intraperitoneal mouse xenograft model. Tissue and serum expression of patients with PDAC were assessed by immunohistochemistry (IHC) and by enzyme linked immunosorbent assays.</p> </sec><sec> <title>Results</title> <p>Presence of lymph node metastasis was correlated with CEACAM 5 and 6 expression (determined by IHC) and tumor recurrence exclusively with CEACAM 6. Patients with CEACAM 5 and 6 expression showed a significantly shortened OS in Kaplan-Meier survival analyses. Elevated CEACAM6 serum values showed a correlation with distant metastasis and. Survival analysis revealed a prolonged OS for patients with low serum CEACAM 1 values. In vitro proliferation and migration capacity was increased in CEACAM knock down PDAC cells, however, mice inoculated with CEACAM knock down cells showed a prolonged overall-survival (OS). The number of spontaneous pulmonary metastasis was increased in the CEACAM knock down group.</p> </sec><sec> <title>Conclusion</title> <p>The effects mediated by CEACAM expression in PDAC are complex, though overexpression is correlated with loco-regional aggressive tumor growth. However, loss of CEACAM can be considered as a part of epithelial-mesenchymal transition and is therefore of rather importance in the process of distant metastasis.</p> </sec>", "link"=>"http://www.mendeley.com/research/carcinoembryonic-antigenrelated-cell-adhesion-molecules-ceacam-1-5-6-biomarkers-pancreatic-cancer", "reader_count"=>40, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>9, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>6, "Student > Bachelor"=>6, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>9, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>6, "Student > Bachelor"=>6, "Professor"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>11, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>15, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>11}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1933739"], "description"=>"<p>Kaplan-Meier survival analysis (log-rank test) depending on CEACAM 1, 5 and 6 expression in immunohistochemistry (IHC) and serum samples (ELISA) for patients with pancreatic ductal adenocarcinoma.</p><p>Overall and disease-free survival.</p>", "links"=>[], "tags"=>["6 expression", "Elevated CEACAM 6 serum values", "pdac", "ihc", "os", "intraperitoneal mouse xenograft model", "CEACAM 5", "lymph node metastasis", "Pancreatic Cancer BackgroundAim", "CEACAM 6. Patients", "serum CEACAM 1 values"], "article_id"=>1324492, "categories"=>["Biological Sciences"], "users"=>["Florian Gebauer", "Daniel Wicklein", "Jennifer Horst", "Philipp Sundermann", "Hanna Maar", "Thomas Streichert", "Michael Tachezy", "Jakob R. Izbicki", "Maximilian Bockhorn", "Udo Schumacher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113023.t002", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overall_and_disease_free_survival_/1324492", "title"=>"Overall and disease-free survival.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-19 21:39:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1933735"], "description"=>"<p>TMA immunohistochemical staining of CEACAM 1 negative (A) and positive (B), CEACAM 5 negative (C) and positive (D), CEACAM 6 negative (E) and positive (F).</p>", "links"=>[], "tags"=>["6 expression", "Elevated CEACAM 6 serum values", "pdac", "ihc", "os", "intraperitoneal mouse xenograft model", "CEACAM 5", "lymph node metastasis", "Pancreatic Cancer BackgroundAim", "CEACAM 6. Patients", "serum CEACAM 1 values"], "article_id"=>1324488, "categories"=>["Biological Sciences"], "users"=>["Florian Gebauer", "Daniel Wicklein", "Jennifer Horst", "Philipp Sundermann", "Hanna Maar", "Thomas Streichert", "Michael Tachezy", "Jakob R. Izbicki", "Maximilian Bockhorn", "Udo Schumacher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113023.g003", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TMA_immunohistochemical_staining_of_CEACAM_1_negative_A_and_positive_B_CEACAM_5_negative_C_and_positive_D_CEACAM_6_negative_E_and_positive_F_/1324488", "title"=>"TMA immunohistochemical staining of CEACAM 1 negative (A) and positive (B), CEACAM 5 negative (C) and positive (D), CEACAM 6 negative (E) and positive (F).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-19 21:39:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1933748"], "description"=>"<div><p>Background</p><p>Aim of this study was to assess the biological function in tumor progression and metastatic process carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 1, 5 and 6 in pancreatic adenocarcinoma (PDAC).</p><p>Experimental Design</p><p>CEACAM knock down cells were established and assessed in vitro and in a subcutaneous and intraperitoneal mouse xenograft model. Tissue and serum expression of patients with PDAC were assessed by immunohistochemistry (IHC) and by enzyme linked immunosorbent assays.</p><p>Results</p><p>Presence of lymph node metastasis was correlated with CEACAM 5 and 6 expression (determined by IHC) and tumor recurrence exclusively with CEACAM 6. Patients with CEACAM 5 and 6 expression showed a significantly shortened OS in Kaplan-Meier survival analyses. Elevated CEACAM6 serum values showed a correlation with distant metastasis and. Survival analysis revealed a prolonged OS for patients with low serum CEACAM 1 values. In vitro proliferation and migration capacity was increased in CEACAM knock down PDAC cells, however, mice inoculated with CEACAM knock down cells showed a prolonged overall-survival (OS). The number of spontaneous pulmonary metastasis was increased in the CEACAM knock down group.</p><p>Conclusion</p><p>The effects mediated by CEACAM expression in PDAC are complex, though overexpression is correlated with loco-regional aggressive tumor growth. However, loss of CEACAM can be considered as a part of epithelial-mesenchymal transition and is therefore of rather importance in the process of distant metastasis.</p></div>", "links"=>[], "tags"=>["6 expression", "Elevated CEACAM 6 serum values", "pdac", "ihc", "os", "intraperitoneal mouse xenograft model", "CEACAM 5", "lymph node metastasis", "Pancreatic Cancer BackgroundAim", "CEACAM 6. Patients", "serum CEACAM 1 values"], "article_id"=>1324501, "categories"=>["Biological Sciences"], "users"=>["Florian Gebauer", "Daniel Wicklein", "Jennifer Horst", "Philipp Sundermann", "Hanna Maar", "Thomas Streichert", "Michael Tachezy", "Jakob R. Izbicki", "Maximilian Bockhorn", "Udo Schumacher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113023", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Carcinoembryonic_Antigen_Related_Cell_Adhesion_Molecules_CEACAM_1_5_and_6_as_Biomarkers_in_Pancreatic_Cancer_/1324501", "title"=>"Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAM) 1, 5 and 6 as Biomarkers in Pancreatic Cancer", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-19 21:39:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1933729"], "description"=>"<p>(A). Basal CEACAM expression varied depending on the CEACAM subtype, highest levels were found for CEACAM 1, intermediate for CEACAM 6 and lowest levels for CEACAM 5. As seen in proliferation (B) and migration assays (C), CEACAM knock down cells showed a higher proliferative and migrative potential compared to control cells. Differences in adhesion on stimulated (TNFα) endothelial cells were not detectable between CEACAM kd and control cells. Neither the average number (D) nor the average adhesion time to the endothelial cells was different (E). Murine xenograft tumors were highly positive for CEACAM 1, 5 and 6. Immunohistochemical staining in control cells showed complete absence of CEACAM expression in immunohistochemistry in knock down cells (F).</p>", "links"=>[], "tags"=>["6 expression", "Elevated CEACAM 6 serum values", "pdac", "ihc", "os", "intraperitoneal mouse xenograft model", "CEACAM 5", "lymph node metastasis", "Pancreatic Cancer BackgroundAim", "CEACAM 6. Patients", "serum CEACAM 1 values"], "article_id"=>1324482, "categories"=>["Biological Sciences"], "users"=>["Florian Gebauer", "Daniel Wicklein", "Jennifer Horst", "Philipp Sundermann", "Hanna Maar", "Thomas Streichert", "Michael Tachezy", "Jakob R. Izbicki", "Maximilian Bockhorn", "Udo Schumacher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113023.g001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CEACAM_levels_decreased_to_lt_5_for_CEACAM_1_5_and_6_after_shRNA_knock_down_as_shown_in_flow_cytometry_/1324482", "title"=>"CEACAM levels decreased to <5% for CEACAM 1, 5 and 6 after shRNA knock down as shown in flow cytometry.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-19 21:39:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1933741"], "description"=>"<p>HR  =  Hazard ratio. T  =  tumor stage. N  =  lymph node stage. M  =  distant metastasis.</p><p>Multivariate cox-regression analysis for immunohistochemical analysis (IHC) and serum analysis (ELISA).</p>", "links"=>[], "tags"=>["6 expression", "Elevated CEACAM 6 serum values", "pdac", "ihc", "os", "intraperitoneal mouse xenograft model", "CEACAM 5", "lymph node metastasis", "Pancreatic Cancer BackgroundAim", "CEACAM 6. Patients", "serum CEACAM 1 values"], "article_id"=>1324494, "categories"=>["Biological Sciences"], "users"=>["Florian Gebauer", "Daniel Wicklein", "Jennifer Horst", "Philipp Sundermann", "Hanna Maar", "Thomas Streichert", "Michael Tachezy", "Jakob R. Izbicki", "Maximilian Bockhorn", "Udo Schumacher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113023.t003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_cox_regression_analysis_for_immunohistochemical_analysis_IHC_and_serum_analysis_ELISA_/1324494", "title"=>"Multivariate cox-regression analysis for immunohistochemical analysis (IHC) and serum analysis (ELISA).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-19 21:39:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1933738"], "description"=>"<p>Immunohistochemical expression of CEACAM 1, 5 and 6, serum expression (ELISA) and correlation with patients' demographic characteristics and clinico-pathological data.</p>", "links"=>[], "tags"=>["6 expression", "Elevated CEACAM 6 serum values", "pdac", "ihc", "os", "intraperitoneal mouse xenograft model", "CEACAM 5", "lymph node metastasis", "Pancreatic Cancer BackgroundAim", "CEACAM 6. Patients", "serum CEACAM 1 values"], "article_id"=>1324491, "categories"=>["Biological Sciences"], "users"=>["Florian Gebauer", "Daniel Wicklein", "Jennifer Horst", "Philipp Sundermann", "Hanna Maar", "Thomas Streichert", "Michael Tachezy", "Jakob R. Izbicki", "Maximilian Bockhorn", "Udo Schumacher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113023.t001", "stats"=>{"downloads"=>3, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemical_expression_of_CEACAM_1_5_and_6_serum_expression_ELISA_and_correlation_with_patients_demographic_characteristics_and_clinico_pathological_data_/1324491", "title"=>"Immunohistochemical expression of CEACAM 1, 5 and 6, serum expression (ELISA) and correlation with patients' demographic characteristics and clinico-pathological data.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-19 21:39:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1933737"], "description"=>"<p>(A–C). CEACAM 1 positive patients showed a median OS of 17.0 months (14.0–20.1 months), CEACAM 1 negative 23.0 months (9.5–36.5 months, P = .279). OS of CEACAM 5 positive patients was 16.0 months (12.8–19.2 months) vs. 22.0 months (4.1–47.9 months) (p = .025). CEACAM 6 positive patients showed an OS of 14.0 months (7.9–20.0) vs. 22.0 months (5.6–38.4 months, P = .010). Survival curves for correlation between overall-survival and CEACAM serum expression (D–F). CEACAM 1 positive patients showed an OS of 11.8 months (2.4–25.2) vs. 18.3 months (10.0–26.2 months, P = .022). Median OS for patients positive for CEACAM 5 was 15.7 months (2.4–32.3 months) vs. 18.6 months (8.7–28.6 months, P = .651), and median OS for patients with CEACAM 6 positivity was 18.8 months (9.5–28.1 months) vs. 12.8 months (3.3–22.3 months, P = .187). Boxplots for CEACAM 1 serum expression (G), CEACAM 5 (H) and CEACAM 6 (I) compared pancreatic ductal adenocarcinoma (PDAC), chronic pancreatic (CP) and healthy blood donors (BD). Receiver operating curve (ROC) for CEACAM serum expression (J).</p>", "links"=>[], "tags"=>["6 expression", "Elevated CEACAM 6 serum values", "pdac", "ihc", "os", "intraperitoneal mouse xenograft model", "CEACAM 5", "lymph node metastasis", "Pancreatic Cancer BackgroundAim", "CEACAM 6. Patients", "serum CEACAM 1 values"], "article_id"=>1324490, "categories"=>["Biological Sciences"], "users"=>["Florian Gebauer", "Daniel Wicklein", "Jennifer Horst", "Philipp Sundermann", "Hanna Maar", "Thomas Streichert", "Michael Tachezy", "Jakob R. Izbicki", "Maximilian Bockhorn", "Udo Schumacher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113023.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_Meier_survival_analysis_log_rank_test_for_correlation_between_overall_survival_OS_and_CEACAM_expression_on_the_TMA_/1324490", "title"=>"Kaplan-Meier survival analysis (log-rank test) for correlation between overall-survival (OS) and CEACAM expression on the TMA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-19 21:39:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1933732"], "description"=>"<p>Intraperitoneally, no differences in the peritoneal carcinomatosis index (PCI) were observed at time of scarification (80 days after injection). CEACAM knock down showed more DNA copies of human DNA in the left lung (P = 0.021) (C) which is correlated with a higher metastatic load in the lung, however, no difference was observed for circulating tumor cells in the blood (D).</p>", "links"=>[], "tags"=>["6 expression", "Elevated CEACAM 6 serum values", "pdac", "ihc", "os", "intraperitoneal mouse xenograft model", "CEACAM 5", "lymph node metastasis", "Pancreatic Cancer BackgroundAim", "CEACAM 6. Patients", "serum CEACAM 1 values"], "article_id"=>1324485, "categories"=>["Biological Sciences"], "users"=>["Florian Gebauer", "Daniel Wicklein", "Jennifer Horst", "Philipp Sundermann", "Hanna Maar", "Thomas Streichert", "Michael Tachezy", "Jakob R. Izbicki", "Maximilian Bockhorn", "Udo Schumacher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113023.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subcutaneous_murine_xenograft_model_showed_prolonged_survival_in_CEACAM_knock_down_group_compared_to_the_control_group_A_/1324485", "title"=>"Subcutaneous murine xenograft model showed prolonged survival in CEACAM knock down group compared to the control group (A).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-19 21:39:56"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[286]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Surgical and invasive medical procedures", "average_usage"=>[248, 388]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[286]}]}
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