Influence of Aerobic Training on the Reduced Vasoconstriction to Angiotensin II in Rats Exposed to Intrauterine Growth Restriction: Possible Role of Oxidative Stress and AT2 Receptor of Angiotensin II
Publication Date
November 18, 2014
Journal
PLOS ONE
Authors
Vanessa Oliveira, Eliana Hiromi Akamine, Maria Helena C. Carvalho, Lisete Compagno Michelini, et al
Volume
9
Issue
11
Pages
e113035
DOI
https://dx.plos.org/10.1371/journal.pone.0113035
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0113035
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25406086
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236150
Europe PMC
http://europepmc.org/abstract/MED/25406086
Web of Science
000347121300072
Scopus
84913528596
Mendeley
http://www.mendeley.com/research/influence-aerobic-training-reduced-vasoconstriction-angiotensin-ii-rats-exposed-intrauterine-growth
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Mendeley | Further Information

{"title"=>"Influence of aerobic training on the reduced vasoconstriction to angiotensin ii in rats exposed to intrauterine growth restriction: Possible role of oxidative stress and at2 receptor of angiotensin II", "type"=>"journal", "authors"=>[{"first_name"=>"Vanessa", "last_name"=>"Oliveira", "scopus_author_id"=>"55357796800"}, {"first_name"=>"Eliana Hiromi", "last_name"=>"Akamine", "scopus_author_id"=>"6506434015"}, {"first_name"=>"Maria Helena C.", "last_name"=>"Carvalho", "scopus_author_id"=>"7201414088"}, {"first_name"=>"Lisete Compagno", "last_name"=>"Michelini", "scopus_author_id"=>"7003379276"}, {"first_name"=>"Zuleica Bruno", "last_name"=>"Fortes", "scopus_author_id"=>"7005995921"}, {"first_name"=>"Tatiana Sousa", "last_name"=>"Cunha", "scopus_author_id"=>"6604001594"}, {"first_name"=>"Maria", "last_name"=>"Do Carmo Franco", "scopus_author_id"=>"56433499900"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84913528596", "pui"=>"600550362", "doi"=>"10.1371/journal.pone.0113035", "isbn"=>"1932-6203", "sgr"=>"84913528596", "pmid"=>"25406086"}, "id"=>"306c66bb-a240-333d-a7f1-75fcbae2b38b", "abstract"=>"Intrauterine growth restriction (IUGR) is associated with impaired vascular function, which contributes to the increased incidence of chronic disease. The aim of this study was to investigate whether aerobic training improves AngII-induced vasoconstriction in IUGR rats. Moreover, we assess the role of superoxide dismutase (SOD) isoforms and NADPH oxidase-derived superoxide anions in this improvement. Female Wistar rats were randomly divided into two groups on day 1 of pregnancy. A control group was fed standard chow ad libitum, and a restricted group was fed 50% of the ad libitum intake throughout gestation. At 8 weeks of age, male offspring from both groups were randomly assigned to 4 experimental groups: sedentary control (SC), trained control (TC), sedentary restricted (SRT), and trained restricted (TRT). The training protocol was performed on a treadmill and consisted of a continuous 60-min session 5 days/week for 10 weeks. Following aerobic training, concentration-response curves to AngII were obtained in endothelium-intact aortic rings. Protein expression of SOD isoforms, AngII receptors and the NADPH oxidase component p47phox was assessed by Western blot analysis. The dihydroethidium was used to evaluate the in situ superoxide levels under basal conditions or in the presence of apocynin, losartan or PD 123,319. Our results indicate that aerobic training can prevent IUGR-associated increases in AngII-dependent vasoconstriction and can restore basal superoxide levels in the aortic rings of TRT rats. Moreover, we observed that aerobic training normalized the increased p47phox protein expression and increased MnSOD and AT2 receptor protein expression in thoracic aortas of SRT rats. In summary, aerobic training can result in an upregulation of antioxidant defense by improved of MnSOD expression and attenuation of NADPH oxidase component p47phox. These effects are accompanied by increased expression of AT2 receptor, which provide positive effects against Ang II-induced superoxide generation, resulting in attenuation of AngII-induced vasoconstriction.", "link"=>"http://www.mendeley.com/research/influence-aerobic-training-reduced-vasoconstriction-angiotensin-ii-rats-exposed-intrauterine-growth", "reader_count"=>17, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>3, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>3, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>4, "Sports and Recreations"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1798533"], "description"=>"<p>(<b>A</b>) Dose-dependent contractions (<b>B</b>) Maximal response to angiotensin II in aortic rings isolated from the sedentary control (SC), sedentary restricted (SRT), trained control (TC), and trained restricted (TRT) groups. Values are expressed as the mean ± SEM from seven animals per group. Two-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training and of their interaction (IUGR X Trained) on the aortic contractile responses. <i>**P = 0.001</i> and <i>***P<0.001</i> in Tukey’s post Hoc test.</p>", "links"=>[], "tags"=>["superoxide dismutase", "Intrauterine Growth Restriction", "Angiotensin II Intrauterine growth restriction", "Aortic rings", "pd", "antioxidant defense", "chow ad libitum", "Protein expression", "Female Wistar rats", "2 receptor", "AngII receptors", "basal superoxide levels", "Reduced Vasoconstriction", "control group", "basal conditions", "day 1", "Western Blot analysis", "oxidative stress", "2 receptor protein expression", "thoracic aortas", "SRT rats", "TRT rats", "MnSOD expression", "IUGR rats", "8 weeks", "superoxide levels", "ad libitum intake", "NADPH oxidase component p 47phox", "p 47phox protein expression", "vasoconstriction", "Rats Exposed", "sc", "aerobic training", "training protocol", "SOD isoforms", "10 weeks", "tc", "Angiotensin II", "Possible Role"], "article_id"=>1245136, "categories"=>["Biological Sciences"], "users"=>["Vanessa Oliveira", "Eliana Hiromi Akamine", "Maria Helena C. Carvalho", "Lisete Compagno Michelini", "Zuleica Bruno Fortes", "Tatiana Sousa Cunha", "Maria do Carmo Franco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113035.g001", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_IUGR_and_aerobic_training_on_the_vascular_reactivity_to_Angiotensin_II_/1245136", "title"=>"Effect of the IUGR and aerobic training on the vascular reactivity to Angiotensin II.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 02:45:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798534"], "description"=>"<p>(<b>A</b>) Histogram and (<b>B</b>) digital images illustrate the presence of superoxide in dihydroethidium (DHE)-treated sections of aortic rings from SC, SRT, TC, and TRT rats. Values are expressed as the means ± SEM from six animals per group. Two-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training and of their interaction (IUGR X Trained). <i>**P = 0.001</i> in Tukey’s post Hoc test.</p>", "links"=>[], "tags"=>["superoxide dismutase", "Intrauterine Growth Restriction", "Angiotensin II Intrauterine growth restriction", "Aortic rings", "pd", "antioxidant defense", "chow ad libitum", "Protein expression", "Female Wistar rats", "2 receptor", "AngII receptors", "basal superoxide levels", "Reduced Vasoconstriction", "control group", "basal conditions", "day 1", "Western Blot analysis", "oxidative stress", "2 receptor protein expression", "thoracic aortas", "SRT rats", "TRT rats", "MnSOD expression", "IUGR rats", "8 weeks", "superoxide levels", "ad libitum intake", "NADPH oxidase component p 47phox", "p 47phox protein expression", "vasoconstriction", "Rats Exposed", "sc", "aerobic training", "training protocol", "SOD isoforms", "10 weeks", "tc", "Angiotensin II", "Possible Role"], "article_id"=>1245137, "categories"=>["Biological Sciences"], "users"=>["Vanessa Oliveira", "Eliana Hiromi Akamine", "Maria Helena C. Carvalho", "Lisete Compagno Michelini", "Zuleica Bruno Fortes", "Tatiana Sousa Cunha", "Maria do Carmo Franco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113035.g002", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_IUGR_and_aerobic_training_on_the_vascular_superoxide_concentration_/1245137", "title"=>"Effect of the IUGR and aerobic training on the vascular superoxide concentration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 02:45:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798535"], "description"=>"<p>Western blot analyses of CuZnSOD (<b>A</b>) and MnSOD (<b>B</b>) protein expression in thoracic aortas from SC, SRT, TC, and TRT rats. Representative immunoblots and the corresponding optical density normalized to the optical density of α-actin. Values are expressed as the mean ± SEM from five animals per group. Two-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training and of their interaction (IUGR X Trained). <i>*P<0.05</i> in Tukey’s post Hoc test.</p>", "links"=>[], "tags"=>["superoxide dismutase", "Intrauterine Growth Restriction", "Angiotensin II Intrauterine growth restriction", "Aortic rings", "pd", "antioxidant defense", "chow ad libitum", "Protein expression", "Female Wistar rats", "2 receptor", "AngII receptors", "basal superoxide levels", "Reduced Vasoconstriction", "control group", "basal conditions", "day 1", "Western Blot analysis", "oxidative stress", "2 receptor protein expression", "thoracic aortas", "SRT rats", "TRT rats", "MnSOD expression", "IUGR rats", "8 weeks", "superoxide levels", "ad libitum intake", "NADPH oxidase component p 47phox", "p 47phox protein expression", "vasoconstriction", "Rats Exposed", "sc", "aerobic training", "training protocol", "SOD isoforms", "10 weeks", "tc", "Angiotensin II", "Possible Role"], "article_id"=>1245138, "categories"=>["Biological Sciences"], "users"=>["Vanessa Oliveira", "Eliana Hiromi Akamine", "Maria Helena C. Carvalho", "Lisete Compagno Michelini", "Zuleica Bruno Fortes", "Tatiana Sousa Cunha", "Maria do Carmo Franco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113035.g003", "stats"=>{"downloads"=>3, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_profile_of_aortic_SOD_isoforms_/1245138", "title"=>"Expression profile of aortic SOD isoforms.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 02:45:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798536"], "description"=>"<p>(<b>A</b>) Histogram and (<b>B</b>) digital images illustrate the presence of superoxide in dihydroethidium (DHE)-treated sections of aortic rings from SC, SRT, TC, and TRT rats under basal conditions and following stimulation with angiotensin II (Ang II: 10<sup>−4 </sup>M). Three-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training, Ang II treatment and of their interactions. Values are expressed as the mean ± SEM from six animals per group. <i>**P = 0.001</i> and <i>*P<0.05</i> in Tukey’s post Hoc test.</p>", "links"=>[], "tags"=>["superoxide dismutase", "Intrauterine Growth Restriction", "Angiotensin II Intrauterine growth restriction", "Aortic rings", "pd", "antioxidant defense", "chow ad libitum", "Protein expression", "Female Wistar rats", "2 receptor", "AngII receptors", "basal superoxide levels", "Reduced Vasoconstriction", "control group", "basal conditions", "day 1", "Western Blot analysis", "oxidative stress", "2 receptor protein expression", "thoracic aortas", "SRT rats", "TRT rats", "MnSOD expression", "IUGR rats", "8 weeks", "superoxide levels", "ad libitum intake", "NADPH oxidase component p 47phox", "p 47phox protein expression", "vasoconstriction", "Rats Exposed", "sc", "aerobic training", "training protocol", "SOD isoforms", "10 weeks", "tc", "Angiotensin II", "Possible Role"], "article_id"=>1245139, "categories"=>["Biological Sciences"], "users"=>["Vanessa Oliveira", "Eliana Hiromi Akamine", "Maria Helena C. Carvalho", "Lisete Compagno Michelini", "Zuleica Bruno Fortes", "Tatiana Sousa Cunha", "Maria do Carmo Franco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113035.g004", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Role_of_the_angiotensin_II_stimulation_on_the_vascular_superoxide_production_/1245139", "title"=>"Role of the angiotensin II stimulation on the vascular superoxide production.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 02:45:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798537"], "description"=>"<p>(<b>A</b>) Histogram and (<b>B</b>) digital images illustrate the presence of superoxide in dihydroethidium (DHE)-treated sections of aortic rings from SC, SRT, TC, and TRT rats under basal conditions and in the presence of losartan (Los: 10<sup>−4 </sup>M). Three-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training, losartan treatment and of their interactions. (<b>C</b>) Representative immunoblots and the corresponding optical density of AT<sub>1</sub> receptors normalized to the optical density of α-actin. Two-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training and of their interaction. Values are expressed as the mean ± SEM from six animals per group. <i>*P<0.05</i> in Tukey’s post Hoc test.</p>", "links"=>[], "tags"=>["superoxide dismutase", "Intrauterine Growth Restriction", "Angiotensin II Intrauterine growth restriction", "Aortic rings", "pd", "antioxidant defense", "chow ad libitum", "Protein expression", "Female Wistar rats", "2 receptor", "AngII receptors", "basal superoxide levels", "Reduced Vasoconstriction", "control group", "basal conditions", "day 1", "Western Blot analysis", "oxidative stress", "2 receptor protein expression", "thoracic aortas", "SRT rats", "TRT rats", "MnSOD expression", "IUGR rats", "8 weeks", "superoxide levels", "ad libitum intake", "NADPH oxidase component p 47phox", "p 47phox protein expression", "vasoconstriction", "Rats Exposed", "sc", "aerobic training", "training protocol", "SOD isoforms", "10 weeks", "tc", "Angiotensin II", "Possible Role"], "article_id"=>1245140, "categories"=>["Biological Sciences"], "users"=>["Vanessa Oliveira", "Eliana Hiromi Akamine", "Maria Helena C. Carvalho", "Lisete Compagno Michelini", "Zuleica Bruno Fortes", "Tatiana Sousa Cunha", "Maria do Carmo Franco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113035.g005", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_AT_1_receptor_antagonist_on_the_vascular_superoxide_production_and_expression_profile_of_aortic_AT_1_receptor_/1245140", "title"=>"Effect of the AT<sub>1</sub> receptor antagonist on the vascular superoxide production and expression profile of aortic AT<sub>1</sub> receptor.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 02:45:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798538"], "description"=>"<p>(<b>A</b>) Histogram and (<b>B</b>) digital images illustrate the presence of superoxide in dihydroethidium (DHE)-treated sections of aortic rings from SC, SRT, TC, and TRT rats under basal conditions and in the presence of apocynin (Apo: 10<sup>−4 </sup>M). Three-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training, apocynin treatment and of their interactions. (<b>C</b>) Representative immunoblots and the corresponding optical density of the p47<sup>phox</sup> subunit normalized to the optical density of α-actin. Two-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training, apocynin treatment and of their interaction. Values are expressed as the mean ± SEM from six animals per group. <i>**P = 0.001</i> and <i>*P<0.05</i> in Tukey’s post Hoc test.</p>", "links"=>[], "tags"=>["superoxide dismutase", "Intrauterine Growth Restriction", "Angiotensin II Intrauterine growth restriction", "Aortic rings", "pd", "antioxidant defense", "chow ad libitum", "Protein expression", "Female Wistar rats", "2 receptor", "AngII receptors", "basal superoxide levels", "Reduced Vasoconstriction", "control group", "basal conditions", "day 1", "Western Blot analysis", "oxidative stress", "2 receptor protein expression", "thoracic aortas", "SRT rats", "TRT rats", "MnSOD expression", "IUGR rats", "8 weeks", "superoxide levels", "ad libitum intake", "NADPH oxidase component p 47phox", "p 47phox protein expression", "vasoconstriction", "Rats Exposed", "sc", "aerobic training", "training protocol", "SOD isoforms", "10 weeks", "tc", "Angiotensin II", "Possible Role"], "article_id"=>1245141, "categories"=>["Biological Sciences"], "users"=>["Vanessa Oliveira", "Eliana Hiromi Akamine", "Maria Helena C. Carvalho", "Lisete Compagno Michelini", "Zuleica Bruno Fortes", "Tatiana Sousa Cunha", "Maria do Carmo Franco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113035.g006", "stats"=>{"downloads"=>3, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_NADPH_oxidase_inhibitor_on_the_vascular_superoxide_production_and_protein_expression_of_aortic_NADPH_subunit_/1245141", "title"=>"Effect of the NADPH-oxidase inhibitor on the vascular superoxide production and protein expression of aortic NADPH subunit.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 02:45:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798539"], "description"=>"<p>(<b>A</b>) Histogram and (<b>B</b>) digital images illustrate the presence of superoxide in dihydroethidium (DHE)-treated sections of aortic rings from SC, SRT, TC, and TRT rats under basal conditions and in the presence of PD 123,319 (PD: 10<sup>−4 </sup>M). Three-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training, PD 123,319 treatment and of their interactions. (<b>C</b>) Representative immunoblots and the corresponding optical density of AT<sub>2</sub> receptors normalized to the optical density of α-actin. Two-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training and of their interaction. Values are expressed as the mean ± SEM from six animals per group. <i>**P = 0.001</i> and <i>*P<0.05</i> in Tukey’s post Hoc test.</p>", "links"=>[], "tags"=>["superoxide dismutase", "Intrauterine Growth Restriction", "Angiotensin II Intrauterine growth restriction", "Aortic rings", "pd", "antioxidant defense", "chow ad libitum", "Protein expression", "Female Wistar rats", "2 receptor", "AngII receptors", "basal superoxide levels", "Reduced Vasoconstriction", "control group", "basal conditions", "day 1", "Western Blot analysis", "oxidative stress", "2 receptor protein expression", "thoracic aortas", "SRT rats", "TRT rats", "MnSOD expression", "IUGR rats", "8 weeks", "superoxide levels", "ad libitum intake", "NADPH oxidase component p 47phox", "p 47phox protein expression", "vasoconstriction", "Rats Exposed", "sc", "aerobic training", "training protocol", "SOD isoforms", "10 weeks", "tc", "Angiotensin II", "Possible Role"], "article_id"=>1245142, "categories"=>["Biological Sciences"], "users"=>["Vanessa Oliveira", "Eliana Hiromi Akamine", "Maria Helena C. Carvalho", "Lisete Compagno Michelini", "Zuleica Bruno Fortes", "Tatiana Sousa Cunha", "Maria do Carmo Franco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113035.g007", "stats"=>{"downloads"=>4, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_AT_2_receptor_antagonist_on_the_vascular_superoxide_production_and_expression_profile_of_aortic_AT_2_receptor_/1245142", "title"=>"Effect of the AT<sub>2</sub> receptor antagonist on the vascular superoxide production and expression profile of aortic AT<sub>2</sub> receptor.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 02:45:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798540"], "description"=>"<p>Values are expressed as the mean ± SEM from six animals per group. Two-way ANOVA analysis was performed to assess the effects of IUGR, aerobic training and of their interaction (IUGR X Trained). <i>**P = 0.001</i> in Tukey’s post Hoc test.</p>", "links"=>[], "tags"=>["superoxide dismutase", "Intrauterine Growth Restriction", "Angiotensin II Intrauterine growth restriction", "Aortic rings", "pd", "antioxidant defense", "chow ad libitum", "Protein expression", "Female Wistar rats", "2 receptor", "AngII receptors", "basal superoxide levels", "Reduced Vasoconstriction", "control group", "basal conditions", "day 1", "Western Blot analysis", "oxidative stress", "2 receptor protein expression", "thoracic aortas", "SRT rats", "TRT rats", "MnSOD expression", "IUGR rats", "8 weeks", "superoxide levels", "ad libitum intake", "NADPH oxidase component p 47phox", "p 47phox protein expression", "vasoconstriction", "Rats Exposed", "sc", "aerobic training", "training protocol", "SOD isoforms", "10 weeks", "tc", "Angiotensin II", "Possible Role"], "article_id"=>1245143, "categories"=>["Biological Sciences"], "users"=>["Vanessa Oliveira", "Eliana Hiromi Akamine", "Maria Helena C. Carvalho", "Lisete Compagno Michelini", "Zuleica Bruno Fortes", "Tatiana Sousa Cunha", "Maria do Carmo Franco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113035.g008", "stats"=>{"downloads"=>3, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_histogram_of_the_AT_1_AT_2_ratio_in_thoracic_aortas_of_SC_SRT_TC_and_TRT_rats_/1245143", "title"=>"Representative histogram of the AT<sub>1</sub>/AT<sub>2</sub> ratio in thoracic aortas of SC, SRT, TC, and TRT rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 02:45:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798541"], "description"=>"<p>Data are mean ±SEM. (n) number of rats.</p>#<p><i>P</i><0.05 <i>vs.</i> SC; TC and TRT after a Tukey’s <i>post hoc</i> test.</p>‡<p><i>P</i><0.05 <i>vs. S</i>C and <sup>‡‡</sup><i>vs.</i> SRT after a <i>Tukey post hoc</i> test.</p><p>Birth Weight, Hemodynamic Measurements, and Maximal Response to Angiotensin II in the experimental groups.</p>", "links"=>[], "tags"=>["superoxide dismutase", "Intrauterine Growth Restriction", "Angiotensin II Intrauterine growth restriction", "Aortic rings", "pd", "antioxidant defense", "chow ad libitum", "Protein expression", "Female Wistar rats", "2 receptor", "AngII receptors", "basal superoxide levels", "Reduced Vasoconstriction", "control group", "basal conditions", "day 1", "Western Blot analysis", "oxidative stress", "2 receptor protein expression", "thoracic aortas", "SRT rats", "TRT rats", "MnSOD expression", "IUGR rats", "8 weeks", "superoxide levels", "ad libitum intake", "NADPH oxidase component p 47phox", "p 47phox protein expression", "vasoconstriction", "Rats Exposed", "sc", "aerobic training", "training protocol", "SOD isoforms", "10 weeks", "tc", "Angiotensin II", "Possible Role"], "article_id"=>1245144, "categories"=>["Biological Sciences"], "users"=>["Vanessa Oliveira", "Eliana Hiromi Akamine", "Maria Helena C. Carvalho", "Lisete Compagno Michelini", "Zuleica Bruno Fortes", "Tatiana Sousa Cunha", "Maria do Carmo Franco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113035.t001", "stats"=>{"downloads"=>4, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Birth_Weight_Hemodynamic_Measurements_and_Maximal_Response_to_Angiotensin_II_in_the_experimental_groups_/1245144", "title"=>"Birth Weight, Hemodynamic Measurements, and Maximal Response to Angiotensin II in the experimental groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-18 02:45:19"}

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Relative Metric

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