Permanent Cardiac Sarcomere Changes in a Rabbit Model of Intrauterine Growth Restriction
Publication Date
November 17, 2014
Journal
PLOS ONE
Authors
Iratxe Torre, Anna González Tendero, Patricia García Cañadilla, Fátima Crispi, et al
Volume
9
Issue
11
Pages
e113067
DOI
https://dx.plos.org/10.1371/journal.pone.0113067
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0113067
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25402351
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234642
Europe PMC
http://europepmc.org/abstract/MED/25402351
Web of Science
000345158700105
Scopus
84913534535
Mendeley
http://www.mendeley.com/research/permanent-cardiac-sarcomere-changes-rabbit-model-intrauterine-growth-restriction
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Mendeley | Further Information

{"title"=>"Permanent cardiac sarcomere changes in a rabbit model of intrauterine growth restriction", "type"=>"journal", "authors"=>[{"first_name"=>"Iratxe", "last_name"=>"Torre", "scopus_author_id"=>"7003962103"}, {"first_name"=>"Anna", "last_name"=>"González-Tendero", "scopus_author_id"=>"54389026500"}, {"first_name"=>"Patricia", "last_name"=>"García-Cañadilla", "scopus_author_id"=>"54388912000"}, {"first_name"=>"Fátima", "last_name"=>"Crispi", "scopus_author_id"=>"8923628700"}, {"first_name"=>"Francisco", "last_name"=>"García-GarciÁa", "scopus_author_id"=>"56433452300"}, {"first_name"=>"Bart", "last_name"=>"Bijnens", "scopus_author_id"=>"7005275311"}, {"first_name"=>"Igor", "last_name"=>"Iruretagoyena", "scopus_author_id"=>"26648529200"}, {"first_name"=>"Joaquin", "last_name"=>"Dopazo", "scopus_author_id"=>"18133480200"}, {"first_name"=>"Ivan", "last_name"=>"Amat-Roldán", "scopus_author_id"=>"8599976700"}, {"first_name"=>"Eduard", "last_name"=>"Gratacós", "scopus_author_id"=>"7005090944"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25402351", "sgr"=>"84913534535", "doi"=>"10.1371/journal.pone.0113067", "scopus"=>"2-s2.0-84913534535", "pui"=>"600550277", "issn"=>"19326203"}, "id"=>"01f3ecbe-1df8-34c9-9445-d4056277a028", "abstract"=>"BACKGROUND: Intrauterine growth restriction (IUGR) induces fetal cardiac remodelling and dysfunction, which persists postnatally and may explain the link between low birth weight and increased cardiovascular mortality in adulthood. However, the cellular and molecular bases for these changes are still not well understood. We tested the hypothesis that IUGR is associated with structural and functional gene expression changes in the fetal sarcomere cytoarchitecture, which remain present in adulthood.\\n\\nMETHODS AND RESULTS: IUGR was induced in New Zealand pregnant rabbits by selective ligation of the utero-placental vessels. Fetal echocardiography demonstrated more globular hearts and signs of cardiac dysfunction in IUGR. Second harmonic generation microscopy (SHGM) showed shorter sarcomere length and shorter A-band and thick-thin filament interaction lengths, that were already present in utero and persisted at 70 postnatal days (adulthood). Sarcomeric M-band (GO: 0031430) functional term was over-represented in IUGR fetal hearts.\\n\\nCONCLUSION: The results suggest that IUGR induces cardiac dysfunction and permanent changes on the sarcomere.", "link"=>"http://www.mendeley.com/research/permanent-cardiac-sarcomere-changes-rabbit-model-intrauterine-growth-restriction", "reader_count"=>33, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Doctoral Student"=>3, "Researcher"=>11, "Student > Ph. D. Student"=>8, "Other"=>1, "Student > Master"=>6, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Doctoral Student"=>3, "Researcher"=>11, "Student > Ph. D. Student"=>8, "Other"=>1, "Student > Master"=>6, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Mathematics"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>15, "Veterinary Science and Veterinary Medicine"=>1, "Physics and Astronomy"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Spain"=>4}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1797326"], "description"=>"<p>A fold change value above 0 indicates up-regulation in IUGR vs. controls.</p><p>Results from most relevant sequences included in M-band functional class identified by FatiScan gene set analysis (M-band (GO: 0031430) block of genes).</p>", "links"=>[], "tags"=>["iugr", "sarcomere cytoarchitecture", "70 postnatal days", "gene expression changes", "new zealand", "dysfunction", "generation microscopy", "rabbit model", "sarcomere length", "Intrauterine Growth Restriction BackgroundIntrauterine growth restriction", "SHGM", "Birth weight", "Fetal echocardiography", "Permanent Cardiac Sarcomere Changes", "adulthood", "globular hearts", "hearts.ConclusionThe results"], "article_id"=>1244123, "categories"=>["Biological Sciences"], "users"=>["Iratxe Torre", "Anna González-Tendero", "Patricia Garcia-Canadilla", "Fatima Crispi", "Francisco García-García", "Bart Bijnens", "Igor Iruretagoyena", "Joaquin Dopazo", "Ivan Amat-Roldan", "Eduard Gratacos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113067.t002", "stats"=>{"downloads"=>2, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_from_most_relevant_sequences_included_in_M_band_functional_class_identified_by_FatiScan_gene_set_analysis_M_band_GO_0031430_block_of_genes_/1244123", "title"=>"Results from most relevant sequences included in M-band functional class identified by FatiScan gene set analysis (M-band (GO: 0031430) block of genes).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-17 03:12:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1797325"], "description"=>"<p>All values are median (interquartile range). P-value was calculated by t-test. <i>g:</i> grams; <i>mm:</i> millimeters; <i>cm/s</i>: centimetres/second. * P-value <0.05.</p><p>Fetal biometric and echocardiographic results in IUGR and control fetuses.</p>", "links"=>[], "tags"=>["iugr", "sarcomere cytoarchitecture", "70 postnatal days", "gene expression changes", "new zealand", "dysfunction", "generation microscopy", "rabbit model", "sarcomere length", "Intrauterine Growth Restriction BackgroundIntrauterine growth restriction", "SHGM", "Birth weight", "Fetal echocardiography", "Permanent Cardiac Sarcomere Changes", "adulthood", "globular hearts", "hearts.ConclusionThe results"], "article_id"=>1244122, "categories"=>["Biological Sciences"], "users"=>["Iratxe Torre", "Anna González-Tendero", "Patricia Garcia-Canadilla", "Fatima Crispi", "Francisco García-García", "Bart Bijnens", "Igor Iruretagoyena", "Joaquin Dopazo", "Ivan Amat-Roldan", "Eduard Gratacos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113067.t001", "stats"=>{"downloads"=>2, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fetal_biometric_and_echocardiographic_results_in_IUGR_and_control_fetuses_/1244122", "title"=>"Fetal biometric and echocardiographic results in IUGR and control fetuses.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-17 03:12:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1797324"], "description"=>"<p>Acyclic graph showing the M-line cellular component significantly over-represented (in red) in IUGR compared to healthy control hearts. In the GO hierarchy, biological knowledge can be represented as a tree where functional terms near the root of the tree make reference to more general concepts while deeper functional terms near the leaves of the tree make reference to more specific concepts. If a gene is annotated to a given level, then is automatically considered to be annotated at all the upper levels up to the root.</p>", "links"=>[], "tags"=>["iugr", "sarcomere cytoarchitecture", "70 postnatal days", "gene expression changes", "new zealand", "dysfunction", "generation microscopy", "rabbit model", "sarcomere length", "Intrauterine Growth Restriction BackgroundIntrauterine growth restriction", "SHGM", "Birth weight", "Fetal echocardiography", "Permanent Cardiac Sarcomere Changes", "adulthood", "globular hearts", "hearts.ConclusionThe results"], "article_id"=>1244121, "categories"=>["Biological Sciences"], "users"=>["Iratxe Torre", "Anna González-Tendero", "Patricia Garcia-Canadilla", "Fatima Crispi", "Francisco García-García", "Bart Bijnens", "Igor Iruretagoyena", "Joaquin Dopazo", "Ivan Amat-Roldan", "Eduard Gratacos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113067.g004", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_ontology_analysis_/1244121", "title"=>"Gene ontology analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-17 03:12:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1797322"], "description"=>"<p><b>A,</b> A representative SHGM image from unstained fetal rabbit left ventricle. The sarcomeres are clearly delimited by thick black lines (Z-discs) and the SHGM signal originates from the thick myosin filaments (in green). In the central region of the myosin filaments appears a thinner black line, identified as the M-band. Scale bar = 20 µm. <b>B</b> and <b>C,</b> show average distances between two consecutive Z-discs (SL) and intrasarcomeric A-bands (ABL), respectively. <b>D,</b> shows thick-thin filament interaction length (TTIL), as the mean width of the A-band-related peaks. Data are expressed as mean ± SD.</p>", "links"=>[], "tags"=>["iugr", "sarcomere cytoarchitecture", "70 postnatal days", "gene expression changes", "new zealand", "dysfunction", "generation microscopy", "rabbit model", "sarcomere length", "Intrauterine Growth Restriction BackgroundIntrauterine growth restriction", "SHGM", "Birth weight", "Fetal echocardiography", "Permanent Cardiac Sarcomere Changes", "adulthood", "globular hearts", "hearts.ConclusionThe results"], "article_id"=>1244119, "categories"=>["Biological Sciences"], "users"=>["Iratxe Torre", "Anna González-Tendero", "Patricia Garcia-Canadilla", "Fatima Crispi", "Francisco García-García", "Bart Bijnens", "Igor Iruretagoyena", "Joaquin Dopazo", "Ivan Amat-Roldan", "Eduard Gratacos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113067.g002", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ultrastructural_sarcomere_changes_in_fetal_hearts_from_IUGR_and_controls_/1244119", "title"=>"Ultrastructural sarcomere changes in fetal hearts from IUGR and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-17 03:12:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1797323"], "description"=>"<p><b>A,</b> Representative SHGM image from unstained adult rabbit left ventricle. Scale bar  = 20 µm. <b>B</b> and <b>C,</b> show average distances between two consecutive Z discs (SL) and two intrasarcomeric A bands (ABL), respectively. <b>D,</b> shows the length of thick-thin filament interaction length (TTIL). Data are expressed as mean ± SD.</p>", "links"=>[], "tags"=>["iugr", "sarcomere cytoarchitecture", "70 postnatal days", "gene expression changes", "new zealand", "dysfunction", "generation microscopy", "rabbit model", "sarcomere length", "Intrauterine Growth Restriction BackgroundIntrauterine growth restriction", "SHGM", "Birth weight", "Fetal echocardiography", "Permanent Cardiac Sarcomere Changes", "adulthood", "globular hearts", "hearts.ConclusionThe results"], "article_id"=>1244120, "categories"=>["Biological Sciences"], "users"=>["Iratxe Torre", "Anna González-Tendero", "Patricia Garcia-Canadilla", "Fatima Crispi", "Francisco García-García", "Bart Bijnens", "Igor Iruretagoyena", "Joaquin Dopazo", "Ivan Amat-Roldan", "Eduard Gratacos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113067.g003", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ultrastructural_sarcomere_changes_in_adult_hearts_from_IUGR_and_controls_/1244120", "title"=>"Ultrastructural sarcomere changes in adult hearts from IUGR and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-17 03:12:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1797321"], "description"=>"<p><b>A</b>, an illustration of the sarcomere elementary parts; <b>B</b>, a sarcomere image by electron microscopy; <b>C</b>, a SHGM image of a myofibril; and <b>D</b>, a SHGM intensity profile along the myofibril showing the distances measured to characterize the sarcomere cytoskeleton: sarcomere length (SL), intra-sarcomeric A-band lengths (ABL) and thick-thin filament interaction length (TTIL).</p>", "links"=>[], "tags"=>["iugr", "sarcomere cytoarchitecture", "70 postnatal days", "gene expression changes", "new zealand", "dysfunction", "generation microscopy", "rabbit model", "sarcomere length", "Intrauterine Growth Restriction BackgroundIntrauterine growth restriction", "SHGM", "Birth weight", "Fetal echocardiography", "Permanent Cardiac Sarcomere Changes", "adulthood", "globular hearts", "hearts.ConclusionThe results"], "article_id"=>1244118, "categories"=>["Biological Sciences"], "users"=>["Iratxe Torre", "Anna González-Tendero", "Patricia Garcia-Canadilla", "Fatima Crispi", "Francisco García-García", "Bart Bijnens", "Igor Iruretagoyena", "Joaquin Dopazo", "Ivan Amat-Roldan", "Eduard Gratacos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113067.g001", "stats"=>{"downloads"=>1, "page_views"=>32, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_representation_of_the_sarcomere_cytoskeleton_distances_/1244118", "title"=>"Schematic representation of the sarcomere cytoskeleton distances.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-17 03:12:43"}

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  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[341, 529]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[285]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 482]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}]}
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