Markers of Bone Metabolism Are Affected by Renal Function and Growth Hormone Therapy in Children with Chronic Kidney Disease
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{"title"=>"Markers of Bone Metabolism Are Affected by Renal Function and Growth Hormone Therapy in Children with Chronic Kidney Disease", "type"=>"journal", "authors"=>[{"first_name"=>"Anke", "last_name"=>"Doyon"}, {"first_name"=>"Dagmar-Christiane", "last_name"=>"Fischer"}, {"first_name"=>"Aysun Karabay", "last_name"=>"Bayazit"}, {"first_name"=>"Nur", "last_name"=>"Canpolat"}, {"first_name"=>"Ali", "last_name"=>"Duzova"}, {"first_name"=>"Betül", "last_name"=>"Sözeri"}, {"first_name"=>"Justine", "last_name"=>"Bacchetta"}, {"first_name"=>"Ayse", "last_name"=>"Balat"}, {"first_name"=>"Anja", "last_name"=>"Büscher"}, {"first_name"=>"Cengiz", "last_name"=>"Candan"}, {"first_name"=>"Nilgun", "last_name"=>"Cakar"}, {"first_name"=>"Osman", "last_name"=>"Donmez"}, {"first_name"=>"Jiri", "last_name"=>"Dusek"}, {"first_name"=>"Martina", "last_name"=>"Heckel"}, {"first_name"=>"Günter", "last_name"=>"Klaus"}, {"first_name"=>"Sevgi", "last_name"=>"Mir"}, {"first_name"=>"Gül", "last_name"=>"Özcelik"}, {"first_name"=>"Lale", "last_name"=>"Sever"}, {"first_name"=>"Rukshana", "last_name"=>"Shroff"}, {"first_name"=>"Enrico", "last_name"=>"Vidal"}, {"first_name"=>"Elke", "last_name"=>"Wühl"}, {"first_name"=>"Matthias", "last_name"=>"Gondan"}, {"first_name"=>"Anette", "last_name"=>"Melk"}, {"first_name"=>"Uwe", "last_name"=>"Querfeld"}, {"first_name"=>"Dieter", "last_name"=>"Haffner"}, {"first_name"=>"Franz", "last_name"=>"Schaefer"}], "year"=>2015, "source"=>"PLOS ONE", "identifiers"=>{"issn"=>"1932-6203", "pmid"=>"25659076", "doi"=>"10.1371/journal.pone.0113482"}, "id"=>"a153b10e-5b8f-3b54-bbeb-efd99d5f6dd7", "abstract"=>"Objectives: The extent and relevance of altered bone metabolism for statural growth in children with chronic kidney disease is controversial. We analyzed the impact of renal dysfunction and recombinant growth hormone therapy on a panel of serum markers of bone metabolism in a large pediatric chronic kidney disease cohort. Methods: Bone alkaline phosphatase (BAP), tartrate-resistant acid phosphatase 5b (TRAP5b), sclerostin and C-terminal FGF-23 (cFGF23) normalized for age and sex were analyzed in 556 children aged 6-18 years with an estimated glomerular filtration rate (eGFR) of 10-60 ml/min/ 1.73m2. 41 children receiving recombinant growth hormone therapy were compared to an untreated matched control group. Results: Standardized levels of BAP, TRAP5b and cFGF-23 were increased whereas sclerostin was reduced. BAP was correlated positively and cFGF-23 inversely with eGFR. Intact serum parathormone was an independent positive predictor of BAP and TRAP5b and negatively associated with sclerostin. BAP and TRAP5B were negatively affected by increased C-reactive protein levels. In children receiving recombinant growth hormone, BAP was higher and TRAP5b lower than in untreated controls. Sclerostin levels were in the normal range and higher than in untreated controls. Serum sclerostin and cFGF-23 independently predicted height standard deviation score, and BAP and TRAP5b the prospective change in height standard deviation score. Conclusion: Markers of bone metabolism indicate a high-bone turnover state in children with chronic kidney disease. Growth hormone induces an osteoanabolic pattern and normalizes osteocyte activity. The osteocyte markers cFGF23 and sclerostin are associated with standardized height, and the markers of bone turnover predict height velocity.", "link"=>"http://www.mendeley.com/research/markers-bone-metabolism-affected-renal-function-growth-hormone-therapy-children-chronic-kidney-disea-3", "reader_count"=>18, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>5, "Other"=>3, "Lecturer > Senior Lecturer"=>2, "Professor"=>3, "Student > Doctoral Student"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>5, "Other"=>3, "Lecturer > Senior Lecturer"=>2, "Professor"=>3, "Student > Doctoral Student"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>2, "Sports and Recreations"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Brazil"=>1, "Australia"=>1, "Portugal"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1883063"], "description"=>"<p>The shaded area depicts the normal range (5<sup>th</sup> to 95<sup>th</sup> percentile of biomarker concentrations in healthy children)[<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113482#pone.0113482.ref008\" target=\"_blank\">8</a>]. Asterisks indicate significant deviation from distribution in the reference population (*: p<0.05, **: p<0.0001 compared to healthy controls).</p>", "links"=>[], "tags"=>["5b", "Intact serum parathormone", "TRAP 5b sclerostin", "normalizes osteocyte activity", "control group.ResultsStandardized levels", "Growth Hormone Therapy", "Chronic Kidney Disease ObjectivesThe extent", "kidney disease", "bone metabolism", "bap", "TRAP 5b", "osteocyte markers cFGF 23", "kidney disease cohort.MethodsBone"], "article_id"=>1302272, "categories"=>["Biological Sciences"], "users"=>["Anke Doyon", "Dagmar-Christiane Fischer", "Aysun Karabay Bayazit", "Nur Canpolat", "Ali Duzova", "Betül Sözeri", "Justine Bacchetta", "Ayse Balat", "Anja Büscher", "Cengiz Candan", "Nilgun Cakar", "Osman Donmez", "Jiri Dusek", "Martina Heckel", "Günter Klaus", "Sevgi Mir", "Gül Özcelik", "Lale Sever", "Rukshana Shroff", "Enrico Vidal", "Elke Wühl", "Matthias Gondan", "Anette Melk", "Uwe Querfeld", "Dieter Haffner", "Franz Schaefer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113482.g002", "stats"=>{"downloads"=>5, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_serum_bone_marker_concentrations_in_510_pediatric_CKD_patients_Data_are_expressed_as_standard_deviation_scores_SDS_/1302272", "title"=>"Distribution of serum bone marker concentrations in 510 pediatric CKD patients. Data are expressed as standard deviation scores (SDS).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-06 03:03:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883070"], "description"=>"<p>BAP SDS was significantly more increased in rhGH treated patients than in the untreated children (p<0.05) (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113482#pone.0113482.g003\" target=\"_blank\">Fig. 3</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113482#pone.0113482.t006\" target=\"_blank\">Table 6</a>). Conversely, TRAP5b SDS was significantly lower in rhGH treated patients than in untreated controls (p<0.05). Sclerostin SDS in rhGH treated patients was not different from healthy controls but significantly higher than in the matched rhGH untreated patients (p<0.005). cFGF-23 did not differ by rhGH treatment status.</p><p>Subject Characteristics for groups matched for GH treatment.</p>", "links"=>[], "tags"=>["5b", "Intact serum parathormone", "TRAP 5b sclerostin", "normalizes osteocyte activity", "control group.ResultsStandardized levels", "Growth Hormone Therapy", "Chronic Kidney Disease ObjectivesThe extent", "kidney disease", "bone metabolism", "bap", "TRAP 5b", "osteocyte markers cFGF 23", "kidney disease cohort.MethodsBone"], "article_id"=>1302279, "categories"=>["Biological Sciences"], "users"=>["Anke Doyon", "Dagmar-Christiane Fischer", "Aysun Karabay Bayazit", "Nur Canpolat", "Ali Duzova", "Betül Sözeri", "Justine Bacchetta", "Ayse Balat", "Anja Büscher", "Cengiz Candan", "Nilgun Cakar", "Osman Donmez", "Jiri Dusek", "Martina Heckel", "Günter Klaus", "Sevgi Mir", "Gül Özcelik", "Lale Sever", "Rukshana Shroff", "Enrico Vidal", "Elke Wühl", "Matthias Gondan", "Anette Melk", "Uwe Querfeld", "Dieter Haffner", "Franz Schaefer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113482.t005", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_Characteristics_for_groups_matched_for_GH_treatment_/1302279", "title"=>"Subject Characteristics for groups matched for GH treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-06 03:03:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883071"], "description"=>"<p>Bone markers in groups matched for GH treatment.</p>", "links"=>[], "tags"=>["5b", "Intact serum parathormone", "TRAP 5b sclerostin", "normalizes osteocyte activity", "control group.ResultsStandardized levels", "Growth Hormone Therapy", "Chronic Kidney Disease ObjectivesThe extent", "kidney disease", "bone metabolism", "bap", "TRAP 5b", "osteocyte markers cFGF 23", "kidney disease cohort.MethodsBone"], "article_id"=>1302280, "categories"=>["Biological Sciences"], "users"=>["Anke Doyon", "Dagmar-Christiane Fischer", "Aysun Karabay Bayazit", "Nur Canpolat", "Ali Duzova", "Betül Sözeri", "Justine Bacchetta", "Ayse Balat", "Anja Büscher", "Cengiz Candan", "Nilgun Cakar", "Osman Donmez", "Jiri Dusek", "Martina Heckel", "Günter Klaus", "Sevgi Mir", "Gül Özcelik", "Lale Sever", "Rukshana Shroff", "Enrico Vidal", "Elke Wühl", "Matthias Gondan", "Anette Melk", "Uwe Querfeld", "Dieter Haffner", "Franz Schaefer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113482.t006", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bone_markers_in_groups_matched_for_GH_treatment_/1302280", "title"=>"Bone markers in groups matched for GH treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-06 03:03:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883066"], "description"=>"<p>Data are given as mean ± SD or median (interquartile range) P values indicate difference of age- and sex-adjusted SDS from reference population. Different superscript letters indicate significant differences (p<0.05) between CKD stages (according to ANOVA using Student-Newman-Keuls grouping).</p><p>A, B & C: Student-Newman-Keuls Grouping—Means with the same letter are not significantly different.</p><p>Distribution of serum bone markers by CKD stage.</p>", "links"=>[], "tags"=>["5b", "Intact serum parathormone", "TRAP 5b sclerostin", "normalizes osteocyte activity", "control group.ResultsStandardized levels", "Growth Hormone Therapy", "Chronic Kidney Disease ObjectivesThe extent", "kidney disease", "bone metabolism", "bap", "TRAP 5b", "osteocyte markers cFGF 23", "kidney disease cohort.MethodsBone"], "article_id"=>1302275, "categories"=>["Biological Sciences"], "users"=>["Anke Doyon", "Dagmar-Christiane Fischer", "Aysun Karabay Bayazit", "Nur Canpolat", "Ali Duzova", "Betül Sözeri", "Justine Bacchetta", "Ayse Balat", "Anja Büscher", "Cengiz Candan", "Nilgun Cakar", "Osman Donmez", "Jiri Dusek", "Martina Heckel", "Günter Klaus", "Sevgi Mir", "Gül Özcelik", "Lale Sever", "Rukshana Shroff", "Enrico Vidal", "Elke Wühl", "Matthias Gondan", "Anette Melk", "Uwe Querfeld", "Dieter Haffner", "Franz Schaefer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113482.t002", "stats"=>{"downloads"=>7, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_serum_bone_markers_by_CKD_stage_/1302275", "title"=>"Distribution of serum bone markers by CKD stage.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-06 03:03:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883065"], "description"=>"<p>Data are given as mean ± SD, median (interquartile range) or n (%) as appropriate.</p><p>At the time of bone marker assessment, 42 children (7.4%) were receiving rhGH treatment, excluding 4 patients who either started or stopped rhGH therapy within 3 months prior to analysis. 38 patients were consistently treated with rhGH during the follow-up period of 6–12 months. rhGH treated patients originated from 7 of the 12 participating countries, had a longer preceding duration of CKD (8.1±4.3 vs 5.9±4.5 years, p<0.003), were taller (-0.89±0.87 vs. -1.4±1.4 SDS, p<0.0002) and showed marginally better current growth rates (0.07±0.38 vs. -0.04±0.38, p = 0.08) compared to all non-rhGH treated patients.</p><p>Subject characteristics.</p>", "links"=>[], "tags"=>["5b", "Intact serum parathormone", "TRAP 5b sclerostin", "normalizes osteocyte activity", "control group.ResultsStandardized levels", "Growth Hormone Therapy", "Chronic Kidney Disease ObjectivesThe extent", "kidney disease", "bone metabolism", "bap", "TRAP 5b", "osteocyte markers cFGF 23", "kidney disease cohort.MethodsBone"], "article_id"=>1302274, "categories"=>["Biological Sciences"], "users"=>["Anke Doyon", "Dagmar-Christiane Fischer", "Aysun Karabay Bayazit", "Nur Canpolat", "Ali Duzova", "Betül Sözeri", "Justine Bacchetta", "Ayse Balat", "Anja Büscher", "Cengiz Candan", "Nilgun Cakar", "Osman Donmez", "Jiri Dusek", "Martina Heckel", "Günter Klaus", "Sevgi Mir", "Gül Özcelik", "Lale Sever", "Rukshana Shroff", "Enrico Vidal", "Elke Wühl", "Matthias Gondan", "Anette Melk", "Uwe Querfeld", "Dieter Haffner", "Franz Schaefer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113482.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_characteristics_/1302274", "title"=>"Subject characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-06 03:03:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883069"], "description"=>"<p>The prospective change in height SDS during one year of observation was positively associated with higher BAP and TRAP5b SDS, lower baseline height SDS and rhGH therapy.</p><p>Interestingly, physical activity showed a positive association to prospective growth.</p><p>A case-control study was performed to obtain an unbiased analysis of the impact of rhGH on the bone marker pattern. For 41 rhGH treated patients an equal number of untreated control subjects matched by age, sex, country of residence, CKD duration, eGFR and serum phosphorus, iPTH and CRP was identified (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113482#pone.0113482.t005\" target=\"_blank\">Table 5</a>).</p><p>Predictors of baseline and prospective change in standardized height in total cohort; results of stepwise multiple linear regression analyses.</p>", "links"=>[], "tags"=>["5b", "Intact serum parathormone", "TRAP 5b sclerostin", "normalizes osteocyte activity", "control group.ResultsStandardized levels", "Growth Hormone Therapy", "Chronic Kidney Disease ObjectivesThe extent", "kidney disease", "bone metabolism", "bap", "TRAP 5b", "osteocyte markers cFGF 23", "kidney disease cohort.MethodsBone"], "article_id"=>1302277, "categories"=>["Biological Sciences"], "users"=>["Anke Doyon", "Dagmar-Christiane Fischer", "Aysun Karabay Bayazit", "Nur Canpolat", "Ali Duzova", "Betül Sözeri", "Justine Bacchetta", "Ayse Balat", "Anja Büscher", "Cengiz Candan", "Nilgun Cakar", "Osman Donmez", "Jiri Dusek", "Martina Heckel", "Günter Klaus", "Sevgi Mir", "Gül Özcelik", "Lale Sever", "Rukshana Shroff", "Enrico Vidal", "Elke Wühl", "Matthias Gondan", "Anette Melk", "Uwe Querfeld", "Dieter Haffner", "Franz Schaefer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113482.t004", "stats"=>{"downloads"=>7, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Predictors_of_baseline_and_prospective_change_in_standardized_height_in_total_cohort_results_of_stepwise_multiple_linear_regression_analyses_/1302277", "title"=>"Predictors of baseline and prospective change in standardized height in total cohort; results of stepwise multiple linear regression analyses.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-06 03:03:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883067"], "description"=>"<p>Predictors of standardized bone marker concentrations; results of stepwise multiple linear regression analyses.</p>", "links"=>[], "tags"=>["5b", "Intact serum parathormone", "TRAP 5b sclerostin", "normalizes osteocyte activity", "control group.ResultsStandardized levels", "Growth Hormone Therapy", "Chronic Kidney Disease ObjectivesThe extent", "kidney disease", "bone metabolism", "bap", "TRAP 5b", "osteocyte markers cFGF 23", "kidney disease cohort.MethodsBone"], "article_id"=>1302276, "categories"=>["Biological Sciences"], "users"=>["Anke Doyon", "Dagmar-Christiane Fischer", "Aysun Karabay Bayazit", "Nur Canpolat", "Ali Duzova", "Betül Sözeri", "Justine Bacchetta", "Ayse Balat", "Anja Büscher", "Cengiz Candan", "Nilgun Cakar", "Osman Donmez", "Jiri Dusek", "Martina Heckel", "Günter Klaus", "Sevgi Mir", "Gül Özcelik", "Lale Sever", "Rukshana Shroff", "Enrico Vidal", "Elke Wühl", "Matthias Gondan", "Anette Melk", "Uwe Querfeld", "Dieter Haffner", "Franz Schaefer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113482.t003", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Predictors_of_standardized_bone_marker_concentrations_results_of_stepwise_multiple_linear_regression_analyses_/1302276", "title"=>"Predictors of standardized bone marker concentrations; results of stepwise multiple linear regression analyses.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-06 03:03:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883064"], "description"=>"<p>Data are expressed as standard deviation scores (SDS). The shaded area depicts the normal range (5<sup>th</sup> to 95<sup>th</sup> percentile of biomarker concentrations in healthy children)<sup>8</sup>. Asterisks indicate significant deviation from distribution in the reference population (*: p<0.05, **: p<0.01).</p>", "links"=>[], "tags"=>["5b", "Intact serum parathormone", "TRAP 5b sclerostin", "normalizes osteocyte activity", "control group.ResultsStandardized levels", "Growth Hormone Therapy", "Chronic Kidney Disease ObjectivesThe extent", "kidney disease", "bone metabolism", "bap", "TRAP 5b", "osteocyte markers cFGF 23", "kidney disease cohort.MethodsBone"], "article_id"=>1302273, "categories"=>["Biological Sciences"], "users"=>["Anke Doyon", "Dagmar-Christiane Fischer", "Aysun Karabay Bayazit", "Nur Canpolat", "Ali Duzova", "Betül Sözeri", "Justine Bacchetta", "Ayse Balat", "Anja Büscher", "Cengiz Candan", "Nilgun Cakar", "Osman Donmez", "Jiri Dusek", "Martina Heckel", "Günter Klaus", "Sevgi Mir", "Gül Özcelik", "Lale Sever", "Rukshana Shroff", "Enrico Vidal", "Elke Wühl", "Matthias Gondan", "Anette Melk", "Uwe Querfeld", "Dieter Haffner", "Franz Schaefer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113482.g003", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_serum_bone_marker_concentrations_in_children_with_and_without_rhGH_treatment_n_41_per_group_/1302273", "title"=>"Distribution of serum bone marker concentrations in children with and without rhGH treatment (n = 41 per group).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-06 03:03:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883062"], "description"=>"<p>Patient inclusion criteria and subgroups for cross-sectional analysis of bone markers, influence of rhGH treatment and predictors of height and growth.</p>", "links"=>[], "tags"=>["5b", "Intact serum parathormone", "TRAP 5b sclerostin", "normalizes osteocyte activity", "control group.ResultsStandardized levels", "Growth Hormone Therapy", "Chronic Kidney Disease ObjectivesThe extent", "kidney disease", "bone metabolism", "bap", "TRAP 5b", "osteocyte markers cFGF 23", "kidney disease cohort.MethodsBone"], "article_id"=>1302271, "categories"=>["Biological Sciences"], "users"=>["Anke Doyon", "Dagmar-Christiane Fischer", "Aysun Karabay Bayazit", "Nur Canpolat", "Ali Duzova", "Betül Sözeri", "Justine Bacchetta", "Ayse Balat", "Anja Büscher", "Cengiz Candan", "Nilgun Cakar", "Osman Donmez", "Jiri Dusek", "Martina Heckel", "Günter Klaus", "Sevgi Mir", "Gül Özcelik", "Lale Sever", "Rukshana Shroff", "Enrico Vidal", "Elke Wühl", "Matthias Gondan", "Anette Melk", "Uwe Querfeld", "Dieter Haffner", "Franz Schaefer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113482.g001", "stats"=>{"downloads"=>4, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_inclusion_criteria_and_subgroups_for_cross_sectional_analysis_of_bone_markers_influence_of_rhGH_treatment_and_predictors_of_height_and_growth_/1302271", "title"=>"Patient inclusion criteria and subgroups for cross-sectional analysis of bone markers, influence of rhGH treatment and predictors of height and growth.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-06 03:03:37"}

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  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"61", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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