Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Pu-Erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in caenorhaditis elegans", "type"=>"journal", "authors"=>[{"first_name"=>"Yihong", "last_name"=>"Ding", "scopus_author_id"=>"56389894200"}, {"first_name"=>"Xiaoju", "last_name"=>"Zou", "scopus_author_id"=>"55618957100"}, {"first_name"=>"Xue", "last_name"=>"Jiang", "scopus_author_id"=>"56512794500"}, {"first_name"=>"Jieyu", "last_name"=>"Wu", "scopus_author_id"=>"56512637100"}, {"first_name"=>"Yuru", "last_name"=>"Zhang", "scopus_author_id"=>"55205193200"}, {"first_name"=>"Dan", "last_name"=>"Chen", "scopus_author_id"=>"56901550400"}, {"first_name"=>"Bin", "last_name"=>"Liang", "scopus_author_id"=>"36114429800"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84922620623", "pui"=>"602151143", "pmid"=>"25659129", "issn"=>"19326203", "scopus"=>"2-s2.0-84922620623", "doi"=>"10.1371/journal.pone.0113815"}, "id"=>"7c0f2136-f142-393e-b9d9-935d99116342", "abstract"=>"Consumption of Pu-erh has been reported to result in numerous health benefits, but the mechanisms underlying purported weight-loss and lowering of lipid are poorly understood. Here, we used the nematode Caenorhaditis elegans to explore the water extract of Pu-erh tea (PTE) functions to reduce fat storage. We found that PTE down-regulates the expression of the master fat regulator SBP-1, a homologue of sterol regulatory element binding protein (SREBP) and its target stearoyl-CoA desaturase (SCD), a key enzyme in fat biosynthesis, leading to an increased ratio of stearic acid (C18:0) to oleic acid (C18:1n-9), and subsequently decreased fat storage. We also found that both the pharyngeal pumping rate and food uptake of C. elegans decreased with exposure to PTE. Collectively, these results provide an experimental basis for explaining the ability of Pu-erh tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD, thereby reducing fat storage.", "link"=>"http://www.mendeley.com/research/puerh-tea-downregulates-sterol-regulatory-elementbinding-protein-stearyolcoa-desaturase-reduce-fat-s", "reader_count"=>10, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84922620623"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84922620623?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84922620623&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84922620623&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84922620623", "dc:identifier"=>"SCOPUS_ID:84922620623", "eid"=>"2-s2.0-84922620623", "dc:title"=>"Pu-Erh tea down-regulates sterol regulatory element-binding protein and stearyol-CoA desaturase to reduce fat storage in caenorhaditis elegans", "dc:creator"=>"Ding Y.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"10", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-02-06", "prism:coverDisplayDate"=>"6 February 2015", "prism:doi"=>"10.1371/journal.pone.0113815", "citedby-count"=>"20", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Chinese Academy of Sciences", "affiliation-city"=>"Beijing", "affiliation-country"=>"China"}], "pubmed-id"=>"25659129", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"0113815", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0113815", "share_count"=>2, "like_count"=>3, "comment_count"=>3, "click_count"=>0, "total_count"=>8}

Counter

  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"102", "xml_views"=>"8", "html_views"=>"811"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"39", "xml_views"=>"1", "html_views"=>"207"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"133"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"63"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"51"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"106"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"5", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1883746"], "description"=>"<p>Pu-erh tea down-regulates the pumping rate, food uptake, as well as the expression of SBP-1 and SCD that reduces the conversion of stearic acid (C18:0) to oleic acid (C18:n-9), eventually reduces the fat accumulation in <i>C</i>. <i>elegans</i>. Green arrow indicated reduction. Dashed arrow indicated unclear relationship.</p>", "links"=>[], "tags"=>["food uptake", "pte", "storage", "element binding protein", "biosynthesi", "scd", "Caenorhaditis elegans Consumption", "nematode Caenorhaditis elegans", "sbp", "acid", "srebp"], "article_id"=>1302750, "categories"=>["Uncategorised"], "users"=>["YiHong Ding", "XiaoJu Zou", "Xue Jiang", "JieYu Wu", "YuRu Zhang", "Dan Chen", "Bin Liang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113815.g006", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_model_of_Pu_erh_tea_reducing_fat_storage_/1302750", "title"=>"A model of Pu-erh tea reducing fat storage.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-06 04:01:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883743"], "description"=>"<p>(a) The pumping rate of pharynx was gradually decreased with the increased concentrations of PTE. Data were the mean ± SEM of 12 worms. (*: P<0.05, **: P<0.01). (b) PTE inhibited the uptake of <i>E</i>. <i>coli</i> food indicated by GFP intensity (∼80% worms showed consistent reduction of expression, around 50 worms totally observed in three biological replicates). Anterior is in left, posterior is in right. Scale bar is 50 um.</p>", "links"=>[], "tags"=>["food uptake", "pte", "storage", "element binding protein", "biosynthesi", "scd", "Caenorhaditis elegans Consumption", "nematode Caenorhaditis elegans", "sbp", "acid", "srebp"], "article_id"=>1302747, "categories"=>["Uncategorised"], "users"=>["YiHong Ding", "XiaoJu Zou", "Xue Jiang", "JieYu Wu", "YuRu Zhang", "Dan Chen", "Bin Liang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113815.g004", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PTE_inhibited_food_uptake_/1302747", "title"=>"PTE inhibited food uptake.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-06 04:01:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883742"], "description"=>"<p>(a) PTE did not affect the expression of FAT-6::GFP (around 60 worms totally observed in three biological replicates), but gradually decreased the fluorescent intensity of FAT-7::GFP and SBP-1::GFP (> 80% worms showed consistent reduction of expression, around 60 worms totally observed in three biological replicates). Scale bar is 20 μm. (b) Relative expression levels of <i>sbp-1</i>, <i>fat-5</i>, <i>fat-6</i>, and <i>fat-7</i> measured by QPCR were significantly decreased with the increased concentrations of PTE. Data were the mean ± SEM of three independent biological replicates. (*: P<0.05, **: P<0.01, ***: P<0.001). (c) Relative expression levels of <i>pod-2</i> and <i>fasn-1</i> measured by QPCR. Data were the mean ± SEM of three independent biological replicates. (d) Fat storage indicated by Nile Red staining of fixation was gradually decreased in N2 worms, but not in <i>sbp-1</i> and <i>fat-6;fat-7</i> worms with the increased concentrations of PTE. The anterior is in left and the posterior is in the right. Scale bar is 10 μm. (e) Lipid droplet size was significantly decreased in N2 worms, but not in <i>sbp-1</i> and <i>fat-6;fat-7</i> worms, with the increased concentrations of PTE. Data were the mean ± SEM of 6 worms. (**: P<0.01, ***: P<0.001). (f) % of TAG/TL of <i>fat-6;fat-7</i> and <i>sbp-1</i> mutants treated with PTE. Data were the mean ± SEM of four independent biological replicates. (g) PTE significantly decreased the fat content of <i>KQ377</i> worms. Data were the mean ± SEM of four independent biological replicates.</p>", "links"=>[], "tags"=>["food uptake", "pte", "storage", "element binding protein", "biosynthesi", "scd", "Caenorhaditis elegans Consumption", "nematode Caenorhaditis elegans", "sbp", "acid", "srebp"], "article_id"=>1302746, "categories"=>["Uncategorised"], "users"=>["YiHong Ding", "XiaoJu Zou", "Xue Jiang", "JieYu Wu", "YuRu Zhang", "Dan Chen", "Bin Liang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113815.g003", "stats"=>{"downloads"=>1, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PTE_down_regulated_the_expression_of_SBP_1_and_SCD_/1302746", "title"=>"PTE down-regulated the expression of SBP-1 and SCD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-06 04:01:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883745"], "description"=>"<p>(a) Mean of daily laid progeny (n = 20 worms for each treatment). (b) Mean of progeny (n = 20 worms for each treatment). (c) Growth rate, n = 442, 560, 496, and 620 worms for 0 g/ml, 0.0125 g/ml, 0.025 g/ml,0.05 g/ml, respectively. (d) Lifespan, n = 189, 287, 303, and 266 worms for 0 g/ml, 0.0125 g/ml, 0.025 g/ml,0.05 g/ml, respectively.</p>", "links"=>[], "tags"=>["food uptake", "pte", "storage", "element binding protein", "biosynthesi", "scd", "Caenorhaditis elegans Consumption", "nematode Caenorhaditis elegans", "sbp", "acid", "srebp"], "article_id"=>1302749, "categories"=>["Uncategorised"], "users"=>["YiHong Ding", "XiaoJu Zou", "Xue Jiang", "JieYu Wu", "YuRu Zhang", "Dan Chen", "Bin Liang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113815.g005", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PTE_affected_growth_brood_size_and_lifespan_/1302749", "title"=>"PTE affected growth, brood size, and lifespan.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-06 04:01:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883741"], "description"=>"<p>PTE significantly decreased the levels of oleic acid (C18:1n-9) and linolenic acid (C18:2), but increased the level of stearic acid (C18:0) (a), decreased the ratio of C18:1n-9/C18:0 (b), changed the levels of oleic acid (C18:1n-9) (c) as well as the ratio of C18:1n-9/C18:0 only in triglycerides (d). Data were presented as mean ± SEM of four independent biological replicates. (*: P<0.05, **: P<0.01, ***: P<0.001).</p>", "links"=>[], "tags"=>["food uptake", "pte", "storage", "element binding protein", "biosynthesi", "scd", "Caenorhaditis elegans Consumption", "nematode Caenorhaditis elegans", "sbp", "acid", "srebp"], "article_id"=>1302745, "categories"=>["Uncategorised"], "users"=>["YiHong Ding", "XiaoJu Zou", "Xue Jiang", "JieYu Wu", "YuRu Zhang", "Dan Chen", "Bin Liang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113815.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PTE_modified_the_level_of_fatty_acid_compositions_/1302745", "title"=>"PTE modified the level of fatty acid compositions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-06 04:01:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883739"], "description"=>"<p>(a) Fat storage indicated by Nile Red staining of fixed late L4 N2 worms treated with different concentrations of PTE. The anterior is in left and the posterior is in the right (Representative sample of around 50 worms totally observed in three biological replicates for each PTE treatment). Scale bar is 50 μm. (b) Relative TAG (triacylglycerol) content in total lipids (triacylglycerol+phospholipids, % TAG/TL) determined by TLC/GC. TAG content was significantly decreased at 0.05 g/ml concentration of PTE (**: P<0.01, *: P<0.05). Data were the mean ± SEM of four independent biological replicates. (c) Quantitation of the lipid droplet size. Lipid droplet size was correspondingly decreased with the increased concentrations of PTE (**: P<0.01, ***: P<0.001). Data were the mean ± SEM of 10 worms. (d) Distribution of lipid droplets. PTE gradually increased the percentage of small size lipid droplets (0–1 um in diameter), but decreased the percentage of large size lipid droplets (>1um in diameter). Data were the mean ± SEM of 10 worms.</p>", "links"=>[], "tags"=>["food uptake", "pte", "storage", "element binding protein", "biosynthesi", "scd", "Caenorhaditis elegans Consumption", "nematode Caenorhaditis elegans", "sbp", "acid", "srebp"], "article_id"=>1302743, "categories"=>["Uncategorised"], "users"=>["YiHong Ding", "XiaoJu Zou", "Xue Jiang", "JieYu Wu", "YuRu Zhang", "Dan Chen", "Bin Liang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0113815.g001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PTE_reduced_fat_storage_and_lipid_droplet_size_/1302743", "title"=>"PTE reduced fat storage and lipid droplet size.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-06 04:01:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/1883753", "https://ndownloader.figshare.com/files/1883754"], "description"=>"<div><p>Consumption of Pu-erh has been reported to result in numerous health benefits, but the mechanisms underlying purported weight-loss and lowering of lipid are poorly understood. Here, we used the nematode <i>Caenorhaditis elegans</i> to explore the water extract of Pu-erh tea (PTE) functions to reduce fat storage. We found that PTE down-regulates the expression of the master fat regulator SBP-1, a homologue of sterol regulatory element binding protein (SREBP) and its target stearoyl-CoA desaturase (SCD), a key enzyme in fat biosynthesis, leading to an increased ratio of stearic acid (C18:0) to oleic acid (C18:1n-9), and subsequently decreased fat storage. We also found that both the pharyngeal pumping rate and food uptake of <i>C. elegans</i> decreased with exposure to PTE. Collectively, these results provide an experimental basis for explaining the ability of Pu-erh tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD, thereby reducing fat storage.</p></div>", "links"=>[], "tags"=>["food uptake", "pte", "storage", "element binding protein", "biosynthesi", "scd", "Caenorhaditis elegans Consumption", "nematode Caenorhaditis elegans", "sbp", "acid", "srebp"], "article_id"=>1302757, "categories"=>["Uncategorised"], "users"=>["YiHong Ding", "XiaoJu Zou", "Xue Jiang", "JieYu Wu", "YuRu Zhang", "Dan Chen", "Bin Liang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0113815.s001", "https://dx.doi.org/10.1371/journal.pone.0113815.s002"], "stats"=>{"downloads"=>4, "page_views"=>36, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Pu_Erh_Tea_Down_Regulates_Sterol_Regulatory_Element_Binding_Protein_and_Stearyol_CoA_Desaturase_to_Reduce_Fat_Storage_in_Caenorhaditis_elegans_/1302757", "title"=>"Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in <i>Caenorhaditis elegans</i>", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-02-06 04:01:31"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"30", "full-text"=>"35", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"62", "full-text"=>"43", "pdf"=>"42", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"35", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"25", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"60", "full-text"=>"25", "pdf"=>"181", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"32", "full-text"=>"21", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"28", "full-text"=>"31", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"31", "full-text"=>"26", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"30", "full-text"=>"31", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"22", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"32", "full-text"=>"50", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"20", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"25", "full-text"=>"30", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"40", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"22", "full-text"=>"52", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"27", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"33", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"37", "full-text"=>"39", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"32", "full-text"=>"40", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"34", "full-text"=>"28", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"35", "full-text"=>"35", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
Loading … Spinner
There are currently no alerts