Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial)
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{"title"=>"Randomised trial of text messaging on adherence to cardiovascular preventive treatment (INTERACT Trial)", "type"=>"journal", "authors"=>[{"first_name"=>"David S.", "last_name"=>"Wald", "scopus_author_id"=>"7005483943"}, {"first_name"=>"Jonathan P.", "last_name"=>"Bestwick", "scopus_author_id"=>"14027999700"}, {"first_name"=>"Lewis", "last_name"=>"Raiman", "scopus_author_id"=>"55847772100"}, {"first_name"=>"Rebecca", "last_name"=>"Brendell", "scopus_author_id"=>"56447149900"}, {"first_name"=>"Nicholas J.", "last_name"=>"Wald", "scopus_author_id"=>"24447332500"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25479285", "doi"=>"10.1371/journal.pone.0114268", "issn"=>"19326203", "pui"=>"600696810", "isbn"=>"1932-6203", "sgr"=>"84917708500", "scopus"=>"2-s2.0-84917708500"}, "id"=>"53ed88e0-534c-32dd-b13b-551575058618", "abstract"=>"BACKGROUND: About one third of patients prescribed blood pressure or lipid-lowering drugs for the prevention of coronary heart disease and stroke do not take their medication as prescribed. We conducted a randomized trial to evaluate text messaging as a means of improving adherence to cardiovascular disease preventive treatment. METHODS: 303 patients taking blood pressure and/or lipid-lowering medications were randomly assigned to being sent text messages (Text group, 151) or not being sent them (No text group, 152). Texts were sent daily for 2 weeks, alternate days for 2 weeks and weekly thereafter for 22 weeks (6 months overall), using an automated computer programme. Patients were asked to respond on whether they had taken their medication, whether the text reminded them to do so if they had forgotten, and if they had not taken their medication to determine if there was a reason for not doing so. At 6 months, use of medication was assessed. RESULTS: Two patients were lost to follow-up, providing data on 301 for analysis. In the No text group 38/151 (25%) took less than 80% of the prescribed regimen (ie. stopped medication completely or took it on fewer than 22 of the last 28 days of follow-up) compared to 14/150 patients (9%) in the Text group - an improvement in adherence affecting 16 per 100 patients (95% CI 7 to 24), p<0.001. The texts reminded 98/151 patients (65%) to take medication on at least one occasion and lead to 20/151 (13%) who stopped taking medication because of concern over efficacy or side-effects, resuming treatment. CONCLUSIONS: In patients taking blood pressure or lipid-lowering treatment for the prevention of cardiovascular disease, text messaging improved medication adherence compared with no text messaging. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN74757601.", "link"=>"http://www.mendeley.com/research/randomised-trial-text-messaging-adherence-cardiovascular-preventive-treatment-interact-trial", "reader_count"=>69, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>20, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>5, "Student > Master"=>11, "Other"=>5, "Student > Bachelor"=>9, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>20, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>5, "Student > Master"=>11, "Other"=>5, "Student > Bachelor"=>9, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>10, "Nursing and Health Professions"=>7, "Mathematics"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>28, "Arts and Humanities"=>2, "Philosophy"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>6, "Social Sciences"=>7, "Computer Science"=>1, "Decision Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>28}, "Social Sciences"=>{"Social Sciences"=>7}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Psychology"=>{"Psychology"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>7}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>10}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>2}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>3, "United Kingdom"=>2, "Switzerland"=>2}, "group_count"=>11}

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  • {"files"=>["https://ndownloader.figshare.com/files/1825781"], "description"=>"<p>Trial Flow Diagram.</p>", "links"=>[], "tags"=>["isrctn", "treatment.Methods 303 patients", "ci", "2 weeks", "medication", "blood pressure", "interact", "text messaging"], "article_id"=>1262368, "categories"=>["Biological Sciences"], "users"=>["David S. Wald", "Jonathan P. Bestwick", "Lewis Raiman", "Rebecca Brendell", "Nicholas J. Wald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114268.g001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trial_Flow_Diagram_/1262368", "title"=>"Trial Flow Diagram.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-12-05 02:54:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1825786"], "description"=>"<div><p>Background</p><p>About one third of patients prescribed blood pressure or lipid-lowering drugs for the prevention of coronary heart disease and stroke do not take their medication as prescribed. We conducted a randomized trial to evaluate text messaging as a means of improving adherence to cardiovascular disease preventive treatment.</p><p>Methods</p><p>303 patients taking blood pressure and/or lipid-lowering medications were randomly assigned to being sent text messages (Text group, 151) or not being sent them (No text group, 152). Texts were sent daily for 2 weeks, alternate days for 2 weeks and weekly thereafter for 22 weeks (6 months overall), using an automated computer programme. Patients were asked to respond on whether they had taken their medication, whether the text reminded them to do so if they had forgotten, and if they had not taken their medication to determine if there was a reason for not doing so. At 6 months, use of medication was assessed.</p><p>Results</p><p>Two patients were lost to follow-up, providing data on 301 for analysis. In the No text group 38/151 (25%) took less than 80% of the prescribed regimen (ie. stopped medication completely or took it on fewer than 22 of the last 28 days of follow-up) compared to 14/150 patients (9%) in the Text group – an improvement in adherence affecting 16 per 100 patients (95% CI 7 to 24), p<0.001. The texts reminded 98/151 patients (65%) to take medication on at least one occasion and lead to 20/151 (13%) who stopped taking medication because of concern over efficacy or side-effects, resuming treatment.</p><p>Conclusions</p><p>In patients taking blood pressure or lipid-lowering treatment for the prevention of cardiovascular disease, text messaging improved medication adherence compared with no text messaging.</p><p>Trial Registration</p><p>Controlled-Trials.com <a href=\"http://controlled-trials.com/ISRCTN74757601\" target=\"_blank\">ISRCTN74757601</a></p></div>", "links"=>[], "tags"=>["isrctn", "treatment.Methods 303 patients", "ci", "2 weeks", "medication", "blood pressure", "interact", "text messaging"], "article_id"=>1262372, "categories"=>["Biological Sciences"], "users"=>["David S. Wald", "Jonathan P. Bestwick", "Lewis Raiman", "Rebecca Brendell", "Nicholas J. Wald"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0114268.s002"], "stats"=>{"downloads"=>15, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Randomised_Trial_of_Text_Messaging_on_Adherence_to_Cardiovascular_Preventive_Treatment_INTERACT_Trial_/1262372", "title"=>"Randomised Trial of Text Messaging on Adherence to Cardiovascular Preventive Treatment (INTERACT Trial)", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-12-05 02:54:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1825783"], "description"=>"<p>ACE - Angiotensin converting enzyme, ARB - Angiotensin Receptor Blocker, CCB – Calcium channel blocker</p><p>Baseline characteristics of the trial participants.</p>", "links"=>[], "tags"=>["isrctn", "treatment.Methods 303 patients", "ci", "2 weeks", "medication", "blood pressure", "interact", "text messaging"], "article_id"=>1262369, "categories"=>["Biological Sciences"], "users"=>["David S. Wald", "Jonathan P. Bestwick", "Lewis Raiman", "Rebecca Brendell", "Nicholas J. Wald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114268.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_the_trial_participants_/1262369", "title"=>"Baseline characteristics of the trial participants.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-05 02:54:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1825784"], "description"=>"<p>*imputed data for 1 patient in Text group (11 v 10 observed) and 3 in the No text group (22 v 19 observed) for patients who could not be contacted.</p><p>Use of medication at 6 months according to trial group.</p>", "links"=>[], "tags"=>["isrctn", "treatment.Methods 303 patients", "ci", "2 weeks", "medication", "blood pressure", "interact", "text messaging"], "article_id"=>1262370, "categories"=>["Biological Sciences"], "users"=>["David S. Wald", "Jonathan P. Bestwick", "Lewis Raiman", "Rebecca Brendell", "Nicholas J. Wald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114268.t002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Use_of_medication_at_6_months_according_to_trial_group_/1262370", "title"=>"Use of medication at 6 months according to trial group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-05 02:54:00"}

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Relative Metric

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