Adiposity in Early, Middle and Later Adult Life and Cardiometabolic Risk Markers in Later Life; Findings from the British Regional Heart Study
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{"title"=>"Adiposity in early, middle and later adult life and cardiometabolic risk markers in later life; Findings from the British regional heart study", "type"=>"journal", "authors"=>[{"first_name"=>"Venediktos V.", "last_name"=>"Kapetanakis", "scopus_author_id"=>"55337674700"}, {"first_name"=>"Alicja R.", "last_name"=>"Rudnicka", "scopus_author_id"=>"6603711082"}, {"first_name"=>"Andrea K.", "last_name"=>"Wathern", "scopus_author_id"=>"36574472400"}, {"first_name"=>"Lucy", "last_name"=>"Lennon", "scopus_author_id"=>"6603033975"}, {"first_name"=>"Olia", "last_name"=>"Papacosta", "scopus_author_id"=>"6603773732"}, {"first_name"=>"Derek G.", "last_name"=>"Cook", "scopus_author_id"=>"7403472903"}, {"first_name"=>"S. Goya", "last_name"=>"Wannamethee", "scopus_author_id"=>"7006543768"}, {"first_name"=>"Peter H.", "last_name"=>"Whincup", "scopus_author_id"=>"7006237290"}, {"first_name"=>"Christopher G.", "last_name"=>"Owen", "scopus_author_id"=>"7202893034"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84916197412", "doi"=>"10.1371/journal.pone.0114289", "sgr"=>"84916197412", "pmid"=>"25474626", "issn"=>"19326203", "pui"=>"600684414"}, "id"=>"119e18a9-a9e3-3072-af0b-0006e6351612", "abstract"=>"OBJECTIVES This research investigates the associations between body mass index (BMI) at 21, 40-59, 60-79 years of age on cardiometabolic risk markers at 60-79 years. METHODS A prospective study of 3464 British men with BMI measured at 40-59 and 60-79 years, when cardiometabolic risk was assessed. BMI at 21 years was ascertained from military records, or recalled from middle-age (adjusted for reporting bias); associations between BMI at different ages and later cardiometabolic risk markers were examined using linear regression. Sensitive period, accumulation and mobility life course models were devised for high BMI (defined as BMI≥75th centile) and compared with a saturated BMI trajectory model. RESULTS At ages 21, 40-59 and 60-79 years, prevalences of overweight (BMI≥25 kg/m2) were 12%, 53%, 70%, and obesity (≥30 kg/m2) 1.6%, 6.6%, and 17.6%, respectively. BMI at 21 years was positively associated with serum insulin, blood glucose, and HbA1c at 60-79 years, with increases of 1.5% (95%CI 0.8,2.3%), 0.4% (0.1,0.6%), 0.3% (0.1,0.4%) per 1 kg/m2, respectively, but showed no associations with blood pressure or blood cholesterol. However, these associations were modest compared to those between BMI at 60-79 years and serum insulin, blood glucose and HbA1c at 60-79 years, with increases of 8.6% (8.0,9.2%), 0.7% (0.5,0.9%), and 0.5% (0.4,0.7%) per 1 kg/m2, respectively. BMI at 60-79 years was also associated with total cholesterol and blood pressure. Associations for BMI at 40-59 years were mainly consistent with those of BMI at 60-79 years. None of the life course models fitted the data as well as the saturated model for serum insulin. A sensitive period at 50 years for glucose and HbA1c and sensitive period at 70 years for blood pressure were identified. CONCLUSIONS In this cohort of men who were thin compared to more contemporary cohorts, BMI in later life was the dominant influence on cardiovascular and diabetes risk. BMI in early adult life may have a small long-term effect on diabetes risk.", "link"=>"http://www.mendeley.com/research/adiposity-early-middle-later-adult-life-cardiometabolic-risk-markers-later-life-findings-british-reg", "reader_count"=>16, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Mathematics"=>1, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>3, "Sports and Recreations"=>1, "Psychology"=>1, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Social Sciences"=>{"Social Sciences"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>6}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1820401"], "description"=>"<p>n: Number of participants (subset of individuals with BMI available at all age periods). For BMI at mean 70 years this includes all available data.</p><p>BMI trajectories: Each triplet corresponds to a different trajectory of high BMI at mean age 21, 50 and 70 years; with 0 and 1 denoting BMI below and above the 75th percentile of the BMI distribution, respectively. For example, (0–0-0) denoted low BMI at all age periods, whilst (0–0-1) signified high BMI at mean age 70 years only.</p><p>Coef: Estimates are differences in risk marker from BMI trajectory 0–0-0. Estimates are adjusted for age at the time when the risk markers were measured, and town as fixed effect.</p><p>Differences in cardiovascular and diabetes risk markers at mean age 70 years, by trajectory of BMI (having a high BMI at different points of the life course) at different ages (mean age 21, 50 and 70 years).</p>", "links"=>[], "tags"=>["life course models", "blood glucose", "diabetes risk", "mobility life course models", "body mass index", "Cardiometabolic Risk Markers", "HbA 1c", "21 years", "British Regional Heart Study Objectives", "ci", "serum insulin", "BMI trajectory model.Results", "blood pressure"], "article_id"=>1259372, "categories"=>["Biological Sciences"], "users"=>["Venediktos V. Kapetanakis", "Alicja R. Rudnicka", "Andrea K. Wathern", "Lucy Lennon", "Olia Papacosta", "Derek G. Cook", "S. Goya Wannamethee", "Peter H. Whincup", "Christopher G. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114289.t004", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differences_in_cardiovascular_and_diabetes_risk_markers_at_mean_age_70_years_by_trajectory_of_BMI_having_a_high_BMI_at_different_points_of_the_life_course_at_different_ages_mean_age_21_50_and_70_years_/1259372", "title"=>"Differences in cardiovascular and diabetes risk markers at mean age 70 years, by trajectory of BMI (having a high BMI at different points of the life course) at different ages (mean age 21, 50 and 70 years).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-04 02:44:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1820398"], "description"=>"<p>n: Number of participants (subset of individuals with BMI available at all age periods).</p><p>Coef: regression coefficient represent difference in cardiovascular risk markers for 1 kg/m2 increase in BMI. Estimates are adjusted for age at the time when the risk markers were measured, and town as a fixed effect.</p><p>Differences in cardiovascular and diabetes risk markers at mean age 70 years for each 1 kg/m<sup>2</sup> increase in BMI separately at mean age 21, 50 and 70 years.</p>", "links"=>[], "tags"=>["life course models", "blood glucose", "diabetes risk", "mobility life course models", "body mass index", "Cardiometabolic Risk Markers", "HbA 1c", "21 years", "British Regional Heart Study Objectives", "ci", "serum insulin", "BMI trajectory model.Results", "blood pressure"], "article_id"=>1259369, "categories"=>["Biological Sciences"], "users"=>["Venediktos V. Kapetanakis", "Alicja R. Rudnicka", "Andrea K. Wathern", "Lucy Lennon", "Olia Papacosta", "Derek G. Cook", "S. Goya Wannamethee", "Peter H. Whincup", "Christopher G. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114289.t002", "stats"=>{"downloads"=>4, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differences_in_cardiovascular_and_diabetes_risk_markers_at_mean_age_70_years_for_each_1_kg_m_2_increase_in_BMI_separately_at_mean_age_21_50_and_70_years_/1259369", "title"=>"Differences in cardiovascular and diabetes risk markers at mean age 70 years for each 1 kg/m<sup>2</sup> increase in BMI separately at mean age 21, 50 and 70 years.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-04 02:44:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1820396"], "description"=>"<p>n: Number of participants (subset of individuals with BMI available at all age periods).</p><p>SD: Standard deviation.</p><p>a: Estimates correspond to geometric mean (Q1, Q3).</p><p>Quintiles of BMI at 21 years are calculated using all available data (including individuals with missing BMI at mean age 50 or 70 years).</p><p>Cohort characteristics in early, middle, and late adulthood in all men, and by quintile of BMI in early adulthood.</p>", "links"=>[], "tags"=>["life course models", "blood glucose", "diabetes risk", "mobility life course models", "body mass index", "Cardiometabolic Risk Markers", "HbA 1c", "21 years", "British Regional Heart Study Objectives", "ci", "serum insulin", "BMI trajectory model.Results", "blood pressure"], "article_id"=>1259367, "categories"=>["Biological Sciences"], "users"=>["Venediktos V. Kapetanakis", "Alicja R. Rudnicka", "Andrea K. Wathern", "Lucy Lennon", "Olia Papacosta", "Derek G. Cook", "S. Goya Wannamethee", "Peter H. Whincup", "Christopher G. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114289.t001", "stats"=>{"downloads"=>6, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cohort_characteristics_in_early_middle_and_late_adulthood_in_all_men_and_by_quintile_of_BMI_in_early_adulthood_/1259367", "title"=>"Cohort characteristics in early, middle, and late adulthood in all men, and by quintile of BMI in early adulthood.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-04 02:44:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1820404"], "description"=>"<div><p><b><i>Objectives:</i></b> This research investigates the associations between body mass index (BMI) at 21, 40–59, 60–79 years of age on cardiometabolic risk markers at 60–79 years.</p><p><b><i>Methods:</i></b> A prospective study of 3464 British men with BMI measured at 40–59 and 60–79 years, when cardiometabolic risk was assessed. BMI at 21 years was ascertained from military records, or recalled from middle-age (adjusted for reporting bias); associations between BMI at different ages and later cardiometabolic risk markers were examined using linear regression. Sensitive period, accumulation and mobility life course models were devised for high BMI (defined as BMI≥75<sup>th</sup> centile) and compared with a saturated BMI trajectory model.</p><p><b><i>Results:</i></b> At ages 21, 40–59 and 60–79 years, prevalences of overweight (BMI≥25 kg/m<sup>2</sup>) were 12%, 53%, 70%, and obesity (≥30 kg/m<sup>2</sup>) 1.6%, 6.6%, and 17.6%, respectively. BMI at 21 years was positively associated with serum insulin, blood glucose, and HbA1c at 60–79 years, with increases of 1.5% (95%CI 0.8,2.3%), 0.4% (0.1,0.6%), 0.3% (0.1,0.4%) per 1 kg/m<sup>2</sup>, respectively, but showed no associations with blood pressure or blood cholesterol. However, these associations were modest compared to those between BMI at 60–79 years and serum insulin, blood glucose and HbA1c at 60–79 years, with increases of 8.6% (8.0,9.2%), 0.7% (0.5,0.9%), and 0.5% (0.4,0.7%) per 1 kg/m<sup>2</sup>, respectively. BMI at 60–79 years was also associated with total cholesterol and blood pressure. Associations for BMI at 40–59 years were mainly consistent with those of BMI at 60–79 years. None of the life course models fitted the data as well as the saturated model for serum insulin. A sensitive period at 50 years for glucose and HbA1c and sensitive period at 70 years for blood pressure were identified.</p><p><b><i>Conclusions:</i></b> In this cohort of men who were thin compared to more contemporary cohorts, BMI in later life was the dominant influence on cardiovascular and diabetes risk. BMI in early adult life may have a small long-term effect on diabetes risk.</p></div>", "links"=>[], "tags"=>["life course models", "blood glucose", "diabetes risk", "mobility life course models", "body mass index", "Cardiometabolic Risk Markers", "HbA 1c", "21 years", "British Regional Heart Study Objectives", "ci", "serum insulin", "BMI trajectory model.Results", "blood pressure"], "article_id"=>1259375, "categories"=>["Biological Sciences"], "users"=>["Venediktos V. Kapetanakis", "Alicja R. Rudnicka", "Andrea K. Wathern", "Lucy Lennon", "Olia Papacosta", "Derek G. Cook", "S. Goya Wannamethee", "Peter H. Whincup", "Christopher G. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114289", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adiposity_in_Early_Middle_and_Later_Adult_Life_and_Cardiometabolic_Risk_Markers_in_Later_Life_Findings_from_the_British_Regional_Heart_Study_/1259375", "title"=>"Adiposity in Early, Middle and Later Adult Life and Cardiometabolic Risk Markers in Later Life; Findings from the British Regional Heart Study", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-04 02:44:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1820385"], "description"=>"<p>Distribution of BMI at mean age 21 years (early adulthood), 50 years (middle-age), and 70 years (late adulthood).</p>", "links"=>[], "tags"=>["life course models", "blood glucose", "diabetes risk", "mobility life course models", "body mass index", "Cardiometabolic Risk Markers", "HbA 1c", "21 years", "British Regional Heart Study Objectives", "ci", "serum insulin", "BMI trajectory model.Results", "blood pressure"], "article_id"=>1259356, "categories"=>["Biological Sciences"], "users"=>["Venediktos V. Kapetanakis", "Alicja R. Rudnicka", "Andrea K. Wathern", "Lucy Lennon", "Olia Papacosta", "Derek G. Cook", "S. Goya Wannamethee", "Peter H. Whincup", "Christopher G. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114289.g001", "stats"=>{"downloads"=>0, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_BMI_at_mean_age_21_years_early_adulthood_50_years_middle_age_and_70_years_late_adulthood_/1259356", "title"=>"Distribution of BMI at mean age 21 years (early adulthood), 50 years (middle-age), and 70 years (late adulthood).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-12-04 02:44:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1820400"], "description"=>"<p>n: Number of participants (subset of individuals with BMI available at all age periods).</p><p>K: percentage of individuals who had high BMI (BMI in the top 25% of the distribution) also at mean age 70 years.</p><p>Coef: regression coefficient for the effect of high BMI (BMI in the top 25% of the distribution) at each sensitive period (mean age 21, 50 or 70 years) as compared with never having had high BMI. Estimates are adjusted for age at the time when the risk markers were measured, and town as fixed effect.</p><p>For each outcome, results are obtained from 3 models fitted separately (one for each period: mean age 21, 50 and 70 years).</p><p>Differences in cardiovascular and diabetes risk markers at mean age 70 years, associated with having high BMI (≥75<sup>th</sup> centile) separately at mean ages 21, 50 and 70 years compared to men with normal BMI at all 3 ages (separate analyses based on sensitive period models).</p>", "links"=>[], "tags"=>["life course models", "blood glucose", "diabetes risk", "mobility life course models", "body mass index", "Cardiometabolic Risk Markers", "HbA 1c", "21 years", "British Regional Heart Study Objectives", "ci", "serum insulin", "BMI trajectory model.Results", "blood pressure"], "article_id"=>1259370, "categories"=>["Biological Sciences"], "users"=>["Venediktos V. Kapetanakis", "Alicja R. Rudnicka", "Andrea K. Wathern", "Lucy Lennon", "Olia Papacosta", "Derek G. Cook", "S. Goya Wannamethee", "Peter H. Whincup", "Christopher G. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114289.t003", "stats"=>{"downloads"=>4, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differences_in_cardiovascular_and_diabetes_risk_markers_at_mean_age_70_years_associated_with_having_high_BMI_75_th_centile_separately_at_mean_ages_21_50_and_70_years_compared_to_men_with_normal_BMI_at_all_3_ages_separate_analyses_based_on_sensitive_perio/1259370", "title"=>"Differences in cardiovascular and diabetes risk markers at mean age 70 years, associated with having high BMI (≥75<sup>th</sup> centile) separately at mean ages 21, 50 and 70 years compared to men with normal BMI at all 3 ages (separate analyses based on sensitive period models).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-04 02:44:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1820394"], "description"=>"<p>Note: Individuals may be moving across quintiles.</p>", "links"=>[], "tags"=>["life course models", "blood glucose", "diabetes risk", "mobility life course models", "body mass index", "Cardiometabolic Risk Markers", "HbA 1c", "21 years", "British Regional Heart Study Objectives", "ci", "serum insulin", "BMI trajectory model.Results", "blood pressure"], "article_id"=>1259365, "categories"=>["Biological Sciences"], "users"=>["Venediktos V. Kapetanakis", "Alicja R. Rudnicka", "Andrea K. Wathern", "Lucy Lennon", "Olia Papacosta", "Derek G. Cook", "S. Goya Wannamethee", "Peter H. Whincup", "Christopher G. Owen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0114289.g002", "stats"=>{"downloads"=>7, "page_views"=>96, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_BMI_at_mean_age_21_50_and_70_years_stratified_by_quintile_of_BMI_distribution_at_age_21_quintiles_formed_by_using_all_available_data_at_age_21_lines_from_bottom_to_top_correspond_to_1_st_2_nd_3_rd_4_th_and_5_th_quintiles_respectively_/1259365", "title"=>"Mean BMI at mean age 21, 50 and 70 years, stratified by quintile of BMI distribution at age 21 (quintiles formed by using all available data at age 21; lines from bottom to top correspond to 1<sup>st</sup>, 2<sup>nd</sup>, 3<sup>rd</sup>, 4<sup>th</sup>, and 5<sup>th</sup> quintiles, respectively).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-12-04 02:44:19"}

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Relative Metric

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