Roles of Caloric Restriction, Ketogenic Diet and Intermittent Fasting during Initiation, Progression and Metastasis of Cancer in Animal Models: A Systematic Review and Meta-Analysis
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{"title"=>"Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: A systematic review and meta-analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Mengmeng", "last_name"=>"Lv", "scopus_author_id"=>"55933830500"}, {"first_name"=>"Xingya", "last_name"=>"Zhu", "scopus_author_id"=>"56013973800"}, {"first_name"=>"Hao", "last_name"=>"Wang", "scopus_author_id"=>"55874566600"}, {"first_name"=>"Feng", "last_name"=>"Wang", "scopus_author_id"=>"56434748300"}, {"first_name"=>"Wenxian", "last_name"=>"Guan", "scopus_author_id"=>"55172260800"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84918531944", "pmid"=>"25502434", "doi"=>"10.1371/journal.pone.0115147", "pui"=>"600738255", "isbn"=>"10.1371/journal.pone.0115147", "arxiv"=>"NIHMS150003", "sgr"=>"84918531944"}, "id"=>"aa756b7d-8585-3924-9b82-66b8fcab74bc", "abstract"=>"BACKGROUND: The role of dietary restriction regimens such as caloric restriction, ketogenic diet and intermittent fasting in development of cancers has been detected via abundant preclinical experiments. However, the conclusions are controversial. We aim to review the relevant animal studies systematically and provide assistance for further clinical studies.\\n\\nMETHODS: Literatures on associations between dietary restriction and cancer published in PubMed in recent twenty years were comprehensively searched. Animal model, tumor type, feeding regimen, study length, sample size, major outcome, conclusion, quality assessment score and the interferential step of cancer were extracted from each eligible study. We analyzed the tumor incidence rates from 21 studies about caloric restriction.\\n\\nRESULTS: Fifty-nine studies were involved in our system review. The involved studies explored roles of dietary restriction during initiation, progression and metastasis of cancer. About 90.9% of the relevant studies showed that caloric restriction plays an anti-cancer role, with the pooled OR (95%CI) of 0.20 (0.12, 0.34) relative to controls. Ketogenic diet was also positively associated with cancer, which was indicated by eight of the nine studies. However, 37.5% of the related studies obtained a negative conclusion that intermittent fasting was not significantly preventive against cancer.\\n\\nCONCLUSIONS: Caloric restriction and ketogenic diet are effective against cancer in animal experiments while the role of intermittent fasting is doubtful and still needs exploration. More clinical experiments are needed and more suitable patterns for humans should be investigated.", "link"=>"http://www.mendeley.com/research/roles-caloric-restriction-ketogenic-diet-intermittent-fasting-during-initiation-progression-metastas", "reader_count"=>160, "reader_count_by_academic_status"=>{"Unspecified"=>7, "Professor > Associate Professor"=>3, "Researcher"=>17, "Student > Doctoral Student"=>7, "Student > Ph. D. 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Student"=>19, "Student > Postgraduate"=>12, "Other"=>11, "Student > Master"=>41, "Student > Bachelor"=>33, "Lecturer"=>5, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>12, "Agricultural and Biological Sciences"=>22, "Veterinary Science and Veterinary Medicine"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>2, "Computer Science"=>1, "Earth and Planetary Sciences"=>1, "Economics, Econometrics and Finance"=>1, "Engineering"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>23, "Nursing and Health Professions"=>23, "Medicine and Dentistry"=>56, "Neuroscience"=>2, "Sports and Recreations"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>3, "Social Sciences"=>2, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>56}, "Social Sciences"=>{"Social Sciences"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>5}, "Psychology"=>{"Psychology"=>3}, "Unspecified"=>{"Unspecified"=>12}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Neuroscience"=>{"Neuroscience"=>2}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Computer Science"=>{"Computer Science"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>23}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>23}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Republic of Singapore"=>1, "Norway"=>1, "Brazil"=>2, "Mexico"=>1, "United Kingdom"=>1, "Spain"=>1}, "group_count"=>3}

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  • {"files"=>["https://ndownloader.figshare.com/files/1839733"], "description"=>"<p>Statistical analyse was performed using STATA (version 12), combined overall odds ratio (OR) was calculated using the random-effect model as heterogeneity existed (I2 = 75.5%, p<0.01).</p>", "links"=>[], "tags"=>["restriction", "tumor incidence rates", "quality assessment score", "ci", "role", "ketogenic diet"], "article_id"=>1268117, "categories"=>["Biological Sciences"], "users"=>["Mengmeng Lv", "Xingya Zhu", "Hao Wang", "Feng Wang", "Wenxian Guan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0115147.g002", "stats"=>{"downloads"=>1, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_plot_for_the_association_between_caloric_restriction_diet_and_tumor_incidence_/1268117", "title"=>"Forest plot for the association between caloric restriction diet and tumor incidence.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-12-11 02:59:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1839737"], "description"=>"<div><p>Background</p><p>The role of dietary restriction regimens such as caloric restriction, ketogenic diet and intermittent fasting in development of cancers has been detected via abundant preclinical experiments. However, the conclusions are controversial. We aim to review the relevant animal studies systematically and provide assistance for further clinical studies.</p><p>Methods</p><p>Literatures on associations between dietary restriction and cancer published in PubMed in recent twenty years were comprehensively searched. Animal model, tumor type, feeding regimen, study length, sample size, major outcome, conclusion, quality assessment score and the interferential step of cancer were extracted from each eligible study. We analyzed the tumor incidence rates from 21 studies about caloric restriction.</p><p>Results</p><p>Fifty-nine studies were involved in our system review. The involved studies explored roles of dietary restriction during initiation, progression and metastasis of cancer. About 90.9% of the relevant studies showed that caloric restriction plays an anti-cancer role, with the pooled OR (95%CI) of 0.20 (0.12, 0.34) relative to controls. Ketogenic diet was also positively associated with cancer, which was indicated by eight of the nine studies. However, 37.5% of the related studies obtained a negative conclusion that intermittent fasting was not significantly preventive against cancer.</p><p>Conclusions</p><p>Caloric restriction and ketogenic diet are effective against cancer in animal experiments while the role of intermittent fasting is doubtful and still needs exploration. More clinical experiments are needed and more suitable patterns for humans should be investigated.</p></div>", "links"=>[], "tags"=>["restriction", "tumor incidence rates", "quality assessment score", "ci", "role", "ketogenic diet"], "article_id"=>1268121, "categories"=>["Biological Sciences"], "users"=>["Mengmeng Lv", "Xingya Zhu", "Hao Wang", "Feng Wang", "Wenxian Guan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0115147", "stats"=>{"downloads"=>3, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Roles_of_Caloric_Restriction_Ketogenic_Diet_and_Intermittent_Fasting_during_Initiation_Progression_and_Metastasis_of_Cancer_in_Animal_Models_A_Systematic_Review_and_Meta_Analysis_/1268121", "title"=>"Roles of Caloric Restriction, Ketogenic Diet and Intermittent Fasting during Initiation, Progression and Metastasis of Cancer in Animal Models: A Systematic Review and Meta-Analysis", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-11 02:59:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1839735"], "description"=>"a<p>Time: Time of study (weeks); <b><sup>b</sup></b>C: Conclusion of the study, “+” indicates a positive conclusion and “-” represents a negative conclusion; <b><sup>c</sup></b>Q: Quality of the study according to a critical checklist of the Stroke Therapy Academic Industry Roundtable; <b><sup>d</sup></b>S: The step(s) of cancer that dietary restriction regimens interfere during the initiation, progression and metastasis of cancer, “I” indicates initiation, “P” indicates progression and “M” indicates metastasis; <b><sup>e</sup></b>TP: transplanted; <b><sup>f</sup></b>C: carbohydrate; <b><sup>g</sup></b> KC: a nutritionally balanced and commercially available ketogenic diet; <b><sup>h</sup></b> SD: standard diet; <b><sup>i</sup></b> KD: ketogenic diet; <b><sup>j</sup></b>/: not specified; <b><sup>k</sup></b>NCKD: no-carbohydrate ketogenic diet.</p><p>Animal experiments of carbohydrate restriction/ketogenic diet and cancer.</p>", "links"=>[], "tags"=>["restriction", "tumor incidence rates", "quality assessment score", "ci", "role", "ketogenic diet"], "article_id"=>1268119, "categories"=>["Biological Sciences"], "users"=>["Mengmeng Lv", "Xingya Zhu", "Hao Wang", "Feng Wang", "Wenxian Guan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0115147.t002", "stats"=>{"downloads"=>1, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Animal_experiments_of_carbohydrate_restriction_ketogenic_diet_and_cancer_/1268119", "title"=>"Animal experiments of carbohydrate restriction/ketogenic diet and cancer.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-11 02:59:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1839736"], "description"=>"a<p>Time: Time of study (weeks); <b><sup>b</sup></b>C: Conclusion of the study, “+” indicates a positive conclusion and “-” represents a negative conclusion; <b><sup>c</sup></b>Q: Quality of the study according to a critical checklist of the Stroke Therapy Academic Industry Roundtable; <b><sup>d</sup></b>S: The step(s) of cancer that dietary restriction regimens interfere during the initiation, progression and metastasis of cancer, “I” indicates initiation, “P” indicates progression and “M” indicates metastasis; <b><sup>e</sup></b>TP: transplanted; <b><sup>f</sup></b>D: Day; <b><sup>g</sup></b>AL: Ad libitum; <b><sup>h</sup></b>CR: caloric restriction; <b><sup>i</sup></b>C: Chemical-induced; <b><sup>j</sup></b>TG: transgenic.</p><p>Animal experiments of intermittent fasting and cancer.</p>", "links"=>[], "tags"=>["restriction", "tumor incidence rates", "quality assessment score", "ci", "role", "ketogenic diet"], "article_id"=>1268120, "categories"=>["Biological Sciences"], "users"=>["Mengmeng Lv", "Xingya Zhu", "Hao Wang", "Feng Wang", "Wenxian Guan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0115147.t003", "stats"=>{"downloads"=>7, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Animal_experiments_of_intermittent_fasting_and_cancer_/1268120", "title"=>"Animal experiments of intermittent fasting and cancer.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-12-11 02:59:38"}
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Relative Metric

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Net::HTTPTooManyRequests

Source
Scopus
Time
2019-08-27 18:06:22 UTC
Target URL
https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0115147)
Trace

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