Proangiogenic Compositions of Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells
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{"title"=>"Proangiogenic compositions of microvesicles derived from human umbilical cord mesenchymal stem cells", "type"=>"journal", "authors"=>[{"first_name"=>"Jianying", "last_name"=>"Chen", "scopus_author_id"=>"23088272400"}, {"first_name"=>"Zhenjun", "last_name"=>"Liu", "scopus_author_id"=>"56488792500"}, {"first_name"=>"Mian Ming", "last_name"=>"Hong", "scopus_author_id"=>"56348822900"}, {"first_name"=>"Hongzhe", "last_name"=>"Zhang", "scopus_author_id"=>"54685563000"}, {"first_name"=>"Can", "last_name"=>"Chen", "scopus_author_id"=>"56447672800"}, {"first_name"=>"Mengyuan", "last_name"=>"Xiao", "scopus_author_id"=>"56349239400"}, {"first_name"=>"Junxian", "last_name"=>"Wang", "scopus_author_id"=>"56448754800"}, {"first_name"=>"Feng", "last_name"=>"Yao", "scopus_author_id"=>"56448004100"}, {"first_name"=>"Mingchuan", "last_name"=>"Ba", "scopus_author_id"=>"56448308700"}, {"first_name"=>"Jinghu", "last_name"=>"Liu", "scopus_author_id"=>"56349359100"}, {"first_name"=>"Zi Kuan", "last_name"=>"Guo", "scopus_author_id"=>"7404658159"}, {"first_name"=>"Jixin", "last_name"=>"Zhong", "scopus_author_id"=>"23010976400"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84918536001", "doi"=>"10.1371/journal.pone.0115316", "sgr"=>"84918536001", "pmid"=>"25514634", "issn"=>"19326203", "pui"=>"600783594"}, "id"=>"47397d63-c2f6-3505-875f-ae381da232c2", "abstract"=>"INTRODUCTION & OBJECTIVE: Microvesicles (MVs) derived from mesenchymal stem cells (MSCs) have been shown to promote angiogenesis. This study was aimed to shed a light on the mechanisms by analyzing the angiogenesis-promoting compositions of MSC-MVs. Also we try to figure out the impact of hypoxia on angiogenesis.\\n\\nMETHODS: MVs were isolated from the culture supernatants of MSCs under hypoxia/normoxia and serum-deprivation condition. The morphological features of MVs were revealed by an electron microscope and the origin of the MVs was identified by a bead-bound assay. An antibody array was used to analyze the expression of angiogenic cytokines from MVs and the parent MSCs as well. The major candidate factors were screened and the results were validated by immune blotting.\\n\\nRESULTS: MSC-MVs were around 80 nm in diameter. They expressed CD29, CD44, and CD73, but not CD31 and CD45. Antibody array showed that both MSCs and MVs expressed many angiogenesis-promoting biomolecules, including interleukin-6 (IL-6), basic fibroblast growth factors (bFGF), and recptor of urokinase-type plasminogen activator (UPAR). MSC-MVs contained angiogenin, vascular endothelial growth factor (VEGF), monocyte chemotactic protein-1 (MCP-1) and the receptor-2 for vascular endothelial growth factor at higher levels than the parent MSCs. Under hypoxic condition most cytokines were expressed in greater quantity than normoxic in MSCs while in MVs there was no significant difference between hypoxic and normoxic conditions except UPAR, Angiogenin, VEGF, IGF, Tie-2/TEK, and IL-6 which were higher in MVs under hypoxic conditions than those in normoxic condition.\\n\\nCONCLUSION: Upon serum-deprivation condition, MSCs could secrete MVs that contain a variety of factors contributing to their angiogenesis-promoting function. And among them, Angiogenin, VEGF, MCP-1, VEGF R2 might be of greater importance than the other cytokines. Also UPAR, Angiogenin, VEGF, IGF, Tie-2/TEK, IL-6 might be responsible for hypoxia-augmented proangiogenic effects of MVs.", "link"=>"http://www.mendeley.com/research/proangiogenic-compositions-microvesicles-derived-human-umbilical-cord-mesenchymal-stem-cells-2", "reader_count"=>38, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>4, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>4, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>5, "Neuroscience"=>1, "Business, Management and Accounting"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Chemistry"=>1, "Psychology"=>1, "Energy"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Energy"=>{"Energy"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>2, "Chile"=>1, "Spain"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1844483"], "description"=>"<p>A. Umbilical cord derived MSCS. B. Adipogenic differentiation of MSCs was examined by Oil Red O staining. C. Osteogenic differentiation was examined by alkaline phosphatase staining. D. Morphological features of MVs under electron microscope.</p>", "links"=>[], "tags"=>["parent MSCs", "fibroblast growth factors", "vegf", "igf", "CD 45. Antibody array", "growth factor", "upar", "Human Umbilical Cord Mesenchymal Stem Cells Introduction", "mv", "il", "mcp"], "article_id"=>1272072, "categories"=>["Uncategorised"], "users"=>["Jianying Chen", "Zhenjun Liu", "Mian Ming Hong", "Hongzhe Zhang", "Can Chen", "Mengyuan Xiao", "Junxian Wang", "Feng Yao", "Mingchuan Ba", "Jinghu Liu", "Zi-Kuan Guo", "Jixin Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0115316.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_MSCs_/1272072", "title"=>"Characteristics of MSCs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-12-16 02:41:54"}
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  • {"files"=>["https://ndownloader.figshare.com/files/1844497"], "description"=>"<p>A represents normoxic condition and B represents hypoxic condition. Results are expressed as mean ± SD. *, P<0.05.</p>", "links"=>[], "tags"=>["parent MSCs", "fibroblast growth factors", "vegf", "igf", "CD 45. Antibody array", "growth factor", "upar", "Human Umbilical Cord Mesenchymal Stem Cells Introduction", "mv", "il", "mcp"], "article_id"=>1272086, "categories"=>["Uncategorised"], "users"=>["Jianying Chen", "Zhenjun Liu", "Mian Ming Hong", "Hongzhe Zhang", "Can Chen", "Mengyuan Xiao", "Junxian Wang", "Feng Yao", "Mingchuan Ba", "Jinghu Liu", "Zi-Kuan Guo", "Jixin Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0115316.g003", "stats"=>{"downloads"=>8, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_cytokine_concentrations_pg_ml_in_MVs_and_parent_MSCs_detected_by_antibody_array_/1272086", "title"=>"Comparison of cytokine concentrations (pg/ml) in MVs and parent MSCs detected by antibody array.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-12-16 02:41:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1844504"], "description"=>"<p>A represents MSCs and B represents MVs. Results are expressed as mean ± SD. *, P<0.05; N.S., P>0.05.</p>", "links"=>[], "tags"=>["parent MSCs", "fibroblast growth factors", "vegf", "igf", "CD 45. Antibody array", "growth factor", "upar", "Human Umbilical Cord Mesenchymal Stem Cells Introduction", "mv", "il", "mcp"], "article_id"=>1272094, "categories"=>["Uncategorised"], "users"=>["Jianying Chen", "Zhenjun Liu", "Mian Ming Hong", "Hongzhe Zhang", "Can Chen", "Mengyuan Xiao", "Junxian Wang", "Feng Yao", "Mingchuan Ba", "Jinghu Liu", "Zi-Kuan Guo", "Jixin Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0115316.g004", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_cytokine_concentrations_pg_ml_under_hypoxic_and_normoxic_conditions_detected_by_antibody_array_in_MSCs_and_MVs_/1272094", "title"=>"Comparison of cytokine concentrations (pg/ml) under hypoxic and normoxic conditions detected by antibody array in MSCs and MVs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-12-16 02:41:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1844490"], "description"=>"<p>A. Detection of MSC-specific marker expression of UMSC by flow cytometric analysis. B. Identification of MSC-MVs by bead-based flow cytometry.</p>", "links"=>[], "tags"=>["parent MSCs", "fibroblast growth factors", "vegf", "igf", "CD 45. Antibody array", "growth factor", "upar", "Human Umbilical Cord Mesenchymal Stem Cells Introduction", "mv", "il", "mcp"], "article_id"=>1272079, "categories"=>["Uncategorised"], "users"=>["Jianying Chen", "Zhenjun Liu", "Mian Ming Hong", "Hongzhe Zhang", "Can Chen", "Mengyuan Xiao", "Junxian Wang", "Feng Yao", "Mingchuan Ba", "Jinghu Liu", "Zi-Kuan Guo", "Jixin Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0115316.g002", "stats"=>{"downloads"=>1, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_cytometric_characterization_of_MSC_and_MV_/1272079", "title"=>"Flow cytometric characterization of MSC and MV.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-12-16 02:41:54"}

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[]}
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