Influences of Gestational Obesity on Associations between Genotypes and Gene Expression Levels in Offspring following Maternal Gastrointestinal Bypass Surgery for Obesity
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{"title"=>"Influences of gestational obesity on associations between genotypes and gene expression levels in offspring following maternal gastrointestinal bypass surgery for obesity", "type"=>"journal", "authors"=>[{"first_name"=>"Frédéric", "last_name"=>"Guénard", "scopus_author_id"=>"24066844500"}, {"first_name"=>"Maxime", "last_name"=>"Lamontagne", "scopus_author_id"=>"53986273900"}, {"first_name"=>"Yohan", "last_name"=>"Bossé", "scopus_author_id"=>"6602449865"}, {"first_name"=>"Yves", "last_name"=>"Deshaies", "scopus_author_id"=>"36910541900"}, {"first_name"=>"Katherine", "last_name"=>"Cianflone", "scopus_author_id"=>"35497578900"}, {"first_name"=>"John G.", "last_name"=>"Kral", "scopus_author_id"=>"7103385941"}, {"first_name"=>"Picard", "last_name"=>"Marceau", "scopus_author_id"=>"7003563556"}, {"first_name"=>"Marie Claude", "last_name"=>"Vohl", "scopus_author_id"=>"7006725579"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84928969311", "doi"=>"10.1371/journal.pone.0117011", "sgr"=>"84928969311", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"25603303", "issn"=>"19326203", "pui"=>"604166044"}, "id"=>"5c96391e-5614-3541-801b-f97a89497894", "abstract"=>"METHODS: Whole-genome genotyping and gene expression analyses in blood of 22 BMS and 23 AMS offspring from 19 mothers were conducted using Illumina HumanOmni-5-Quad and HumanHT-12 v4 Expression BeadChips, respectively. Using PLINK we analyzed interactions between offspring gene variations and maternal surgical status on offspring gene expression levels. Altered biological functions and pathways were identified and visualized using DAVID and Ingenuity Pathway Analysis. RESULTS: Significant interactions (p </= 1.22 x 10(-12)) were found for 525 among the 16,060 expressed transcripts: 1.9% of tested SNPs were involved. Gene function and pathway analysis demonstrated enrichment of transcription and of cellular metabolism functions and overrepresentation of cellular stress and signaling, immune response, inflammation, growth, proliferation and development pathways. CONCLUSION: We suggest that impaired maternal gestational metabolic fitness interacts with offspring gene variations modulating gene expression levels, providing potential mechanisms explaining improved cardiometabolic risk profiles of AMS offspring related to ameliorated maternal lipid and carbohydrate metabolism.", "link"=>"http://www.mendeley.com/research/influences-gestational-obesity-associations-between-genotypes-gene-expression-levels-offspring-follo", "reader_count"=>13, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1868447"], "description"=>"<p>Offspring characteristics.</p>", "links"=>[], "tags"=>["metabolism functions", "Obesity Maternal obesity", "offspring gene variations", "cardiometabolic risk profiles", "plink", "snp", "offspring gene expression levels", "offspring gene variations modulating gene expression levels", "pathway analysis", "Ingenuity Pathway Analysis.ResultsSignificant interactions", "weight gain", "pathway genes", "cardiometabolic risk", "AMS offspring", "22 BMS", "23 AMS offspring", "Gene function", "Maternal Gastrointestinal Bypass Surgery", "development pathways.ConclusionWe", "gene expression analyses", "19 mothers", "gene expression levels", "Gestational Obesity", "Carbohydrate metabolism"], "article_id"=>1291344, "categories"=>["Biological Sciences"], "users"=>["Frédéric Guénard", "Maxime Lamontagne", "Yohan Bossé", "Yves Deshaies", "Katherine Cianflone", "John G. Kral", "Picard Marceau", "Marie-Claude Vohl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117011.t001", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Offspring_characteristics_/1291344", "title"=>"Offspring characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-01-20 02:57:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1868450", "https://ndownloader.figshare.com/files/1868451", "https://ndownloader.figshare.com/files/1875480", "https://ndownloader.figshare.com/files/1868452", "https://ndownloader.figshare.com/files/1868453"], "description"=>"<div><p>Maternal obesity and excess gestational weight gain with compromised metabolic fitness predispose offspring to lifelong obesity and its comorbidities. We demonstrated that compared to offspring born before maternal gastrointestinal bypass surgery (BMS) those born after (AMS) were less obese, with less cardiometabolic risk reflected in the expression and methylation of diabetes, immune and inflammatory pathway genes. Here we examine relationships between gestational obesity and offspring gene variations on expression levels.</p><p>Methods</p><p>Whole-genome genotyping and gene expression analyses in blood of 22 BMS and 23 AMS offspring from 19 mothers were conducted using Illumina HumanOmni-5-Quad and HumanHT-12 v4 Expression BeadChips, respectively. Using PLINK we analyzed interactions between offspring gene variations and maternal surgical status on offspring gene expression levels. Altered biological functions and pathways were identified and visualized using DAVID and Ingenuity Pathway Analysis.</p><p>Results</p><p>Significant interactions (p ≤ 1.22x10<sup>-12</sup>) were found for 525 among the 16,060 expressed transcripts: 1.9% of tested SNPs were involved. Gene function and pathway analysis demonstrated enrichment of transcription and of cellular metabolism functions and overrepresentation of cellular stress and signaling, immune response, inflammation, growth, proliferation and development pathways.</p><p>Conclusion</p><p>We suggest that impaired maternal gestational metabolic fitness interacts with offspring gene variations modulating gene expression levels, providing potential mechanisms explaining improved cardiometabolic risk profiles of AMS offspring related to ameliorated maternal lipid and carbohydrate metabolism.</p></div>", "links"=>[], "tags"=>["metabolism functions", "Obesity Maternal obesity", "offspring gene variations", "cardiometabolic risk profiles", "plink", "snp", "offspring gene expression levels", "offspring gene variations modulating gene expression levels", "pathway analysis", "Ingenuity Pathway Analysis.ResultsSignificant interactions", "weight gain", "pathway genes", "cardiometabolic risk", "AMS offspring", "22 BMS", "23 AMS offspring", "Gene function", "Maternal Gastrointestinal Bypass Surgery", "development pathways.ConclusionWe", "gene expression analyses", "19 mothers", "gene expression levels", "Gestational Obesity", "Carbohydrate metabolism"], "article_id"=>1291347, "categories"=>["Biological Sciences"], "users"=>["Frédéric Guénard", "Maxime Lamontagne", "Yohan Bossé", "Yves Deshaies", "Katherine Cianflone", "John G. Kral", "Picard Marceau", "Marie-Claude Vohl"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0117011.s001", "https://dx.doi.org/10.1371/journal.pone.0117011.s002", "https://dx.doi.org/10.1371/journal.pone.0117011.s003", "https://dx.doi.org/10.1371/journal.pone.0117011.s004", "https://dx.doi.org/10.1371/journal.pone.0117011.s005"], "stats"=>{"downloads"=>10, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Influences_of_Gestational_Obesity_on_Associations_between_Genotypes_and_Gene_Expression_Levels_in_Offspring_following_Maternal_Gastrointestinal_Bypass_Surgery_for_Obesity_/1291347", "title"=>"Influences of Gestational Obesity on Associations between Genotypes and Gene Expression Levels in Offspring following Maternal Gastrointestinal Bypass Surgery for Obesity", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-01-20 02:57:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1868448"], "description"=>"<p>Most significant SNP-by-maternal treatment interactions.</p>", "links"=>[], "tags"=>["metabolism functions", "Obesity Maternal obesity", "offspring gene variations", "cardiometabolic risk profiles", "plink", "snp", "offspring gene expression levels", "offspring gene variations modulating gene expression levels", "pathway analysis", "Ingenuity Pathway Analysis.ResultsSignificant interactions", "weight gain", "pathway genes", "cardiometabolic risk", "AMS offspring", "22 BMS", "23 AMS offspring", "Gene function", "Maternal Gastrointestinal Bypass Surgery", "development pathways.ConclusionWe", "gene expression analyses", "19 mothers", "gene expression levels", "Gestational Obesity", "Carbohydrate metabolism"], "article_id"=>1291345, "categories"=>["Biological Sciences"], "users"=>["Frédéric Guénard", "Maxime Lamontagne", "Yohan Bossé", "Yves Deshaies", "Katherine Cianflone", "John G. Kral", "Picard Marceau", "Marie-Claude Vohl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117011.t002", "stats"=>{"downloads"=>3, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Most_significant_SNP_by_maternal_treatment_interactions_/1291345", "title"=>"Most significant SNP-by-maternal treatment interactions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-01-20 02:57:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1868449"], "description"=>"<p>Most represented transcripts from the list of significant interactions.</p>", "links"=>[], "tags"=>["metabolism functions", "Obesity Maternal obesity", "offspring gene variations", "cardiometabolic risk profiles", "plink", "snp", "offspring gene expression levels", "offspring gene variations modulating gene expression levels", "pathway analysis", "Ingenuity Pathway Analysis.ResultsSignificant interactions", "weight gain", "pathway genes", "cardiometabolic risk", "AMS offspring", "22 BMS", "23 AMS offspring", "Gene function", "Maternal Gastrointestinal Bypass Surgery", "development pathways.ConclusionWe", "gene expression analyses", "19 mothers", "gene expression levels", "Gestational Obesity", "Carbohydrate metabolism"], "article_id"=>1291346, "categories"=>["Biological Sciences"], "users"=>["Frédéric Guénard", "Maxime Lamontagne", "Yohan Bossé", "Yves Deshaies", "Katherine Cianflone", "John G. Kral", "Picard Marceau", "Marie-Claude Vohl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117011.t003", "stats"=>{"downloads"=>11, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Most_represented_transcripts_from_the_list_of_significant_interactions_/1291346", "title"=>"Most represented transcripts from the list of significant interactions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-01-20 02:57:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1868446"], "description"=>"<p>The number of submitted transcripts in each pathway is reported in histogram bars. Histogram bars for pathways related to cellular stress and signaling (black), immune response and inflammation (dark grey), and growth, proliferation and development (light grey) are highlighted. Unrelated pathways are shown in white.</p>", "links"=>[], "tags"=>["metabolism functions", "Obesity Maternal obesity", "offspring gene variations", "cardiometabolic risk profiles", "plink", "snp", "offspring gene expression levels", "offspring gene variations modulating gene expression levels", "pathway analysis", "Ingenuity Pathway Analysis.ResultsSignificant interactions", "weight gain", "pathway genes", "cardiometabolic risk", "AMS offspring", "22 BMS", "23 AMS offspring", "Gene function", "Maternal Gastrointestinal Bypass Surgery", "development pathways.ConclusionWe", "gene expression analyses", "19 mothers", "gene expression levels", "Gestational Obesity", "Carbohydrate metabolism"], "article_id"=>1291343, "categories"=>["Biological Sciences"], "users"=>["Frédéric Guénard", "Maxime Lamontagne", "Yohan Bossé", "Yves Deshaies", "Katherine Cianflone", "John G. Kral", "Picard Marceau", "Marie-Claude Vohl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117011.g001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathways_enriched_from_transcripts_demonstrating_significant_interactions_/1291343", "title"=>"Pathways enriched from transcripts demonstrating significant interactions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-01-20 02:57:17"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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