Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis
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{"title"=>"Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: A meta-analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Qiang", "last_name"=>"Cai", "scopus_author_id"=>"57190226332"}, {"first_name"=>"Jian", "last_name"=>"Wu", "scopus_author_id"=>"57196090215"}, {"first_name"=>"Qu", "last_name"=>"Cai", "scopus_author_id"=>"14059619800"}, {"first_name"=>"Er Zhen", "last_name"=>"Chen", "scopus_author_id"=>"14219049800"}, {"first_name"=>"Zhao Yan", "last_name"=>"Jiang", "scopus_author_id"=>"7404279002"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pmid"=>"25680115", "scopus"=>"2-s2.0-84923017817", "doi"=>"10.1371/journal.pone.0117173", "pui"=>"602311231", "isbn"=>"1932-6203", "sgr"=>"84923017817"}, "id"=>"860d0e16-45b8-3d08-9569-ee275aa9a192", "abstract"=>"BACKGROUND: The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk.\\n\\nMETHODS: Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2).\\n\\nRESULTS: A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03-1.39, P = 0.02, I2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11-1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12-1.71, P = 0.003, I2 = 93%).\\n\\nCONCLUSIONS: Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.", "link"=>"http://www.mendeley.com/research/association-between-glu504lys-polymorphism-aldh2-gene-cancer-risk-metaanalysis", "reader_count"=>7, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1931484", "https://ndownloader.figshare.com/files/1931485", "https://ndownloader.figshare.com/files/1931486"], "description"=>"<div><p>Background</p><p>The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk.</p><p>Methods</p><p>Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2).</p><p>Results</p><p>A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03–1.39, <i>P</i> = 0.02, <i>I<sup>2</sup></i> = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11–1.73, <i>P</i> = 0.004, <i>I<sup>2</sup></i> = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12–1.71, <i>P</i> = 0.003, <i>I<sup>2</sup></i> = 93%).</p><p>Conclusions</p><p>Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.</p></div>", "links"=>[], "tags"=>["Review Manager software", "cancer risk.MethodsEligible publications", "ALDH 2 Glu 504Lys polymorphism", "Glu 504Lys Polymorphism", "ci", "ALDH 2 Gene", "cancer risk", "UADT cancer risk"], "article_id"=>1323181, "categories"=>["Biological Sciences"], "users"=>["Qiang Cai", "Jian Wu", "Qu Cai", "Er-Zhen Chen", "Zhao-Yan Jiang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0117173.s001", "https://dx.doi.org/10.1371/journal.pone.0117173.s002", "https://dx.doi.org/10.1371/journal.pone.0117173.s003"], "stats"=>{"downloads"=>7, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_Glu504Lys_Polymorphism_of_ALDH2_Gene_and_Cancer_Risk_A_Meta_Analysis_/1323181", "title"=>"Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-02-13 18:31:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/1931482"], "description"=>"<p>Individuals with the variant allele (504Lys) had 52% increased risk of esophageal cancer (OR = 1.52, 95%CI: 1.12–2.08, <i>P</i> = 0.008), 22% risk of head and neck cancer (OR = 1.22, 95%CI: 1.07–1.39, <i>P</i> = 0.003) and 18% risk of gastric cancer (OR = 1.18, 95%CI: 1.03–1.35, <i>P</i> = 0.02).</p>", "links"=>[], "tags"=>["Review Manager software", "cancer risk.MethodsEligible publications", "ALDH 2 Glu 504Lys polymorphism", "Glu 504Lys Polymorphism", "ci", "ALDH 2 Gene", "cancer risk", "UADT cancer risk"], "article_id"=>1323179, "categories"=>["Biological Sciences"], "users"=>["Qiang Cai", "Jian Wu", "Qu Cai", "Er-Zhen Chen", "Zhao-Yan Jiang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117173.g003", "stats"=>{"downloads"=>2, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_plot_of_UADT_cancer_risk_associated_with_the_ALDH2_Glu504Lys_polymorphism_in_position_specific_analyses_/1323179", "title"=>"Forest plot of UADT cancer risk associated with the ALDH2 Glu504Lys polymorphism in position-specific analyses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-13 18:31:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/1931483"], "description"=>"<p><sup>a</sup>: Number of studies.</p><p><sup>b</sup>: Fix-effects model was used when <i>I</i><sup>2</sup> <50%; otherwise, random-effects model was used.</p><p><sup>c</sup>: Stratified according to subjects >300 in both case and control groups or not.</p><p>Combined, studies conducted on both population- and hospital-based control group; NA, not available.</p><p>Stratification analyses of the ALDH2 Glu504Lys polymorphism on cancer risk.</p>", "links"=>[], "tags"=>["Review Manager software", "cancer risk.MethodsEligible publications", "ALDH 2 Glu 504Lys polymorphism", "Glu 504Lys Polymorphism", "ci", "ALDH 2 Gene", "cancer risk", "UADT cancer risk"], "article_id"=>1323180, "categories"=>["Biological Sciences"], "users"=>["Qiang Cai", "Jian Wu", "Qu Cai", "Er-Zhen Chen", "Zhao-Yan Jiang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117173.t002", "stats"=>{"downloads"=>6, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Stratification_analyses_of_the_ALDH2_Glu504Lys_polymorphism_on_cancer_risk_/1323180", "title"=>"Stratification analyses of the ALDH2 Glu504Lys polymorphism on cancer risk.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-13 18:31:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/1931480"], "description"=>"<p>Flow diagram of search strategy and study selection.</p>", "links"=>[], "tags"=>["Review Manager software", "cancer risk.MethodsEligible publications", "ALDH 2 Glu 504Lys polymorphism", "Glu 504Lys Polymorphism", "ci", "ALDH 2 Gene", "cancer risk", "UADT cancer risk"], "article_id"=>1323177, "categories"=>["Biological Sciences"], "users"=>["Qiang Cai", "Jian Wu", "Qu Cai", "Er-Zhen Chen", "Zhao-Yan Jiang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117173.g001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_diagram_of_search_strategy_and_study_selection_/1323177", "title"=>"Flow diagram of search strategy and study selection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-13 18:31:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/1931481"], "description"=>"<p>In the genotypic model, the comparison of Lys+ with Glu/Glu genotype generated a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03–1.39, <i>P</i> = 0.02, <i>I<sup>2</sup></i> = 92%).</p>", "links"=>[], "tags"=>["Review Manager software", "cancer risk.MethodsEligible publications", "ALDH 2 Glu 504Lys polymorphism", "Glu 504Lys Polymorphism", "ci", "ALDH 2 Gene", "cancer risk", "UADT cancer risk"], "article_id"=>1323178, "categories"=>["Biological Sciences"], "users"=>["Qiang Cai", "Jian Wu", "Qu Cai", "Er-Zhen Chen", "Zhao-Yan Jiang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0117173.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_plot_showed_the_overall_cancer_risk_in_association_with_the_polymorphism_of_ALDH2_gene_Glu504Lys_polymorphism_/1323178", "title"=>"Forest plot showed the overall cancer risk in association with the polymorphism of ALDH2 gene Glu504Lys polymorphism.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-13 18:31:32"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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