The ER Stress-Mediated Mitochondrial Apoptotic Pathway and MAPKs Modulate Tachypacing-Induced Apoptosis in HL-1 Atrial Myocytes
Publication Date
February 17, 2015
Journal
PLOS ONE
Authors
Jiaojiao Shi, Qi Jiang, Xiangwei Ding, Wenhua Xu, et al
Volume
10
Issue
2
Pages
e0117567
DOI
https://dx.plos.org/10.1371/journal.pone.0117567
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117567
Scopus
84928911828
Mendeley
http://www.mendeley.com/research/er-stressmediated-mitochondrial-apoptotic-pathway-mapks-modulate-tachypacinginduced-apoptosis-hl1-at
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Mendeley | Further Information

{"title"=>"The ER stress-mediated mitochondrial apoptotic pathway and MAPKs modulate tachypacing-induced apoptosis in HL-1 atrial myocytes", "type"=>"journal", "authors"=>[{"first_name"=>"Jiaojiao", "last_name"=>"Shi", "scopus_author_id"=>"56179009800"}, {"first_name"=>"Qi", "last_name"=>"Jiang", "scopus_author_id"=>"56179404800"}, {"first_name"=>"Xiangwei", "last_name"=>"Ding", "scopus_author_id"=>"56621868600"}, {"first_name"=>"Wenhua", "last_name"=>"Xu", "scopus_author_id"=>"56621710200"}, {"first_name"=>"Dao W.", "last_name"=>"Wang", "scopus_author_id"=>"55682745700"}, {"first_name"=>"Minglong", "last_name"=>"Chen", "scopus_author_id"=>"7406352614"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25689866", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0117567", "issn"=>"19326203", "scopus"=>"2-s2.0-84928911828", "pui"=>"604166120", "sgr"=>"84928911828"}, "id"=>"14a9326c-8f3f-30de-984b-71ff422ec468", "abstract"=>"BACKGROUND AND OBJECT: Cell apoptosis is a contributing factor in the initiation, progression and relapse of atrial fibrillation (AF), a life-threatening illness accompanied with stroke and heart failure. However, the regulatory cascade of apoptosis is intricate and remains unidentified, especially in the setting of AF. The aim of this study was to explore the roles of endoplasmic reticulum (ER) stress, mitochondrial apoptotic pathway (MAP), mitogen-activated protein kinases (MAPKs), and their cross-talking in tachypacing-induced apoptosis.\\n\\nMETHODS AND RESULTS: HL-1 cells were cultured in the presence of tachypacing for 24 h to simulate atrial tachycardia remodeling. Results showed that tachypacing reduced cell viability measured by the cell counting kit-8, dissipated mitochondrial membrane potential detected by JC-1 staining and resulted in approximately 50% apoptosis examined by Hoechst staining and annexin V/propidium iodide staining. In addition, the proteins involved in ER stress, MAP and MAPKs were universally up-regulated or activated via phosphorylation, as confirmed by western blotting; and reversely silencing of ER stress, caspase-3 (the ultimate executor of MAP) and MAPKs with specific inhibitors prior to pacing partially alleviated apoptosis. An inhibitor of ER stress was applied to further investigate the responses of mitochondria and MAPKs to ER stress, and results indicated that suppression of ER stress comprehensively but incompletely attenuated the activation of MAP and MAPKs aroused by tachypacing, with the exception of ERK1/2, one branch of MAPKs.\\n\\nCONCLUSIONS: Our study suggested tachypacing-induced apoptosis is regulated by ER stress-mediated MAP and MAPKs. Thus, the above three components are all promising anti-apoptotic targets in AF patients and ER stress appears to play a dominant role due to its comprehensive effects.", "link"=>"http://www.mendeley.com/research/er-stressmediated-mitochondrial-apoptotic-pathway-mapks-modulate-tachypacinginduced-apoptosis-hl1-at", "reader_count"=>18, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>5, "Student > Master"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>5, "Student > Master"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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