Genetic Diversity of Mycobacterium tuberculosis from Guadalajara, Mexico and Identification of a Rare Multidrug Resistant Beijing Genotype
Publication Date
February 19, 2015
Journal
PLOS ONE
Authors
Samantha Flores Treviño, Rayo Morfín Otero, Eduardo Rodríguez Noriega, Esteban González Díaz, et al
Volume
10
Issue
2
Pages
e0118095
DOI
https://dx.plos.org/10.1371/journal.pone.0118095
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0118095
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25695431
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335057
Europe PMC
http://europepmc.org/abstract/MED/25695431
Web of Science
000350062300042
Scopus
84923250529
Mendeley
http://www.mendeley.com/research/genetic-diversity-mycobacterium-tuberculosis-guadalajara-mexico-identification-rare-multidrug-resist
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Mendeley | Further Information

{"title"=>"Genetic diversity of Mycobacterium tuberculosis from Guadalajara, Mexico and identification of a rare multidrug resistant Beijing genotype", "type"=>"journal", "authors"=>[{"first_name"=>"Samantha", "last_name"=>"Flores-Treviño", "scopus_author_id"=>"55915642100"}, {"first_name"=>"Rayo", "last_name"=>"Morfín-Otero", "scopus_author_id"=>"55989716200"}, {"first_name"=>"Eduardo", "last_name"=>"Rodríguez-Noriega", "scopus_author_id"=>"55989727300"}, {"first_name"=>"Esteban", "last_name"=>"González-Díaz", "scopus_author_id"=>"56002723100"}, {"first_name"=>"Héctor R.", "last_name"=>"Pérez-Gómez", "scopus_author_id"=>"36460087700"}, {"first_name"=>"Virgilio", "last_name"=>"Bocanegra-García", "scopus_author_id"=>"15128569800"}, {"first_name"=>"Lucio", "last_name"=>"Vera-Cabrera", "scopus_author_id"=>"6602180896"}, {"first_name"=>"Elvira", "last_name"=>"Garza-González", "scopus_author_id"=>"6603391592"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"602421780", "sgr"=>"84923250529", "issn"=>"19326203", "pmid"=>"25695431", "scopus"=>"2-s2.0-84923250529", "doi"=>"10.1371/journal.pone.0118095", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"f4af9abf-279c-39dd-82bf-93dc2427057a", "abstract"=>"Determining the genetic diversity of M. tuberculosis strains allows identification of the distinct Mycobacterium tuberculosis genotypes responsible for tuberculosis in different regions. Several studies have reported the genetic diversity of M. tuberculosis strains in Mexico, but little information is available from the state of Jalisco. Therefore, the aim of this study was to determine the genetic diversity of Mycobacterium tuberculosis clinical isolates from Western Mexico. Sixty-eight M. tuberculosis isolates were tested for susceptibility to first-line drugs using manual Mycobacteria Growth Indicator Tube method and genotyped using spoligotyping and IS6110-restriction fragment length polymorphism (RFLP) pattern analyses. Forty-seven (69.1%) isolates were grouped into 10 clusters and 21 isolates displayed single patterns by spoligotyping. Three of the 21 single patterns corresponded to orphan patterns in the SITVITWEB database, and 1 new type that contained 2 isolates was created. The most prevalent lineages were T (38.2%), Haarlem (17.7%), LAM (17.7%), X (7.4%), S (5.9%), EAI (1.5%) and Beijing (1.5%). Six (12.8%) of the clustered isolates were MDR, and type 406 of the Beijing family was among the MDR isolates. Seventeen (26.2%) isolates were grouped into 8 clusters and 48 isolates displayed single patterns by IS6110-RFLP. Combination of IS6110-RFLP and spoligotyping reduced the clustering rate to 20.0%. The results show that T, Haarlem, and LAM are predominant lineages among clinical isolates of M. tuberculosis in Guadalajara, Mexico. Clustering rates indicated low transmission of MDR strains. We detected a rare Beijing genotype, SIT406, which was a highly resistant strain. This is the first report of this Beijing genotype in Latin America.", "link"=>"http://www.mendeley.com/research/genetic-diversity-mycobacterium-tuberculosis-guadalajara-mexico-identification-rare-multidrug-resist", "reader_count"=>30, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>4, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>4, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>7, "Neuroscience"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1912084"], "description"=>"<p>Lineage, Spoligotype International Type (SIT) as defined in the SITVITWEB proprietary database of the Pasteur Institute of Guadeloupe, and the strain identifications are shown.</p>", "links"=>[], "tags"=>["sitvitweb", "sit", "lam", "spoligotyping", "pattern", "Mycobacterium tuberculosis genotypes", "Mycobacterium tuberculosis", "mdr", "Beijing genotype", "Mycobacteria Growth Indicator Tube method", "diversity", "tuberculosis strains", "rflp", "eai", "Rare Multidrug Resistant Beijing Genotype"], "article_id"=>1313310, "categories"=>["Uncategorised"], "users"=>["Samantha Flores-Treviño", "Rayo Morfin-Otero", "Eduardo Rodriguez-Noriega", "Esteban Gonzalez-Diaz", "Héctor R. Pérez-Gómez", "Virgilio Bocanegra-García", "Lucio Vera-Cabrera", "Elvira Garza-González"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118095.g001", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spoligotype_tree_of_M_tuberculosis_isolates_n_68_/1313310", "title"=>"Spoligotype tree of <i>M. tuberculosis</i> isolates (n = 68).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-19 03:10:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1912089"], "description"=>"<p><sup><i>a</i></sup>In the SITVITWEB database, the spoligo (shared) international type (SIT) numbers designate spoligotypes shared by two or more patient isolates.</p><p>*SIT3434 is a newly created shared type due to two strains belonging to a new pattern within this study.</p><p><sup><i>b</i></sup>Clade designations according to the SITVITWEB database: Beijing clade, East African-Indian (EAI) clade and 9 sublineages, Haarlem (H) clade and 3 sublineages, Latin American-Mediterranean (LAM) clade and 12 sublineages, the ancestral “Manu” family and 3 sublineages, the S clade, the IS<i>6110</i>-low-banding X clade and 3 sublineages, and an ill-defined T clade with 5 sublineages. Unk, unknown patterns within any of the major clades described in the database.</p><p>Description of shared types found in this study.</p>", "links"=>[], "tags"=>["sitvitweb", "sit", "lam", "spoligotyping", "pattern", "Mycobacterium tuberculosis genotypes", "Mycobacterium tuberculosis", "mdr", "Beijing genotype", "Mycobacteria Growth Indicator Tube method", "diversity", "tuberculosis strains", "rflp", "eai", "Rare Multidrug Resistant Beijing Genotype"], "article_id"=>1313315, "categories"=>["Uncategorised"], "users"=>["Samantha Flores-Treviño", "Rayo Morfin-Otero", "Eduardo Rodriguez-Noriega", "Esteban Gonzalez-Diaz", "Héctor R. Pérez-Gómez", "Virgilio Bocanegra-García", "Lucio Vera-Cabrera", "Elvira Garza-González"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118095.t002", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Description_of_shared_types_found_in_this_study_/1313315", "title"=>"Description of shared types found in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-19 03:10:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1912087"], "description"=>"<p>Drug resistance profile indicates resistance to I: isoniazid; R: rifampicin; S: streptomycin and E: ethambutol.</p>", "links"=>[], "tags"=>["sitvitweb", "sit", "lam", "spoligotyping", "pattern", "Mycobacterium tuberculosis genotypes", "Mycobacterium tuberculosis", "mdr", "Beijing genotype", "Mycobacteria Growth Indicator Tube method", "diversity", "tuberculosis strains", "rflp", "eai", "Rare Multidrug Resistant Beijing Genotype"], "article_id"=>1313313, "categories"=>["Uncategorised"], "users"=>["Samantha Flores-Treviño", "Rayo Morfin-Otero", "Eduardo Rodriguez-Noriega", "Esteban Gonzalez-Diaz", "Héctor R. Pérez-Gómez", "Virgilio Bocanegra-García", "Lucio Vera-Cabrera", "Elvira Garza-González"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118095.g002", "stats"=>{"downloads"=>1, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IS6110_RFLP_clustering_patterns_spoligopatterns_and_drug_resistance_profiles_of_M_tuberculosis_isolates_/1313313", "title"=>"IS6110-RFLP clustering patterns, spoligopatterns and drug resistance profiles of <i>M. tuberculosis</i> isolates.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-19 03:10:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1912088"], "description"=>"<p>Orphan strains had spoligotype patterns that did not match a preexisting pattern in the SITVITWEB database.</p><p>Description of orphan strains found in this study.</p>", "links"=>[], "tags"=>["sitvitweb", "sit", "lam", "spoligotyping", "pattern", "Mycobacterium tuberculosis genotypes", "Mycobacterium tuberculosis", "mdr", "Beijing genotype", "Mycobacteria Growth Indicator Tube method", "diversity", "tuberculosis strains", "rflp", "eai", "Rare Multidrug Resistant Beijing Genotype"], "article_id"=>1313314, "categories"=>["Uncategorised"], "users"=>["Samantha Flores-Treviño", "Rayo Morfin-Otero", "Eduardo Rodriguez-Noriega", "Esteban Gonzalez-Diaz", "Héctor R. Pérez-Gómez", "Virgilio Bocanegra-García", "Lucio Vera-Cabrera", "Elvira Garza-González"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118095.t001", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Description_of_orphan_strains_found_in_this_study_/1313314", "title"=>"Description of orphan strains found in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-19 03:10:19"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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