The Polysaccharide Capsule of Streptococcus pneumonia Partially Impedes MyD88-Mediated Immunity during Pneumonia in Mice
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{"title"=>"The polysaccharide capsule of streptococcus pneumonia partially impedes myd88- Mediated immunity during pneumonia in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Alex F.", "last_name"=>"De Vos", "scopus_author_id"=>"21034000000"}, {"first_name"=>"Mark C.", "last_name"=>"Dessing", "scopus_author_id"=>"8882234800"}, {"first_name"=>"Adriana J J", "last_name"=>"Lammers", "scopus_author_id"=>"35317979500"}, {"first_name"=>"Alexander P N A", "last_name"=>"De Porto", "scopus_author_id"=>"35770444200"}, {"first_name"=>"Sandrine", "last_name"=>"Florquin", "scopus_author_id"=>"56238343600"}, {"first_name"=>"Onno J.", "last_name"=>"De Boer", "scopus_author_id"=>"6603769630"}, {"first_name"=>"Regina", "last_name"=>"De Beer", "scopus_author_id"=>"25624715700"}, {"first_name"=>"Sanne", "last_name"=>"Terpstra", "scopus_author_id"=>"55557200100"}, {"first_name"=>"Hester J.", "last_name"=>"Bootsma", "scopus_author_id"=>"7003601080"}, {"first_name"=>"Peter W.", "last_name"=>"Hermans", "scopus_author_id"=>"7101909804"}, {"first_name"=>"Cornelis T.", "last_name"=>"Van Veer", "scopus_author_id"=>"56530731700"}, {"first_name"=>"Tom Der", "last_name"=>"Van Poll", "scopus_author_id"=>"6507324574"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84923677298", "pui"=>"602524998", "doi"=>"10.1371/journal.pone.0118181", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "sgr"=>"84923677298", "pmid"=>"25700108"}, "id"=>"ca7b71fc-efbd-3a90-b831-366f05f81a6f", "abstract"=>"Toll-like receptors (TLR) and the downstream adaptor protein MyD88 are considered crucial for protective immunity during bacterial infections. Streptococcus (S.) pneumoniae is a human respiratory pathogen and a large majority of clinical pneumococcal isolates expresses an external polysaccharide capsule. We here sought to determine the role of pneumococcal capsule in MyD88-mediated antibacterial defense during S. pneumonia pneumonia. Wild type (WT) and Myd88(-/-) mice were inoculated intranasally with serotype 2 S. pneumoniae D39 or with an isogenic capsule locus deletion mutant (D39∆cps), and analysed for bacterial outgrowth and inflammatory responses in the lung. As compared to WT mice, Myd88(-/-) mice infected with D39 demonstrated a modestly impaired bacterial clearance accompanied by decreased inflammatory responses in the lung. Strikingly, while WT mice rapidly cleared D39∆cps, Myd88(-/-) mice showed 105-fold higher bacterial burdens in their lungs and dissemination to blood 24 hours after infection. These data suggest that the pneumococcal capsule impairs recognition of TLR ligands expressed by S. pneumoniae and thereby partially impedes MyD88-mediated antibacterial defense.", "link"=>"http://www.mendeley.com/research/polysaccharide-capsule-streptococcus-pneumonia-partially-impedes-myd88-mediated-immunity-during-pneu", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1914461"], "description"=>"<p>Lung levels of TNF-α (A and B), IL-1β (C and D) and IL-6 (E and F) of wild type (WT, black bars) and Myd88<sup>-/-</sup> mice (MyD88 KO, white bars) at 6 and 48 hours after inoculation with D39 (A/C/E) or at 6 or 24 hours post inoculation of D39Δ<i>cps</i> (B/D/F). Data are mean ± SEM (N = 6–8 mice per group at each time point). *P<0.05, **P<0.005, ***P<0.0005 vs WT mice.</p>", "links"=>[], "tags"=>["serotype 2 S", "WT mice", "adaptor protein MyD 88", "tlr", "infection", "streptococcus", "isogenic capsule locus deletion", "blood 24 hours", "pneumoniae D 39", "MYD", "pneumococcal capsule impairs recognition", "response"], "article_id"=>1313902, "categories"=>["Biological Sciences"], "users"=>["Alex F. de Vos", "Mark C. Dessing", "Adriana J. J. Lammers", "Alexander P. N. A. de Porto", "Sandrine Florquin", "Onno J. de Boer", "Regina de Beer", "Sanne Terpstra", "Hester J. Bootsma", "Peter W. Hermans", "Cornelis van ‘t Veer", "Tom van der Poll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118181.g004", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reduced_cytokine_production_in_the_lung_of_Myd88_mice_during_infection_with_D39_or_D39_916_cps_/1313902", "title"=>"Reduced cytokine production in the lung of Myd88<sup>-/-</sup> mice during infection with D39 or D39Δ<i>cps</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-20 02:52:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1914462"], "description"=>"<p>KC/CXCL1 (A and B) and MIP2/CCL2 (C and D) of wild type (WT, black bars) and Myd88<sup>-/-</sup> mice (MyD88 KO, white bars) at the indicated time points after inoculation with D39 (A/C) or at 6 or 24 hours post inoculation D39Δ<i>cps</i> (B/D). Data are mean ± SEM (N = 6–8 mice per group at each time point). ***P<0.0005 vs WT mice.</p>", "links"=>[], "tags"=>["serotype 2 S", "WT mice", "adaptor protein MyD 88", "tlr", "infection", "streptococcus", "isogenic capsule locus deletion", "blood 24 hours", "pneumoniae D 39", "MYD", "pneumococcal capsule impairs recognition", "response"], "article_id"=>1313903, "categories"=>["Biological Sciences"], "users"=>["Alex F. de Vos", "Mark C. Dessing", "Adriana J. J. Lammers", "Alexander P. N. A. de Porto", "Sandrine Florquin", "Onno J. de Boer", "Regina de Beer", "Sanne Terpstra", "Hester J. Bootsma", "Peter W. Hermans", "Cornelis van ‘t Veer", "Tom van der Poll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118181.g005", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reduced_chemokine_production_in_the_lung_of_Myd88_mice_during_infection_with_D39_or_D39_916_cps_/1313903", "title"=>"Reduced chemokine production in the lung of Myd88<sup>-/-</sup> mice during infection with D39 or D39Δ<i>cps</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-20 02:52:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1914438"], "description"=>"<p>(A) Bacterial loads in lung homogenates of wild type mice (WT, black bars) and Myd88<sup>-/-</sup> mice (MyD88 KO, white bars) at 6 and 48 hours after infection with 5x10<sup>6</sup> CFU <i>S. pneumoniae</i> D39, and (B), 6 and 24 hours after infection with 1x10<sup>8</sup> CFU D39Δ<i>cps</i>. BC+ indicates the number of positive blood cultures. Data are mean ± SEM. (N = 6–8 mice per group at each time point). *P<0.05, **P<0.005, ***P<0.0005 vs WT mice.</p>", "links"=>[], "tags"=>["serotype 2 S", "WT mice", "adaptor protein MyD 88", "tlr", "infection", "streptococcus", "isogenic capsule locus deletion", "blood 24 hours", "pneumoniae D 39", "MYD", "pneumococcal capsule impairs recognition", "response"], "article_id"=>1313884, "categories"=>["Biological Sciences"], "users"=>["Alex F. de Vos", "Mark C. Dessing", "Adriana J. J. Lammers", "Alexander P. N. A. de Porto", "Sandrine Florquin", "Onno J. de Boer", "Regina de Beer", "Sanne Terpstra", "Hester J. Bootsma", "Peter W. Hermans", "Cornelis van ‘t Veer", "Tom van der Poll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118181.g001", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enhanced_susceptibility_of_Myd88_mice_for_D39_or_D39_916_cps_/1313884", "title"=>"Enhanced susceptibility of Myd88<sup>-/-</sup> mice for D39 or D39Δ<i>cps</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-20 02:52:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1914456"], "description"=>"<p>Representative Ly6-C/G stainings of lung sections obtained 6 h after induction of pneumococcal pneumonia with D39 in WT and Myd88<sup>-/-</sup> mice (A and B) and with D39Δ<i>cps</i> in WT mice and Myd88<sup>-/-</sup> mice (E and F). Original magnification 20x. Percentage lung area with Ly6-C/G-positive neutrophils was quantified by digital image analysis as described in methods section for wild type (WT, black bars) and Myd88<sup>-/-</sup> mice (MyD88 KO, white bars)(C and G). Levels of MPO in lung homogenates of wild type (WT, black bars) and Myd88<sup>-/-</sup> mice (MyD88 KO, white bars) inoculated with D39 at 6 and 48 hours after challenge, or inoculated with D39Δcps (D and H) at 6 and 24 hours after challenge were determined by ELISA. Data are mean ± SEM (N = 5–8 mice per group at each time point). *P<0.05, ***P<0.0005 vs WT mice.</p>", "links"=>[], "tags"=>["serotype 2 S", "WT mice", "adaptor protein MyD 88", "tlr", "infection", "streptococcus", "isogenic capsule locus deletion", "blood 24 hours", "pneumoniae D 39", "MYD", "pneumococcal capsule impairs recognition", "response"], "article_id"=>1313898, "categories"=>["Biological Sciences"], "users"=>["Alex F. de Vos", "Mark C. Dessing", "Adriana J. J. Lammers", "Alexander P. N. A. de Porto", "Sandrine Florquin", "Onno J. de Boer", "Regina de Beer", "Sanne Terpstra", "Hester J. Bootsma", "Peter W. Hermans", "Cornelis van ‘t Veer", "Tom van der Poll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118181.g003", "stats"=>{"downloads"=>3, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reduced_neutrophil_infiltration_in_the_lung_in_Myd88_mice_during_infection_with_D39_or_D39_916_cps_/1313898", "title"=>"Reduced neutrophil infiltration in the lung in Myd88 <sup>-/-</sup> mice during infection with D39 or D39Δ<i>cps</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-20 02:52:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1914453"], "description"=>"<p>Representative lung sections obtained 6 or 48 h after induction of pneumococcal pneumonia with D39 in WT (A and D) and Myd88<sup>-/-</sup> mice (B and E) and 6 or 24 h after inoculation with D39Δ<i>cps</i> in WT mice (G and J) and MyD88<sup>-/-</sup> mice (H and K). Haematoxylin and eosin stainings show different levels of inflammation. Original magnification 20x. Findings were quantified by histology scoring, as described in methods section for wild type (WT, black bars) and Myd88<sup>-/-</sup> mice (MyD88 KO, white bars). Data are mean ± SEM (N = 5–8 mice per group at each time point). **P<0.005 vs WT mice.</p>", "links"=>[], "tags"=>["serotype 2 S", "WT mice", "adaptor protein MyD 88", "tlr", "infection", "streptococcus", "isogenic capsule locus deletion", "blood 24 hours", "pneumoniae D 39", "MYD", "pneumococcal capsule impairs recognition", "response"], "article_id"=>1313895, "categories"=>["Biological Sciences"], "users"=>["Alex F. de Vos", "Mark C. Dessing", "Adriana J. J. Lammers", "Alexander P. N. A. de Porto", "Sandrine Florquin", "Onno J. de Boer", "Regina de Beer", "Sanne Terpstra", "Hester J. Bootsma", "Peter W. Hermans", "Cornelis van ‘t Veer", "Tom van der Poll"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118181.g002", "stats"=>{"downloads"=>0, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lung_pathology_in_WT_and_Myd88_mice_during_infection_with_capsulated_and_unencapsulated_D39_/1313895", "title"=>"Lung pathology in WT and Myd88<sup>-/-</sup> mice during infection with capsulated and unencapsulated D39.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-20 02:52:41"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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