Diversity and Antioxidant Activity of Culturable Endophytic Fungi from Alpine Plants of Rhodiola crenulata, R. angusta, and R. sachalinensis
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{"title"=>"Diversity and antioxidant activity of culturable endophytic fungi from alpine plants of Rhodiola crenulata, R. angusta, and R. sachalinensis", "type"=>"journal", "authors"=>[{"first_name"=>"Jin Long", "last_name"=>"Cui", "scopus_author_id"=>"36672607300"}, {"first_name"=>"Ting Ting", "last_name"=>"Guo", "scopus_author_id"=>"56089860700"}, {"first_name"=>"Zhen Xing", "last_name"=>"Ren", "scopus_author_id"=>"14058850700"}, {"first_name"=>"Na Sha", "last_name"=>"Zhang", "scopus_author_id"=>"56089731200"}, {"first_name"=>"Meng Liang", "last_name"=>"Wang", "scopus_author_id"=>"10640262700"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"604134955", "doi"=>"10.1371/journal.pone.0118204", "scopus"=>"2-s2.0-84929485349", "isbn"=>"1932-6203", "pmid"=>"25768014", "sgr"=>"84929485349", "issn"=>"19326203"}, "id"=>"4d0d7558-38cb-30ae-8854-306f3582272e", "abstract"=>"Rhodiola spp. are rare and endangered alpine plants widely used as medicines and food additives by many civilizations since ancient times. Their main effective ingredients (such as salidroside and p-tyrosol) are praised to exhibit pharmacologic effects on high-altitude sickness and possess anti-aging and other adaptogenic capacities based on their antioxidant properties. In this study, 347 endophytic fungi were isolated from R. crenulata, R. angusta, and R. sachalinensis, and the molecular diversity and antioxidant activities of these fungi were investigated for the first time. These fungi were categorized into 180 morphotypes based on cultural characteristics, and their rRNA gene ITS sequences were analyzed by BLAST search in the GenBank database. Except for 12 unidentified fungi (6.67%), all others were affiliated to at least 57 genera in 20 orders of four phyla, namely, Ascomycota (88.89%), Basidiomycota (2.78%), Zygomycota (1.11%), and Glomeromycota (0.56%), which exhibited high abundance and diversity. Antioxidant assay showed that the DPPH radical-scavenging rates of 114 isolates (63.33%) were >50%, and those of five isolates (Rct45, Rct63, Rct64, Rac76, and Rsc57) were >90%. The EC50 values of five antioxidant assays suggested significant potential of these fungi on scavenging DPPH•, O2-•, and OH• radicals, as well as scavenging nitrite and chelating Fe2+, which showed preference and selection between endophytic fungi and their hosts. Further research also provided the first evidence that Rac12 could produce salidrosides and p-tyrosol. Results suggested that versatile endophytic fungi associated with Rhodiola known as antioxidants could be exploited as potential sources of novel antioxidant products.", "link"=>"http://www.mendeley.com/research/diversity-antioxidant-activity-culturable-endophytic-fungi-alpine-plants-rhodiola-crenulata-r-angust", "reader_count"=>35, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Chemistry"=>3, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "reader_count_by_country"=>{"United States"=>1, "Spain"=>1}, "group_count"=>0}

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  • {"files"=>["https://ndownloader.figshare.com/files/1948620"], "description"=>"<div><p><i>Rhodiola</i> spp. are rare and endangered alpine plants widely used as medicines and food additives by many civilizations since ancient times. Their main effective ingredients (such as salidroside and <i>p</i>-tyrosol) are praised to exhibit pharmacologic effects on high-altitude sickness and possess anti-aging and other adaptogenic capacities based on their antioxidant properties. In this study, 347 endophytic fungi were isolated from <i>R. crenulata</i>, <i>R. angusta</i>, and <i>R. sachalinensis</i>, and the molecular diversity and antioxidant activities of these fungi were investigated for the first time. These fungi were categorized into 180 morphotypes based on cultural characteristics, and their rRNA gene ITS sequences were analyzed by BLAST search in the GenBank database. Except for 12 unidentified fungi (6.67%), all others were affiliated to at least 57 genera in 20 orders of four phyla, namely, Ascomycota (88.89%), Basidiomycota (2.78%), Zygomycota (1.11%), and Glomeromycota (0.56%), which exhibited high abundance and diversity. Antioxidant assay showed that the DPPH radical-scavenging rates of 114 isolates (63.33%) were >50%, and those of five isolates (Rct45, Rct63, Rct64, Rac76, and Rsc57) were >90%. The EC50 values of five antioxidant assays suggested significant potential of these fungi on scavenging DPPH•, O<sub>2</sub>−•, and OH• radicals, as well as scavenging nitrite and chelating Fe<sup>2+</sup>, which showed preference and selection between endophytic fungi and their hosts. Further research also provided the first evidence that Rac12 could produce salidrosides and p-tyrosol. Results suggested that versatile endophytic fungi associated with Rhodiola known as antioxidants could be exploited as potential sources of novel antioxidant products.</p></div>", "links"=>[], "tags"=>["EC 50 values", "oh", "rct", "exhibit pharmacologic effects", "sachalinensis Rhodiola spp", "novel antioxidant products", "Culturable Endophytic Fungi", "dpph", "endophytic fungi", "blast", "347 endophytic fungi"], "article_id"=>1335572, "categories"=>["Biological Sciences"], "users"=>["Jin-Long Cui", "Ting-Ting Guo", "Zhen-Xing Ren", "Na-Sha Zhang", "Meng-Liang Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118204", "stats"=>{"downloads"=>5, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Diversity_and_Antioxidant_Activity_of_Culturable_Endophytic_Fungi_from_Alpine_Plants_of_Rhodiola_crenulata_R_angusta_and_R_sachalinensis_/1335572", "title"=>"Diversity and Antioxidant Activity of Culturable Endophytic Fungi from Alpine Plants of <i>Rhodiola crenulata</i>, <i>R. angusta</i>, and <i>R. sachalinensis</i>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-13 04:32:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1948618"], "description"=>"<p>Endophytic fungi were affiliated to at least 11, 13, and 14 orders in <i>R</i>. <i>crenulata</i>, <i>R</i>. <i>angusta</i>, and <i>R</i>. <i>sachalinensis</i>, respectively, which exhibited high diversity.</p>", "links"=>[], "tags"=>["EC 50 values", "oh", "rct", "exhibit pharmacologic effects", "sachalinensis Rhodiola spp", "novel antioxidant products", "Culturable Endophytic Fungi", "dpph", "endophytic fungi", "blast", "347 endophytic fungi"], "article_id"=>1335570, "categories"=>["Biological Sciences"], "users"=>["Jin-Long Cui", "Ting-Ting Guo", "Zhen-Xing Ren", "Na-Sha Zhang", "Meng-Liang Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118204.g001", "stats"=>{"downloads"=>3, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Location_of_three_Rhodiola_plants_and_distributions_of_endophytic_fungi_in_their_hosts_/1335570", "title"=>"Location of three <i>Rhodiola</i> plants and distributions of endophytic fungi in their hosts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-13 04:32:51"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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