Cultivation and Differentiation Change Nuclear Localization of Chromosome Centromeres in Human Mesenchymal Stem Cells
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{"title"=>"Cultivation and differentiation change nuclear localization of chromosome centromeres in human mesenchymal stem cells", "type"=>"journal", "authors"=>[{"first_name"=>"Yana I.", "last_name"=>"Voldgorn", "scopus_author_id"=>"46861730600"}, {"first_name"=>"Elmira P.", "last_name"=>"Adilgereeva", "scopus_author_id"=>"56560170900"}, {"first_name"=>"Evgeny D.", "last_name"=>"Nekrasov", "scopus_author_id"=>"55263442300"}, {"first_name"=>"Alexander V.", "last_name"=>"Lavrov", "scopus_author_id"=>"8557773500"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84925127210", "sgr"=>"84925127210", "pui"=>"603024416", "pmid"=>"25775427", "doi"=>"10.1371/journal.pone.0118350"}, "id"=>"0d6caa9a-522e-3a3d-91ae-5006f15b60c0", "abstract"=>"Chromosome arrangement in the interphase nucleus is not accidental. Strong evidences support that nuclear localization is an important mechanism of epigenetic regulation of gene expression. The purpose of this research was to identify differences in the localization of centromeres of chromosomes 6, 12, 18 and X in human mesenchymal stem cells depending on differentiation and cultivating time. We analyzed centromere positions in more than 4000 nuclei in 19 mesenchymal stem cell cultures before and after prolonged cultivation and after differentiation into osteogenic and adipogenic directions. We found a centromere reposition of HSAX at late passages and after differentiation in osteogenic direction as well as of HSA12 and HSA18 after adipogenic differentiation. The observed changes of the nuclear structure are new nuclear characteristics of the studied cells which may reflect regulatory changes of gene expression during the studied processes.", "link"=>"http://www.mendeley.com/research/cultivation-differentiation-change-nuclear-localization-chromosome-centromeres-human-mesenchymal-ste", "reader_count"=>12, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Master"=>6, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Master"=>6, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>3, "Sports and Recreations"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1950893"], "description"=>"<p>The sizes of the colored circles show the frequency of finding the centromere in the particular radial interval. Braun—HSA6, yellow—HSA12, light-blue—HSA18, violet—HSAX (female), green—HSAX (male).</p>", "links"=>[], "tags"=>["differentiation", "centromere", "Human Mesenchymal Stem Cells Chromosome arrangement", "Strong evidences support", "adipogenic", "gene expression", "mesenchymal", "localization", "hsa", "Differentiation Change Nuclear Localization", "HSAX", "osteogenic"], "article_id"=>1337461, "categories"=>["Biological Sciences"], "users"=>["Yana I. Voldgorn", "Elmira P. Adilgereeva", "Evgeny D. Nekrasov", "Alexander V. Lavrov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118350.g006", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_distribution_of_RDCs_of_HSA12_HSA18_HSA6_1080_HSAX_in_MSC_nucleus_/1337461", "title"=>"Schematic distribution of RDCs of HSA12, HSA18, HSA6 и HSAX in MSC nucleus.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 05:09:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950892"], "description"=>"<p>RDCs of HSAX in female cells change osteogenic differentiation of MSC (p = 0,04). Dashed line demonstrates random distribution for comparison.</p>", "links"=>[], "tags"=>["differentiation", "centromere", "Human Mesenchymal Stem Cells Chromosome arrangement", "Strong evidences support", "adipogenic", "gene expression", "mesenchymal", "localization", "hsa", "Differentiation Change Nuclear Localization", "HSAX", "osteogenic"], "article_id"=>1337460, "categories"=>["Biological Sciences"], "users"=>["Yana I. Voldgorn", "Elmira P. Adilgereeva", "Evgeny D. Nekrasov", "Alexander V. Lavrov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118350.g005", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RDCs_of_HSAX_in_female_cells_before_and_after_osteogenic_differentiation_/1337460", "title"=>"RDCs of HSAX in female cells before and after osteogenic differentiation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 05:09:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950889"], "description"=>"<p>RDCs of HSA6, HSA12 and HSA18 (A) significantly differ from random distribution (χ2 criterion, p = 10–9, p = 10–12 and p = 10–73 for HSA6, HSA12 and HSA18, respectively). For RDCs of HSAX in female and male cultures (B) the difference between random and non-random distribution was not significant (p = 0,09 and p = 0,3 for HSAX in female and male cells, respectively), however combined data from female and male cells gave statistical power to fix the expected differences (p = 0.03).</p>", "links"=>[], "tags"=>["differentiation", "centromere", "Human Mesenchymal Stem Cells Chromosome arrangement", "Strong evidences support", "adipogenic", "gene expression", "mesenchymal", "localization", "hsa", "Differentiation Change Nuclear Localization", "HSAX", "osteogenic"], "article_id"=>1337457, "categories"=>["Biological Sciences"], "users"=>["Yana I. Voldgorn", "Elmira P. Adilgereeva", "Evgeny D. Nekrasov", "Alexander V. Lavrov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118350.g002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RDCs_of_HSA6_HSA12_HSA18_and_HSAX_and_the_random_signal_distribution_in_the_volume_of_the_nucleus_/1337457", "title"=>"RDCs of HSA6, HSA12, HSA18 and HSAX, and the random signal distribution in the volume of the nucleus.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 05:09:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950888"], "description"=>"<p>The nucleus is counterstained with DAPI. The centromere signals are seen as red and green dots. The following characteristics of the nuclear are shown: r is the distance from the nuclear mass center (MC) to the center of the signal, R is radius passing through the center of the signal to the nuclear edge; L is the distance between centromeres; α—is the angle between the signals of two centromeres. We determined relative distance of the centromere (RDC) as r/R for each signal. The distance (L) between all pairs of signals and angels (alfa) were also measured.</p>", "links"=>[], "tags"=>["differentiation", "centromere", "Human Mesenchymal Stem Cells Chromosome arrangement", "Strong evidences support", "adipogenic", "gene expression", "mesenchymal", "localization", "hsa", "Differentiation Change Nuclear Localization", "HSAX", "osteogenic"], "article_id"=>1337456, "categories"=>["Biological Sciences"], "users"=>["Yana I. Voldgorn", "Elmira P. Adilgereeva", "Evgeny D. Nekrasov", "Alexander V. Lavrov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118350.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nuclear_characteristics_/1337456", "title"=>"Nuclear characteristics.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 05:09:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950903"], "description"=>"<div><p>Chromosome arrangement in the interphase nucleus is not accidental. Strong evidences support that nuclear localization is an important mechanism of epigenetic regulation of gene expression. The purpose of this research was to identify differences in the localization of centromeres of chromosomes 6, 12, 18 and X in human mesenchymal stem cells depending on differentiation and cultivating time. We analyzed centromere positions in more than 4000 nuclei in 19 mesenchymal stem cell cultures before and after prolonged cultivation and after differentiation into osteogenic and adipogenic directions. We found a centromere reposition of HSAX at late passages and after differentiation in osteogenic direction as well as of HSA12 and HSA18 after adipogenic differentiation. The observed changes of the nuclear structure are new nuclear characteristics of the studied cells which may reflect regulatory changes of gene expression during the studied processes.</p></div>", "links"=>[], "tags"=>["differentiation", "centromere", "Human Mesenchymal Stem Cells Chromosome arrangement", "Strong evidences support", "adipogenic", "gene expression", "mesenchymal", "localization", "hsa", "Differentiation Change Nuclear Localization", "HSAX", "osteogenic"], "article_id"=>1337465, "categories"=>["Biological Sciences"], "users"=>["Yana I. Voldgorn", "Elmira P. Adilgereeva", "Evgeny D. Nekrasov", "Alexander V. Lavrov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118350", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cultivation_and_Differentiation_Change_Nuclear_Localization_of_Chromosome_Centromeres_in_Human_Mesenchymal_Stem_Cells_/1337465", "title"=>"Cultivation and Differentiation Change Nuclear Localization of Chromosome Centromeres in Human Mesenchymal Stem Cells", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-16 05:09:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950895"], "description"=>"<p>Statistical characteristics of RDCs of the HSA6, HSA12, HSA18 and HSAX.</p>", "links"=>[], "tags"=>["differentiation", "centromere", "Human Mesenchymal Stem Cells Chromosome arrangement", "Strong evidences support", "adipogenic", "gene expression", "mesenchymal", "localization", "hsa", "Differentiation Change Nuclear Localization", "HSAX", "osteogenic"], "article_id"=>1337463, "categories"=>["Biological Sciences"], "users"=>["Yana I. Voldgorn", "Elmira P. Adilgereeva", "Evgeny D. Nekrasov", "Alexander V. Lavrov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118350.t001", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Statistical_characteristics_of_RDCs_of_the_HSA6_HSA12_HSA18_and_HSAX_/1337463", "title"=>"Statistical characteristics of RDCs of the HSA6, HSA12, HSA18 and HSAX.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-16 05:09:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950894"], "description"=>"<p>RDCs of HSA12 differ between MSC cells at early passages, after adipogenic differentiation (p = 0,008) and lymphocytes (p<10<sup>–9</sup>).</p>", "links"=>[], "tags"=>["differentiation", "centromere", "Human Mesenchymal Stem Cells Chromosome arrangement", "Strong evidences support", "adipogenic", "gene expression", "mesenchymal", "localization", "hsa", "Differentiation Change Nuclear Localization", "HSAX", "osteogenic"], "article_id"=>1337462, "categories"=>["Biological Sciences"], "users"=>["Yana I. Voldgorn", "Elmira P. Adilgereeva", "Evgeny D. Nekrasov", "Alexander V. Lavrov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118350.g007", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RDCs_of_HSA12_in_MSC_at_early_passages_after_adipogenic_differentiation_and_in_lymphocytes_/1337462", "title"=>"RDCs of HSA12 in MSC at early passages, after adipogenic differentiation and in lymphocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 05:09:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950891"], "description"=>"<p>RDCs of HSA12 (A) and HSA18 (B) both change after adipogenic differentiation of MSC (p = 0,008 for HSA12 and p = 0,0001 for HSA18). Dashed line demonstrates random distribution for comparison.</p>", "links"=>[], "tags"=>["differentiation", "centromere", "Human Mesenchymal Stem Cells Chromosome arrangement", "Strong evidences support", "adipogenic", "gene expression", "mesenchymal", "localization", "hsa", "Differentiation Change Nuclear Localization", "HSAX", "osteogenic"], "article_id"=>1337459, "categories"=>["Biological Sciences"], "users"=>["Yana I. Voldgorn", "Elmira P. Adilgereeva", "Evgeny D. Nekrasov", "Alexander V. Lavrov"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118350.g004", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RDCs_of_HSA12_and_HSA18_before_and_after_adipogenic_differentiation_/1337459", "title"=>"RDCs of HSA12 and HSA18 before and after adipogenic differentiation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 05:09:52"}
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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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Net::HTTPInternalServerError

Source
Counter
Time
2019-04-06 02:41:41 UTC
Target URL
http://counter-101.soma.plos.org/api/v1.0/stats/doi/10.1371%2Fjournal.pone.0118350
Trace

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/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
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/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'