Prediction of Poor Prognosis in Breast Cancer Patients Based on MicroRNA-21 Expression: A Meta-Analysis
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{"title"=>"Prediction of poor prognosis in breast cancer patients based on MicroRNA-21 expression: A meta-analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Yanyan", "last_name"=>"Wang", "scopus_author_id"=>"57194243700"}, {"first_name"=>"Yujie", "last_name"=>"Zhang", "scopus_author_id"=>"56049092300"}, {"first_name"=>"Chi", "last_name"=>"Pan", "scopus_author_id"=>"55200267800"}, {"first_name"=>"Feixia", "last_name"=>"Ma", "scopus_author_id"=>"56525978400"}, {"first_name"=>"Suzhan", "last_name"=>"Zhang", "scopus_author_id"=>"23391621200"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84923362449", "pmid"=>"25706383", "sgr"=>"84923362449", "doi"=>"10.1371/journal.pone.0118647", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "pui"=>"602475449"}, "id"=>"5962c556-0e4f-3491-83e6-9cc8f01b7dad", "abstract"=>"Background MicroRNA-21 (miRNA-21 or miR-21) may act as a prognostic biomarker of cancer. However, the available evidence is controversial. Therefore, the present meta-analysis summarizes this evidence and evaluates the prognostic role of this gene in breast cancer. Methods The meta-analysis was conducted by searching the databases of PubMed, EMBASE, Web of Science and Chinese database-China National Knowledge Infrastructure (CNKI). Data were extracted from studies that investigated the association between miR-21 expression and survival outcomes in breast cancer patients. With respect to survival outcomes, the pooled hazard ratios (HRs) of miR-21 were calculated given a 95% confidence interval (CI). Results Our meta-analysis identified a total of 10 studies involving 1,439 cases. Further investigation demonstrated that a high miR-21 expression can predict poor overall survival (OS) (HR = 2.57, 95% CI: 1.37—4.81, P = 0.003) and shortened disease-free/recurrence-free survival (DFS/RFS) (HR = 1.45, 95% CI: 1.16—1.82, P = 0.001) in breast cancer patients. Moreover, high miR-21 expression was significantly correlated with lowered OS in the Asian group (HR = 5.07, 95% CI: 2.89—8.92, P < 0.001), but not in the Caucasian cohort (HR = 1.44, 95% CI: 0.99—2.10, P = 0.058). Furthermore, odds ratios (ORs) showed that up-regulated miR-21 levels were associated with multiple clinical characteristics. Conclusion Our results indicated that miR-21 can predict unfavorable prognoses in breast cancer patients, especially in Asians.", "link"=>"http://www.mendeley.com/research/prediction-poor-prognosis-breast-cancer-patients-based-microrna21-expression-metaanalysis", "reader_count"=>13, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>4, "Materials Science"=>1, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>6}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}}, "reader_count_by_country"=>{"Denmark"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1920990"], "description"=>"<p>Flow diagram of the study selection process.</p>", "links"=>[], "tags"=>["os", "or", "hr", "embase", "breast cancer patients", "expression", "survival outcomes", "ci", "dfs", "CNKI", "mir"], "article_id"=>1315579, "categories"=>["Biological Sciences"], "users"=>["Yanyan Wang", "Yujie Zhang", "Chi Pan", "Feixia Ma", "Suzhan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118647.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_diagram_of_the_study_selection_process_/1315579", "title"=>"Flow diagram of the study selection process.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-23 03:35:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1920992"], "description"=>"<p>Forest plots of the relationship between elevated miR-21 level and OS (A) and DFS/RFS (B).</p>", "links"=>[], "tags"=>["os", "or", "hr", "embase", "breast cancer patients", "expression", "survival outcomes", "ci", "dfs", "CNKI", "mir"], "article_id"=>1315582, "categories"=>["Biological Sciences"], "users"=>["Yanyan Wang", "Yujie Zhang", "Chi Pan", "Feixia Ma", "Suzhan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118647.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_plots_of_the_relationship_between_elevated_miR_21_level_and_OS_A_and_DFS_RFS_B_/1315582", "title"=>"Forest plots of the relationship between elevated miR-21 level and OS (A) and DFS/RFS (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-23 03:35:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1920994"], "description"=>"<p>Funnel plot for publication bias analysis: (A) OS; (B) DFS/RFS.</p>", "links"=>[], "tags"=>["os", "or", "hr", "embase", "breast cancer patients", "expression", "survival outcomes", "ci", "dfs", "CNKI", "mir"], "article_id"=>1315584, "categories"=>["Biological Sciences"], "users"=>["Yanyan Wang", "Yujie Zhang", "Chi Pan", "Feixia Ma", "Suzhan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118647.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Funnel_plot_for_publication_bias_analysis_A_OS_B_DFS_RFS_/1315584", "title"=>"Funnel plot for publication bias analysis: (A) OS; (B) DFS/RFS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-23 03:35:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1920997"], "description"=>"<p>Sensitivity analysis for OS (A) and DFS/RFS (B).</p>", "links"=>[], "tags"=>["os", "or", "hr", "embase", "breast cancer patients", "expression", "survival outcomes", "ci", "dfs", "CNKI", "mir"], "article_id"=>1315587, "categories"=>["Biological Sciences"], "users"=>["Yanyan Wang", "Yujie Zhang", "Chi Pan", "Feixia Ma", "Suzhan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118647.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sensitivity_analysis_for_OS_A_and_DFS_RFS_B_/1315587", "title"=>"Sensitivity analysis for OS (A) and DFS/RFS (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-23 03:35:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1920999"], "description"=>"<p>Abbreviations: FFPE, formalin-fixed paraffin-embedded; AP, author provided; SC, survival curve; NM, not mentioned; OS, overall survival; DFS, disease-free survival; RFS, recurrence-free survival; TNBC, triple-negative breast cancer; Müller-b, results before therapy; Müller-a, results after therapy.</p><p>*The extracted OS data is obviously not consistent with the survival curve, so only provided RFS is used for analysis.</p><p>Main characteristics of enrolled studies.</p>", "links"=>[], "tags"=>["os", "or", "hr", "embase", "breast cancer patients", "expression", "survival outcomes", "ci", "dfs", "CNKI", "mir"], "article_id"=>1315589, "categories"=>["Biological Sciences"], "users"=>["Yanyan Wang", "Yujie Zhang", "Chi Pan", "Feixia Ma", "Suzhan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118647.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Main_characteristics_of_enrolled_studies_/1315589", "title"=>"Main characteristics of enrolled studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-23 03:35:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1921001"], "description"=>"<p>Abbreviations: qRT-PCR, quantitative real-time PCR; M, multivariate analysis; U, Univariate analysis; KM, Kaplan–Meier analysis; NM, not mentioned; OS, overall survival; DFS, disease-free survival; RFS, recurrence-free survival; Müller-b, results before therapy; Müller-a, results after therapy.</p><p>Main results of enrolled studies.</p>", "links"=>[], "tags"=>["os", "or", "hr", "embase", "breast cancer patients", "expression", "survival outcomes", "ci", "dfs", "CNKI", "mir"], "article_id"=>1315591, "categories"=>["Biological Sciences"], "users"=>["Yanyan Wang", "Yujie Zhang", "Chi Pan", "Feixia Ma", "Suzhan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118647.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Main_results_of_enrolled_studies_/1315591", "title"=>"Main results of enrolled studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-23 03:35:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1921002"], "description"=>"<p>Subgroup analyses of pooled hazard ratios for overall survival with elevated miR-21 expression.</p>", "links"=>[], "tags"=>["os", "or", "hr", "embase", "breast cancer patients", "expression", "survival outcomes", "ci", "dfs", "CNKI", "mir"], "article_id"=>1315592, "categories"=>["Biological Sciences"], "users"=>["Yanyan Wang", "Yujie Zhang", "Chi Pan", "Feixia Ma", "Suzhan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118647.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subgroup_analyses_of_pooled_hazard_ratios_for_overall_survival_with_elevated_miR_21_expression_/1315592", "title"=>"Subgroup analyses of pooled hazard ratios for overall survival with elevated miR-21 expression.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-23 03:35:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1921003"], "description"=>"<p>Meta-analyses of miR-21 Expression Classified by clinicopathologic parameters.</p>", "links"=>[], "tags"=>["os", "or", "hr", "embase", "breast cancer patients", "expression", "survival outcomes", "ci", "dfs", "CNKI", "mir"], "article_id"=>1315593, "categories"=>["Biological Sciences"], "users"=>["Yanyan Wang", "Yujie Zhang", "Chi Pan", "Feixia Ma", "Suzhan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118647.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Meta_analyses_of_miR_21_Expression_Classified_by_clinicopathologic_parameters_/1315593", "title"=>"Meta-analyses of miR-21 Expression Classified by clinicopathologic parameters.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-23 03:35:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1921004", "https://ndownloader.figshare.com/files/1921005", "https://ndownloader.figshare.com/files/1921006"], "description"=>"<div><p>Background</p><p>MicroRNA-21 (miRNA-21 or miR-21) may act as a prognostic biomarker of cancer. However, the available evidence is controversial. Therefore, the present meta-analysis summarizes this evidence and evaluates the prognostic role of this gene in breast cancer.</p><p>Methods</p><p>The meta-analysis was conducted by searching the databases of PubMed, EMBASE, Web of Science and Chinese database-China National Knowledge Infrastructure (CNKI). Data were extracted from studies that investigated the association between miR-21 expression and survival outcomes in breast cancer patients. With respect to survival outcomes, the pooled hazard ratios (HRs) of miR-21 were calculated given a 95% confidence interval (CI).</p><p>Results</p><p>Our meta-analysis identified a total of 10 studies involving 1,439 cases. Further investigation demonstrated that a high miR-21 expression can predict poor overall survival (OS) (HR = 2.57, 95% CI: 1.37—4.81, <i>P</i> = 0.003) and shortened disease-free/recurrence-free survival (DFS/RFS) (HR = 1.45, 95% CI: 1.16—1.82, <i>P</i> = 0.001) in breast cancer patients. Moreover, high miR-21 expression was significantly correlated with lowered OS in the Asian group (HR = 5.07, 95% CI: 2.89—8.92, <i>P</i> < 0.001), but not in the Caucasian cohort (HR = 1.44, 95% CI: 0.99—2.10, <i>P</i> = 0.058). Furthermore, odds ratios (ORs) showed that up-regulated miR-21 levels were associated with multiple clinical characteristics.</p><p>Conclusion</p><p>Our results indicated that miR-21 can predict unfavorable prognoses in breast cancer patients, especially in Asians.</p></div>", "links"=>[], "tags"=>["os", "or", "hr", "embase", "breast cancer patients", "expression", "survival outcomes", "ci", "dfs", "CNKI", "mir"], "article_id"=>1315594, "categories"=>["Biological Sciences"], "users"=>["Yanyan Wang", "Yujie Zhang", "Chi Pan", "Feixia Ma", "Suzhan Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118647.s001", "https://dx.doi.org/10.1371/journal.pone.0118647.s002", "https://dx.doi.org/10.1371/journal.pone.0118647.s003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prediction_of_Poor_Prognosis_in_Breast_Cancer_Patients_Based_on_MicroRNA_21_Expression_A_Meta_Analysis_/1315594", "title"=>"Prediction of Poor Prognosis in Breast Cancer Patients Based on MicroRNA-21 Expression: A Meta-Analysis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-02-23 03:35:07"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"53", "full-text"=>"54", "pdf"=>"34", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"31", "full-text"=>"37", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"71", "full-text"=>"72", "pdf"=>"84", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"27", "full-text"=>"27", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"38", "full-text"=>"46", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"42", "full-text"=>"36", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"24", "full-text"=>"30", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"24", "full-text"=>"23", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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