Tissue Engineering for Human Urethral Reconstruction: Systematic Review of Recent Literature
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Mendeley | Further Information

{"title"=>"Tissue Engineering for Human Urethral Reconstruction: Systematic Review of Recent Literature", "type"=>"journal", "authors"=>[{"first_name"=>"Vincent", "last_name"=>"de Kemp"}, {"first_name"=>"Petra", "last_name"=>"de Graaf"}, {"first_name"=>"Joost O.", "last_name"=>"Fledderus"}, {"first_name"=>"J. L. H.", "last_name"=>"Ruud Bosch"}, {"first_name"=>"Laetitia M. O.", "last_name"=>"de Kort"}], "year"=>2015, "source"=>"PLOS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0118653", "pmid"=>"25689740", "isbn"=>"1932-6203"}, "id"=>"8a27981f-9a1f-30b7-a23b-b0b33722e15c", "abstract"=>"BACKGROUND Techniques to treat urethral stricture and hypospadias are restricted, as substitution of the unhealthy urethra with tissue from other origins (skin, bladder or buccal mucosa) has some limitations. Therefore, alternative sources of tissue for use in urethral reconstructions are considered, such as ex vivo engineered constructs. PURPOSE To review recent literature on tissue engineering for human urethral reconstruction. METHODS A search was made in the PubMed and Embase databases restricted to the last 25 years and the English language. RESULTS A total of 45 articles were selected describing the use of tissue engineering in urethral reconstruction. The results are discussed in four groups: autologous cell cultures, matrices/scaffolds, cell-seeded scaffolds, and clinical results of urethral reconstructions using these materials. Different progenitor cells were used, isolated from either urine or adipose tissue, but slightly better results were obtained with in vitro expansion of urothelial cells from bladder washings, tissue biopsies from the bladder (urothelium) or the oral cavity (buccal mucosa). Compared with a synthetic scaffold, a biological scaffold has the advantage of bioactive extracellular matrix proteins on its surface. When applied clinically, a non-seeded matrix only seems suited for use as an onlay graft. When a tubularized substitution is the aim, a cell-seeded construct seems more beneficial. CONCLUSIONS Considerable experience is available with tissue engineering of urethral tissue in vitro, produced with cells of different origin. Clinical and in vivo experiments show promising results.", "link"=>"http://www.mendeley.com/research/tissue-engineering-human-urethral-reconstruction-systematic-review-recent-literature", "reader_count"=>41, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>4, "Biochemistry, Genetics and Molecular Biology"=>4, "Materials Science"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>15, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>2, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Colombia"=>1, "Australia"=>1, "Spain"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1908504"], "description"=>"<p>The database search was performed on 5 November 2013 according to the PRISMA statement [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118653#pone.0118653.ref004\" target=\"_blank\">4</a>]. For more details on the search strategy see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118653#sec007\" target=\"_blank\">Methods</a> section.</p>", "links"=>[], "tags"=>["Tissue engineering", "Different progenitor cells", "scaffold", "urethral reconstruction.MethodsA search", "autologous cell cultures", "vivo experiments show", "buccal mucosa", "Human Urethral Reconstruction", "Recent Literature BackgroundTechniques", "urethral reconstructions", "bioactive extracellular matrix proteins"], "article_id"=>1310642, "categories"=>["Biological Sciences"], "users"=>["Vincent de Kemp", "Petra de Graaf", "Joost O. Fledderus", "J. L. H. Ruud Bosch", "Laetitia M. O. de Kort"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118653.g001", "stats"=>{"downloads"=>3, "page_views"=>74, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Search_strategy_and_selection_of_the_studies_for_the_present_review_n_44_/1310642", "title"=>"Search strategy and selection of the studies for the present review (n = 44).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-17 02:44:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1908505"], "description"=>"<p>n/a, not applicable</p><p>Studies investigating autologous cells (n = 18).</p>", "links"=>[], "tags"=>["Tissue engineering", "Different progenitor cells", "scaffold", "urethral reconstruction.MethodsA search", "autologous cell cultures", "vivo experiments show", "buccal mucosa", "Human Urethral Reconstruction", "Recent Literature BackgroundTechniques", "urethral reconstructions", "bioactive extracellular matrix proteins"], "article_id"=>1310643, "categories"=>["Biological Sciences"], "users"=>["Vincent de Kemp", "Petra de Graaf", "Joost O. Fledderus", "J. L. H. Ruud Bosch", "Laetitia M. O. de Kort"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118653.t001", "stats"=>{"downloads"=>8, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Studies_investigating_autologous_cells_n_18_/1310643", "title"=>"Studies investigating autologous cells (n = 18).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-17 02:44:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1908506"], "description"=>"<p>Studies investigating scaffolds and cell-seeded scaffolds (n = 19).</p>", "links"=>[], "tags"=>["Tissue engineering", "Different progenitor cells", "scaffold", "urethral reconstruction.MethodsA search", "autologous cell cultures", "vivo experiments show", "buccal mucosa", "Human Urethral Reconstruction", "Recent Literature BackgroundTechniques", "urethral reconstructions", "bioactive extracellular matrix proteins"], "article_id"=>1310644, "categories"=>["Biological Sciences"], "users"=>["Vincent de Kemp", "Petra de Graaf", "Joost O. Fledderus", "J. L. H. Ruud Bosch", "Laetitia M. O. de Kort"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118653.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Studies_investigating_scaffolds_and_cell_seeded_scaffolds_n_19_/1310644", "title"=>"Studies investigating scaffolds and cell-seeded scaffolds (n = 19).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-17 02:44:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1908507"], "description"=>"<p>n/a, not applicable</p><p>Results of clinical studies using TE techniques (n = 6).</p>", "links"=>[], "tags"=>["Tissue engineering", "Different progenitor cells", "scaffold", "urethral reconstruction.MethodsA search", "autologous cell cultures", "vivo experiments show", "buccal mucosa", "Human Urethral Reconstruction", "Recent Literature BackgroundTechniques", "urethral reconstructions", "bioactive extracellular matrix proteins"], "article_id"=>1310645, "categories"=>["Biological Sciences"], "users"=>["Vincent de Kemp", "Petra de Graaf", "Joost O. Fledderus", "J. L. H. Ruud Bosch", "Laetitia M. O. de Kort"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118653.t003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_clinical_studies_using_TE_techniques_n_6_/1310645", "title"=>"Results of clinical studies using TE techniques (n = 6).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-17 02:44:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1908508", "https://ndownloader.figshare.com/files/1908509"], "description"=>"<div><p>Background</p><p>Techniques to treat urethral stricture and hypospadias are restricted, as substitution of the unhealthy urethra with tissue from other origins (skin, bladder or buccal mucosa) has some limitations. Therefore, alternative sources of tissue for use in urethral reconstructions are considered, such as <i>ex vivo</i> engineered constructs.</p><p>Purpose</p><p>To review recent literature on tissue engineering for human urethral reconstruction.</p><p>Methods</p><p>A search was made in the PubMed and Embase databases restricted to the last 25 years and the English language.</p><p>Results</p><p>A total of 45 articles were selected describing the use of tissue engineering in urethral reconstruction. The results are discussed in four groups: autologous cell cultures, matrices/scaffolds, cell-seeded scaffolds, and clinical results of urethral reconstructions using these materials. Different progenitor cells were used, isolated from either urine or adipose tissue, but slightly better results were obtained with <i>in vitro</i> expansion of urothelial cells from bladder washings, tissue biopsies from the bladder (urothelium) or the oral cavity (buccal mucosa). Compared with a synthetic scaffold, a biological scaffold has the advantage of bioactive extracellular matrix proteins on its surface. When applied clinically, a non-seeded matrix only seems suited for use as an onlay graft. When a tubularized substitution is the aim, a cell-seeded construct seems more beneficial.</p><p>Conclusions</p><p>Considerable experience is available with tissue engineering of urethral tissue <i>in vitro</i>, produced with cells of different origin. Clinical and <i>in vivo</i> experiments show promising results.</p></div>", "links"=>[], "tags"=>["Tissue engineering", "Different progenitor cells", "scaffold", "urethral reconstruction.MethodsA search", "autologous cell cultures", "vivo experiments show", "buccal mucosa", "Human Urethral Reconstruction", "Recent Literature BackgroundTechniques", "urethral reconstructions", "bioactive extracellular matrix proteins"], "article_id"=>1310646, "categories"=>["Biological Sciences"], "users"=>["Vincent de Kemp", "Petra de Graaf", "Joost O. Fledderus", "J. L. H. Ruud Bosch", "Laetitia M. O. de Kort"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118653.s001", "https://dx.doi.org/10.1371/journal.pone.0118653.s002"], "stats"=>{"downloads"=>10, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tissue_Engineering_for_Human_Urethral_Reconstruction_Systematic_Review_of_Recent_Literature_/1310646", "title"=>"Tissue Engineering for Human Urethral Reconstruction: Systematic Review of Recent Literature", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-02-17 02:44:42"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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