Repeatability of Quantitative Sodium Magnetic Resonance Imaging for Estimating Pseudo-Intracellular Sodium Concentration and Pseudo-Extracellular Volume Fraction in Brain at 3 T
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{"title"=>"Repeatability of quantitative sodium magnetic resonance imaging for estimating pseudo-intracellular sodium concentration and pseudo-extracellular volume fraction in brain at 3 T", "type"=>"journal", "authors"=>[{"first_name"=>"Guillaume", "last_name"=>"Madelin", "scopus_author_id"=>"8720404900"}, {"first_name"=>"James", "last_name"=>"Babb", "scopus_author_id"=>"7102232878"}, {"first_name"=>"Ding", "last_name"=>"Xia", "scopus_author_id"=>"54981460100"}, {"first_name"=>"Ravinder R.", "last_name"=>"Regatte", "scopus_author_id"=>"6601956541"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0118692", "sgr"=>"84928914734", "scopus"=>"2-s2.0-84928914734", "issn"=>"19326203", "pui"=>"604166186"}, "id"=>"8a4b6174-69b4-39b9-9841-f9b95f0fe4f3", "abstract"=>"The purpose of this study is to assess the repeatability of the quantification of pseudo-intracellular sodium concentration (C1) and pseudo-extracellular volume fraction (α) estimated in brain in vivo using sodium magnetic resonance (MRI) at 3 T. Eleven healthy subjects were scanned twice, with two sodium MRI acquisitions (with and without fluid suppression by inversion recovery), and two double inversion recovery (DIR) proton MRI. DIR MRIs were used to create masks of gray and white matter (GM, WM), that were subsequently applied to the C1 and α maps calculated from sodium MRI and a tissue three-compartment model, in order to measure the distributions of these two parameters in GM, WM or full brain (GM+WM) separately. The mean, median, mode, standard deviation (std), skewness and kurtosis of the C1 and α distributions in whole GM, WM and full brain were calculated for each subject, averaged over all data, and used as parameters for the repeatability assessment. The coefficient of variation (CV) was calculated as a measure of reliability for the detection of intra-subject changes in C1 and αfor each parameter, while intraclass correlation (ICC) was used as a measure of repeatability. It was found that the CV of most of the parameters was around 10-20% (except for C1 kurtosis which is about 40%) for C1 and α measurements, and that ICC was moderate to very good (0.4 to 0.9) for C1 parameters and for some of the α parameters (mainly skewness and kurtosis). In conclusion, the proposed method could allow to reliably detect changes of 50% and above of the different measurement parameters of C1 and αin neuropathologies (multiple sclerosis, tumor, stroke, Alzheimer's disease) compared to healthy subjects, and that skewness and kurtosis of the distributions of C1 and αseem to be the more sensitive parameters to these changes.", "link"=>"http://www.mendeley.com/research/repeatability-quantitative-sodium-magnetic-resonance-imaging-estimating-pseudointracellular-sodium-c", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Librarian"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Librarian"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>1, "Social Sciences"=>1, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1940147", "https://ndownloader.figshare.com/files/1940148"], "description"=>"<div><p>The purpose of this study is to assess the repeatability of the quantification of pseudo-intracellular sodium concentration (C<sub>1</sub>) and pseudo-extracellular volume fraction (α) estimated in brain in vivo using sodium magnetic resonance (MRI) at 3 T. Eleven healthy subjects were scanned twice, with two sodium MRI acquisitions (with and without fluid suppression by inversion recovery), and two double inversion recovery (DIR) proton MRI. DIR MRIs were used to create masks of gray and white matter (GM, WM), that were subsequently applied to the C<sub>1</sub> and α maps calculated from sodium MRI and a tissue three-compartment model, in order to measure the distributions of these two parameters in GM, WM or full brain (GM+WM) separately. The mean, median, mode, standard deviation (std), skewness and kurtosis of the C<sub>1</sub> and α distributions in whole GM, WM and full brain were calculated for each subject, averaged over all data, and used as parameters for the repeatability assessment. The coefficient of variation (CV) was calculated as a measure of reliability for the detection of intra-subject changes in C<sub>1</sub> and αfor each parameter, while intraclass correlation (ICC) was used as a measure of repeatability. It was found that the CV of most of the parameters was around 10–20% (except for C<sub>1</sub> kurtosis which is about 40%) for C<sub>1</sub> and α measurements, and that ICC was moderate to very good (0.4 to 0.9) for C<sub>1</sub> parameters and for some of the α parameters (mainly skewness and kurtosis). In conclusion, the proposed method could allow to reliably detect changes of 50% and above of the different measurement parameters of C<sub>1</sub> and αin neuropathologies (multiple sclerosis, tumor, stroke, Alzheimer’s disease) compared to healthy subjects, and that skewness and kurtosis of the distributions of C<sub>1</sub> and αseem to be the more sensitive parameters to these changes.</p></div>", "links"=>[], "tags"=>["wm", "repeatability", "gm", "skewnes", "subject", "C 1 parameters", "sodium MRI acquisitions", "cv", "3 T", "C 1", "C 1 kurtosis", "dir", "icc"], "article_id"=>1328795, "categories"=>["Biological Sciences"], "users"=>["Guillaume Madelin", "James F. Babb", "Ding Xia", "Ravinder R. Regatte"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118692.s001", "https://dx.doi.org/10.1371/journal.pone.0118692.s002"], "stats"=>{"downloads"=>24, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Repeatability_of_Quantitative_Sodium_Magnetic_Resonance_Imaging_for_Estimating_Pseudo_Intracellular_Sodium_Concentration_and_Pseudo_Extracellular_Volume_Fraction_in_Brain_at_3_T_/1328795", "title"=>"Repeatability of Quantitative Sodium Magnetic Resonance Imaging for Estimating Pseudo-Intracellular Sodium Concentration and Pseudo-Extracellular Volume Fraction in Brain at 3 T", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-03-09 08:16:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940146"], "description"=>"<p>Mean and standard deviation (two first columns) of mean, median, mode, standard deviation (std), skewness and kurtosis of <i>α</i> were calculated over all data (n = 22, from 11 volunteers scanned twice). Note that the mean and std over all data were labeled mean<sub>all</sub> and std<sub>all</sub> to avoid confusion with the mean and std of the measurements of C<sub>1</sub> and <i>α</i> for each volunteer and scan. Inter- and intra-subject variance (Inter-Var and Intra-Var respectively), coefficient of variation (CV, in %) and intra-class correlation (ICC) were calculated as described in the Statistical analysis section (see text). NA: Not available; the CV is not appropriate for measures (e.g., skewness) that are not inherently non-negative. Symbols represent subjective evaluation of CV and ICC: •• = very good (ICC ⩾ 0.8 or CV ⩽ 10%), • = good (0.6 ⩽ ICC < 0.8 or 10% < CV ⩽ 20%), ∘ = fair/moderate (0.4 ⩽ ICC < 0.6 or 20% < CV ⩽ 30%), ◊ = poor (ICC < 0.4 or CV ⩾ 30%).</p><p>Repeatability of pseudo-extracellular volume fraction (<i>α</i>).</p>", "links"=>[], "tags"=>["wm", "repeatability", "gm", "skewnes", "subject", "C 1 parameters", "sodium MRI acquisitions", "cv", "3 T", "C 1", "C 1 kurtosis", "dir", "icc"], "article_id"=>1328794, "categories"=>["Biological Sciences"], "users"=>["Guillaume Madelin", "James F. Babb", "Ding Xia", "Ravinder R. Regatte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118692.t002", "stats"=>{"downloads"=>4, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Repeatability_of_pseudo_extracellular_volume_fraction_945_/1328794", "title"=>"Repeatability of pseudo-extracellular volume fraction (<i>α</i>).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-09 08:16:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940141"], "description"=>"<p><b>A</b>. (<b>1</b>) Sodium MRI acquisition with and without IR, and proton DIR acquisition. (<b>2</b>) Linear regression of reference phantoms signals. (<b>3</b>) Calculation of aTSC and aISC maps. (<b>4</b>) Calculation of the masks of GM, WM and full brain (GM+WM) from DIR data. (<b>5</b>) Multiplication of sodium maps by the masks. <b>B</b>. Three-compartment model: compartment 1 = intracellular space of volume V<sub>1</sub> and sodium concentration C<sub>1</sub>; compartment 2 = extracellular space of volume V<sub>2</sub>, sodium concentration C<sub>2</sub> and extracellular volume fraction <i>α</i>; compartment 3 = solid compartment of volume V<sub><i>s</i></sub> and no sodium. Total volume is V<sub><i>t</i></sub> = V<sub>1</sub>+ V<sub>2</sub> +V<sub><i>s</i></sub>. Water volume fraction is denoted w. <b>C</b>. C<sub>1</sub> and <i>α</i> maps in full brain, GM, and WM calculated from aTSC, aISC and the 3-compartment model. <b>D</b>. Histograms of C<sub>1</sub> and <i>α</i> values over the whole full brain, whole GM and whole WM data. GM = gray matter, WM = white matter, GM+WM = full brain. Reproduced from Figs. <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118692#pone.0118692.g001\" target=\"_blank\">1</a>–<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118692#pone.0118692.g004\" target=\"_blank\">4</a> from Ref. [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118692#pone.0118692.ref023\" target=\"_blank\">23</a>].</p>", "links"=>[], "tags"=>["wm", "repeatability", "gm", "skewnes", "subject", "C 1 parameters", "sodium MRI acquisitions", "cv", "3 T", "C 1", "C 1 kurtosis", "dir", "icc"], "article_id"=>1328789, "categories"=>["Biological Sciences"], "users"=>["Guillaume Madelin", "James F. Babb", "Ding Xia", "Ravinder R. Regatte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118692.g001", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_the_brain_data_MRI_acquisition_and_processing_/1328789", "title"=>"Summary of the brain data MRI acquisition and processing.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-09 08:16:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940145"], "description"=>"<p>Mean and standard deviation (two first columns) of mean, median, mode, standard deviation (std), skewness and kurtosis of C<sub>1</sub> were calculated over all data (n = 22, from 11 volunteers scanned twice). Note that the mean and std over all data were labeled mean<sub>all</sub> and std<sub>all</sub> to avoid confusion with the mean and std of the measurements of C<sub>1</sub> and <i>α</i> for each volunteer and scan. Inter- and intra-subject variance (Inter-Var and Intra-Var respectively), coefficient of variation (CV, in %) and intra-class correlation (ICC) were calculated as described in the Statistical analysis section (see text). NA: Not available; the CV is not appropriate for measures (e.g., skewness) that are not inherently non-negative. Symbols represent subjective evaluation of CV and ICC: •• = very good (ICC ⩾ 0.8 or CV ⩽ 10%), • = good (0.6 ⩽ ICC < 0.8 or 10% < CV ⩽ 20%), ∘ = fair/moderate (0.4 ⩽ ICC < 0.6 or 20% < CV ⩽ 30%), ◊ = poor (ICC < 0.4 or CV ⩾ 30%).</p><p>Repeatability of pseudo-intracellular sodium concentration (C<sub>1</sub>).</p>", "links"=>[], "tags"=>["wm", "repeatability", "gm", "skewnes", "subject", "C 1 parameters", "sodium MRI acquisitions", "cv", "3 T", "C 1", "C 1 kurtosis", "dir", "icc"], "article_id"=>1328793, "categories"=>["Biological Sciences"], "users"=>["Guillaume Madelin", "James F. Babb", "Ding Xia", "Ravinder R. Regatte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118692.t001", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Repeatability_of_pseudo_intracellular_sodium_concentration_C_1_/1328793", "title"=>"Repeatability of pseudo-intracellular sodium concentration (C<sub>1</sub>).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-09 08:16:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940143"], "description"=>"<p><b>A</b>. Mean and std of C<sub>1</sub>. <b>B</b>. Median and mode of C<sub>1</sub>. <b>C</b>. Mean and std of <i>α</i>. <b>D</b>. Median and mode of <i>α</i>. GM = gray matter, WM = white matter, Full = full brain (GM+WM).</p>", "links"=>[], "tags"=>["wm", "repeatability", "gm", "skewnes", "subject", "C 1 parameters", "sodium MRI acquisitions", "cv", "3 T", "C 1", "C 1 kurtosis", "dir", "icc"], "article_id"=>1328791, "categories"=>["Biological Sciences"], "users"=>["Guillaume Madelin", "James F. Babb", "Ding Xia", "Ravinder R. Regatte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118692.g003", "stats"=>{"downloads"=>7, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plots_of_mean_median_mode_and_standard_deviation_std_of_the_C_1_and_945_distributions_from_11_volunteers_scanned_twice_1_st_scan_vs_2_nd_scan_/1328791", "title"=>"Plots of mean, median, mode and standard deviation (std) of the C<sub>1</sub> and <i>α</i> distributions from 11 volunteers scanned twice (1<sup>st</sup> scan vs. 2<sup>nd</sup> scan).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-09 08:16:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940144"], "description"=>"<p><b>A</b>. Skewness of C<sub>1</sub> and <i>α</i>. <b>B</b>. Kurtosis of C<sub>1</sub> and <i>α</i>. GM = gray matter, WM = white matter, Full = full brain (GM+WM).</p>", "links"=>[], "tags"=>["wm", "repeatability", "gm", "skewnes", "subject", "C 1 parameters", "sodium MRI acquisitions", "cv", "3 T", "C 1", "C 1 kurtosis", "dir", "icc"], "article_id"=>1328792, "categories"=>["Biological Sciences"], "users"=>["Guillaume Madelin", "James F. Babb", "Ding Xia", "Ravinder R. Regatte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118692.g004", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plots_of_skewness_and_kurtosis_of_the_C_1_and_945_distributions_from_11_volunteers_scanned_twice_1_st_scan_vs_2_nd_scan_/1328792", "title"=>"Plots of skewness and kurtosis of the C<sub>1</sub> and <i>α</i> distributions from 11 volunteers scanned twice (1<sup>st</sup> scan vs. 2<sup>nd</sup> scan).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-09 08:16:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940142"], "description"=>"<p><b>A</b>. Scan 1: C<sub>1</sub> and <i>α</i> maps. <b>B</b>. Scan 1: C<sub>1</sub> and <i>α</i> distributions. <b>C</b>. Scan 2: C<sub>1</sub> and <i>α</i> maps. <b>D</b>. Scan 2: C<sub>1</sub> and <i>α</i> distributions. Transverse slices were matched visually as well as possible.</p>", "links"=>[], "tags"=>["wm", "repeatability", "gm", "skewnes", "subject", "C 1 parameters", "sodium MRI acquisitions", "cv", "3 T", "C 1", "C 1 kurtosis", "dir", "icc"], "article_id"=>1328790, "categories"=>["Biological Sciences"], "users"=>["Guillaume Madelin", "James F. Babb", "Ding Xia", "Ravinder R. Regatte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118692.g002", "stats"=>{"downloads"=>2, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_scan_rescan_C_1_and_945_maps_1_transverse_slice_and_distributions_over_whole_GM_WM_and_full_brain_for_one_volunteer_/1328790", "title"=>"Examples of scan-rescan C<sub>1</sub> and <i>α</i> maps (1 transverse slice) and distributions (over whole GM, WM and full brain) for one volunteer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-09 08:16:49"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
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  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
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  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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