In Utero Exposure to Diethylstilbestrol and Blood DNA Methylation in Women Ages 40–59 Years from the Sister Study
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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1940357", "https://ndownloader.figshare.com/files/1940358", "https://ndownloader.figshare.com/files/1940359", "https://ndownloader.figshare.com/files/1940360"], "description"=>"<div><p><i>In utero</i> exposure to diethylstilbestrol (DES) has been associated with increased risk of adverse health outcomes such as fertility problems and vaginal as well as breast cancer. Animal studies have linked prenatal DES exposure to lasting DNA methylation changes. We investigated genome-wide DNA methylation and <i>in utero</i> DES exposure in a sample of non-Hispanic white women aged 40–59 years from the Sister Study, a large United States cohort study of women with a family history of breast cancer. Using questionnaire information from women and their mothers, we selected 100 women whose mothers reported taking DES while pregnant and 100 control women whose mothers had not taken DES. DNA methylation in blood was measured at 485,577 CpG sites using the Illumina HumanMethylation450 BeadChip. Associations between CpG methylation and DES exposure status were analyzed using robust linear regression with adjustment for blood cell composition and multiple comparisons. Although four CpGs had p<10<sup>5</sup>, after accounting for multiple comparisons using the false discovery rate (FDR), none reached genome-wide significance. In conclusion, adult women exposed to DES <i>in utero</i> had no evidence of large persistent changes in blood DNA methylation.</p></div>", "links"=>[], "tags"=>["utero DES exposure", "Illumina HumanMethylation 450 BeadChip", "blood DNA methylation", "United States cohort study", "Sister Study", "fdr", "DES exposure status", "blood cell composition", "cpg", "breast cancer", "DNA methylation changes", "100 control women"], "article_id"=>1328936, "categories"=>["Biological Sciences"], "users"=>["Sophia Harlid", "Zongli Xu", "Vijayalakshmi Panduri", "Aimee A. D’Aloisio", "Lisa A. DeRoo", "Dale P. Sandler", "Jack A. Taylor"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0118757.s001", "https://dx.doi.org/10.1371/journal.pone.0118757.s002", "https://dx.doi.org/10.1371/journal.pone.0118757.s003", "https://dx.doi.org/10.1371/journal.pone.0118757.s004"], "stats"=>{"downloads"=>8, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_Utero_Exposure_to_Diethylstilbestrol_and_Blood_DNA_Methylation_in_Women_Ages_40_59_Years_from_the_Sister_Study/1328936", "title"=>"<i>In Utero</i> Exposure to Diethylstilbestrol and Blood DNA Methylation in Women Ages 40–59 Years from the Sister Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-03-09 09:22:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940354"], "description"=>"<p>Log<sub>10</sub> transformed DES association p-values for individual CpGs are plotted in relation to their chromosome location. No CpGs reached genome wide significance.</p>", "links"=>[], "tags"=>["utero DES exposure", "Illumina HumanMethylation 450 BeadChip", "blood DNA methylation", "United States cohort study", "Sister Study", "fdr", "DES exposure status", "blood cell composition", "cpg", "breast cancer", "DNA methylation changes", "100 control women"], "article_id"=>1328933, "categories"=>["Biological Sciences"], "users"=>["Sophia Harlid", "Zongli Xu", "Vijayalakshmi Panduri", "Aimee A. D’Aloisio", "Lisa A. DeRoo", "Dale P. Sandler", "Jack A. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118757.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Manhattan_plot_/1328933", "title"=>"Manhattan plot.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-09 09:22:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940355"], "description"=>"<p>All CpGs are ordered from 5’ to 3’. Y axis shows the difference in mean beta values of exposed and unexposed women. Circle color depicts methylation status of individual CpGs (Black = Hyper-methylated [≥70%], Grey = Semi-methylated [<70%>30%], White = Hypo-methylated [≤30%]). All sites were selected based on annotations from the Illumina manifest. A) Genes that are up regulated in mice exposed to DES. B) Genes that are down regulated in mice exposed to DES.</p>", "links"=>[], "tags"=>["utero DES exposure", "Illumina HumanMethylation 450 BeadChip", "blood DNA methylation", "United States cohort study", "Sister Study", "fdr", "DES exposure status", "blood cell composition", "cpg", "breast cancer", "DNA methylation changes", "100 control women"], "article_id"=>1328934, "categories"=>["Biological Sciences"], "users"=>["Sophia Harlid", "Zongli Xu", "Vijayalakshmi Panduri", "Aimee A. D’Aloisio", "Lisa A. DeRoo", "Dale P. Sandler", "Jack A. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118757.g002", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_CpGs_in_the_5_8217_end_of_9_genes_associated_with_differential_methylation_in_animal_models_exposed_to_DES_/1328934", "title"=>"Distribution of CpGs in the 5’end of 9 genes associated with differential methylation in animal models exposed to DES.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-09 09:22:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940356"], "description"=>"<p><sup>a</sup>Age at menopause was ascertained among the 45 exposed and 45 unexposed women who were postmenopausal</p><p><sup>b</sup>HRT was ascertained among postmenopausal women only</p><p><sup>c</sup>Column % does not add to 100% due to missing data</p><p><sup>d</sup>Based on Chi-Square test</p><p>Baseline characteristics of DES-exposed and unexposed women selected from the Sister Study.</p>", "links"=>[], "tags"=>["utero DES exposure", "Illumina HumanMethylation 450 BeadChip", "blood DNA methylation", "United States cohort study", "Sister Study", "fdr", "DES exposure status", "blood cell composition", "cpg", "breast cancer", "DNA methylation changes", "100 control women"], "article_id"=>1328935, "categories"=>["Biological Sciences"], "users"=>["Sophia Harlid", "Zongli Xu", "Vijayalakshmi Panduri", "Aimee A. D’Aloisio", "Lisa A. DeRoo", "Dale P. Sandler", "Jack A. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118757.t001", "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_DES_exposed_and_unexposed_women_selected_from_the_Sister_Study_/1328935", "title"=>"Baseline characteristics of DES-exposed and unexposed women selected from the Sister Study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-09 09:22:13"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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