Involvement of CX3CL1/CX3CR1 Signaling in Spinal Long Term Potentiation
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{"title"=>"Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation", "type"=>"journal", "authors"=>[{"first_name"=>"Chao", "last_name"=>"Bian", "scopus_author_id"=>"56079852600"}, {"first_name"=>"Zhi Qi", "last_name"=>"Zhao", "scopus_author_id"=>"7404148138"}, {"first_name"=>"Yu Qiu", "last_name"=>"Zhang", "scopus_author_id"=>"55978429900"}, {"first_name"=>"Ning", "last_name"=>"Lü", "scopus_author_id"=>"35311283300"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84929497582", "pui"=>"604114652", "doi"=>"10.1371/journal.pone.0118842", "sgr"=>"84929497582", "pmid"=>"25768734"}, "id"=>"1aa0e25b-fff3-3b12-9329-c09e7062cb62", "abstract"=>"The long-term potentiation (LTP) of spinal C-fiber-evoked field potentials is considered as a fundamental mechanism of central sensitization in the spinal cord. Accumulating evidence has showed the contribution of spinal microglia to spinal LTP and pathological pain. As a key signaling of neurons-microglia interactions, the involvement of CX3CL1/CX3CR1 signaling in pathological pain has also been investigated extensively. The present study examined whether CX3CL1/CX3CR1 signaling plays a role in spinal LTP. The results showed that 10-trains tetanic stimulation (100 Hz, 2s) of the sciatic nerve (TSS) produced a significant LTP of C-fiber-evoked field potentials lasting for over 3 h in the rat spinal dorsal horn. Blockade of CX3CL1/CX3CR1 signaling with an anti-CX3CR1 neutralizing antibody (CX3CR1 AB) markedly suppressed TSS-induced LTP. Exogenous CX3CL1 significantly potentiated 3-trains TSS-induced LTP in rats. Consistently, spinal LTP of C-fiber-evoked field potentials was also induced by TSS (100 Hz, 1s, 4 trains) in all C57BL/6 wild type (WT) mice. However, in CX3CR1-/- mice, TSS failed to induce LTP and behavioral hypersensitivity, confirming an essential role of CX3CR1 in spinal LTP induction. Furthermore, blockade of IL-18 or IL-23, the potential downstream factors of CX3CL1/CX3CR1 signaling, with IL-18 BP or anti-IL-23 neutralizing antibody (IL-23 AB), obviously suppressed spinal LTP in rats. These results suggest that CX3CL1/CX3CR1 signaling is involved in LTP of C-fiber-evoked field potentials in the rodent spinal dorsal horn.", "link"=>"http://www.mendeley.com/research/involvement-cx3cl1cx3cr1-signaling-spinal-long-term-potentiation", "reader_count"=>19, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>4, "Neuroscience"=>6, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>6}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1947678"], "description"=>"<p>(A) As compared with 10-trains TSS-induced LTP, 3-trains TSS induced a LTP with smaller potentiated extent. While exogenous CX3CL1 (0.75 μg/30 μl) was applied 30 min before TSS, 3-trains TSS-induced LTP was robustly potentiated. (B) The facilitative effect of exogenous CX3CL1 (0.75 μg/30 μl) on 3 trains TSS-induced LTP was completely blocked by CX3CR1 AB (30 μg/30 μl), which was applied 2 h before TSS (1.5 h before delivering CX3CL1). (C) There was a delayed facilitative effect of 3.75 μg/30 μl exogenous CX3CL1 on baseline C-response, as compared with control PBS, and no influence of CX3CL1 was observed on baseline C-response at the dose of 0.75 μg/30 μl. (D) Western blot showed 30 min after 10-trains TSS, the expression of membrane-bound CX3CL1 was evidently reduced in the spinal dorsal horn, whereas soluble CX3CL1 level was upregulated in spinal CSF. Inset: the membrane-bound CX3CL1 and soluble CX3CL1 were detected at the 95 kDa and 72 kDa band respectively in the spinal dorsal horn (SDH) and CSF by an anti-CX3CL1 antibody. (E) ELASA assay showed that soluble CX3CL1 in the CSF was significantly upregulated at 30 min after TSS. (F) Western blot showed that Cathepsin S level was upregulated in the CSF at 30 min after TSS. * p<0.05 vs. Sham control.</p>", "links"=>[], "tags"=>["Exogenous CX 3CL", "wt", "bp", "CX 3CR AB", "tss", "57BL", "CX 3CL Signaling", "Spinal Long Term Potentiation", "dorsal horn", "CX 3CL", "ltp", "potential", "Cx 3cr mice", "il"], "article_id"=>1334840, "categories"=>["Biological Sciences"], "users"=>["Chao Bian", "Zhi-Qi Zhao", "Yu-Qiu Zhang", "Ning Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118842.g004", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Involvement_of_CX3CL1_in_spinal_LTP_/1334840", "title"=>"Involvement of CX3CL1 in spinal LTP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-13 03:27:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1947675"], "description"=>"<p>Double immunofluorescence reveals that CX3CL1 co-localized with NeuN (neuronal marker) and GFAP (astrocyte marker), no immunoreactive singal in Iba1-labled microglia (A); CX3CR1 was expressed in Iba1-labled microglia in naïve rats and failed to co-localize with NeuN and GFAP (B).</p>", "links"=>[], "tags"=>["Exogenous CX 3CL", "wt", "bp", "CX 3CR AB", "tss", "57BL", "CX 3CL Signaling", "Spinal Long Term Potentiation", "dorsal horn", "CX 3CL", "ltp", "potential", "Cx 3cr mice", "il"], "article_id"=>1334837, "categories"=>["Biological Sciences"], "users"=>["Chao Bian", "Zhi-Qi Zhao", "Yu-Qiu Zhang", "Ning Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118842.g001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_CX3CL1_and_CX3CR1_in_the_spinal_dorsal_horn_/1334837", "title"=>"Expression of CX3CL1 and CX3CR1 in the spinal dorsal horn.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-13 03:27:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1947676"], "description"=>"<p>Spinal LTP of C-fiber-evoked field potentials was induced by 10-trains tetanic stimulation of the sciatic nerve (TSS); conversely, it was not formed in the sham group (no TSS applied). a & b, the representative C-responses (gray area) in TSS group; c & d, the representative C-responses (gray area) in the sham group.</p>", "links"=>[], "tags"=>["Exogenous CX 3CL", "wt", "bp", "CX 3CR AB", "tss", "57BL", "CX 3CL Signaling", "Spinal Long Term Potentiation", "dorsal horn", "CX 3CL", "ltp", "potential", "Cx 3cr mice", "il"], "article_id"=>1334838, "categories"=>["Biological Sciences"], "users"=>["Chao Bian", "Zhi-Qi Zhao", "Yu-Qiu Zhang", "Ning Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118842.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_representative_spinal_long_term_potentiation_LTP_of_C_fiber_evoked_field_potentials_/1334838", "title"=>"A representative spinal long-term potentiation (LTP) of C-fiber-evoked field potentials.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-13 03:27:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1947679"], "description"=>"<p>(A & B) In the spinal cord, IL-18 was mainly produced in Iba1-labled microglia and co-localized with CX3CR1 (A); both IL-18R and IL-23 were expressed in astrocytes (B). (C) As compared with control (PBS, 0.01M 30 μl), the spinal LTP was obviously suppressed by administrating IL-18BP (7 μg/30 μl) 20 min before 10-trains TSS. (D) Similarly, the spinal LTP was also suppressed by an anti-IL-23 neutralizing antibody (IL-23 AB, 6 μg/30 μl), which was administrated 40 min before 10-trains TSS.</p>", "links"=>[], "tags"=>["Exogenous CX 3CL", "wt", "bp", "CX 3CR AB", "tss", "57BL", "CX 3CL Signaling", "Spinal Long Term Potentiation", "dorsal horn", "CX 3CL", "ltp", "potential", "Cx 3cr mice", "il"], "article_id"=>1334841, "categories"=>["Biological Sciences"], "users"=>["Chao Bian", "Zhi-Qi Zhao", "Yu-Qiu Zhang", "Ning Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118842.g005", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Contribution_of_IL_18_and_IL_23_to_spinal_LTP_/1334841", "title"=>"Contribution of IL-18 and IL-23 to spinal LTP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-13 03:27:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1947677"], "description"=>"<p>(A & B) When an anti-CX3CR1 neutralizing antibody (CX3CR1 AB, 30 μg/30 μl) was administrated 2 h before TSS, 10-trains TSS-induced spinal LTP was evidently suppressed (A). Simultaneously, the expression of CX3CR1 in spinal dorsal horn was also decreased by CX3CR1 AB (B). * p<0.05 vs. IgG control. (C) TSS stably induced spinal LTP of C-fiber-evoked field potentials in wild type mice, but failed to induce in CX3CL1 knockout mice. (D & E) TSS-induced mechanical allodynia (D) and thermal hyperalgesia (E) only occurred in wild type mice but not in CX3CL1 knockout mice. ** p>0.01 vs. Baseline (before TSS).</p>", "links"=>[], "tags"=>["Exogenous CX 3CL", "wt", "bp", "CX 3CR AB", "tss", "57BL", "CX 3CL Signaling", "Spinal Long Term Potentiation", "dorsal horn", "CX 3CL", "ltp", "potential", "Cx 3cr mice", "il"], "article_id"=>1334839, "categories"=>["Biological Sciences"], "users"=>["Chao Bian", "Zhi-Qi Zhao", "Yu-Qiu Zhang", "Ning Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118842.g003", "stats"=>{"downloads"=>2, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Involvement_of_CX3CR1_in_spinal_LTP_/1334839", "title"=>"Involvement of CX3CR1 in spinal LTP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-13 03:27:58"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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