Recurrent Invasive Pneumococcal Disease in Children: Underlying Clinical Conditions, and Immunological and Microbiological Characteristics
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{"title"=>"Recurrent invasive pneumococcal disease in children: Underlying clinical conditions, and immunological and microbiological characteristics", "type"=>"journal", "authors"=>[{"first_name"=>"Laia", "last_name"=>"Alsina", "scopus_author_id"=>"6507744450"}, {"first_name"=>"Maria G.", "last_name"=>"Basteiro", "scopus_author_id"=>"56623102100"}, {"first_name"=>"Hector D.", "last_name"=>"De Paz", "scopus_author_id"=>"56616429300"}, {"first_name"=>"Melania", "last_name"=>"Iñigo", "scopus_author_id"=>"56622920800"}, {"first_name"=>"Mariona F.", "last_name"=>"De Sevilla", "scopus_author_id"=>"35810010400"}, {"first_name"=>"Miriam", "last_name"=>"Triviño", "scopus_author_id"=>"55918970400"}, {"first_name"=>"Manel", "last_name"=>"Juan", "scopus_author_id"=>"7006971346"}, {"first_name"=>"Carmen", "last_name"=>"Muñoz-Almagro", "scopus_author_id"=>"6603569864"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25738983", "sgr"=>"84928920424", "doi"=>"10.1371/journal.pone.0118848", "scopus"=>"2-s2.0-84928920424", "pui"=>"604166272", "issn"=>"19326203"}, "id"=>"dc747391-d9fd-398d-a419-e582099ed957", "abstract"=>"PURPOSE Clinical, immunological and microbiological characteristics of recurrent invasive pneumococcal disease (IPD) in children were evaluated, differentiating relapse from reinfection, in order to identify specific risk factors for both conditions. METHODS All patients <18 years-old with recurrent IPD admitted to a tertiary-care pediatric center from January 2004 to December 2011 were evaluated. An episode of IPD was defined as the presence of clinical findings of infection together with isolation and/or pneumococcal DNA detection by Real-Time PCR in any sterile body fluid. Recurrent IPD was defined as 2 or more episodes in the same individual at least 1 month apart. Among recurrent IPD, we differentiated relapse (same pneumococcal isolate) from reinfection. RESULTS 593 patients were diagnosed with IPD and 10 patients died. Among survivors, 23 episodes of recurrent IPD were identified in 10 patients (1.7%). Meningitis was the most frequent form of recurrent IPD (10 episodes/4 children) followed by recurrent empyema (8 episodes/4 children). Three patients with recurrent empyema caused by the same pneumococcal clone ST306 were considered relapses and showed high bacterial load in their first episode. In contrast, all other episodes of recurrent IPD were considered reinfections. Overall, the rate of relapse of IPD was 0.5% and the rate of reinfection 1.2%. Five out of 7 patients with reinfection had an underlying risk factor: cerebrospinal fluid leak (n = 3), chemotherapy treatment (n = 1) and a homozygous mutation in MyD88 gene (n = 1). No predisposing risk factors were found in the remainder. CONCLUSIONS recurrent IPD in children is a rare condition associated with an identifiable risk factor in case of reinfection in almost 80% of cases. In contrast, recurrent IPD with pleuropneumonia is usually a relapse of infection.", "link"=>"http://www.mendeley.com/research/recurrent-invasive-pneumococcal-disease-children-underlying-clinical-conditions-immunological-microb", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>4, "Neuroscience"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>6}}, "reader_count_by_country"=>{"Brazil"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1935292"], "description"=>"<p>P, patient identification; ST, sequence type by Multi-locus sequence typing; MDR, Multi-drug resistant strain; PCV-7, 7-valent polysaccharide-protein conjugate vaccine; PCV 13, 13-valent polysaccharide-protein conjugate vaccine; PPV-23, 23-valent pneumococcal polysaccharide vaccine; CSF, cerebrospinal fluid; NA, Not available; MIC, minimal inhibitory concentration; Pen, penicillin; Ery, erythromycin; Cm, chloramphenicol; Tet, tetracycline; Ctx, Cefotaxime; Bold text, resistant strain according to MICs for <i>Streptococcus pneumonia</i>. EUCAST Clinical Meningeal Breakpoints.</p><p><sup>a</sup>NA, ST were not available in episodes identified only by PCR.</p><p>Microbiological characteristics of patients with recurrent invasive pneumococcal disease.</p>", "links"=>[], "tags"=>["MyD 88 gene", "risk factors", "ipd", "pcr", "Recurrent Invasive Pneumococcal Disease", "reinfection.Results 593 patients", "dna", "risk factor", "relapse", "pneumococcal clone ST 306", "Microbiological Characteristics PurposeClinical", "cerebrospinal fluid leak", "episode"], "article_id"=>1325668, "categories"=>["Biological Sciences"], "users"=>["Laia Alsina", "Maria G. Basteiro", "Hector D. de Paz", "Melania Iñigo", "Mariona F. de Sevilla", "Miriam Triviño", "Manel Juan", "Carmen Muñoz-Almagro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118848.t002", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microbiological_characteristics_of_patients_with_recurrent_invasive_pneumococcal_disease_/1325668", "title"=>"Microbiological characteristics of patients with recurrent invasive pneumococcal disease.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-04 03:24:37"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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