Complex Interaction of Deferasirox and Pythium insidiosum: Iron-Dependent Attenuation of Growth In Vitro and Immunotherapy-Like Enhancement of Immune Responses In Vivo
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{"title"=>"Complex interaction of deferasirox and pythium insidiosum: Iron-dependent attenuation of growth in vitro and immunotherapy-like enhancement of immune responses in vivo", "type"=>"journal", "authors"=>[{"first_name"=>"Régis A.", "last_name"=>"Zanette", "scopus_author_id"=>"23977072200"}, {"first_name"=>"Paula E R", "last_name"=>"Bitencourt", "scopus_author_id"=>"35975610900"}, {"first_name"=>"Dimitrios P.", "last_name"=>"Kontoyiannis", "scopus_author_id"=>"35377023000"}, {"first_name"=>"Rafael A.", "last_name"=>"Fighera", "scopus_author_id"=>"6603189318"}, {"first_name"=>"Mariana M.", "last_name"=>"Flores", "scopus_author_id"=>"35185092000"}, {"first_name"=>"Glaucia D.", "last_name"=>"Kommers", "scopus_author_id"=>"6602851369"}, {"first_name"=>"Priscila S.", "last_name"=>"Silva", "scopus_author_id"=>"55838371400"}, {"first_name"=>"Aline", "last_name"=>"Ludwig", "scopus_author_id"=>"56328593000"}, {"first_name"=>"Maria B.", "last_name"=>"Moretto", "scopus_author_id"=>"7004081382"}, {"first_name"=>"Sydney H.", "last_name"=>"Alves", "scopus_author_id"=>"7102193984"}, {"first_name"=>"Janio M.", "last_name"=>"Santurio", "scopus_author_id"=>"6603541757"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84929457181", "doi"=>"10.1371/journal.pone.0118932", "sgr"=>"84929457181", "isbn"=>"1932-6203", "pmid"=>"25738758", "issn"=>"19326203", "pui"=>"604166233"}, "id"=>"8cb2822b-c6ab-3545-a6d6-92f50511b480", "abstract"=>"Pythium insidiosum iron acquisition mechanisms are unknown. We previously showed that the iron chelator deferasirox had weak activity in vitro and in rabbits with experimental pythiosis. Here we show that deferasirox causes damage to P. insidiosum hyphae in vitro, but that activity is diminished in the presence of exogenous iron. The tissue activity of the proinflammatory enzyme adenosine deaminase and the histological pattern observed in pythiosis lesions of rabbits treated with deferasirox were similar to the ones in animals treated with immunotherapy.", "link"=>"http://www.mendeley.com/research/complex-interaction-deferasirox-pythium-insidiosum-irondependent-attenuation-growth-vitro-immunother-1", "reader_count"=>8, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Other"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Other"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>2, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Mexico"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1934779"], "description"=>"<div><p><i>Pythium insidiosum</i> iron acquisition mechanisms are unknown. We previously showed that the iron chelator deferasirox had weak activity <i>in vitro</i> and in rabbits with experimental pythiosis. Here we show that deferasirox causes damage to <i>P</i>. <i>insidiosum</i> hyphae <i>in vitro</i>, but that activity is diminished in the presence of exogenous iron. The tissue activity of the proinflammatory enzyme adenosine deaminase and the histological pattern observed in pythiosis lesions of rabbits treated with deferasirox were similar to the ones in animals treated with immunotherapy.</p></div>", "links"=>[], "tags"=>["deferasirox causes damage", "Immune Responses", "insidiosum hyphae", "proinflammatory enzyme adenosine deaminase", "tissue activity", "Pythium insidiosum", "pythiosis lesions", "Vivo Pythium insidiosum iron acquisition mechanisms", "iron chelator deferasirox", "exogenous iron", "histological pattern", "Complex Interaction"], "article_id"=>1325310, "categories"=>["Biological Sciences"], "users"=>["Régis A. Zanette", "Paula E. R. Bitencourt", "Dimitrios P. Kontoyiannis", "Rafael A. Fighera", "Mariana M. Flores", "Glaucia D. Kommers", "Priscila S. Silva", "Aline Ludwig", "Maria B. Moretto", "Sydney H. Alves", "Janio M. Santurio"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118932", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Complex_Interaction_of_Deferasirox_and_Pythium_insidiosum_Iron_Dependent_Attenuation_of_Growth_In_Vitro_and_Immunotherapy_Like_Enhancement_of_Immune_Responses_In_Vivo_/1325310", "title"=>"Complex Interaction of Deferasirox and <i>Pythium insidiosum</i>: Iron-Dependent Attenuation of Growth <i>In Vitro</i> and Immunotherapy-Like Enhancement of Immune Responses <i>In Vivo</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-04 02:42:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1934768"], "description"=>"<p><i>P</i>. <i>insidiosum</i> germlings were exposed to deferasirox at the MIC (50 μg/ml) (b1, b2), 0.125% iron (c1, c2) or both (d1, d2) for 6h. Untreated germlings were used as negative controls (a1, a2). Mycelia subsequently were stained with DiBAC and observed with bright-field (a1 to d1) and fluorescent microscopy (a2 to d2). The fluorescence of the dark pictures is indicative of hyphal damage.</p>", "links"=>[], "tags"=>["deferasirox causes damage", "Immune Responses", "insidiosum hyphae", "proinflammatory enzyme adenosine deaminase", "tissue activity", "Pythium insidiosum", "pythiosis lesions", "Vivo Pythium insidiosum iron acquisition mechanisms", "iron chelator deferasirox", "exogenous iron", "histological pattern", "Complex Interaction"], "article_id"=>1325299, "categories"=>["Biological Sciences"], "users"=>["Régis A. Zanette", "Paula E. R. Bitencourt", "Dimitrios P. Kontoyiannis", "Rafael A. Fighera", "Mariana M. Flores", "Glaucia D. Kommers", "Priscila S. Silva", "Aline Ludwig", "Maria B. Moretto", "Sydney H. Alves", "Janio M. Santurio"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118932.g002", "stats"=>{"downloads"=>1, "page_views"=>64, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DiBAC_viability_stain_/1325299", "title"=>"DiBAC viability stain.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-04 02:42:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1934766"], "description"=>"<p><i>P</i>. <i>insidiosum</i> zoospores were grown in RPMI 1640 in the presence of deferasirox (50 μg/ml), 0.125% iron (FeCl<sub>3</sub>) or both. No growth was observed in the presence of deferasirox at the MIC concentration (50 μg/ml). The addition of iron abrogated the inhibitory effect of deferasirox, but the treatment with FeCl<sub>3</sub> alone did not promote growth to levels compared to control (RPMI only). Values represent the means ± SEM of three separate experiments.</p>", "links"=>[], "tags"=>["deferasirox causes damage", "Immune Responses", "insidiosum hyphae", "proinflammatory enzyme adenosine deaminase", "tissue activity", "Pythium insidiosum", "pythiosis lesions", "Vivo Pythium insidiosum iron acquisition mechanisms", "iron chelator deferasirox", "exogenous iron", "histological pattern", "Complex Interaction"], "article_id"=>1325297, "categories"=>["Biological Sciences"], "users"=>["Régis A. Zanette", "Paula E. R. Bitencourt", "Dimitrios P. Kontoyiannis", "Rafael A. Fighera", "Mariana M. Flores", "Glaucia D. Kommers", "Priscila S. Silva", "Aline Ludwig", "Maria B. Moretto", "Sydney H. Alves", "Janio M. Santurio"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118932.g001", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_XTT_reduction_assay_/1325297", "title"=>"XTT reduction assay.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-04 02:42:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1934774"], "description"=>"<p><b>A</b>) Representative histological sections of rabbit pythiosis lesions (H&E stain, 40x magnification). a) Placebo, area of necrosis and fibroplasia with eosinophilic infiltrate and rare lymphocytes and plasma cells; b) immunotherapy, area of fibroplasia with increased number of lymphocytes and plasma cells and moderate quantities of eosinophils and macrophages; c) deferasirox, area of fibroplasia mainly composed of lymphoplasmacytic infiltrate and rare eosinophils; d) deferasirox and immunotherapy, area of fibroplasia with prominent lymphoplasmacytic infiltrate and rare eosinophils. <b>B</b>) Expression of ADA in rabbit pythiosis lesions. ADA activity was significantly increased in all treated groups when compared to placebo (*<i>P</i> = 0.03). Values are shown as means ± SEM. <b>C</b>) A negative correlation was observed between lesion ADA activity and lesion size (Pearson <i>r</i> = -0.53; <i>P</i> = 0.02).</p>", "links"=>[], "tags"=>["deferasirox causes damage", "Immune Responses", "insidiosum hyphae", "proinflammatory enzyme adenosine deaminase", "tissue activity", "Pythium insidiosum", "pythiosis lesions", "Vivo Pythium insidiosum iron acquisition mechanisms", "iron chelator deferasirox", "exogenous iron", "histological pattern", "Complex Interaction"], "article_id"=>1325305, "categories"=>["Biological Sciences"], "users"=>["Régis A. Zanette", "Paula E. R. Bitencourt", "Dimitrios P. Kontoyiannis", "Rafael A. Fighera", "Mariana M. Flores", "Glaucia D. Kommers", "Priscila S. Silva", "Aline Ludwig", "Maria B. Moretto", "Sydney H. Alves", "Janio M. Santurio"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0118932.g003", "stats"=>{"downloads"=>2, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histology_and_enzymatic_activity_of_rabbit_pythiosis_lesions_/1325305", "title"=>"Histology and enzymatic activity of rabbit pythiosis lesions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-04 02:42:55"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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