Neonatal Infection with Species C Adenoviruses Confirmed in Viable Cord Blood Lymphocytes
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{"title"=>"Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes", "type"=>"journal", "authors"=>[{"first_name"=>"David A.", "last_name"=>"Ornelles", "scopus_author_id"=>"6701797359"}, {"first_name"=>"Linda R.", "last_name"=>"Gooding", "scopus_author_id"=>"7005897184"}, {"first_name"=>"C.", "last_name"=>"Garnett-Benson", "scopus_author_id"=>"55987464100"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84929191701", "pui"=>"604166224", "pmid"=>"25764068", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0119256", "sgr"=>"84929191701"}, "id"=>"6cfa92aa-4bec-3850-9b00-113ede92d12b", "abstract"=>"<p>Credible but conflicting reports address the frequency of prenatal infection by species C adenovirus. This question is important because these viruses persist in lymphoid cells and suppress double-stranded DNA-break repair. Consequently, prenatal adenovirus infections may generate the aberrant clones of lymphocytes that precede development of childhood acute lymphoblastic leukemia (ALL). The present study was designed to overcome technical limitations of prior work by processing cord blood lymphocytes within a day of collection, and by analyzing sufficient numbers of lymphocytes to detect adenovirus-containing cells at the lower limits determined by our previous studies of tonsil lymphocytes. By this approach, adenoviral DNA was identified in 19 of 517 (3.7%) samples, providing definitive evidence for the occurrence of prenatal infection with species C adenoviruses in a significant fraction of neonates predominantly of African American and Hispanic ancestry. Cord blood samples were also tested for the presence of the <italic>ETV6-RUNX1</italic> translocation, the most common genetic abnormality in childhood ALL. Using a nested PCR assay, the <italic>ETV6-RUNX1</italic> transcript was detected in four of 196 adenovirus-negative samples and one of 14 adenovirus-positive cord blood samples. These findings indicate that this method will be suitable for determining concordance between adenovirus infection and the leukemia-associated translocations in newborns.</p>", "link"=>"http://www.mendeley.com/research/neonatal-infection-species-c-adenoviruses-confirmed-viable-cord-blood-lymphocytes", "reader_count"=>6, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>2}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1946306"], "description"=>"<p><sup>1</sup>The 95% confidence interval for the fraction of <i>ETV6-RUNX1</i> fusion transcript-positive samples was calculated according to the method of Agresti and Coull [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119256#pone.0119256.ref019\" target=\"_blank\">19</a>].</p><p>Detection of <i>ETV6-RUNX1</i> fusion transcript in cord blood RNA.</p>", "links"=>[], "tags"=>["Neonatal infection", "Hispanic ancestry", "adenoviral DNA", "Lymphoblastic leukemia", "processing cord blood lymphocytes", "species C adenoviruses", "Viable Cord Blood Lymphocytes Credible", "childhood", "etv", "Species C Adenoviruses Confirmed", "lymphoid cells", "reports address", "adenovirus infections", "adenovirus infection", "PCR assay", "African American", "species C adenovirus", "tonsil lymphocytes", "translocation", "cord blood samples"], "article_id"=>1333897, "categories"=>["Uncategorised"], "users"=>["David A. Ornelles", "Linda R. Gooding", "C. Garnett-Benson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119256.t002", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detection_of_ETV6_RUNX1_fusion_transcript_in_cord_blood_RNA_/1333897", "title"=>"Detection of <i>ETV6-RUNX1</i> fusion transcript in cord blood RNA.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-12 03:08:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946304"], "description"=>"<p>200 ng of RNA purified from umbilical vein cord blood lymphocytes was reverse transcribed using random hexamers as primers. (A) The integrity of the RNA in the numbered cord blood samples was confirmed by amplification of a 384 bp sequence spanning the junction of exons 3 and 4 of the β-2-microglobulin gene. Positive controls included RNA from the BJAB and UoCB4 cell lines (+RT). Negative controls included salmon sperm DNA (SS DNA) and the exclusion of reverse transcriptase (NRT). Lanes containing the 100 bp DNA ladder reference are indicated by M. (B) A 200 bp amplicon obtained from a nested PCR assay indicates the presence of the <i>ETV6-RUNX1</i> transcript. Representative results show the products of three technical replicates from four numbered cord blood samples, salmon sperm DNA as a negative control, and a 10<sup>-2</sup> dilution of the <i>ETV6-RUNX1</i>-positive UoCB4 cells among BJAB cells as a positive control. Samples in which at least two of three technical replicates were detected from cDNA generated independently in two laboratories and in which no product was observed when reverse transcriptase was omitted were considered to contain the <i>ETV6-RUNX1</i> fusion transcript. (C) The <i>ETV6-RUNX1</i> amplicon generated from cord blood sample 392 was subjected to sequencing with the primers used to generate the product. The sequencing electropherogram from one of two reactions demonstrates the structure of the expected fusion transcript.</p>", "links"=>[], "tags"=>["Neonatal infection", "Hispanic ancestry", "adenoviral DNA", "Lymphoblastic leukemia", "processing cord blood lymphocytes", "species C adenoviruses", "Viable Cord Blood Lymphocytes Credible", "childhood", "etv", "Species C Adenoviruses Confirmed", "lymphoid cells", "reports address", "adenovirus infections", "adenovirus infection", "PCR assay", "African American", "species C adenovirus", "tonsil lymphocytes", "translocation", "cord blood samples"], "article_id"=>1333895, "categories"=>["Uncategorised"], "users"=>["David A. Ornelles", "Linda R. Gooding", "C. Garnett-Benson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119256.g003", "stats"=>{"downloads"=>3, "page_views"=>34, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detection_of_the_ETV6_RUNX1_fusion_transcript_by_reverse_transcription_followed_by_PCR_/1333895", "title"=>"Detection of the <i>ETV6-RUNX1</i> fusion transcript by reverse transcription followed by PCR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:08:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946305"], "description"=>"<p><sup>1</sup>The 95% confidence interval for the fraction of adenoviral DNA-positive samples was calculated according to the method of Agresti and Coull [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119256#pone.0119256.ref019\" target=\"_blank\">19</a>].</p><p>Adenoviral DNA status as a function of mother’s demographics and infant gender.</p>", "links"=>[], "tags"=>["Neonatal infection", "Hispanic ancestry", "adenoviral DNA", "Lymphoblastic leukemia", "processing cord blood lymphocytes", "species C adenoviruses", "Viable Cord Blood Lymphocytes Credible", "childhood", "etv", "Species C Adenoviruses Confirmed", "lymphoid cells", "reports address", "adenovirus infections", "adenovirus infection", "PCR assay", "African American", "species C adenovirus", "tonsil lymphocytes", "translocation", "cord blood samples"], "article_id"=>1333896, "categories"=>["Uncategorised"], "users"=>["David A. Ornelles", "Linda R. Gooding", "C. Garnett-Benson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119256.t001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adenoviral_DNA_status_as_a_function_of_mother_8217_s_demographics_and_infant_gender_/1333896", "title"=>"Adenoviral DNA status as a function of mother’s demographics and infant gender.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-12 03:08:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946299"], "description"=>"<p>Lymphocytes enriched by Ficoll density gradient centrifugation were evaluated for adenoviral DNA by a nested PCR assay targeting a conserved region of the hexon gene. Four replicates of each numbered cord blood sample were analyzed. As a positive control, five copies of the type 2 adenovirus genome were added to the fourth replicate (+Ad). Lanes indicated by ‘M’ contained a 100-bp ladder reference. The position of DNA standards corresponding to 500, 400, 300, 200, and 100 bp were determined from a brighter exposure and are indicated. Cord blood samples 390 and 391 represent a negative and positive sample, respectively. These samples were reevaluated because of the failure of the positive control (390) and because the diagnostic 310 bp PCR product was observed in only two of three test samples (391). Samples were considered evaluable if the positive control amplified. Samples were considered to contain adenoviral DNA if the appropriate PCR product was observed in at least five of six technical replicates. All positive samples were evaluated on at least two occasions.</p>", "links"=>[], "tags"=>["Neonatal infection", "Hispanic ancestry", "adenoviral DNA", "Lymphoblastic leukemia", "processing cord blood lymphocytes", "species C adenoviruses", "Viable Cord Blood Lymphocytes Credible", "childhood", "etv", "Species C Adenoviruses Confirmed", "lymphoid cells", "reports address", "adenovirus infections", "adenovirus infection", "PCR assay", "African American", "species C adenovirus", "tonsil lymphocytes", "translocation", "cord blood samples"], "article_id"=>1333890, "categories"=>["Uncategorised"], "users"=>["David A. Ornelles", "Linda R. Gooding", "C. Garnett-Benson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119256.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detection_of_adenoviral_DNA_in_umbilical_vein_cord_blood_/1333890", "title"=>"Detection of adenoviral DNA in umbilical vein cord blood.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:08:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946307"], "description"=>"<p>Adenovirus genome load in selected adenoviral DNA-positive samples.</p>", "links"=>[], "tags"=>["Neonatal infection", "Hispanic ancestry", "adenoviral DNA", "Lymphoblastic leukemia", "processing cord blood lymphocytes", "species C adenoviruses", "Viable Cord Blood Lymphocytes Credible", "childhood", "etv", "Species C Adenoviruses Confirmed", "lymphoid cells", "reports address", "adenovirus infections", "adenovirus infection", "PCR assay", "African American", "species C adenovirus", "tonsil lymphocytes", "translocation", "cord blood samples"], "article_id"=>1333898, "categories"=>["Uncategorised"], "users"=>["David A. Ornelles", "Linda R. Gooding", "C. Garnett-Benson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119256.t003", "stats"=>{"downloads"=>3, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adenovirus_genome_load_in_selected_adenoviral_DNA_positive_samples_/1333898", "title"=>"Adenovirus genome load in selected adenoviral DNA-positive samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-12 03:08:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946301"], "description"=>"<p>The number of lymphocytes in cord blood samples that either contain (Present) or do not contain (Absent) adenoviral DNA show similar distributions. Median values of 3.8×10<sup>6</sup> and 3.4×10<sup>6</sup> are indicated by the solid horizontal line. The box spans the interquartile range of log-transformed values. Values beyond 1.5-times the interquartile range are plotted as open circles and whiskers indicate the range of values less than 1.5-times the interquartile range.</p>", "links"=>[], "tags"=>["Neonatal infection", "Hispanic ancestry", "adenoviral DNA", "Lymphoblastic leukemia", "processing cord blood lymphocytes", "species C adenoviruses", "Viable Cord Blood Lymphocytes Credible", "childhood", "etv", "Species C Adenoviruses Confirmed", "lymphoid cells", "reports address", "adenovirus infections", "adenovirus infection", "PCR assay", "African American", "species C adenovirus", "tonsil lymphocytes", "translocation", "cord blood samples"], "article_id"=>1333892, "categories"=>["Uncategorised"], "users"=>["David A. Ornelles", "Linda R. Gooding", "C. Garnett-Benson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119256.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_detection_of_adenoviral_DNA_is_unrelated_to_the_number_of_lymphocytes_recovered_in_the_cord_blood_/1333892", "title"=>"The detection of adenoviral DNA is unrelated to the number of lymphocytes recovered in the cord blood.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:08:48"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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