Insights into European Drug Shortages: A Survey of Hospital Pharmacists
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{"title"=>"Insights into european drug shortages: A survey of hospital pharmacists", "type"=>"generic", "authors"=>[{"first_name"=>"Pauwels", "last_name"=>"Kim", "scopus_author_id"=>"56562328400"}, {"first_name"=>"Steven", "last_name"=>"Simoens", "scopus_author_id"=>"15119725000"}, {"first_name"=>"Minne", "last_name"=>"Casteels", "scopus_author_id"=>"7004408053"}, {"first_name"=>"Isabelle", "last_name"=>"Huys", "scopus_author_id"=>"6603110865"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"603024453", "sgr"=>"84925252115", "issn"=>"19326203", "pmid"=>"25775406", "scopus"=>"2-s2.0-84925252115", "doi"=>"10.1371/journal.pone.0119322", "isbn"=>"1524-4733"}, "id"=>"c76b8ec2-5dc7-36c3-85e4-e34f8a6d16ce", "abstract"=>"Drug shortages are a complex and global phenomenon. When a drug cannot be delivered at the moment of patient demand, every stakeholder in the health care system is affected. The aim of this study was to investigate the characteristics, clinical impact, financial impact and management of drug shortages in European hospital pharmacies and identify opportunities for prevention and mitigation of drug shortages in Europe. An online survey was designed based on a review of the literature and interviews and was sent to subscribers of Hospital Pharmacy Europe between June and September 2013. Forty-five percent of respondents (n = 161) indicated that life sustaining or life preserving drugs such as oncology drugs were affected by drug shortages. More than 30% of respondents indicated that drug shortages in Europe were always or often associated with increased costs for hospitals, increased personnel costs and more expensive alternative drugs (n = 161). On the question when information about a drug shortage was obtained, 42% of respondents answered that information from the pharmaceutical company was obtained at the time of no delivery, 50% indicated that information from the wholesaler was obtained at the time of no delivery, while 40% of respondents indicated that information was never or rarely received from the government (n = 161). Fifty seven percent of respondents strongly agreed that an obligation to the producer to notify further shortages could help to solve the problem (n = 161). These results showed that pharmaceutical companies and wholesalers are already involved in the management of drug shortages, while a role is still reserved for the government. Mandatory notification in advance and centralized information can help to reduce workload for hospital pharmacists, will allow early anticipation of drug shortages and will facilitate mitigation of the clinical impact on patients.", "link"=>"http://www.mendeley.com/research/insights-european-drug-shortages-survey-hospital-pharmacists", "reader_count"=>58, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>6, "Student > Master"=>18, "Other"=>4, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>6, "Student > Master"=>18, "Other"=>4, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>3, "Unspecified"=>4, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>19, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>18, "Business, Management and Accounting"=>1, "Chemistry"=>2, "Social Sciences"=>3, "Computer Science"=>1, "Economics, Econometrics and Finance"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>18}}, "group_count"=>5}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1950186"], "description"=>"<div><p>Drug shortages are a complex and global phenomenon. When a drug cannot be delivered at the moment of patient demand, every stakeholder in the health care system is affected. The aim of this study was to investigate the characteristics, clinical impact, financial impact and management of drug shortages in European hospital pharmacies and identify opportunities for prevention and mitigation of drug shortages in Europe. An online survey was designed based on a review of the literature and interviews and was sent to subscribers of <i>Hospital Pharmacy Europe</i> between June and September 2013. Forty-five percent of respondents (n = 161) indicated that life sustaining or life preserving drugs such as oncology drugs were affected by drug shortages. More than 30% of respondents indicated that drug shortages in Europe were always or often associated with increased costs for hospitals, increased personnel costs and more expensive alternative drugs (n = 161). On the question when information about a drug shortage was obtained, 42% of respondents answered that information from the pharmaceutical company was obtained at the time of no delivery, 50% indicated that information from the wholesaler was obtained at the time of no delivery, while 40% of respondents indicated that information was never or rarely received from the government (n = 161). Fifty seven percent of respondents strongly agreed that an obligation to the producer to notify further shortages could help to solve the problem (n = 161). These results showed that pharmaceutical companies and wholesalers are already involved in the management of drug shortages, while a role is still reserved for the government. Mandatory notification in advance and centralized information can help to reduce workload for hospital pharmacists, will allow early anticipation of drug shortages and will facilitate mitigation of the clinical impact on patients.</p></div>", "links"=>[], "tags"=>["respondent", "European hospital pharmacies", "drug shortages", "information", "Hospital Pharmacists Drug shortages", "Hospital Pharmacy Europe", "health care system", "European Drug Shortages"], "article_id"=>1336903, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Kim Pauwels", "Steven Simoens", "Minne Casteels", "Isabelle Huys"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119322", "stats"=>{"downloads"=>10, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Insights_into_European_Drug_Shortages_A_Survey_of_Hospital_Pharmacists_/1336903", "title"=>"Insights into European Drug Shortages: A Survey of Hospital Pharmacists", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-16 04:13:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950185"], "description"=>"<p>The relative number of respondents per answer was shown (n = 161). The answer “always” and “often” as well as “never” and “rarely” are grouped for the sake of clarity.</p>", "links"=>[], "tags"=>["respondent", "European hospital pharmacies", "drug shortages", "information", "Hospital Pharmacists Drug shortages", "Hospital Pharmacy Europe", "health care system", "European Drug Shortages"], "article_id"=>1336902, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Kim Pauwels", "Steven Simoens", "Minne Casteels", "Isabelle Huys"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119322.g006", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Answers_to_the_question_8220_What_do_you_think_are_the_causes_for_drug_shortages_over_the_last_12_months_8221_/1336902", "title"=>"Answers to the question “What do you think are the causes for drug shortages over the last 12 months?”", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 04:13:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950182"], "description"=>"<p>A. Answers to the question “Are cancer drugs affected by drug shortages?”. The relative number of respondents per answer was shown for Europe (n = 161), Northern Europe (n = 55), Eastern Europe (n = 26), Southern Europe (n = 34), Western Europe (n = 46), the UK (n = 44), Belgium (n = 11) and the Netherlands (n = 16). B. Answers to the question “If yes, are these affected drugs mostly generic or originator drugs?”. C. Answers to the question “Are these affected drugs mostly cheap or expensive?”. D. Answers to the question “What is the most affected form?”. For Figs. B-D, only respondents who indicated the disease domain were affected by shortages were considered. The relative number of respondents was shown for Europe (n = 83), Northern Europe (n = 18), Eastern Europe (n = 17), Southern Europe (n = 20), Western Europe (n = 27), Belgium (n = 4), the Netherlands (n = 13).</p>", "links"=>[], "tags"=>["respondent", "European hospital pharmacies", "drug shortages", "information", "Hospital Pharmacists Drug shortages", "Hospital Pharmacy Europe", "health care system", "European Drug Shortages"], "article_id"=>1336899, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Kim Pauwels", "Steven Simoens", "Minne Casteels", "Isabelle Huys"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119322.g003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_drug_shortages_for_cancer_drugs_per_region_and_country_/1336899", "title"=>"Characteristics of drug shortages for cancer drugs per region and country.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 04:13:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950181"], "description"=>"<p>A. Answers to the question “Are anti-infective drugs affected by drug shortages?”. The relative number of respondents per answer was shown for Europe (n = 161), Northern Europe (n = 55), Eastern Europe (n = 26), Southern Europe (n = 34), Western Europe (n = 46), the UK (n = 44), Belgium (n = 11) and the Netherlands (n = 16). B. Answers to the question “If yes, are these affected drugs mostly generic or originator drugs?”. C. Answers to the question “Are these affected drugs mostly cheap or expensive?”. D. Answers to the question “What is the most affected form?”. For Figs. B-D, respondents who indicated the disease domain is affected were considered. The relative number of respondents was shown for Europe (n = 69), Northern Europe (n = 24), Eastern Europe (n = 10), Southern Europe (n = 13), Western Europe (n = 21), the UK (n = 17), the Netherlands (n = 9).</p>", "links"=>[], "tags"=>["respondent", "European hospital pharmacies", "drug shortages", "information", "Hospital Pharmacists Drug shortages", "Hospital Pharmacy Europe", "health care system", "European Drug Shortages"], "article_id"=>1336898, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Kim Pauwels", "Steven Simoens", "Minne Casteels", "Isabelle Huys"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119322.g002", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_drug_shortages_for_anti_infective_drugs_per_region_and_country_/1336898", "title"=>"Characteristics of drug shortages for anti-infective drugs per region and country.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 04:13:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950184"], "description"=>"<p>The relative number of respondents per answer was shown (n = 161). The answer “always” and “often” as well as “never” and “rarely” were grouped for the sake of clarity.</p>", "links"=>[], "tags"=>["respondent", "European hospital pharmacies", "drug shortages", "information", "Hospital Pharmacists Drug shortages", "Hospital Pharmacy Europe", "health care system", "European Drug Shortages"], "article_id"=>1336901, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Kim Pauwels", "Steven Simoens", "Minne Casteels", "Isabelle Huys"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119322.g005", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Answers_to_the_question_8220_Which_financial_consequence_has_a_drug_shortage_already_caused_in_your_hospital_8221_/1336901", "title"=>"Answers to the question “Which financial consequence has a drug shortage already caused in your hospital?”", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 04:13:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950183"], "description"=>"<p>The relative number of respondents per answer was shown (n = 161). The answer “always” and “often” as well as “never” and “rarely” were grouped for the sake of clarity.</p>", "links"=>[], "tags"=>["respondent", "European hospital pharmacies", "drug shortages", "information", "Hospital Pharmacists Drug shortages", "Hospital Pharmacy Europe", "health care system", "European Drug Shortages"], "article_id"=>1336900, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Kim Pauwels", "Steven Simoens", "Minne Casteels", "Isabelle Huys"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119322.g004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Answers_to_the_question_8220_What_clinical_impact_has_a_drug_shortage_already_caused_in_your_hospital_8221_/1336900", "title"=>"Answers to the question “What clinical impact has a drug shortage already caused in your hospital?”", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 04:13:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1950180"], "description"=>"<p>Respondents who indicated that particular types of medicines suffered more from shortages than others were considered. The relative number of respondents per answer was shown for Europe (n = 128), Northern Europe (n = 8), Eastern Europe (n = 20), Southern Europe (n = 30), Western Europe (n = 16), the UK (n = 29), Belgium (n = 9) and the Netherlands (n = 15).</p>", "links"=>[], "tags"=>["respondent", "European hospital pharmacies", "drug shortages", "information", "Hospital Pharmacists Drug shortages", "Hospital Pharmacy Europe", "health care system", "European Drug Shortages"], "article_id"=>1336897, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Kim Pauwels", "Steven Simoens", "Minne Casteels", "Isabelle Huys"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119322.g001", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Drug_types_affected_by_drug_shortages_according_to_the_respondents_/1336897", "title"=>"Drug types affected by drug shortages according to the respondents.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-16 04:13:35"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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