Leptin Signaling Is Required for Adaptive Changes in Food Intake, but Not Energy Expenditure, in Response to Different Thermal Conditions
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{"title"=>"Leptin signaling is required for adaptive changes in food intake, but not energy expenditure, in response to different thermal conditions", "type"=>"journal", "authors"=>[{"first_name"=>"Karl J.", "last_name"=>"Kaiyala", "scopus_author_id"=>"6602722553"}, {"first_name"=>"Kayoko", "last_name"=>"Ogimoto", "scopus_author_id"=>"10040751100"}, {"first_name"=>"Jarrell T.", "last_name"=>"Nelson", "scopus_author_id"=>"56542243500"}, {"first_name"=>"Michael W.", "last_name"=>"Schwartz", "scopus_author_id"=>"56050473600"}, {"first_name"=>"Gregory J.", "last_name"=>"Morton", "scopus_author_id"=>"7004903549"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84924371088", "doi"=>"10.1371/journal.pone.0119391", "sgr"=>"84924371088", "pmid"=>"25756181", "issn"=>"19326203", "pui"=>"602854977"}, "id"=>"be9f57c4-27a6-3168-a72c-777af913037d", "abstract"=>"Survival of free-living animals depends on the ability to maintain core body temperature in the face of rapid and dramatic changes in their thermal environment. If food intake is not adjusted to meet the changing energy demands associated with changes of ambient temperature, a serious challenge to body energy stores can occur. To more fully understand the coupling of thermoregulation to energy homeostasis in normal animals and to investigate the role of the adipose hormone leptin to this process, comprehensive measures of energy homeostasis and core temperature were obtained in leptin-deficient ob/ob mice and their wild-type (WT) littermate controls when housed under cool (14°C), usual (22°C) or ∼ thermoneutral (30°C) conditions. Our findings extend previous evidence that WT mice robustly defend normothermia in response to either a lowering (14°C) or an increase (30°C) of ambient temperature without changes in body weight or body composition. In contrast, leptin-deficient, ob/ob mice fail to defend normothermia at ambient temperatures lower than thermoneutrality and exhibit marked losses of both body fat and lean mass when exposed to cooler environments (14°C). Our findings further demonstrate a strong inverse relationship between ambient temperature and energy expenditure in WT mice, a relationship that is preserved in ob/ob mice. However, thermal conductance analysis indicates defective heat retention in ob/ob mice, irrespective of temperature. While a negative relationship between ambient temperature and energy intake also exists in WT mice, this relationship is disrupted in ob/ob mice. Thus, to meet the thermoregulatory demands of different ambient temperatures, leptin signaling is required for adaptive changes in both energy intake and thermal conductance. A better understanding of the mechanisms coupling thermoregulation to energy homeostasis may lead to the development of new approaches for the treatment of obesity.", "link"=>"http://www.mendeley.com/research/leptin-signaling-required-adaptive-changes-food-intake-not-energy-expenditure-response-different-the-1", "reader_count"=>21, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Master"=>1, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Master"=>1, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>9, "Neuroscience"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1942323"], "description"=>"<p>(A) Energy expenditure (EE) and energy intake (EI) expressed as percentages of the values observed at thermoneutrality vs. ambient temperature and (B) whole body thermal conductance calculated from mean 24h energy expenditure <i>vs</i>. ambient temperature in wild-type (WT) and leptin-deficient <i>ob/ob</i> mice using the traditional method [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119391#pone.0119391.ref013\" target=\"_blank\">13</a>] (n = 8/group). (C) Comparison of traditional <i>vs</i>. regression methods for estimating whole body thermal conductance as functions of the core minus ambient (Tc—Ta) temperature difference based on 24h data (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119391#pone.0119391.s001\" target=\"_blank\">S1 Fig.</a>). Mean±SEM. ***p<0.001.</p>", "links"=>[], "tags"=>["adipose hormone leptin", "WT mice", "ambient temperature", "core body temperature", "ob", "energy intake", "energy homeostasis", "body energy stores", "ambient temperatures", "relationship"], "article_id"=>1330560, "categories"=>["Biological Sciences"], "users"=>["Karl J. Kaiyala", "Kayoko Ogimoto", "Jarrell T. Nelson", "Michael W. Schwartz", "Gregory J. Morton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119391.g005", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adaptive_changes_of_energy_intake_but_not_energy_expenditure_in_response_to_different_ambient_temperatures_requires_leptin_signaling_/1330560", "title"=>"Adaptive changes of energy intake, but not energy expenditure in response to different ambient temperatures, requires leptin signaling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-10 02:49:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1942321"], "description"=>"<p>(<b>A</b>) Photoperiod-averaged energy intake profiles and (<b>B</b>) the relationship between energy intake and ambient temperature in adult male <i>ob/ob</i> mice and wild-type (WT) littermate controls housed under different ambient temperature conditions (n = 8/group). Mean±SEM. ***p<0.001, *p<0.05.</p>", "links"=>[], "tags"=>["adipose hormone leptin", "WT mice", "ambient temperature", "core body temperature", "ob", "energy intake", "energy homeostasis", "body energy stores", "ambient temperatures", "relationship"], "article_id"=>1330558, "categories"=>["Biological Sciences"], "users"=>["Karl J. Kaiyala", "Kayoko Ogimoto", "Jarrell T. Nelson", "Michael W. Schwartz", "Gregory J. Morton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119391.g003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Leptin_signaling_is_required_for_adaptive_changes_in_energy_intake_in_response_to_a_thermal_challenge_/1330558", "title"=>"Leptin signaling is required for adaptive changes in energy intake in response to a thermal challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-10 02:49:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1942331"], "description"=>"<div><p>Survival of free-living animals depends on the ability to maintain core body temperature in the face of rapid and dramatic changes in their thermal environment. If food intake is not adjusted to meet the changing energy demands associated with changes of ambient temperature, a serious challenge to body energy stores can occur. To more fully understand the coupling of thermoregulation to energy homeostasis in normal animals and to investigate the role of the adipose hormone leptin to this process, comprehensive measures of energy homeostasis and core temperature were obtained in leptin-deficient <i>ob/ob</i> mice and their wild-type (WT) littermate controls when housed under cool (14°C), usual (22°C) or ∼ thermoneutral (30°C) conditions. Our findings extend previous evidence that WT mice robustly defend normothermia in response to either a lowering (14°C) or an increase (30°C) of ambient temperature without changes in body weight or body composition. In contrast, leptin-deficient, <i>ob/ob</i> mice fail to defend normothermia at ambient temperatures lower than thermoneutrality and exhibit marked losses of both body fat and lean mass when exposed to cooler environments (14°C). Our findings further demonstrate a strong inverse relationship between ambient temperature and energy expenditure in WT mice, a relationship that is preserved in <i>ob/ob</i> mice. However, thermal conductance analysis indicates defective heat retention in <i>ob/ob</i> mice, irrespective of temperature. While a negative relationship between ambient temperature and energy intake also exists in WT mice, this relationship is disrupted in <i>ob/ob</i> mice. Thus, to meet the thermoregulatory demands of different ambient temperatures, leptin signaling is required for adaptive changes in both energy intake and thermal conductance. A better understanding of the mechanisms coupling thermoregulation to energy homeostasis may lead to the development of new approaches for the treatment of obesity.</p></div>", "links"=>[], "tags"=>["adipose hormone leptin", "WT mice", "ambient temperature", "core body temperature", "ob", "energy intake", "energy homeostasis", "body energy stores", "ambient temperatures", "relationship"], "article_id"=>1330563, "categories"=>["Biological Sciences"], "users"=>["Karl J. Kaiyala", "Kayoko Ogimoto", "Jarrell T. Nelson", "Michael W. Schwartz", "Gregory J. Morton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119391", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Leptin_Signaling_Is_Required_for_Adaptive_Changes_in_Food_Intake_but_Not_Energy_Expenditure_in_Response_to_Different_Thermal_Conditions_/1330563", "title"=>"Leptin Signaling Is Required for Adaptive Changes in Food Intake, but Not Energy Expenditure, in Response to Different Thermal Conditions", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-10 02:49:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1942330"], "description"=>"<p>(<b>A</b>) Ambulatory activity across all photoperiods, (<b>B</b>) photoperiod-averaged ambulatory activity and (<b>C</b>) the relationship between ambulatory activity and ambient temperature in adult male <i>ob/ob</i> mice and wild-type (WT) littermate controls housed under different ambient temperature conditions (n = 8/group). Mean±SEM. ****p<0.0001, ***p<0.001.</p>", "links"=>[], "tags"=>["adipose hormone leptin", "WT mice", "ambient temperature", "core body temperature", "ob", "energy intake", "energy homeostasis", "body energy stores", "ambient temperatures", "relationship"], "article_id"=>1330562, "categories"=>["Biological Sciences"], "users"=>["Karl J. Kaiyala", "Kayoko Ogimoto", "Jarrell T. Nelson", "Michael W. Schwartz", "Gregory J. Morton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119391.g006", "stats"=>{"downloads"=>4, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ambulatory_activity_levels_do_not_change_at_different_ambient_temperatures_/1330562", "title"=>"Ambulatory activity levels do not change at different ambient temperatures.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-10 02:49:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1942320"], "description"=>"<p>(<b>A</b>) Study design, (<b>B</b>) body weight, (<b>C</b>) fat mass, (<b>D</b>) change in body weight, (<b>E</b>) change in fat mass and (<b>F</b>) change in lean body mass in adult male <i>ob/ob</i> mice and wild-type (WT) littermate controls housed under different ambient temperature conditions (n = 8/group). Arrowheads mark measures of body weight and composition. Mean±SEM. ****p<0.0001, ***p<0.001, *p<0.05.</p>", "links"=>[], "tags"=>["adipose hormone leptin", "WT mice", "ambient temperature", "core body temperature", "ob", "energy intake", "energy homeostasis", "body energy stores", "ambient temperatures", "relationship"], "article_id"=>1330557, "categories"=>["Biological Sciences"], "users"=>["Karl J. Kaiyala", "Kayoko Ogimoto", "Jarrell T. Nelson", "Michael W. Schwartz", "Gregory J. Morton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119391.g002", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Leptin_deficient_animals_are_unable_to_maintain_energy_homeostasis_in_response_to_a_thermal_challenge_/1330557", "title"=>"Leptin deficient animals are unable to maintain energy homeostasis in response to a thermal challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-10 02:49:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1942319"], "description"=>"<p>(<b>A</b>) Study design, (<b>B</b>) change in body weight, (<b>C</b>) core body temperature across all photoperiods, (<b>D</b>) photoperiod-averaged core body temperature profiles, and (<b>E</b>) the relationship between core temperature and ambient temperature in adult male <i>ob/ob</i> mice and wild-type (WT) littermate controls implanted with temperature transponders for continuous measures of core body temperature and housed under different ambient temperature conditions (n = 7/group). Arrowheads mark measures of body weight. Mean±SEM. ****p<0.0001, ***p<0.001, *p<0.05.</p>", "links"=>[], "tags"=>["adipose hormone leptin", "WT mice", "ambient temperature", "core body temperature", "ob", "energy intake", "energy homeostasis", "body energy stores", "ambient temperatures", "relationship"], "article_id"=>1330556, "categories"=>["Biological Sciences"], "users"=>["Karl J. Kaiyala", "Kayoko Ogimoto", "Jarrell T. Nelson", "Michael W. Schwartz", "Gregory J. Morton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119391.g001", "stats"=>{"downloads"=>2, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Leptin_deficient_animals_fail_to_defend_normothermia_at_temperatures_lower_than_thermoneutrality_/1330556", "title"=>"Leptin deficient animals fail to defend normothermia at temperatures lower than thermoneutrality.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-10 02:49:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1942322"], "description"=>"<p>(<b>A</b>) Energy expenditure across all photoperiods, (<b>B</b>) photoperiod-averaged energy expenditure (EE) profiles and (<b>C</b>) the relationship between energy expenditure and ambient temperature in adult male <i>ob/ob</i> mice and wild-type (WT) littermate controls housed under different ambient temperature conditions (n = 8/group). (D) Regression of natural log (ln) of mean 24h EE values on the natural log of the mean difference between core temperature (Tc) and ambient temperature (Ta) (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119391#pone.0119391.s001\" target=\"_blank\">S1 Fig.</a>). Mean±SEM. ****p<0.0001, ***p<0.001, **p<0.01.</p>", "links"=>[], "tags"=>["adipose hormone leptin", "WT mice", "ambient temperature", "core body temperature", "ob", "energy intake", "energy homeostasis", "body energy stores", "ambient temperatures", "relationship"], "article_id"=>1330559, "categories"=>["Biological Sciences"], "users"=>["Karl J. Kaiyala", "Kayoko Ogimoto", "Jarrell T. Nelson", "Michael W. Schwartz", "Gregory J. Morton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119391.g004", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Leptin_deficiency_does_not_impair_the_whole_body_heat_production_response_to_cold_stress_in_mice_/1330559", "title"=>"Leptin deficiency does not impair the whole body heat production response to cold stress in mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-10 02:49:11"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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