Silver-Zinc Redox-Coupled Electroceutical Wound Dressing Disrupts Bacterial Biofilm
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{"title"=>"Silver-Zinc Redox-Coupled electroceutical wound dressing disrupts bacterial biofilm", "type"=>"journal", "authors"=>[{"first_name"=>"Banerjee", "last_name"=>"Jaideep", "scopus_author_id"=>"56575066000"}, {"first_name"=>"Das Ghatak", "last_name"=>"Piya", "scopus_author_id"=>"56575186900"}, {"first_name"=>"Roy", "last_name"=>"Sashwati", "scopus_author_id"=>"7404587610"}, {"first_name"=>"Khanna", "last_name"=>"Savita", "scopus_author_id"=>"7401552371"}, {"first_name"=>"Hemann", "last_name"=>"Craig", "scopus_author_id"=>"56574814600"}, {"first_name"=>"Deng", "last_name"=>"Binbin", "scopus_author_id"=>"56575085900"}, {"first_name"=>"Das", "last_name"=>"Amitava", "scopus_author_id"=>"56575063900"}, {"first_name"=>"L. Zweier", "last_name"=>"Jay", "scopus_author_id"=>"7102521744"}, {"first_name"=>"Wozniak", "last_name"=>"Daniel", "scopus_author_id"=>"7005575242"}, {"first_name"=>"K. Sen", "last_name"=>"Chandan", "scopus_author_id"=>"7103412896"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25803639", "sgr"=>"84925881099", "doi"=>"10.1371/journal.pone.0119531", "scopus"=>"2-s2.0-84925881099", "pui"=>"603281549", "issn"=>"19326203"}, "id"=>"40e16634-9b27-3dfa-b215-5292b4ff9b72", "abstract"=>"Pseudomonas aeruginosa biofilm is commonly associated with chronic wound infection. A FDA approved wireless electroceutical dressing (WED), which in the presence of conductive wound exudate gets activated to generate electric field (0.3-0.9V), was investigated for its anti-biofilm properties. Growth of pathogenic P. aeruginosa strain PAO1 in LB media was markedly arrested in the presence of the WED. Scanning electron microscopy demonstrated that WED markedly disrupted biofilm integrity in a setting where silver dressing was ineffective. Biofilm thickness and number of live bacterial cells were decreased in the presence of WED. Quorum sensing genes lasR and rhlR and activity of electric field sensitive enzyme, glycerol-3-phosphate dehydrogenase was also repressed by WED. This work provides first electron paramagnetic resonance spectroscopy evidence demonstrating that WED serves as a spontaneous source of reactive oxygen species. Redox-sensitive multidrug efflux systems mexAB and mexEF were repressed by WED. Taken together, these observations provide first evidence supporting the anti-biofilm properties of WED.", "link"=>"http://www.mendeley.com/research/silverzinc-redoxcoupled-electroceutical-wound-dressing-disrupts-bacterial-biofilm", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>3, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>3, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>5, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemical Engineering"=>1, "Chemistry"=>2, "Social Sciences"=>1, "Materials Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Materials Science"=>{"Materials Science"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Belgium"=>1, "United Kingdom"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1983918"], "description"=>"<p>Addition of 500U Catalase does not attenuate EPR signal but is attenuated using both 500U SOD and 500U Catalase, n = 3</p>", "links"=>[], "tags"=>["fda", "presence", "biofilm integrity", "conductive wound exudate", "wound infection", "Biofilm Pseudomonas aeruginosa biofilm", "Biofilm thickness", "scanning electron microscopy", "Reactive oxygen species", "resonance spectroscopy evidence", "wed", "silver dressing", "electroceutical dressing", "genes lasR", "LB media", "aeruginosa strain PAO 1"], "article_id"=>1352149, "categories"=>["Uncategorised"], "users"=>["Jaideep Banerjee", "Piya Das Ghatak", "Sashwati Roy", "Savita Khanna", "Craig Hemann", "Binbin Deng", "Amitava Das", "Jay L. Zweier", "Daniel Wozniak", "Chandan K. Sen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119531.g006", "stats"=>{"downloads"=>3, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WED_generates_superoxide_A_EPR_spectra_using_20mM_DIPPMPO_demonstrates_spin_adduct_generation_upon_exposure_to_dressings_for_40_mins_in_PBS_/1352149", "title"=>"WED generates superoxide (A) EPR spectra using 20mM DIPPMPO demonstrates spin adduct generation upon exposure to dressings for 40 mins in PBS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 02:46:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1983917"], "description"=>"<p>CLSM micrographs of mature PAO1 biofilm stained with live-dead stain after treatment with placebo, WED or Ag control. The green fluorescence indicates live bacteria while the red indicates dead bacteria, n = 3.</p>", "links"=>[], "tags"=>["fda", "presence", "biofilm integrity", "conductive wound exudate", "wound infection", "Biofilm Pseudomonas aeruginosa biofilm", "Biofilm thickness", "scanning electron microscopy", "Reactive oxygen species", "resonance spectroscopy evidence", "wed", "silver dressing", "electroceutical dressing", "genes lasR", "LB media", "aeruginosa strain PAO 1"], "article_id"=>1352148, "categories"=>["Uncategorised"], "users"=>["Jaideep Banerjee", "Piya Das Ghatak", "Sashwati Roy", "Savita Khanna", "Craig Hemann", "Binbin Deng", "Amitava Das", "Jay L. Zweier", "Daniel Wozniak", "Chandan K. Sen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119531.g005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WED_impairs_cell_viability_/1352148", "title"=>"WED impairs cell viability.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 02:46:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1983904"], "description"=>"<p><b>(A)</b> Side-view and thickness of in-vitro static mature biofilm treated with placebo or WED, n = 3 <b>(B)</b> X,Y,Z projection of same <b>(C)</b> Orthogonal view of same at slices 6, 12 and 22 out of total 25 slices acquired.</p>", "links"=>[], "tags"=>["fda", "presence", "biofilm integrity", "conductive wound exudate", "wound infection", "Biofilm Pseudomonas aeruginosa biofilm", "Biofilm thickness", "scanning electron microscopy", "Reactive oxygen species", "resonance spectroscopy evidence", "wed", "silver dressing", "electroceutical dressing", "genes lasR", "LB media", "aeruginosa strain PAO 1"], "article_id"=>1352143, "categories"=>["Uncategorised"], "users"=>["Jaideep Banerjee", "Piya Das Ghatak", "Sashwati Roy", "Savita Khanna", "Craig Hemann", "Binbin Deng", "Amitava Das", "Jay L. Zweier", "Daniel Wozniak", "Chandan K. Sen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119531.g002", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PAO1_staining_demonstrates_impaired_biofilm_formation_by_WED_/1352143", "title"=>"PAO1 staining demonstrates impaired biofilm formation by WED.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 02:46:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1983905"], "description"=>"<p>CLSM images of in-vitro static mature PAO1 biofilm grown treated with placebo, WED or Ag control and stained with EPS antibody, n = 3.</p>", "links"=>[], "tags"=>["fda", "presence", "biofilm integrity", "conductive wound exudate", "wound infection", "Biofilm Pseudomonas aeruginosa biofilm", "Biofilm thickness", "scanning electron microscopy", "Reactive oxygen species", "resonance spectroscopy evidence", "wed", "silver dressing", "electroceutical dressing", "genes lasR", "LB media", "aeruginosa strain PAO 1"], "article_id"=>1352144, "categories"=>["Uncategorised"], "users"=>["Jaideep Banerjee", "Piya Das Ghatak", "Sashwati Roy", "Savita Khanna", "Craig Hemann", "Binbin Deng", "Amitava Das", "Jay L. Zweier", "Daniel Wozniak", "Chandan K. Sen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119531.g003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WED_impairs_extracellular_polymeric_substance_EPS_production_/1352144", "title"=>"WED impairs extracellular polymeric substance (EPS) production.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 02:46:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1983900"], "description"=>"<p><b>(A)</b> Energy Dispersive X-Ray Spectroscopy (EDS) elemental analysis of Ag/Zn WED. <b>a.</b> Scanning Electron Microscope (SEM) image; <b>b.</b> Light Microscope Image; <b>c</b>. and <b>d.</b> Close-up view of gold and silver dots under light microscope. <b>e-h.</b> EDS element maps of Zn (blue), Silver (red), Oxygen (green) and Carbon (Magenta). <b>(B,C)</b> Absorbance and CFU measurement from planktonic PAO1 culture in presence of placebo or Ag/Zn WED, n = 4 <b>(D) (i)</b> schematic diagram for experimental design showing dressing embedded in the agar plate. <b>(ii, iii)</b> Zone of inhibition above WED is marked with red dotted line, while no such zone was observed over the placebo dressing, n = 4 <b>(E)</b> Biofilm formation measured by absorbance at 540 nm, n = 4 <b>(F)</b> Biofilm co-aggregation observed in the placebo treated overnight PAO1 culture was not observed in WED treated overnight cultures, n = 3.</p>", "links"=>[], "tags"=>["fda", "presence", "biofilm integrity", "conductive wound exudate", "wound infection", "Biofilm Pseudomonas aeruginosa biofilm", "Biofilm thickness", "scanning electron microscopy", "Reactive oxygen species", "resonance spectroscopy evidence", "wed", "silver dressing", "electroceutical dressing", "genes lasR", "LB media", "aeruginosa strain PAO 1"], "article_id"=>1352139, "categories"=>["Uncategorised"], "users"=>["Jaideep Banerjee", "Piya Das Ghatak", "Sashwati Roy", "Savita Khanna", "Craig Hemann", "Binbin Deng", "Amitava Das", "Jay L. Zweier", "Daniel Wozniak", "Chandan K. Sen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119531.g001", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anti_bacterial_properties_of_WED_/1352139", "title"=>"Anti-bacterial properties of WED.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 02:46:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1983922"], "description"=>"<p>Measurement of glycerol-3-Phosphate dehydrogenase enzyme activity from mature PAO1 biofilms treated with placebo or WED <b>A.</b> OD measured in the kinetic mode. <b>B.</b> GPDH activity calculated using the formula: Glycerol-3-Phosphate dehydrogenase activity = B/(ΔT X V) x Dilution Factor = nmol/min/ml, where: B = NADH amount from Standard Curve (nmol). ΔT = reaction time (min). V = sample volume added into the reaction well (ml), n = 3.</p>", "links"=>[], "tags"=>["fda", "presence", "biofilm integrity", "conductive wound exudate", "wound infection", "Biofilm Pseudomonas aeruginosa biofilm", "Biofilm thickness", "scanning electron microscopy", "Reactive oxygen species", "resonance spectroscopy evidence", "wed", "silver dressing", "electroceutical dressing", "genes lasR", "LB media", "aeruginosa strain PAO 1"], "article_id"=>1352153, "categories"=>["Uncategorised"], "users"=>["Jaideep Banerjee", "Piya Das Ghatak", "Sashwati Roy", "Savita Khanna", "Craig Hemann", "Binbin Deng", "Amitava Das", "Jay L. Zweier", "Daniel Wozniak", "Chandan K. Sen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119531.g009", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WED_inhibits_glycerol_3_phosphate_dehydrogenase_activity_/1352153", "title"=>"WED inhibits glycerol-3-phosphate dehydrogenase activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 02:46:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1983921"], "description"=>"<p><b>(A)</b> Real-time PCR was performed to assess quorum sensing gene expression with RNA isolated from mature PAO1 biofilm exposed to placebo or WED. <i>rpoD</i> and <i>proC</i> was used as housekeeping control, n = 3. <b>(B)</b> Pyocyanin production (green color) in overnight PAO1 culture followed by exposure to placebo or WED, n = 3.</p>", "links"=>[], "tags"=>["fda", "presence", "biofilm integrity", "conductive wound exudate", "wound infection", "Biofilm Pseudomonas aeruginosa biofilm", "Biofilm thickness", "scanning electron microscopy", "Reactive oxygen species", "resonance spectroscopy evidence", "wed", "silver dressing", "electroceutical dressing", "genes lasR", "LB media", "aeruginosa strain PAO 1"], "article_id"=>1352152, "categories"=>["Uncategorised"], "users"=>["Jaideep Banerjee", "Piya Das Ghatak", "Sashwati Roy", "Savita Khanna", "Craig Hemann", "Binbin Deng", "Amitava Das", "Jay L. Zweier", "Daniel Wozniak", "Chandan K. Sen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119531.g008", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WED_silences_quorum_sensing_genes_and_pyocyanin_production_/1352152", "title"=>"WED silences quorum sensing genes and pyocyanin production.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 02:46:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1983919"], "description"=>"<p>WED represses redox-sensitive multidrug efflux genes in <i>P</i>. <i>aeruginosa</i> Real-time PCR was performed to assess mex gene expression post-treatment with placebo, WED or 3mM DTT, n = 3.</p>", "links"=>[], "tags"=>["fda", "presence", "biofilm integrity", "conductive wound exudate", "wound infection", "Biofilm Pseudomonas aeruginosa biofilm", "Biofilm thickness", "scanning electron microscopy", "Reactive oxygen species", "resonance spectroscopy evidence", "wed", "silver dressing", "electroceutical dressing", "genes lasR", "LB media", "aeruginosa strain PAO 1"], "article_id"=>1352150, "categories"=>["Uncategorised"], "users"=>["Jaideep Banerjee", "Piya Das Ghatak", "Sashwati Roy", "Savita Khanna", "Craig Hemann", "Binbin Deng", "Amitava Das", "Jay L. Zweier", "Daniel Wozniak", "Chandan K. Sen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119531.g007", "stats"=>{"downloads"=>6, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WED_represses_redox_sensitive_multidrug_efflux_genes_in_P_aeruginosa_Real_time_PCR_was_performed_to_assess_mex_gene_expression_post_treatment_with_placebo_WED_or_3mM_DTT_n_3_/1352150", "title"=>"WED represses redox-sensitive multidrug efflux genes in <i>P</i>. <i>aeruginosa</i> Real-time PCR was performed to assess mex gene expression post-treatment with placebo, WED or 3mM DTT, n = 3.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 02:46:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1983915"], "description"=>"<p>Scanning Electron Microscope images of in-vitro static mature PAO1 biofilm treated with placebo, WED or Ag control shown at 2500X, 5000X and 10000X magnifications, n = 3.</p>", "links"=>[], "tags"=>["fda", "presence", "biofilm integrity", "conductive wound exudate", "wound infection", "Biofilm Pseudomonas aeruginosa biofilm", "Biofilm thickness", "scanning electron microscopy", "Reactive oxygen species", "resonance spectroscopy evidence", "wed", "silver dressing", "electroceutical dressing", "genes lasR", "LB media", "aeruginosa strain PAO 1"], "article_id"=>1352146, "categories"=>["Uncategorised"], "users"=>["Jaideep Banerjee", "Piya Das Ghatak", "Sashwati Roy", "Savita Khanna", "Craig Hemann", "Binbin Deng", "Amitava Das", "Jay L. Zweier", "Daniel Wozniak", "Chandan K. Sen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119531.g004", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WED_impairs_biofilm_structural_integrity_/1352146", "title"=>"WED impairs biofilm structural integrity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 02:46:28"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"36", "full-text"=>"41", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"28", "full-text"=>"33", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
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  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
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  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"21", "full-text"=>"26", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"30", "full-text"=>"38", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"24", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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