Can Acupuncture Treatment Be Double-Blinded? An Evaluation of Double-Blind Acupuncture Treatment of Postoperative Pain
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{"title"=>"Can acupuncture treatment be double-blinded? An evaluation of double-blind acupuncture treatment of postoperative pain", "type"=>"journal", "authors"=>[{"first_name"=>"Lene", "last_name"=>"Vase", "scopus_author_id"=>"6506276662"}, {"first_name"=>"Sara", "last_name"=>"Baram", "scopus_author_id"=>"55776569400"}, {"first_name"=>"Nobuari", "last_name"=>"Takakura", "scopus_author_id"=>"7006044136"}, {"first_name"=>"Miho", "last_name"=>"Takayama", "scopus_author_id"=>"26429000000"}, {"first_name"=>"Hiroyoshi", "last_name"=>"Yajima", "scopus_author_id"=>"35363190500"}, {"first_name"=>"Akiko", "last_name"=>"Kawase", "scopus_author_id"=>"35484605800"}, {"first_name"=>"Lars", "last_name"=>"Schuster", "scopus_author_id"=>"56538154600"}, {"first_name"=>"Ted J.", "last_name"=>"Kaptchuk", "scopus_author_id"=>"26643513100"}, {"first_name"=>"Søren", "last_name"=>"Schou", "scopus_author_id"=>"57200347354"}, {"first_name"=>"Troels Staehelin", "last_name"=>"Jensen", "scopus_author_id"=>"7401539634"}, {"first_name"=>"Robert", "last_name"=>"Zachariae", "scopus_author_id"=>"7003276395"}, {"first_name"=>"Peter", "last_name"=>"Svensson", "scopus_author_id"=>"7103121346"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25747157", "sgr"=>"84924095403", "doi"=>"10.1371/journal.pone.0119612", "scopus"=>"2-s2.0-84924095403", "pui"=>"602763493", "isbn"=>"1932-6203", "issn"=>"19326203"}, "id"=>"686ee5a6-5659-3e77-9866-3071433f394a", "abstract"=>"Blinding protects against bias but the success of blinding is seldom assessed and reported in clinical trials including studies of acupuncture where blinding represents a major challenge. Recently, needles with the potential for double-blinding were developed, so we tested if acupuncture can be double-blinded in a randomized study of sixty-seven patients with acute pain ≥ 3 (0-10 scale following third molar removal) who received active acupuncture with a penetrating needle or placebo acupuncture with a non-penetrating needle. To test if acupuncture was administered double-blind, patients and acupuncturists were asked about perceived treatment allocation at the end of the study. To test if there were clues which led to identification of the treatment, deep dull pain associated with needle application and rotation (termed \"de qi\" in East Asian medicine), and patients' pain levels were assessed. Perceived treatment allocation depended on actual group allocation (p < 0.015) for both patients and acupuncturists, indicating that the needles were not successful in double-blinding. Up to 68% of patients and 83% of acupuncturists correctly identified the treatment, but for patients the distribution was not far from 50/50. Also, there was a significant interaction between actual or perceived treatment and the experience of de qi (p = 0.027), suggesting that the experience of de qi and possible non-verbal clues contributed to correct identification of the treatment. Yet, of the patients who perceived the treatment as active or placebo, 50% and 23%, respectively, reported de qi. Patients' acute pain levels did not influence the perceived treatment. In conclusion, acupuncture treatment was not fully double-blinded which is similar to observations in pharmacological studies. Still, the non-penetrating needle is the only needle that allows some degree of practitioner blinding. The study raises questions about alternatives to double-blind randomized clinical trials in the assessment of acupuncture treatment.", "link"=>"http://www.mendeley.com/research/acupuncture-treatment-doubleblinded-evaluation-doubleblind-acupuncture-treatment-postoperative-pain", "reader_count"=>36, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Librarian"=>2, "Researcher"=>3, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>11, "Student > Bachelor"=>6, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Librarian"=>2, "Researcher"=>3, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>11, "Student > Bachelor"=>6, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>9, "Medicine and Dentistry"=>21, "Neuroscience"=>1, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>21}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>9}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Australia"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/4336981"], "description"=>"<p>Patients who developed pain levels of ≥ 3 (0–10) up to 4 hours following surgical removal of one mandibular third molar were randomized to receive active acupuncture (AA) or placebo acupuncture (PA) for 30 minutes. Pain levels were measured at pretreatment, halfway through the session, and at the end of the session. Needles were rotated during insertion, halfway through the session, and at the end of the session right before they were removed. The patients and the acupuncturist were asked about the experience of <i>de qi</i> right after insertion of the needle and at the end of the study, respectively. Both the patients and the acupuncturist reported perceived treatment allocation at the end of the study.</p>", "links"=>[], "tags"=>["qi", "Perceived treatment allocation", "acupuncture treatment", "Postoperative Pain Blinding"], "article_id"=>2673502, "categories"=>["Medicine", "Cell Biology", "Neuroscience", "Physiology", "Pharmacology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Science Policy", "Plant Biology"], "users"=>["Lene Vase", "Sara Baram", "Nobuari Takakura", "Miho Takayama", "Hiroyoshi Yajima", "Akiko Kawase", "Lars Schuster", "Ted J. Kaptchuk", "Søren Schou", "Troels Staehelin Jensen", "Robert Zachariae", "Peter Svensson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119612.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Study_design_/2673502", "title"=>"Study design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-06 15:04:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/4336966"], "description"=>"<p>The five acupuncture points.</p>", "links"=>[], "tags"=>["qi", "Perceived treatment allocation", "acupuncture treatment", "Postoperative Pain Blinding"], "article_id"=>2673487, "categories"=>["Medicine", "Cell Biology", "Neuroscience", "Physiology", "Pharmacology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Science Policy", "Plant Biology"], "users"=>["Lene Vase", "Sara Baram", "Nobuari Takakura", "Miho Takayama", "Hiroyoshi Yajima", "Akiko Kawase", "Lars Schuster", "Ted J. Kaptchuk", "Søren Schou", "Troels Staehelin Jensen", "Robert Zachariae", "Peter Svensson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119612.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Acupuncture_points_/2673487", "title"=>"Acupuncture points.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-06 15:04:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/4337020"], "description"=>"<p>Acupuncturists’ perceived treatment allocation in relation to actual treatment allocation.</p>", "links"=>[], "tags"=>["qi", "Perceived treatment allocation", "acupuncture treatment", "Postoperative Pain Blinding"], "article_id"=>2673541, "categories"=>["Medicine", "Cell Biology", "Neuroscience", "Physiology", "Pharmacology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Science Policy", "Plant Biology"], "users"=>["Lene Vase", "Sara Baram", "Nobuari Takakura", "Miho Takayama", "Hiroyoshi Yajima", "Akiko Kawase", "Lars Schuster", "Ted J. Kaptchuk", "Søren Schou", "Troels Staehelin Jensen", "Robert Zachariae", "Peter Svensson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119612.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Acupuncturists_perceived_treatment_allocation_in_relation_to_actual_treatment_allocation_/2673541", "title"=>"Acupuncturists’ perceived treatment allocation in relation to actual treatment allocation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-06 15:04:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/4336942"], "description"=>"<p>Each needle assembly comprises an opaque guide tube (1) and upper stuffing (2) to provide resistance to the needle body during its passage through the guide tube. The body of the penetrating needle (3) is longer than the guide tube by an amount equal to the insertion depth, but the body of the non-penetrating needle (4) is only long enough to allow its blunt tip to press against the skin when the needle body is advanced to its limit. The non-penetrating needle contains stuffing at the bottom as well (5) to give a sensation similar to that of skin puncture and tissue penetration. Both needles have a stopper (6) that prevents the needle handle (7) from advancing further when the sharp tip of the penetrating needle (8) or the blunt tip of the non-penetrating needle (9) reaches the specified position. The pedestal (10) on each needle is adhesive, allowing it to adhere firmly to the skin surface. The diameter of the needles used in this study was 0.16 mm.</p>", "links"=>[], "tags"=>["qi", "Perceived treatment allocation", "acupuncture treatment", "Postoperative Pain Blinding"], "article_id"=>2673463, "categories"=>["Medicine", "Cell Biology", "Neuroscience", "Physiology", "Pharmacology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Science Policy", "Plant Biology"], "users"=>["Lene Vase", "Sara Baram", "Nobuari Takakura", "Miho Takayama", "Hiroyoshi Yajima", "Akiko Kawase", "Lars Schuster", "Ted J. Kaptchuk", "Søren Schou", "Troels Staehelin Jensen", "Robert Zachariae", "Peter Svensson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119612.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Active_and_placebo_needles_/2673463", "title"=>"Active and placebo needles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-06 15:04:26"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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