Comparison of Clinical Efficacy and Safety between Indacaterol and Tiotropium in COPD: Meta-Analysis of Randomized Controlled Trials
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{"title"=>"Comparison of Clinical Efficacy and Safety between Indacaterol and Tiotropium in COPD: Meta-Analysis of Randomized Controlled Trials", "type"=>"journal", "authors"=>[{"first_name"=>"Jung Soo", "last_name"=>"Kim"}, {"first_name"=>"Jinkyeong", "last_name"=>"Park"}, {"first_name"=>"Seong Yong", "last_name"=>"Lim"}, {"first_name"=>"Yeon-Mok", "last_name"=>"Oh"}, {"first_name"=>"Kwang Ha", "last_name"=>"Yoo"}, {"first_name"=>"Yong Bum", "last_name"=>"Park"}, {"first_name"=>"Seung Soo", "last_name"=>"Sheen"}, {"first_name"=>"Min-Ji", "last_name"=>"Kim"}, {"first_name"=>"K. C.", "last_name"=>"Carriere"}, {"first_name"=>"Ji Ye", "last_name"=>"Jung"}, {"first_name"=>"Hye Yun", "last_name"=>"Park"}], "year"=>2015, "source"=>"PLOS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0119948", "pmid"=>"25799171"}, "id"=>"70a0fad4-d1cb-3a05-845d-ad6b1ed95730", "abstract"=>"Two once-daily inhaled bronchodilators, indacaterol and tiotropium, are widely used as first-line therapy in stable COPD patients. This study was performed to compare the clinical efficacy and safety between indacaterol and tiotropium in patients with moderate-to-severe COPD. MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched to identify all published randomized controlled trials (RCTs). The primary outcome was trough forced expiratory volume in 1 second (FEV1) at week 12. Four RCTs were eligible for inclusion (three RCTs with moderate-to-severe COPD patients and one RCT with only severe COPD patients). Trough FEV1 at weeks 12 and 26 were not significantly different between indacaterol and tiotropium by the standardized mean difference with 0.014 (95% CI, -0.036, 0.063, I2= 23.5%) and with 0.037 (95% CI, -0.059 to 0.133, I2= 0%) along with differences in means of 0.003L and 0.014L, respectively. Indacaterol and tiotropium also showed similar St. George`s Respiratory Questionnaire (SGRQ) total scores and percentages of patients with SGRQ improvement (≥ 4 units) at week 26. The incidences of nasopharyngitis, serious cardiovascular events, and serious adverse events were not different between indacaterol and tiotropium, while those of cough (OR = 1.68, P < 0.001, and RR = 1.63) and COPD worsening (OR = 1.18, P = 0.003, and RR = 1.12) were higher for indacaterol than tiotropium. However, when one study with only severe COPD patients was removed from the meta-analysis, the difference in the incidence of COPD worsening between indacaterol and tiotropium became non-significant (OR = 1.13, P = 0.204, and RR = 1.09). The clinical efficacy and serious adverse events between indacaterol and tiotropium were equivocal in patients with moderate-to-severe COPD. Cough is a common complaint associated with indacaterol, and COPD worsening needs to be carefully monitored in severe COPD patients when treated with indacaterol.", "link"=>"http://www.mendeley.com/research/comparison-clinical-efficacy-safety-between-indacaterol-tiotropium-copd-metaanalysis-randomized-cont-1", "reader_count"=>13, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Brazil"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1982677"], "description"=>"<p>COPD = Chronic obstructive pulmonary disease.</p><p>*INTENSITY study was not included in the analysis of serious cardiovascular event.</p><p><sup>†</sup>Serous cardiovascular events of INHANCE study were analyzed with both indacaterol 150ug and 300ug group.</p><p><sup>‡</sup>INVIGORATE study with only severe COPD patients was excluded in subgroup analysis.</p><p>Adverse events of Indacaterol vs. Tiotropium monotherapy.</p>", "links"=>[], "tags"=>["rr", "medline", "Randomized Controlled Trials", "embase", "sgrq", "indacaterol", "COPD patients", "tiotropium", "Cochrane Central Register", "ci", "rct", "trough FEV 1"], "article_id"=>1351145, "categories"=>["Biological Sciences"], "users"=>["Jung Soo Kim", "Jinkyeong Park", "Seong Yong Lim", "Yeon-Mok Oh", "Kwang Ha Yoo", "Yong Bum Park", "Seung Soo Sheen", "Min-Ji Kim", "K. C. Carriere", "Ji Ye Jung", "Hye Yun Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119948.t003", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adverse_events_of_Indacaterol_vs_Tiotropium_monotherapy_/1351145", "title"=>"Adverse events of Indacaterol vs. Tiotropium monotherapy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-23 05:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1982675"], "description"=>"<p>(A) Pooled standardized difference in means for SGRQ total score at week 26 with 95% CIs of eligible studies comparing indacaterol vs tiotropium. (B) Pooled odds ratio for percentage of patients with MCID (decrease ≥ 4 units) of SGRQ total score at week 26 of eligible studies comparing indacaterol vs tiotropium. SGRQ = St. George`s Respiratory Questionnaire; MCID = minimal clinically important difference; SGRQ = St. George`s Respiratory Questionnaire.</p>", "links"=>[], "tags"=>["rr", "medline", "Randomized Controlled Trials", "embase", "sgrq", "indacaterol", "COPD patients", "tiotropium", "Cochrane Central Register", "ci", "rct", "trough FEV 1"], "article_id"=>1351143, "categories"=>["Biological Sciences"], "users"=>["Jung Soo Kim", "Jinkyeong Park", "Seong Yong Lim", "Yeon-Mok Oh", "Kwang Ha Yoo", "Yong Bum Park", "Seung Soo Sheen", "Min-Ji Kim", "K. C. Carriere", "Ji Ye Jung", "Hye Yun Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119948.g004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Indacaterol_versus_Tiotropium_on_SGRQ_at_week_26_/1351143", "title"=>"Indacaterol versus Tiotropium on SGRQ at week 26.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-23 05:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1982676"], "description"=>"<p>COPD = Chronic obstructive pulmonary disease; OR = Odds ratio.</p><p>Risk of bias amongst included studies.</p>", "links"=>[], "tags"=>["rr", "medline", "Randomized Controlled Trials", "embase", "sgrq", "indacaterol", "COPD patients", "tiotropium", "Cochrane Central Register", "ci", "rct", "trough FEV 1"], "article_id"=>1351144, "categories"=>["Biological Sciences"], "users"=>["Jung Soo Kim", "Jinkyeong Park", "Seong Yong Lim", "Yeon-Mok Oh", "Kwang Ha Yoo", "Yong Bum Park", "Seung Soo Sheen", "Min-Ji Kim", "K. C. Carriere", "Ji Ye Jung", "Hye Yun Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119948.t002", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Risk_of_bias_amongst_included_studies_/1351144", "title"=>"Risk of bias amongst included studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-23 05:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1982674"], "description"=>"<p>FEV<sub>1 =</sub> forced expiratory volume in 1 second; df = degrees of freedom.</p>", "links"=>[], "tags"=>["rr", "medline", "Randomized Controlled Trials", "embase", "sgrq", "indacaterol", "COPD patients", "tiotropium", "Cochrane Central Register", "ci", "rct", "trough FEV 1"], "article_id"=>1351142, "categories"=>["Biological Sciences"], "users"=>["Jung Soo Kim", "Jinkyeong Park", "Seong Yong Lim", "Yeon-Mok Oh", "Kwang Ha Yoo", "Yong Bum Park", "Seung Soo Sheen", "Min-Ji Kim", "K. C. Carriere", "Ji Ye Jung", "Hye Yun Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119948.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Indacaterol_versus_Tiotropium_on_trough_FEV_1_at_week_26_/1351142", "title"=>"Indacaterol versus Tiotropium on trough FEV<sub>1</sub> at week 26.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-23 05:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1982670"], "description"=>"<p>RCT = randomized controlled trial.</p>", "links"=>[], "tags"=>["rr", "medline", "Randomized Controlled Trials", "embase", "sgrq", "indacaterol", "COPD patients", "tiotropium", "Cochrane Central Register", "ci", "rct", "trough FEV 1"], "article_id"=>1351138, "categories"=>["Biological Sciences"], "users"=>["Jung Soo Kim", "Jinkyeong Park", "Seong Yong Lim", "Yeon-Mok Oh", "Kwang Ha Yoo", "Yong Bum Park", "Seung Soo Sheen", "Min-Ji Kim", "K. C. Carriere", "Ji Ye Jung", "Hye Yun Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119948.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flowchart_for_identification_of_studies_used_/1351138", "title"=>"Flowchart for identification of studies used.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-23 05:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1982679", "https://ndownloader.figshare.com/files/1982680"], "description"=>"<div><p>Two once-daily inhaled bronchodilators, indacaterol and tiotropium, are widely used as first-line therapy in stable COPD patients. This study was performed to compare the clinical efficacy and safety between indacaterol and tiotropium in patients with moderate-to-severe COPD. MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched to identify all published randomized controlled trials (RCTs). The primary outcome was trough forced expiratory volume in 1 second (FEV<sub>1</sub>) at week 12. Four RCTs were eligible for inclusion (three RCTs with moderate-to-severe COPD patients and one RCT with only severe COPD patients). Trough FEV<sub>1</sub> at weeks 12 and 26 were not significantly different between indacaterol and tiotropium by the standardized mean difference with 0.014 (95% CI, -0.036, 0.063, <i>I<sup>2</sup></i>= 23.5%) and with 0.037 (95% CI, -0.059 to 0.133, <i>I<sup>2</sup></i>= 0%) along with differences in means of 0.003L and 0.014L, respectively. Indacaterol and tiotropium also showed similar St. George`s Respiratory Questionnaire (SGRQ) total scores and percentages of patients with SGRQ improvement (≥ 4 units) at week 26. The incidences of nasopharyngitis, serious cardiovascular events, and serious adverse events were not different between indacaterol and tiotropium, while those of cough (OR = 1.68, <i>P</i> < 0.001, and RR = 1.63) and COPD worsening (OR = 1.18, <i>P</i> = 0.003, and RR = 1.12) were higher for indacaterol than tiotropium. However, when one study with only severe COPD patients was removed from the meta-analysis, the difference in the incidence of COPD worsening between indacaterol and tiotropium became non-significant (OR = 1.13, <i>P</i> = 0.204, and RR = 1.09). The clinical efficacy and serious adverse events between indacaterol and tiotropium were equivocal in patients with moderate-to-severe COPD. Cough is a common complaint associated with indacaterol, and COPD worsening needs to be carefully monitored in severe COPD patients when treated with indacaterol.</p></div>", "links"=>[], "tags"=>["rr", "medline", "Randomized Controlled Trials", "embase", "sgrq", "indacaterol", "COPD patients", "tiotropium", "Cochrane Central Register", "ci", "rct", "trough FEV 1"], "article_id"=>1351147, "categories"=>["Biological Sciences"], "users"=>["Jung Soo Kim", "Jinkyeong Park", "Seong Yong Lim", "Yeon-Mok Oh", "Kwang Ha Yoo", "Yong Bum Park", "Seung Soo Sheen", "Min-Ji Kim", "K. C. Carriere", "Ji Ye Jung", "Hye Yun Park"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0119948.s001", "https://dx.doi.org/10.1371/journal.pone.0119948.s002"], "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_Clinical_Efficacy_and_Safety_between_Indacaterol_and_Tiotropium_in_COPD_Meta_Analysis_of_Randomized_Controlled_Trials_/1351147", "title"=>"Comparison of Clinical Efficacy and Safety between Indacaterol and Tiotropium in COPD: Meta-Analysis of Randomized Controlled Trials", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-03-23 05:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1982672"], "description"=>"<p>FEV<sub>1 =</sub> forced expiratory volume in 1 second; df = degrees of freedom.</p>", "links"=>[], "tags"=>["rr", "medline", "Randomized Controlled Trials", "embase", "sgrq", "indacaterol", "COPD patients", "tiotropium", "Cochrane Central Register", "ci", "rct", "trough FEV 1"], "article_id"=>1351140, "categories"=>["Biological Sciences"], "users"=>["Jung Soo Kim", "Jinkyeong Park", "Seong Yong Lim", "Yeon-Mok Oh", "Kwang Ha Yoo", "Yong Bum Park", "Seung Soo Sheen", "Min-Ji Kim", "K. C. Carriere", "Ji Ye Jung", "Hye Yun Park"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0119948.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Indacaterol_versus_Tiotropium_on_trough_FEV_1_at_week_12_/1351140", "title"=>"Indacaterol versus Tiotropium on trough FEV<sub>1</sub> at week 12.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-23 05:23:44"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"26", "pdf"=>"19", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
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  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
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  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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