Cost-Effectiveness of Adding Bedaquiline to Drug Regimens for the Treatment of Multidrug-Resistant Tuberculosis in the UK
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{"title"=>"Cost-effectiveness of adding bedaquiline to drug regimens for the treatment of multidrug-resistant tuberculosis in the UK", "type"=>"journal", "authors"=>[{"first_name"=>"Lara J.", "last_name"=>"Wolfson", "scopus_author_id"=>"7005107363"}, {"first_name"=>"Anna", "last_name"=>"Walker", "scopus_author_id"=>"56581010400"}, {"first_name"=>"Robert", "last_name"=>"Hettle", "scopus_author_id"=>"55178454600"}, {"first_name"=>"Xiaoyan", "last_name"=>"Lu", "scopus_author_id"=>"56580726000"}, {"first_name"=>"Chrispin", "last_name"=>"Kambili", "scopus_author_id"=>"6507889626"}, {"first_name"=>"Andrew", "last_name"=>"Murungi", "scopus_author_id"=>"57193924309"}, {"first_name"=>"Gerhart", "last_name"=>"Knerer", "scopus_author_id"=>"53881550200"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84926389223", "issn"=>"19326203", "scopus"=>"2-s2.0-84926389223", "pmid"=>"25794045", "pui"=>"603270852", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0120763"}, "id"=>"f7c2113a-b222-39a7-9bc9-33dea12e37b3", "abstract"=>"OBJECTIVE: To evaluate the cost-effectiveness of adding bedaquiline to a background regimen (BR) of drugs for multidrug-resistant tuberculosis (MDR-TB) in the United Kingdom (UK).\\n\\nMETHODS: A cohort-based Markov model was developed to estimate the incremental cost-effectiveness ratio of bedaquiline plus BR (BBR) versus BR alone (BR) in the treatment of MDR-TB, over a 10-year time horizon. A National Health Service (NHS) and personal social services perspective was considered. Cost-effectiveness was evaluated in terms of Quality-Adjusted Life Years (QALYs) and Disability-Adjusted Life Years (DALYs). Data were sourced from a phase II, placebo-controlled trial, NHS reference costs, and the literature; the US list price of bedaquiline was used and converted to pounds (£18,800). Costs and effectiveness were discounted at a rate of 3.5% per annum. Probabilistic and deterministic sensitivity analysis was conducted.\\n\\nRESULTS: The total discounted cost per patient (pp) on BBR was £106,487, compared with £117,922 for BR. The total discounted QALYs pp were 5.16 for BBR and 4.01 for BR. The addition of bedaquiline to a BR resulted in a cost-saving of £11,434 and an additional 1.14 QALYs pp over a 10-year period, and is therefore considered to be the dominant (less costly and more effective) strategy over BR. BBR remained dominant in the majority of sensitivity analyses, with a 81% probability of being dominant versus BR in the probabilistic analysis.\\n\\nCONCLUSIONS: In the UK, bedaquiline is likely to be cost-effective and cost-saving, compared with the current MDR-TB standard of care under a range of scenarios. Cost-savings over a 10-year period were realized from reductions in length of hospitalization, which offset the bedaquiline drug costs. The cost-benefit conclusions held after several sensitivity analyses, thus validating assumptions made, and suggesting that the results would hold even if the actual price of bedaquiline in the UK were higher than in the US.", "link"=>"http://www.mendeley.com/research/costeffectiveness-adding-bedaquiline-drug-regimens-treatment-multidrugresistant-tuberculosis-uk", "reader_count"=>54, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>12, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>7, "Student > Master"=>13, "Student > Bachelor"=>5, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>12, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>7, "Student > Master"=>13, "Student > Bachelor"=>5, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>2, "Arts and Humanities"=>1, "Business, Management and Accounting"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>2, "Engineering"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>3, "Medicine and Dentistry"=>27, "Pharmacology, Toxicology and Pharmaceutical Science"=>4, "Social Sciences"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>27}, "Social Sciences"=>{"Social Sciences"=>4}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>4}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Canada"=>2, "United States"=>2, "Brazil"=>1, "South Africa"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1965604"], "description"=>"<p>MDR-TB: multi-drug resistant tuberculosis; TB: tuberculosis. *Transitions to the death state are possible from every state, but not shown on the diagram for clarity.</p>", "links"=>[], "tags"=>["br", "sensitivity analyses", "1.14 QALYs pp", "bbr", "National Health Service", "NHS reference costs", "daly", "uk", "ii", "bedaquiline drug costs"], "article_id"=>1346497, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Lara J. Wolfson", "Anna Walker", "Robert Hettle", "Xiaoyan Lu", "Chrispin Kambili", "Andrew Murungi", "Gerhart Knerer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0120763.g001", "stats"=>{"downloads"=>0, "page_views"=>34, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Markov_model_state_structure_/1346497", "title"=>"Markov model state structure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-20 05:14:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1965607"], "description"=>"<p>BR: background regimen; NHS: National Health Service; PSS: Personal Social Services; QALY: quality adjusted life-year</p>", "links"=>[], "tags"=>["br", "sensitivity analyses", "1.14 QALYs pp", "bbr", "National Health Service", "NHS reference costs", "daly", "uk", "ii", "bedaquiline drug costs"], "article_id"=>1346500, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Lara J. Wolfson", "Anna Walker", "Robert Hettle", "Xiaoyan Lu", "Chrispin Kambili", "Andrew Murungi", "Gerhart Knerer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0120763.g002", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cost_effectiveness_plane_for_bedaquiline_BR_versus_BR_only_from_a_UK_NHS_and_PSS_perspective_/1346500", "title"=>"Cost-effectiveness plane for bedaquiline + BR versus BR only from a UK NHS and PSS perspective.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-20 05:14:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1965611"], "description"=>"<p>BR: background regimen</p>", "links"=>[], "tags"=>["br", "sensitivity analyses", "1.14 QALYs pp", "bbr", "National Health Service", "NHS reference costs", "daly", "uk", "ii", "bedaquiline drug costs"], "article_id"=>1346504, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Lara J. Wolfson", "Anna Walker", "Robert Hettle", "Xiaoyan Lu", "Chrispin Kambili", "Andrew Murungi", "Gerhart Knerer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0120763.g003", "stats"=>{"downloads"=>2, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cost_effectiveness_acceptability_curve_for_bedaquiline_BR_versus_BR_only_from_a_UK_payer_perspective_assuming_price_of_163_18_800_per_treatment_course_/1346504", "title"=>"Cost-effectiveness acceptability curve for bedaquiline + BR versus BR only from a UK payer perspective (assuming price of £18,800 per treatment course).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-20 05:14:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1965614"], "description"=>"<p>* Fixed ranges of +/- 20% were chosen due to the lack of available ranges in the literature. BR: background regimen; ICER: incremental cost-effectiveness ratio; QALY: quality adjusted life-year; TB: tuberculosis</p>", "links"=>[], "tags"=>["br", "sensitivity analyses", "1.14 QALYs pp", "bbr", "National Health Service", "NHS reference costs", "daly", "uk", "ii", "bedaquiline drug costs"], "article_id"=>1346506, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Lara J. Wolfson", "Anna Walker", "Robert Hettle", "Xiaoyan Lu", "Chrispin Kambili", "Andrew Murungi", "Gerhart Knerer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0120763.g004", "stats"=>{"downloads"=>0, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tornado_diagram_representing_deterministic_sensitivity_analysis_based_on_incremental_cost_per_QALY_/1346506", "title"=>"Tornado diagram representing deterministic sensitivity analysis based on incremental cost per QALY.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-20 05:14:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1965615"], "description"=>"<p>All costs reported in 2013 values</p><p>BR: background regimen; QALYs: quality adjusted life-years; DALYs: disability adjusted life-years</p><p>Total and incremental results for bedaquiline + BR vs. BR alone (UK base case).</p>", "links"=>[], "tags"=>["br", "sensitivity analyses", "1.14 QALYs pp", "bbr", "National Health Service", "NHS reference costs", "daly", "uk", "ii", "bedaquiline drug costs"], "article_id"=>1346507, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Lara J. Wolfson", "Anna Walker", "Robert Hettle", "Xiaoyan Lu", "Chrispin Kambili", "Andrew Murungi", "Gerhart Knerer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0120763.t003", "stats"=>{"downloads"=>5, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_and_incremental_results_for_bedaquiline_BR_vs_BR_alone_UK_base_case_/1346507", "title"=>"Total and incremental results for bedaquiline + BR vs. BR alone (UK base case).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-20 05:14:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1965616"], "description"=>"<p>All costs reported in 2013 values</p><p>BR: background regimen; TB: tuberculosis</p><p>Total and per patient costs, split by category (UK base case).</p>", "links"=>[], "tags"=>["br", "sensitivity analyses", "1.14 QALYs pp", "bbr", "National Health Service", "NHS reference costs", "daly", "uk", "ii", "bedaquiline drug costs"], "article_id"=>1346508, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Lara J. Wolfson", "Anna Walker", "Robert Hettle", "Xiaoyan Lu", "Chrispin Kambili", "Andrew Murungi", "Gerhart Knerer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0120763.t004", "stats"=>{"downloads"=>3, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_and_per_patient_costs_split_by_category_UK_base_case_/1346508", "title"=>"Total and per patient costs, split by category (UK base case).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-20 05:14:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1965618", "https://ndownloader.figshare.com/files/1965619", "https://ndownloader.figshare.com/files/1965620", "https://ndownloader.figshare.com/files/1965621", "https://ndownloader.figshare.com/files/1965622"], "description"=>"<div><p>Objective</p><p>To evaluate the cost-effectiveness of adding bedaquiline to a background regimen (BR) of drugs for multidrug-resistant tuberculosis (MDR-TB) in the United Kingdom (UK).</p><p>Methods</p><p>A cohort-based Markov model was developed to estimate the incremental cost-effectiveness ratio of bedaquiline plus BR (BBR) versus BR alone (BR) in the treatment of MDR-TB, over a 10-year time horizon. A National Health Service (NHS) and personal social services perspective was considered. Cost-effectiveness was evaluated in terms of Quality-Adjusted Life Years (QALYs) and Disability-Adjusted Life Years (DALYs). Data were sourced from a phase II, placebo-controlled trial, NHS reference costs, and the literature; the US list price of bedaquiline was used and converted to pounds (£18,800). Costs and effectiveness were discounted at a rate of 3.5% per annum. Probabilistic and deterministic sensitivity analysis was conducted.</p><p>Results</p><p>The total discounted cost per patient (pp) on BBR was £106,487, compared with £117,922 for BR. The total discounted QALYs pp were 5.16 for BBR and 4.01 for BR. The addition of bedaquiline to a BR resulted in a cost-saving of £11,434 and an additional 1.14 QALYs pp over a 10-year period, and is therefore considered to be the dominant (less costly and more effective) strategy over BR. BBR remained dominant in the majority of sensitivity analyses, with a 81% probability of being dominant versus BR in the probabilistic analysis.</p><p>Conclusions</p><p>In the UK, bedaquiline is likely to be cost-effective and cost-saving, compared with the current MDR-TB standard of care under a range of scenarios. Cost-savings over a 10-year period were realized from reductions in length of hospitalization, which offset the bedaquiline drug costs. The cost-benefit conclusions held after several sensitivity analyses, thus validating assumptions made, and suggesting that the results would hold even if the actual price of bedaquiline in the UK were higher than in the US.</p></div>", "links"=>[], "tags"=>["br", "sensitivity analyses", "1.14 QALYs pp", "bbr", "National Health Service", "NHS reference costs", "daly", "uk", "ii", "bedaquiline drug costs"], "article_id"=>1346510, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Lara J. Wolfson", "Anna Walker", "Robert Hettle", "Xiaoyan Lu", "Chrispin Kambili", "Andrew Murungi", "Gerhart Knerer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0120763.s001", "https://dx.doi.org/10.1371/journal.pone.0120763.s002", "https://dx.doi.org/10.1371/journal.pone.0120763.s003", "https://dx.doi.org/10.1371/journal.pone.0120763.s004", "https://dx.doi.org/10.1371/journal.pone.0120763.s005"], "stats"=>{"downloads"=>29, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cost_Effectiveness_of_Adding_Bedaquiline_to_Drug_Regimens_for_the_Treatment_of_Multidrug_Resistant_Tuberculosis_in_the_UK_/1346510", "title"=>"Cost-Effectiveness of Adding Bedaquiline to Drug Regimens for the Treatment of Multidrug-Resistant Tuberculosis in the UK", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-03-20 05:14:13"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"50", "full-text"=>"80", "pdf"=>"36", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"41", "full-text"=>"41", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"49", "full-text"=>"56", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"39", "full-text"=>"50", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"35", "full-text"=>"37", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"46", "full-text"=>"43", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"26", "full-text"=>"23", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"34", "full-text"=>"23", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"42", "full-text"=>"34", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"26", "full-text"=>"25", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"28", "full-text"=>"28", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"24", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"32", "full-text"=>"34", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"32", "full-text"=>"31", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"26", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"27", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"26", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"26", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"24", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"1", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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