Analysis of Expression of Programmed Cell Death 1 Ligand 1 (PD-L1) in Malignant Pleural Mesothelioma (MPM)
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{"title"=>"Analysis of expression of programmed cell death 1 ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM)", "type"=>"journal", "authors"=>[{"first_name"=>"Susana", "last_name"=>"Cedrés", "scopus_author_id"=>"24174365600"}, {"first_name"=>"Santiago", "last_name"=>"Ponce-Aix", "scopus_author_id"=>"56556844200"}, {"first_name"=>"Jon", "last_name"=>"Zugazagoitia", "scopus_author_id"=>"42762704800"}, {"first_name"=>"Irene", "last_name"=>"Sansano", "scopus_author_id"=>"36515381800"}, {"first_name"=>"Ana", "last_name"=>"Enguita", "scopus_author_id"=>"24767407600"}, {"first_name"=>"Alejandro", "last_name"=>"Navarro-Mendivil", "scopus_author_id"=>"56556980600"}, {"first_name"=>"Alex", "last_name"=>"Martinez-Marti", "scopus_author_id"=>"55347345100"}, {"first_name"=>"Pablo", "last_name"=>"Martinez", "scopus_author_id"=>"7202906668"}, {"first_name"=>"Enriqueta", "last_name"=>"Felip", "scopus_author_id"=>"7004187097"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84925004185", "doi"=>"10.1371/journal.pone.0121071", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"25774992", "issn"=>"19326203", "arxiv"=>"NIHMS150003", "scopus"=>"2-s2.0-84925004185", "pui"=>"603024348"}, "id"=>"0c78d695-089b-3ec3-9dd9-acc12e7f569f", "abstract"=>"BACKGROUND: The increasing incidence and poor outcome associated with MPM requires finding effective treatment for this disease. PD1/PD-L1 pathway plays a central role in tumor immune evasion and appears to be predictive and prognostic marker. PD-L1 is expressed in many different human cancers but its role in MPM has yet to be established. The aim of this study is to evaluate the expression of PD-L1 in MPM.\\n\\nMETHODS: 119 MPM patients (p) from two institutions between November 2002 and February 2014 were reviewed. Formalin-fixed, paraffin-embedded tissue was stained with anti-PD-L1 (clone E1L3N). Cases showing more than 1% of tumor cells expression of PD-L1 were considered positive.\\n\\nRESULTS: PD-L1 was analyzed in 77 p with tumor tissue available and was positive in 20.7% p (14 samples in membrane, 16 in cytoplasm and 4 in immune infiltrate). PD-L1 intensity was weak in 56.2%, moderate in 25% and strong in 18.7% p. There was a significant relationship between PD-L1 expression and histology (PD-L1 expression 37.5% in no-epithelioid tumor and 13.2% in epithelioid; p=0.033). The median survival in p PD-L1 positive was 4.79 vs 16.3 months in p PD-L1 negative (p=0.012).\\n\\nCONCLUSIONS: We have shown PD-L1 is expressed in 20% of patients, associated with no epithelioid histology and poor prognostic in MPM. Our results suggest PD-L1 warrants further exploration in selecting p for immunotherapy.", "link"=>"http://www.mendeley.com/research/analysis-expression-programmed-cell-death-1-ligand-1-pdl1-malignant-pleural-mesothelioma-mpm-1", "reader_count"=>41, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>3, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>5, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>3, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>5, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>4, "Medicine and Dentistry"=>25, "Agricultural and Biological Sciences"=>8, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>25}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Japan"=>1}, "group_count"=>0}

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Figshare

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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