Topical Application of Lithium Chloride on the Pulp Induces Dentin Regeneration
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{"title"=>"Topical application of lithium chloride on the pulp induces dentin regeneration", "type"=>"journal", "authors"=>[{"first_name"=>"Kazuya", "last_name"=>"Ishimoto", "scopus_author_id"=>"57187949700"}, {"first_name"=>"Satoru", "last_name"=>"Hayano", "scopus_author_id"=>"36156904300"}, {"first_name"=>"Takeshi", "last_name"=>"Yanagita", "scopus_author_id"=>"37116323300"}, {"first_name"=>"Hiroshi", "last_name"=>"Kurosaka", "scopus_author_id"=>"11839162500"}, {"first_name"=>"Noriaki", "last_name"=>"Kawanabe", "scopus_author_id"=>"6507709394"}, {"first_name"=>"Shinsuke", "last_name"=>"Itoh", "scopus_author_id"=>"55633677700"}, {"first_name"=>"Mitsuaki", "last_name"=>"Ono", "scopus_author_id"=>"24725122900"}, {"first_name"=>"Takuo", "last_name"=>"Kuboki", "scopus_author_id"=>"7005617568"}, {"first_name"=>"Hiroshi", "last_name"=>"Kamioka", "scopus_author_id"=>"7004799118"}, {"first_name"=>"Takashi", "last_name"=>"Yamashiro", "scopus_author_id"=>"55416765600"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"603466256", "sgr"=>"84961364281", "issn"=>"19326203", "pmid"=>"25812134", "scopus"=>"2-s2.0-84961364281", "doi"=>"10.1371/journal.pone.0121938"}, "id"=>"8dd2d5e5-8106-3c68-8095-e9bc29a20383", "abstract"=>"We herein describe a novel procedure for dentin regeneration that mimics the biological processes of tooth development in nature. The canonical Wnt signaling pathway is an important regulator of the Dentin sialophosphoprotein (Dspp) expression. Our approach mimics the biological processes underlying tooth development in nature and focuses on the activation of canonical Wnt signaling to trigger the natural process of dentinogenesis. The coronal portion of the dentin and the underlying pulp was removed from the first molars. We applied lithium chloride (LiCl), an activator of canonical Wnt signaling, on the amputated pulp surface to achieve transdifferentiation toward odontoblasts from the surrounding pulpal cells. MicroCT and microscopic analyses demonstrated that the topical application of LiCl induced dentin repair, including the formation of a complete dentin bridge. LiCl-induced dentin is a tubular dentin in which the pulp cells are not embedded within the matrix, as in primary dentin. In contrast, a dentin bridge was not induced in the control group treated with pulp capping with material carriers alone, although osteodentin without tubular formation was induced at a comparatively deeper position from the pulp exposure site. We also evaluated the influence of LiCl on differentiation toward odontoblasts in vitro. In the mDP odontoblast cell line, LiCl activated the mRNA expression of Dspp, Axin2 and Kallikrein 4 (Klk4) and downregulated the Osteopontin (Osp) expression. These results provide a scientific basis for the biomimetic regeneration of dentin using LiCl as a new capping material to activate dentine regeneration.", "link"=>"http://www.mendeley.com/research/topical-application-lithium-chloride-pulp-induces-dentin-regeneration", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Master"=>4, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Master"=>4, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>7}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1990967"], "description"=>"<p>(A) Three-dimensional reconstructed image of the intact lower first molars in a 10-week-old rat. (B) Virtual sagittal slices were obtained in the control (C) and experimental groups (D-F). (C) No dentin bridges were observed in any of the control mice. (D-F) Series of reconstructed images showing that LiCl treatment induced dentin bridge formation over the exposed pulp surface. (G) Virtual coronal slices were obtained in the experimental group. (H,I) Reconstructed coronal images also illustrated deposition of reparative tissues (H). Abbreviations: M1, first molars; ab, alveolar bone; pu, pulp; db, dentin bridge. Scale bars, 1 mm.</p>", "links"=>[], "tags"=>["dentin bridge", "pulp exposure site", "Pulp Induces Dentin Regeneration", "tooth development", "licl", "canonical Wnt", "mDP odontoblast cell line"], "article_id"=>1357717, "categories"=>["Biological Sciences"], "users"=>["Kazuya Ishimoto", "Satoru Hayano", "Takeshi Yanagita", "Hiroshi Kurosaka", "Noriaki Kawanabe", "Shinsuke Itoh", "Mitsuaki Ono", "Takuo Kuboki", "Hiroshi Kamioka", "Takashi Yamashiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0121938.g002", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reconstructed_micro_CT_images_and_two_dimensional_virtual_slices_/1357717", "title"=>"Reconstructed micro-CT images and two-dimensional virtual slices.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 04:49:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1990984"], "description"=>"<p>(A) The <i>Dspp</i> mRNA expression was confirmed in the pulp cells beneath the dentin bridges. (B) Higher magnification image of the solid box in panel A showing the <i>Dspp</i> mRNA expression in the pulp cells. Abbreviations: de, dentin; pu, pulp; rd, regenerative dentin, db, dentin bridge. Arrowheads indicate Dspp transcripts. Scale bars, 50 μm in A; 10 μm in B.</p>", "links"=>[], "tags"=>["dentin bridge", "pulp exposure site", "Pulp Induces Dentin Regeneration", "tooth development", "licl", "canonical Wnt", "mDP odontoblast cell line"], "article_id"=>1357726, "categories"=>["Biological Sciences"], "users"=>["Kazuya Ishimoto", "Satoru Hayano", "Takeshi Yanagita", "Hiroshi Kurosaka", "Noriaki Kawanabe", "Shinsuke Itoh", "Mitsuaki Ono", "Takuo Kuboki", "Hiroshi Kamioka", "Takashi Yamashiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0121938.g004", "stats"=>{"downloads"=>3, "page_views"=>48, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_situ_hybridization_for_Dspp_mRNA_in_the_pulp_in_the_LiCl_group_/1357726", "title"=>"<i>In situ</i> hybridization for <i>Dspp</i> mRNA in the pulp in the LiCl group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 04:49:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1990985"], "description"=>"<p>(A and B) mDP were harvested until they reached confluence. The cells were then cultured with (A) or without (B) 10 mM of LiCl for seven days before being processed for the real-time RT-PCR analysis. (C-G) Effects of LiCl on the expression of osteogenic and odontogenic markers on quantitative RT-PCR. Values are the average ± SD of triplicate wells, and are representative of three independent experiments performed. (C-E) LiCl treatment significantly upregulated the expression of the odontogenic markers <i>Dspp</i> (*, <i>p</i><0.05; C) and <i>Klk4</i> (*, <i>p</i><0.05; E) and the Wnt canonical marker <i>Axin2</i> (*, <i>p</i><0.05; D). (F) The <i>Alp</i> expression was not affected. (G) In contrast, LiCl treatment significantly downregulated the expression of the osteogenic markers <i>Opn</i> (*, <i>p</i><0.05). Scale bars, 100 μm in A and B.</p>", "links"=>[], "tags"=>["dentin bridge", "pulp exposure site", "Pulp Induces Dentin Regeneration", "tooth development", "licl", "canonical Wnt", "mDP odontoblast cell line"], "article_id"=>1357727, "categories"=>["Biological Sciences"], "users"=>["Kazuya Ishimoto", "Satoru Hayano", "Takeshi Yanagita", "Hiroshi Kurosaka", "Noriaki Kawanabe", "Shinsuke Itoh", "Mitsuaki Ono", "Takuo Kuboki", "Hiroshi Kamioka", "Takashi Yamashiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0121938.g005", "stats"=>{"downloads"=>1, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_LiCl_on_the_expression_of_osteogenic_and_odontogenic_markers_/1357727", "title"=>"Effects of LiCl on the expression of osteogenic and odontogenic markers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 04:49:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1990982"], "description"=>"<p>Reparative dentin formation was evaluated on the serial sections in the control (A-E) and LiCl (F-J) groups at four weeks after pulpotomy. (A,F) Pulpotomy was performed in the first molars (M1), and the coronal part of the pulp was removed (asterisk). (B) In the control molars, no reparative dentin bridges were observed beneath the pulp exposure site. However, hard reparative tissue was detected along the residual root dentin surface (arrows). (C) Higher magnification view of the dot box in panel B. Necrotic and disintegrated tissue was observed just beneath the pulp exposure site (arrow heads). (D,E) Bright (D) and dark (E) field images at higher magnification of the solid box in panel B. Dentin tubules were observed in the residual dentin (de), whereas a tubular structure was hardly detected in the deposited reparative tissue (rd). (F-G) The LiCl group exhibited dentin bridges beneath the exposed surface, and the reparative tissue further expanded in the direction of the apex (red arrows). (H) Higher magnification view of the dot box in panel G. A tubular structure was evident in the dentin bridges (red arrows), with only a few cells entrapped in the matrix. (I,J) Bright (I) and dark (J) field images at higher magnification of the solid box in panel G. The reparative matrix in the LiCl group was more condensed, with a well-developed tubular structure, than that observed in the control group. The figure represented the similar results from independent samples. Abbreviations: M1, the first upper molar; mr, mesial root; ab, alveolar bone; de, dentin; pu, pulp; rd, regenerative dentin, db, dentin bridge. Scale bars, 100 μm in A,F; 50 μm in B,G; 20 μm in C,H; 10 μm in D,E,I,J.</p>", "links"=>[], "tags"=>["dentin bridge", "pulp exposure site", "Pulp Induces Dentin Regeneration", "tooth development", "licl", "canonical Wnt", "mDP odontoblast cell line"], "article_id"=>1357724, "categories"=>["Biological Sciences"], "users"=>["Kazuya Ishimoto", "Satoru Hayano", "Takeshi Yanagita", "Hiroshi Kurosaka", "Noriaki Kawanabe", "Shinsuke Itoh", "Mitsuaki Ono", "Takuo Kuboki", "Hiroshi Kamioka", "Takashi Yamashiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0121938.g003", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histological_micrographs_H_E_of_sagittal_sections_of_the_first_upper_molars_/1357724", "title"=>"Histological micrographs (H-E) of sagittal sections of the first upper molars.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 04:49:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1990961"], "description"=>"<p>The coronal portion of the pulp was removed in the first molars of the 6-week-old Wistar rats. (A) Before pulpotomy. (B) Pulpotomy was performed using a small round bur (b). (C) The wound surface of the sectioned pulps was treated with a LiCl-containing pulp capping agent (cp). A non-LiCl agent was used as a negative control. (D) The cavities were subsequently filled with composite resin (re). Abbreviations: M1, first molar; de, dentin; pu, pulp; ab, alveolar bone; b, bur; cp, capping material; re, resin.</p>", "links"=>[], "tags"=>["dentin bridge", "pulp exposure site", "Pulp Induces Dentin Regeneration", "tooth development", "licl", "canonical Wnt", "mDP odontoblast cell line"], "article_id"=>1357711, "categories"=>["Biological Sciences"], "users"=>["Kazuya Ishimoto", "Satoru Hayano", "Takeshi Yanagita", "Hiroshi Kurosaka", "Noriaki Kawanabe", "Shinsuke Itoh", "Mitsuaki Ono", "Takuo Kuboki", "Hiroshi Kamioka", "Takashi Yamashiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0121938.g001", "stats"=>{"downloads"=>1, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pulpotomy_procedure_/1357711", "title"=>"Pulpotomy procedure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-26 04:49:38"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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