Pachymic Acid Inhibits Growth and Induces Apoptosis of Pancreatic Cancer In Vitro and In Vivo by Targeting ER Stress
Publication Date
April 27, 2015
Journal
PLOS ONE
Authors
Shujie Cheng, Kristen Swanson, Isaac Eliaz, Jeanette N. Mc Clintick, et al
Volume
10
Issue
4
Pages
e0122270
DOI
https://dx.plos.org/10.1371/journal.pone.0122270
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0122270
Scopus
84928569293
Mendeley
http://www.mendeley.com/research/pachymic-acid-inhibits-growth-induces-apoptosis-pancreatic-cancer-vitro-vivo-targeting-er-stress-2
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Mendeley | Further Information

{"title"=>"Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress", "type"=>"journal", "authors"=>[{"first_name"=>"Shujie", "last_name"=>"Cheng", "scopus_author_id"=>"56595911500"}, {"first_name"=>"Kristen", "last_name"=>"Swanson", "scopus_author_id"=>"56606791900"}, {"first_name"=>"Isaac", "last_name"=>"Eliaz", "scopus_author_id"=>"14628244000"}, {"first_name"=>"Jeanette N.", "last_name"=>"McClintick", "scopus_author_id"=>"6602972634"}, {"first_name"=>"George E.", "last_name"=>"Sandusky", "scopus_author_id"=>"7003964012"}, {"first_name"=>"Daniel", "last_name"=>"Sliva", "scopus_author_id"=>"56187342000"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0122270", "sgr"=>"84928569293", "pui"=>"604006307", "scopus"=>"2-s2.0-84928569293", "issn"=>"19326203", "pmid"=>"25915041"}, "id"=>"94f179b3-db46-35e4-b324-9c9fcfb61d68", "abstract"=>"Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effect of PA on human chemotherapy resistant pancreatic cancer. PA triggered apoptosis in gemcitabine-resistant pancreatic cancer cells PANC-1 and MIA PaCa-2. Comparative gene expression array analysis demonstrated that endoplasmic reticulum (ER) stress was induced by PA through activation of heat shock response and unfolded protein response related genes. Induced ER stress was confirmed by increasing expression of XBP-1s, ATF4, Hsp70, CHOP and phospho-eIF2α. Moreover, ER stress inhibitor tauroursodeoxycholic acid (TUDCA) blocked PA induced apoptosis. In addition, 25 mg kg-1 of PA significantly suppressed MIA PaCa-2 tumor growth in vivo without toxicity, which correlated with induction of apoptosis and expression of ER stress related proteins in tumor tissues. Taken together, growth inhibition and induction of apoptosis by PA in gemcitabine-resistant pancreatic cancer cells were associated with ER stress activation both in vitro and in vivo. PA may be potentially exploited for the use in treatment of chemotherapy resistant pancreatic cancer.", "link"=>"http://www.mendeley.com/research/pachymic-acid-inhibits-growth-induces-apoptosis-pancreatic-cancer-vitro-vivo-targeting-er-stress-2", "reader_count"=>11, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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