Association between P16INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies
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{"title"=>"Association between P16<sup>INK4a</sup> promoter methylation and HNSCC: A meta-analysis of 21 published studies", "type"=>"journal", "authors"=>[{"first_name"=>"Hao", "last_name"=>"Shi", "scopus_author_id"=>"55865060300"}, {"first_name"=>"Xiong", "last_name"=>"Chen", "scopus_author_id"=>"26659548100"}, {"first_name"=>"Cheng", "last_name"=>"Lu", "scopus_author_id"=>"57199465432"}, {"first_name"=>"Changmei", "last_name"=>"Gu", "scopus_author_id"=>"55864558500"}, {"first_name"=>"Hongwei", "last_name"=>"Jiang", "scopus_author_id"=>"56585034500"}, {"first_name"=>"Ruiwei", "last_name"=>"Meng", "scopus_author_id"=>"56585468600"}, {"first_name"=>"Xun", "last_name"=>"Niu", "scopus_author_id"=>"56009260100"}, {"first_name"=>"Yangxin", "last_name"=>"Huang", "scopus_author_id"=>"36968026700"}, {"first_name"=>"Meixia", "last_name"=>"Lu", "scopus_author_id"=>"55460841400"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84926613138", "pui"=>"603600214", "doi"=>"10.1371/journal.pone.0122302", "pmid"=>"25835498", "scopus"=>"2-s2.0-84926613138", "issn"=>"19326203", "isbn"=>"1932-6203"}, "id"=>"406c1174-b9bd-3bb2-96b9-b7e74e96e7df", "abstract"=>"BACKGROUND: The p16INK4a is an important tumor suppressor gene (TSG) and aberrant methylation of promoter is known to be a major inactivation mechanism of the tumor suppressor and tumor-related genes. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of head and neck squamous cell carcinoma (HNSCC). However, some studies have reported differences in the methylation frequencies of P16INK4a promoter between cancer and the corresponding control group. Therefore, we conducted a meta-analysis to better identify the association.\\n\\nMETHODS: PubMed, Ovid, ISI Web of Science, and EMBASE were searched to identify eligible studies to evaluate the association of p16INK4a promoter methylation and HNSCC. Odds ratio (ORs) and 95% confidence intervals (95%CI) were calculated to evaluate the strength of association between p16INK4a promoter methylation and HNSCC.\\n\\nRESULTS: A total of twenty-one studies with 1155 cases and 1017 controls were included in the meta-analysis. The frequencies of p16INK4a promoter methylation in the cancer group were significantly higher than those in the control group (cancer group: median: 46.67%, range = 7.84%-95.12%; control group: median: 18.37%, range = 0-83.33%; respectively). The pooled odds ratio was 3.37 (95%CI = 2.32-4.90) in the cancer group versus the corresponding control group under the random-effects model.\\n\\nCONCLUSION: This meta-analysis of 21 published studies identified that aberrant methylation of p16INK4a promoter was found to be significantly associated with HNSCC.", "link"=>"http://www.mendeley.com/research/association-between-p16supink4asup-promoter-methylation-hnscc-metaanalysis-21-published-studies", "reader_count"=>7, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2003909"], "description"=>"<p>M: <i>p16</i><sup><i>INK4a</i></sup> promoter methylated; U: <i>p16</i><sup><i>INK4a</i></sup> promoter unmethylated</p><p>#: A: Autologous (the control from the HNSCC themselves); H: Heterogeneous (the control from other individuals, including blood, serum, saliva or tissue).</p><p>Characteristics of studies included in the study characteristics of included studies.</p>", "links"=>[], "tags"=>["tumor suppressor gene", "Aberrant TSG methylation", "cancer group", "association", "Studies BackgroundThe p 16INK", "or", "control group", "p 16INK promoter", "P 16INK Promoter Methylation", "isi", "embase", "hnscc", "ci"], "article_id"=>1366325, "categories"=>["Biological Sciences"], "users"=>["Hao Shi", "Xiong Chen", "Cheng Lu", "Changmei Gu", "Hongwei Jiang", "RuiWei Meng", "Xun Niu", "Yangxin Huang", "Meixia Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122302.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_studies_included_in_the_study_characteristics_of_included_studies_/1366325", "title"=>"Characteristics of studies included in the study characteristics of included studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-02 15:29:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003908"], "description"=>"<p>The Begg’s funnel plot for assessment of publication bias in the meta-analysis.</p>", "links"=>[], "tags"=>["tumor suppressor gene", "Aberrant TSG methylation", "cancer group", "association", "Studies BackgroundThe p 16INK", "or", "control group", "p 16INK promoter", "P 16INK Promoter Methylation", "isi", "embase", "hnscc", "ci"], "article_id"=>1366324, "categories"=>["Biological Sciences"], "users"=>["Hao Shi", "Xiong Chen", "Cheng Lu", "Changmei Gu", "Hongwei Jiang", "RuiWei Meng", "Xun Niu", "Yangxin Huang", "Meixia Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122302.g003", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Begg_8217_s_funnel_plot_for_assessment_of_publication_bias_in_the_meta_analysis_/1366324", "title"=>"The Begg’s funnel plot for assessment of publication bias in the meta-analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-02 15:29:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003913", "https://ndownloader.figshare.com/files/2003914"], "description"=>"<div><p>Background</p><p>The <i>p16<sup>INK4a</sup></i> is an important tumor suppressor gene (TSG) and aberrant methylation of promoter is known to be a major inactivation mechanism of the tumor suppressor and tumor-related genes. Aberrant TSG methylation was considered an important epigenetic silencing mechanism in the progression of head and neck squamous cell carcinoma (HNSCC). However, some studies have reported differences in the methylation frequencies of <i>P<sup>16INK4a</sup></i> promoter between cancer and the corresponding control group. Therefore, we conducted a meta-analysis to better identify the association.</p><p>Methods</p><p>PubMed, Ovid, ISI Web of Science, and EMBASE were searched to identify eligible studies to evaluate the association of <i>p16<sup>INK4a</sup></i> promoter methylation and HNSCC. Odds ratio (ORs) and 95% confidence intervals (95%CI) were calculated to evaluate the strength of association between <i>p16<sup>INK4a</sup></i> promoter methylation and HNSCC.</p><p>Results</p><p>A total of twenty-one studies with 1155 cases and 1017 controls were included in the meta-analysis. The frequencies of <i>p16<sup>INK4a</sup></i> promoter methylation in the cancer group were significantly higher than those in the control group (cancer group: median: 46.67%, range = 7.84%-95.12%; control group: median: 18.37%, range = 0–83.33%; respectively). The pooled odds ratio was 3.37 (95%CI = 2.32–4.90) in the cancer group versus the corresponding control group under the random-effects model.</p><p>Conclusion</p><p>This meta-analysis of 21 published studies identified that aberrant methylation of <i>p16<sup>INK4a</sup></i> promoter was found to be significantly associated with HNSCC.</p></div>", "links"=>[], "tags"=>["tumor suppressor gene", "Aberrant TSG methylation", "cancer group", "association", "Studies BackgroundThe p 16INK", "or", "control group", "p 16INK promoter", "P 16INK Promoter Methylation", "isi", "embase", "hnscc", "ci"], "article_id"=>1366329, "categories"=>["Biological Sciences"], "users"=>["Hao Shi", "Xiong Chen", "Cheng Lu", "Changmei Gu", "Hongwei Jiang", "RuiWei Meng", "Xun Niu", "Yangxin Huang", "Meixia Lu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0122302.s001", "https://dx.doi.org/10.1371/journal.pone.0122302.s002"], "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Association_between_P16_INK4a_Promoter_Methylation_and_HNSCC_A_Meta_Analysis_of_21_Published_Studies/1366329", "title"=>"Association between <i>P16<sup>INK4a</sup></i> Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-04-02 15:29:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003911"], "description"=>"<p>Mixed-effects model of Meta-regression analysis.</p>", "links"=>[], "tags"=>["tumor suppressor gene", "Aberrant TSG methylation", "cancer group", "association", "Studies BackgroundThe p 16INK", "or", "control group", "p 16INK promoter", "P 16INK Promoter Methylation", "isi", "embase", "hnscc", "ci"], "article_id"=>1366327, "categories"=>["Biological Sciences"], "users"=>["Hao Shi", "Xiong Chen", "Cheng Lu", "Changmei Gu", "Hongwei Jiang", "RuiWei Meng", "Xun Niu", "Yangxin Huang", "Meixia Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122302.t003", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mixed_effects_model_of_Meta_regression_analysis_/1366327", "title"=>"Mixed-effects model of Meta-regression analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-02 15:29:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003912"], "description"=>"<p>†: the fixed-effects model</p><p>‡: the random-effects model</p><p>$: non-tissue: serum, saliva and blood</p><p>Subgroup analysis of the association between <i>p16<sup>INK4a</sup></i> promoter methylation and HNSCC.</p>", "links"=>[], "tags"=>["tumor suppressor gene", "Aberrant TSG methylation", "cancer group", "association", "Studies BackgroundThe p 16INK", "or", "control group", "p 16INK promoter", "P 16INK Promoter Methylation", "isi", "embase", "hnscc", "ci"], "article_id"=>1366328, "categories"=>["Biological Sciences"], "users"=>["Hao Shi", "Xiong Chen", "Cheng Lu", "Changmei Gu", "Hongwei Jiang", "RuiWei Meng", "Xun Niu", "Yangxin Huang", "Meixia Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122302.t004", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subgroup_analysis_of_the_association_between_p16_INK4a_promoter_methylation_and_HNSCC_/1366328", "title"=>"Subgroup analysis of the association between <i>p16<sup>INK4a</sup></i> promoter methylation and HNSCC.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-02 15:29:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003910"], "description"=>"<p>Sensitivity analysis of pooled OR for <i>p16<sup>INK4a</sup></i> methylation and HNSCC under the random-effects model.</p>", "links"=>[], "tags"=>["tumor suppressor gene", "Aberrant TSG methylation", "cancer group", "association", "Studies BackgroundThe p 16INK", "or", "control group", "p 16INK promoter", "P 16INK Promoter Methylation", "isi", "embase", "hnscc", "ci"], "article_id"=>1366326, "categories"=>["Biological Sciences"], "users"=>["Hao Shi", "Xiong Chen", "Cheng Lu", "Changmei Gu", "Hongwei Jiang", "RuiWei Meng", "Xun Niu", "Yangxin Huang", "Meixia Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122302.t002", "stats"=>{"downloads"=>7, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sensitivity_analysis_of_pooled_OR_for_p16_INK4a_methylation_and_HNSCC_under_the_random_effects_model_/1366326", "title"=>"Sensitivity analysis of pooled OR for <i>p16<sup>INK4a</sup></i> methylation and HNSCC under the random-effects model.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-02 15:29:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003907"], "description"=>"<p>Summary estimates for <i>p16<sup>INK4a</sup></i> promoter methylation frequency associated with HNSCC by meta-analysis.</p>", "links"=>[], "tags"=>["tumor suppressor gene", "Aberrant TSG methylation", "cancer group", "association", "Studies BackgroundThe p 16INK", "or", "control group", "p 16INK promoter", "P 16INK Promoter Methylation", "isi", "embase", "hnscc", "ci"], "article_id"=>1366323, "categories"=>["Biological Sciences"], "users"=>["Hao Shi", "Xiong Chen", "Cheng Lu", "Changmei Gu", "Hongwei Jiang", "RuiWei Meng", "Xun Niu", "Yangxin Huang", "Meixia Lu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122302.g002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_estimates_for_p16_INK4a_promoter_methylation_frequency_associated_with_HNSCC_by_meta_analysis_/1366323", "title"=>"Summary estimates for <i>p16<sup>INK4a</sup></i> promoter methylation frequency associated with HNSCC by meta-analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-02 15:29:06"}
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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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