A Genetic Predictive Model for Canine Hip Dysplasia: Integration of Genome Wide Association Study (GWAS) and Candidate Gene Approaches
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{"title"=>"A genetic predictive model for canine hip dysplasia: Integration of Genome Wide Association Study (GWAS) and candidate gene approaches", "type"=>"journal", "authors"=>[{"first_name"=>"Nerea", "last_name"=>"Bartolomé", "scopus_author_id"=>"36893979300"}, {"first_name"=>"Sergi", "last_name"=>"Segarra", "scopus_author_id"=>"50661798900"}, {"first_name"=>"Marta", "last_name"=>"Artieda", "scopus_author_id"=>"9843507400"}, {"first_name"=>"Olga", "last_name"=>"Francino", "scopus_author_id"=>"6602074559"}, {"first_name"=>"Elisenda", "last_name"=>"Sánchez", "scopus_author_id"=>"56612749700"}, {"first_name"=>"Magdalena", "last_name"=>"Szczypiorska", "scopus_author_id"=>"36656373500"}, {"first_name"=>"Joaquim", "last_name"=>"Casellas", "scopus_author_id"=>"9245199300"}, {"first_name"=>"Diego", "last_name"=>"Tejedor", "scopus_author_id"=>"6701520339"}, {"first_name"=>"Joaquín", "last_name"=>"Cerdeira", "scopus_author_id"=>"56613205100"}, {"first_name"=>"Antonio", "last_name"=>"Martínez", "scopus_author_id"=>"23982942300"}, {"first_name"=>"Alfonso", "last_name"=>"Velasco", "scopus_author_id"=>"56612924200"}, {"first_name"=>"Armand", "last_name"=>"Sánchez", "scopus_author_id"=>"7401886980"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84928816631", "doi"=>"10.1371/journal.pone.0122558", "pui"=>"604107804", "pmid"=>"25874693", "scopus"=>"2-s2.0-84928816631", "issn"=>"19326203"}, "id"=>"f09f2a49-a4d1-33b0-b6db-b72ae39787a7", "abstract"=>"Canine hip dysplasia is one of the most prevalent developmental orthopedic diseases in dogs worldwide. Unfortunately, the success of eradication programs against this disease based on radiographic diagnosis is low. Adding the use of diagnostic genetic tools to the current phenotype-based approach might be beneficial. The aim of this study was to develop a genetic prognostic test for early diagnosis of hip dysplasia in Labrador Retrievers. To develop our DNA test, 775 Labrador Retrievers were recruited. For each dog, a blood sample and a ventrodorsal hip radiograph were taken. Dogs were divided into two groups according to their FCI hip score: control (A/B) and case (D/E). C dogs were not included in the sample. Genetic characterization combining a GWAS and a candidate gene strategy using SNPs allowed a case-control population association study. A mathematical model which included 7 SNPs was developed using logistic regression. The model showed a good accuracy (Area under the ROC curve = 0.85) and was validated in an independent population of 114 dogs. This prognostic genetic test represents a useful tool for choosing the most appropriate therapeutic approach once genetic predisposition to hip dysplasia is known. Therefore, it allows a more individualized management of the disease. It is also applicable during genetic selection processes, since breeders can benefit from the information given by this test as soon as a blood sample can be collected, and act accordingly. In the authors' opinion, a shift towards genomic screening might importantly contribute to reducing canine hip dysplasia in the future. In conclusion, based on genetic and radiographic information from Labrador Retrievers with hip dysplasia, we developed an accurate predictive genetic test for early diagnosis of hip dysplasia in Labrador Retrievers. However, further research is warranted in order to evaluate the validity of this genetic test in other dog breeds.", "link"=>"http://www.mendeley.com/research/genetic-predictive-model-canine-hip-dysplasia-integration-genome-wide-association-study-gwas-candida", "reader_count"=>35, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Student > Doctoral Student"=>2, "Researcher"=>9, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>10}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Student > Doctoral Student"=>2, "Researcher"=>9, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>10}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>4, "Veterinary Science and Veterinary Medicine"=>10}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>10}}, "reader_count_by_country"=>{"Belgium"=>1, "Ireland"=>1, "Denmark"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2016165", "https://ndownloader.figshare.com/files/2016167", "https://ndownloader.figshare.com/files/2016168"], "description"=>"<div><p>Canine hip dysplasia is one of the most prevalent developmental orthopedic diseases in dogs worldwide. Unfortunately, the success of eradication programs against this disease based on radiographic diagnosis is low. Adding the use of diagnostic genetic tools to the current phenotype-based approach might be beneficial. The aim of this study was to develop a genetic prognostic test for early diagnosis of hip dysplasia in Labrador Retrievers. To develop our DNA test, 775 Labrador Retrievers were recruited. For each dog, a blood sample and a ventrodorsal hip radiograph were taken. Dogs were divided into two groups according to their FCI hip score: control (A/B) and case (D/E). C dogs were not included in the sample. Genetic characterization combining a GWAS and a candidate gene strategy using SNPs allowed a case-control population association study. A mathematical model which included 7 SNPs was developed using logistic regression. The model showed a good accuracy (Area under the ROC curve = 0.85) and was validated in an independent population of 114 dogs. This prognostic genetic test represents a useful tool for choosing the most appropriate therapeutic approach once genetic predisposition to hip dysplasia is known. Therefore, it allows a more individualized management of the disease. It is also applicable during genetic selection processes, since breeders can benefit from the information given by this test as soon as a blood sample can be collected, and act accordingly. In the authors’ opinion, a shift towards genomic screening might importantly contribute to reducing canine hip dysplasia in the future. In conclusion, based on genetic and radiographic information from Labrador Retrievers with hip dysplasia, we developed an accurate predictive genetic test for early diagnosis of hip dysplasia in Labrador Retrievers. However, further research is warranted in order to evaluate the validity of this genetic test in other dog breeds.</p></div>", "links"=>[], "tags"=>["hip dysplasia", "genome Wide Association Study", "snp", "GWAS", "candidate gene strategy", "blood sample", "roc", "Candidate Gene Approaches Canine hip dysplasia", "FCI hip score", "775 Labrador Retrievers", "Canine Hip Dysplasia", "dna", "Genetic Predictive Model", "Labrador Retrievers", "ventrodorsal hip radiograph", "diagnosis"], "article_id"=>1376469, "categories"=>["Uncategorised"], "users"=>["Nerea Bartolomé", "Sergi Segarra", "Marta Artieda", "Olga Francino", "Elisenda Sánchez", "Magdalena Szczypiorska", "Joaquim Casellas", "Diego Tejedor", "Joaquín Cerdeira", "Antonio Martinez", "Alfonso Velasco", "Armand Sanchez"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0122558.s001", "https://dx.doi.org/10.1371/journal.pone.0122558.s002", "https://dx.doi.org/10.1371/journal.pone.0122558.s003"], "stats"=>{"downloads"=>5, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_Genetic_Predictive_Model_for_Canine_Hip_Dysplasia_Integration_of_Genome_Wide_Association_Study_GWAS_and_Candidate_Gene_Approaches_/1376469", "title"=>"A Genetic Predictive Model for Canine Hip Dysplasia: Integration of Genome Wide Association Study (GWAS) and Candidate Gene Approaches", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-04-13 03:22:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2016164"], "description"=>"<p>Se: sensitivity; Sp: specificity</p><p>Predictive accuracy of the logistic model for Canine hip dysplasia.</p>", "links"=>[], "tags"=>["hip dysplasia", "genome Wide Association Study", "snp", "GWAS", "candidate gene strategy", "blood sample", "roc", "Candidate Gene Approaches Canine hip dysplasia", "FCI hip score", "775 Labrador Retrievers", "Canine Hip Dysplasia", "dna", "Genetic Predictive Model", "Labrador Retrievers", "ventrodorsal hip radiograph", "diagnosis"], "article_id"=>1376468, "categories"=>["Uncategorised"], "users"=>["Nerea Bartolomé", "Sergi Segarra", "Marta Artieda", "Olga Francino", "Elisenda Sánchez", "Magdalena Szczypiorska", "Joaquim Casellas", "Diego Tejedor", "Joaquín Cerdeira", "Antonio Martinez", "Alfonso Velasco", "Armand Sanchez"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122558.t003", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Predictive_accuracy_of_the_logistic_model_for_Canine_hip_dysplasia_/1376468", "title"=>"Predictive accuracy of the logistic model for Canine hip dysplasia.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-13 03:22:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2016161"], "description"=>"<p>We developed a multivariate predictive model for CHD by means of forward logistic regression using as predictors the SNPs significant after controlling for FDR. We tested our model discrimination via the Hosmer_Lemeshow statistic and the receiver operating characteristic (ROC) curve with 95% CIs.</p>", "links"=>[], "tags"=>["hip dysplasia", "genome Wide Association Study", "snp", "GWAS", "candidate gene strategy", "blood sample", "roc", "Candidate Gene Approaches Canine hip dysplasia", "FCI hip score", "775 Labrador Retrievers", "Canine Hip Dysplasia", "dna", "Genetic Predictive Model", "Labrador Retrievers", "ventrodorsal hip radiograph", "diagnosis"], "article_id"=>1376465, "categories"=>["Uncategorised"], "users"=>["Nerea Bartolomé", "Sergi Segarra", "Marta Artieda", "Olga Francino", "Elisenda Sánchez", "Magdalena Szczypiorska", "Joaquim Casellas", "Diego Tejedor", "Joaquín Cerdeira", "Antonio Martinez", "Alfonso Velasco", "Armand Sanchez"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122558.g003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ROC_curve_of_the_predictive_model_for_CHD_/1376465", "title"=>"ROC curve of the predictive model for CHD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-13 03:22:06"}
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  • {"files"=>["https://ndownloader.figshare.com/files/2016158"], "description"=>"<p>80,116 SNPs dispersed genome-wide were used. X-axis is principle component 1 and y-axis is principle component 2. Cases and controls were clustering together.</p>", "links"=>[], "tags"=>["hip dysplasia", "genome Wide Association Study", "snp", "GWAS", "candidate gene strategy", "blood sample", "roc", "Candidate Gene Approaches Canine hip dysplasia", "FCI hip score", "775 Labrador Retrievers", "Canine Hip Dysplasia", "dna", "Genetic Predictive Model", "Labrador Retrievers", "ventrodorsal hip radiograph", "diagnosis"], "article_id"=>1376462, "categories"=>["Uncategorised"], "users"=>["Nerea Bartolomé", "Sergi Segarra", "Marta Artieda", "Olga Francino", "Elisenda Sánchez", "Magdalena Szczypiorska", "Joaquim Casellas", "Diego Tejedor", "Joaquín Cerdeira", "Antonio Martinez", "Alfonso Velasco", "Armand Sanchez"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122558.g001", "stats"=>{"downloads"=>0, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Principal_Component_Analysis_PCA_plot_of_the_study_development_cohort_/1376462", "title"=>"Principal Component Analysis (PCA) plot of the study development cohort.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-13 03:22:06"}
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PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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