Molecular Characterization of Melanoma Cases in Denmark Suspected of Genetic Predisposition
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{"title"=>"Molecular characterization of melanoma cases in Denmark suspected of genetic predisposition", "type"=>"journal", "authors"=>[{"first_name"=>"Karin A.W.", "last_name"=>"Wadt", "scopus_author_id"=>"55242394000"}, {"first_name"=>"Lauren G.", "last_name"=>"Aoude", "scopus_author_id"=>"37071789400"}, {"first_name"=>"Lotte", "last_name"=>"Krogh", "scopus_author_id"=>"8409466000"}, {"first_name"=>"Lone", "last_name"=>"Sunde", "scopus_author_id"=>"6603960162"}, {"first_name"=>"Anders", "last_name"=>"Bojesen", "scopus_author_id"=>"57191567707"}, {"first_name"=>"Karen", "last_name"=>"Grønskov", "scopus_author_id"=>"6603366727"}, {"first_name"=>"Nine", "last_name"=>"Wartacz", "scopus_author_id"=>"56572784200"}, {"first_name"=>"Jakob", "last_name"=>"Ek", "scopus_author_id"=>"7005284447"}, {"first_name"=>"Morten", "last_name"=>"Tolstrup-Andersen", "scopus_author_id"=>"56572811300"}, {"first_name"=>"Mette", "last_name"=>"Klarskov-Andersen", "scopus_author_id"=>"56123675100"}, {"first_name"=>"Åke", "last_name"=>"Borg", "scopus_author_id"=>"7102940500"}, {"first_name"=>"Steffen", "last_name"=>"Heegaard", "scopus_author_id"=>"7004251127"}, {"first_name"=>"Jens F.", "last_name"=>"Kiilgaard", "scopus_author_id"=>"6602384350"}, {"first_name"=>"Thomas V.O.", "last_name"=>"Hansen", "scopus_author_id"=>"57199388397"}, {"first_name"=>"Kerenaftali", "last_name"=>"Klein", "scopus_author_id"=>"55207707600"}, {"first_name"=>"Göran", "last_name"=>"Jönsson", "scopus_author_id"=>"8979686400"}, {"first_name"=>"Krzysztof T.", "last_name"=>"Drzewiecki", "scopus_author_id"=>"35480119800"}, {"first_name"=>"Morten", "last_name"=>"Dunø", "scopus_author_id"=>"55880133900"}, {"first_name"=>"Nicholas K.", "last_name"=>"Hayward", "scopus_author_id"=>"36804082100"}, {"first_name"=>"Anne M.", "last_name"=>"Gerdes", "scopus_author_id"=>"16746264700"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"25803691", "scopus"=>"2-s2.0-84925612085", "doi"=>"10.1371/journal.pone.0122662", "sgr"=>"84925612085", "pui"=>"603281461"}, "id"=>"a0b9168c-0882-34bc-b485-a4c2a1c2401f", "abstract"=>"Both environmental and host factors influence risk of cutaneous melanoma (CM), and worldwide, the incidence varies depending on constitutional determinants of skin type and pigmentation, latitude, and patterns of sun exposure. We performed genetic analysis of CDKN2A, CDK4, BAP1, MC1R, and MITFp.E318K in Danish high-risk melanoma cases and found CDKN2A germline mutations in 11.3% of CM families with three or more affected individuals, including four previously undescribed mutations. Rare mutations were also seen in CDK4 and BAP1, while MC1R variants were common, occurring at more than twice the frequency compared to Danish controls. The MITF p.E318K variant similarly occurred at an approximately three-fold higher frequency in melanoma cases than controls. To conclude, we propose that mutation screening of CDKN2A and CDK4 in Denmark should predominantly be performed in families with at least 3 cases of CM. In addition, we recommend that testing of BAP1 should not be conducted routinely in CM families but should be reserved for families with CM and uveal melanoma, or mesothelioma.", "link"=>"http://www.mendeley.com/research/molecular-characterization-melanoma-cases-denmark-suspected-genetic-predisposition", "reader_count"=>25, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>7, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>8, "Business, Management and Accounting"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Uruguay"=>1, "Denmark"=>2}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1984631"], "description"=>"<p>Minor allele frequency (MAF) and odds ratio (OR) of <i>MC1R</i> variants in melanoma cases/families compared to the Danish population.</p>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352699, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662.t005", "stats"=>{"downloads"=>5, "page_views"=>67, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Minor_allele_frequency_MAF_and_odds_ratio_OR_of_MC1R_variants_in_melanoma_cases_families_compared_to_the_Danish_population_/1352699", "title"=>"Minor allele frequency (MAF) and odds ratio (OR) of <i>MC1R</i> variants in melanoma cases/families compared to the Danish population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-24 03:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1984630"], "description"=>"<p><i>BAP1</i> analysed in individuals and families with CM and/or UM and mesothelioma.</p>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352698, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662.t004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BAP1_analysed_in_individuals_and_families_with_CM_and_or_UM_and_mesothelioma_/1352698", "title"=>"<i>BAP1</i> analysed in individuals and families with CM and/or UM and mesothelioma.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-24 03:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1984625"], "description"=>"<p>Age-specific penetrance curves for CM in Danish <i>CDKN2A</i> mutation carriers.</p>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352693, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Age_specific_penetrance_curves_for_CM_in_Danish_CDKN2A_mutation_carriers_/1352693", "title"=>"Age-specific penetrance curves for CM in Danish <i>CDKN2A</i> mutation carriers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 03:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1984622"], "description"=>"<p>Flow-chart of melanoma cases included in the study.</p>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352689, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_of_melanoma_cases_included_in_the_study_/1352689", "title"=>"Flow-chart of melanoma cases included in the study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-24 03:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1984633"], "description"=>"<p>MAF and OR of <i>MITF</i> p.E318K in this study compared to the Danish population, and compared to other cohorts of CM patients.</p>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352701, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662.t007", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MAF_and_OR_of_MITF_p_E318K_in_this_study_compared_to_the_Danish_population_and_compared_to_other_cohorts_of_CM_patients_/1352701", "title"=>"MAF and OR of <i>MITF</i> p.E318K in this study compared to the Danish population, and compared to other cohorts of CM patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-24 03:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1984632"], "description"=>"<p>Using Cox regression</p><p>Hazard ratios for CM in <i>CDKN2A</i> carriers according to <i>MC1R</i> genotype, compared to all <i>CDKN2A</i> carriers.</p>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352700, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662.t006", "stats"=>{"downloads"=>4, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hazard_ratios_for_CM_in_CDKN2A_carriers_according_to_MC1R_genotype_compared_to_all_CDKN2A_carriers_/1352700", "title"=>"Hazard ratios for CM in <i>CDKN2A</i> carriers according to <i>MC1R</i> genotype, compared to all <i>CDKN2A</i> carriers.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-24 03:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1984627"], "description"=>"<p>Families with a <i>BAP1</i> mutation are not included, nor are individuals with UM.</p><p>Age at first melanoma in <i>CDKN2A</i> mutation carriers compared to age of first melanoma in individuals with melanoma and no <i>CDKN2A</i> mutation.</p>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352695, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662.t002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Age_at_first_melanoma_in_CDKN2A_mutation_carriers_compared_to_age_of_first_melanoma_in_individuals_with_melanoma_and_no_CDKN2A_mutation_/1352695", "title"=>"Age at first melanoma in <i>CDKN2A</i> mutation carriers compared to age of first melanoma in individuals with melanoma and no <i>CDKN2A</i> mutation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-24 03:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1984628"], "description"=>"<p><i>CDKN2A</i> analysis of individuals with CM.</p>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352696, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662.t003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CDKN2A_analysis_of_individuals_with_CM_/1352696", "title"=>"<i>CDKN2A</i> analysis of individuals with CM.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-24 03:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1984626"], "description"=>"<p>SCC: squamous cell carcinoma</p><p>CLL: chronic lymphocytic leukemia</p><p>RCC: renal cell carcinoma</p><p>Characteristics of the 13 individuals/families with identified <i>CDKN2A</i> mutations.</p>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352694, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662.t001", "stats"=>{"downloads"=>8, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_13_individuals_families_with_identified_CDKN2A_mutations_/1352694", "title"=>"Characteristics of the 13 individuals/families with identified <i>CDKN2A</i> mutations.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-24 03:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1984635"], "description"=>"<div><p>Both environmental and host factors influence risk of cutaneousmelanoma (CM), and worldwide, the incidence varies depending on constitutional determinants of skin type and pigmentation, latitude, and patterns of sun exposure. We performed genetic analysis of <i>CDKN2A</i>, <i>CDK4</i>, <i>BAP1</i>, <i>MC1R</i>, and <i>MITF</i>p.E318K in Danish high-risk melanoma cases and found <i>CDKN2A</i> germline mutations in 11.3% of CM families with three or more affected individuals, including four previously undescribed mutations. Rare mutations were also seen in <i>CDK4</i> and <i>BAP1</i>, while <i>MC1R</i> variants were common, occurring at more than twice the frequency compared to Danish controls. The <i>MITF</i> p.E318K variant similarly occurred at an approximately three-fold higher frequency in melanoma cases than controls. To conclude, we propose that mutation screening of <i>CDKN2A</i> and <i>CDK4</i> in Denmark should predominantly be performed in families with at least 3 cases of CM. In addition, we recommend that testing of <i>BAP1</i> should not be conducted routinely in CM families but should be reserved for families with CM and uveal melanoma, or mesothelioma.</p></div>", "links"=>[], "tags"=>["bap", "melanoma cases", "danish", "MC 1R variants", "host factors influence risk", "CDK 4", "denmark", "MITF p.E 318K variant", "CM families", "CDKN 2A germline mutations", "frequency"], "article_id"=>1352703, "categories"=>["Uncategorised"], "users"=>["Karin A. W. Wadt", "Lauren G. Aoude", "Lotte Krogh", "Lone Sunde", "Anders Bojesen", "Karen Grønskov", "Nine Wartacz", "Jakob Ek", "Morten Tolstrup-Andersen", "Mette Klarskov-Andersen", "Åke Borg", "Steffen Heegaard", "Jens F. Kiilgaard", "Thomas V. O. Hansen", "Kerenaftali Klein", "Göran Jönsson", "Krzysztof T. Drzewiecki", "Morten Dunø", "Nicholas K. Hayward", "Anne-Marie Gerdes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122662", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Molecular_Characterization_of_Melanoma_Cases_in_Denmark_Suspected_of_Genetic_Predisposition_/1352703", "title"=>"Molecular Characterization of Melanoma Cases in Denmark Suspected of Genetic Predisposition", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-24 03:44:27"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
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  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"28", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"29", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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