Interstitial Fluid Colloid Osmotic Pressure in Healthy Children
Publication Date
April 08, 2015
Journal
PLOS ONE
Authors
Hans Jørgen Timm Guthe, Marianne Indrebø, Torbjørn Nedrebø, Gunnar Norgård, et al
Volume
10
Issue
4
Pages
e0122779
DOI
https://dx.plos.org/10.1371/journal.pone.0122779
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0122779
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25853713
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390290
Europe PMC
http://europepmc.org/abstract/MED/25853713
Scopus
84928922940
Mendeley
http://www.mendeley.com/research/interstitial-fluid-colloid-osmotic-pressure-healthy-children-1
Events
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2010392"], "description"=>"<p>CONSORT flow diagram.</p>", "links"=>[], "tags"=>["transvascular fluid exchange", "monitoring fluid balance", "Healthy Children ObjectiveThe colloid", "8 years", "fluid COP values", "Nylon wicks", "10 years", "fluid samples.ResultsThe", "implantation time", "Interstitial Fluid Colloid Osmotic Pressure", "COP values", "age groups", "Gender Difference", "colloid osmometer", "plasma COP", "Arbitrary division", "fluid imbalance", "reference values", "nct"], "article_id"=>1371653, "categories"=>["Uncategorised"], "users"=>["Hans Jørgen Timm Guthe", "Marianne Indrebø", "Torbjørn Nedrebø", "Gunnar Norgård", "Helge Wiig", "Ansgar Berg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122779.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CONSORT_flow_diagram_/1371653", "title"=>"CONSORT flow diagram.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-08 03:38:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2010393"], "description"=>"<p>*Blood loss greater than 10% of estimated CBV (n = 11).</p>", "links"=>[], "tags"=>["transvascular fluid exchange", "monitoring fluid balance", "Healthy Children ObjectiveThe colloid", "8 years", "fluid COP values", "Nylon wicks", "10 years", "fluid samples.ResultsThe", "implantation time", "Interstitial Fluid Colloid Osmotic Pressure", "COP values", "age groups", "Gender Difference", "colloid osmometer", "plasma COP", "Arbitrary division", "fluid imbalance", "reference values", "nct"], "article_id"=>1371654, "categories"=>["Uncategorised"], "users"=>["Hans Jørgen Timm Guthe", "Marianne Indrebø", "Torbjørn Nedrebø", "Gunnar Norgård", "Helge Wiig", "Ansgar Berg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122779.g002", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Recruitment_of_patients_and_distribution_of_samples_/1371654", "title"=>"Recruitment of patients and distribution of samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-08 03:38:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2010394"], "description"=>"<p>Colloid osmotic pressure in plasma (p) and interstitium (i) (arm and leg merged) related to age. There was significant difference in pressures between 2–3 years and 8–10 years for plasma (P < 0.05, *) and between first three age groups and 8–10 years (P < 0.01, **) in interstitial fluid.</p>", "links"=>[], "tags"=>["transvascular fluid exchange", "monitoring fluid balance", "Healthy Children ObjectiveThe colloid", "8 years", "fluid COP values", "Nylon wicks", "10 years", "fluid samples.ResultsThe", "implantation time", "Interstitial Fluid Colloid Osmotic Pressure", "COP values", "age groups", "Gender Difference", "colloid osmometer", "plasma COP", "Arbitrary division", "fluid imbalance", "reference values", "nct"], "article_id"=>1371655, "categories"=>["Uncategorised"], "users"=>["Hans Jørgen Timm Guthe", "Marianne Indrebø", "Torbjørn Nedrebø", "Gunnar Norgård", "Helge Wiig", "Ansgar Berg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122779.g003", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Colloid_osmotic_pressure_in_plasma_and_interstitium_/1371655", "title"=>"Colloid osmotic pressure in plasma and interstitium.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-08 03:38:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2010395"], "description"=>"<p>Colloid osmotic pressure from wicks after implantation in arm vs. leg related to age. There was no significant difference in the pressures obtained in arm and leg.</p>", "links"=>[], "tags"=>["transvascular fluid exchange", "monitoring fluid balance", "Healthy Children ObjectiveThe colloid", "8 years", "fluid COP values", "Nylon wicks", "10 years", "fluid samples.ResultsThe", "implantation time", "Interstitial Fluid Colloid Osmotic Pressure", "COP values", "age groups", "Gender Difference", "colloid osmometer", "plasma COP", "Arbitrary division", "fluid imbalance", "reference values", "nct"], "article_id"=>1371656, "categories"=>["Uncategorised"], "users"=>["Hans Jørgen Timm Guthe", "Marianne Indrebø", "Torbjørn Nedrebø", "Gunnar Norgård", "Helge Wiig", "Ansgar Berg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122779.g004", "stats"=>{"downloads"=>0, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Colloid_osmotic_pressure_in_arm_and_leg_/1371656", "title"=>"Colloid osmotic pressure in arm and leg.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-08 03:38:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2010396"], "description"=>"<p>(ΔCOP = COP<sub>p</sub>—COP<sub>i</sub> (arm and leg merged)) ΔCOP related to age, with significant difference between 4–5 years and 2–3 years (P = 0.017 *) and between 6–7 years and 2–3 years (P < 0.001 ***).</p>", "links"=>[], "tags"=>["transvascular fluid exchange", "monitoring fluid balance", "Healthy Children ObjectiveThe colloid", "8 years", "fluid COP values", "Nylon wicks", "10 years", "fluid samples.ResultsThe", "implantation time", "Interstitial Fluid Colloid Osmotic Pressure", "COP values", "age groups", "Gender Difference", "colloid osmometer", "plasma COP", "Arbitrary division", "fluid imbalance", "reference values", "nct"], "article_id"=>1371657, "categories"=>["Uncategorised"], "users"=>["Hans Jørgen Timm Guthe", "Marianne Indrebø", "Torbjørn Nedrebø", "Gunnar Norgård", "Helge Wiig", "Ansgar Berg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0122779.g005", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transcapillary_gradient_in_COP_/1371657", "title"=>"Transcapillary gradient in COP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-08 03:38:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2010397", "https://ndownloader.figshare.com/files/2010398", "https://ndownloader.figshare.com/files/2010399", "https://ndownloader.figshare.com/files/2010400", "https://ndownloader.figshare.com/files/2010401"], "description"=>"<div><p>Objective</p><p>The colloid osmotic pressure (COP) of plasma and interstitial fluid play important roles in transvascular fluid exchange. COP values for monitoring fluid balance in healthy and sick children have not been established. This study set out to determine reference values of COP in healthy children.</p><p>Materials and Methods</p><p>COP in plasma and interstitial fluid harvested from nylon wicks was measured in 99 healthy children from 2 to 10 years of age. Nylon wicks were implanted subcutaneously in arm and leg while patients were sedated and intubated during a minor surgical procedure. COP was analyzed in a colloid osmometer designed for small fluid samples.</p><p>Results</p><p>The mean plasma COP in all children was 25.6 ± 3.3 mmHg. Arbitrary division of children in four different age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8-10 years had significant higher COP both in plasma and interstitial fluid. There were no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity. Prolonged implantation time did not affect interstitial COP.</p><p>Conclusion</p><p>Plasma and interstitial COP in healthy children are comparable to adults and COP seems to increase with age in children. Knowledge of the interaction between colloid osmotic forces can be helpful in diseases associated with fluid imbalance and may be crucial in deciding different fluid treatment options.</p><p>Trial Registration</p><p>ClinicalTrials.gov <a href=\"https://clinicaltrials.gov/ct2/show/NCT01044641?term=guthe&rank=2\" target=\"_blank\">NCT01044641</a></p></div>", "links"=>[], "tags"=>["transvascular fluid exchange", "monitoring fluid balance", "Healthy Children ObjectiveThe colloid", "8 years", "fluid COP values", "Nylon wicks", "10 years", "fluid samples.ResultsThe", "implantation time", "Interstitial Fluid Colloid Osmotic Pressure", "COP values", "age groups", "Gender Difference", "colloid osmometer", "plasma COP", "Arbitrary division", "fluid imbalance", "reference values", "nct"], "article_id"=>1371658, "categories"=>["Uncategorised"], "users"=>["Hans Jørgen Timm Guthe", "Marianne Indrebø", "Torbjørn Nedrebø", "Gunnar Norgård", "Helge Wiig", "Ansgar Berg"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0122779.s001", "https://dx.doi.org/10.1371/journal.pone.0122779.s002", "https://dx.doi.org/10.1371/journal.pone.0122779.s003", "https://dx.doi.org/10.1371/journal.pone.0122779.s004", "https://dx.doi.org/10.1371/journal.pone.0122779.s005"], "stats"=>{"downloads"=>18, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Interstitial_Fluid_Colloid_Osmotic_Pressure_in_Healthy_Children_/1371658", "title"=>"Interstitial Fluid Colloid Osmotic Pressure in Healthy Children", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-04-08 03:38:05"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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