Serum Levels of Oxylipins in Achilles Tendinopathy: An Exploratory Study
Publication Date
April 13, 2015
Journal
PLOS ONE
Authors
Sandra Gouveia Figueira, Malin L. Nording, Jamie E. Gaida, Sture Forsgren, et al
Volume
10
Issue
4
Pages
e0123114
DOI
https://dx.plos.org/10.1371/journal.pone.0123114
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0123114
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25875933
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395257
Europe PMC
http://europepmc.org/abstract/MED/25875933
Web of Science
000352845100135
Scopus
84929484509
Mendeley
http://www.mendeley.com/research/serum-levels-oxylipins-achilles-tendinopathy-exploratory-study
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Serum levels of oxylipins in achilles tendinopathy: An exploratory study", "type"=>"journal", "authors"=>[{"first_name"=>"Sandra", "last_name"=>"Gouveia-Figueira", "scopus_author_id"=>"56010618100"}, {"first_name"=>"Malin L.", "last_name"=>"Nording", "scopus_author_id"=>"55898199200"}, {"first_name"=>"Jamie E.", "last_name"=>"Gaida", "scopus_author_id"=>"6508288642"}, {"first_name"=>"Sture", "last_name"=>"Forsgren", "scopus_author_id"=>"15850134000"}, {"first_name"=>"Håkan", "last_name"=>"Alfredson", "scopus_author_id"=>"7005278619"}, {"first_name"=>"Christopher J.", "last_name"=>"Fowler", "scopus_author_id"=>"7203059995"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pmid"=>"25875933", "pui"=>"604107910", "scopus"=>"2-s2.0-84929484509", "doi"=>"10.1371/journal.pone.0123114", "sgr"=>"84929484509"}, "id"=>"5b742804-0015-32cf-be37-c649b64f837f", "abstract"=>"BACKGROUND: Linoleic acid-derived oxidation products are found in experimental pain models. However, little is known about the levels of such oxylipins in human pain. In consequence, in the present study, we have undertaken a lipidomic profiling of oxylipins in blood serum from patients with Achilles tendinopathy and controls. METHODOLOGY/PRINCIPAL FINDINGS: A total of 34 oxylipins were analysed in the serum samples. At a significance level of P<0.00147 (<0.05/34), two linoleic acid-derived oxylipins, 13-hydroxy-10E,12Z-octadecadienoic (13-HODE) and 12(13)-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) were present at significantly higher levels in the Achilles tendinopathy samples. This difference remained significant when the dataset was controlled for age, gender and body-mass index. In contrast, 0/21 of the arachidonic acid- and 0/4 of the dihomo-gamma-linolenic acid, eicosapentaenoic acid or docosahenaenoic acid-derived oxylipins were higher in the patient samples at this level of significance. The area under the Receiver-Operator Characteristic (ROC) curve for 12,13-DiHOME was 0.91 (P<0.0001). Levels of four N-acylethanolamines were also analysed and found not to be significantly different between the controls and the patients at the level of P<0.0125 (<0.05/4). CONCLUSIONS/SIGNIFICANCE: It is concluded from this exploratory study that abnormal levels of linoleic acid-derived oxylipins are seen in blood serum from patients with Achilles tendinopathy. Given the ability of two of these, 9- and 13-HODE to activate transient receptor potential vanilloid 1, it is possible that these changes may contribute to the symptoms seen in Achilles tendinopathy.", "link"=>"http://www.mendeley.com/research/serum-levels-oxylipins-achilles-tendinopathy-exploratory-study", "reader_count"=>26, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>1, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>8, "Arts and Humanities"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Sports and Recreations"=>2, "Chemistry"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Chemistry"=>{"Chemistry"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "United States"=>1}, "group_count"=>2}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84929484509"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84929484509?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84929484509&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84929484509&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84929484509", "dc:identifier"=>"SCOPUS_ID:84929484509", "eid"=>"2-s2.0-84929484509", "dc:title"=>"Serum levels of oxylipins in achilles tendinopathy: An exploratory study", "dc:creator"=>"Gouveia-Figueira S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"10", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-04-13", "prism:coverDisplayDate"=>"13 April 2015", "prism:doi"=>"10.1371/journal.pone.0123114", "citedby-count"=>"13", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Umeå Universitet", "affiliation-city"=>"Umea", "affiliation-country"=>"Sweden"}], "pubmed-id"=>"25875933", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0123114", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0123114", "share_count"=>1, "like_count"=>1, "comment_count"=>0, "click_count"=>0, "total_count"=>2}

Twitter

Counter

  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"34", "xml_views"=>"5", "html_views"=>"258"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"94"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"184"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"92"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"3", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2018084"], "description"=>"<p>The PCA factor was determined from the mean-centered and Pareto-scaled log<sub>10</sub> oxylipin values for the six derivatives. A single factor with eigenvalue >1 was returned, with a component matrix log<sub>10</sub> 9(S)-HODE, 0.924; log<sub>10</sub> 13-HODE, 0.934; log<sub>10</sub> 9,10-DiHOME, 0.795; log<sub>10</sub> 12,13-DiHOME, 0.853; log<sub>10</sub> 9,10,13-TriHOME, 0.852 and log<sub>10</sub> 9,12,13-TriHOME, 0.848. The Kaiser-Meyer-Olkin Measure of sampling adequacy was 0.818. The P values for the corrected model and intercepts are not shown but were significant in all cases except for the intercept for the PCA factor (which is mean-centered) as dependent variable.</p><p>Univariate general linear model significance levels for the log<sub>10</sub> values of HODE, DiHOME, TriHOME derivatives and for the derived PCA factor.</p>", "links"=>[], "tags"=>["Blood serum", "HODE", "acid", "roc", "Achilles tendinopathy samples", "Achilles tendinopathy", "oxylipin"], "article_id"=>1377883, "categories"=>["Uncategorised"], "users"=>["Sandra Gouveia-Figueira", "Malin L. Nording", "Jamie E. Gaida", "Sture Forsgren", "Håkan Alfredson", "Christopher J. Fowler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123114.t004", "stats"=>{"downloads"=>5, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Univariate_general_linear_model_significance_levels_for_the_log_10_values_of_HODE_DiHOME_TriHOME_derivatives_and_for_the_derived_PCA_factor_/1377883", "title"=>"Univariate general linear model significance levels for the log<sub>10</sub> values of HODE, DiHOME, TriHOME derivatives and for the derived PCA factor.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-13 05:50:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/2018083"], "description"=>"<p>Shown are medians, interquartile range and total ranges for the lipids (N = 16 for controls, N = 15 for the Achilles tendinosis group), classified according to the polyunsaturated fatty acid from which they are derived. P values are derived from the Mann-Whitney U-test.</p><p>Oxylipin levels (pg/mL) in the blood serum samples from controls and patients with Achilles tendinopathy.</p>", "links"=>[], "tags"=>["Blood serum", "HODE", "acid", "roc", "Achilles tendinopathy samples", "Achilles tendinopathy", "oxylipin"], "article_id"=>1377882, "categories"=>["Uncategorised"], "users"=>["Sandra Gouveia-Figueira", "Malin L. Nording", "Jamie E. Gaida", "Sture Forsgren", "Håkan Alfredson", "Christopher J. Fowler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123114.t003", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Oxylipin_levels_pg_mL_in_the_blood_serum_samples_from_controls_and_patients_with_Achilles_tendinopathy_/1377882", "title"=>"Oxylipin levels (pg/mL) in the blood serum samples from controls and patients with Achilles tendinopathy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-13 05:50:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/2018078"], "description"=>"<p>Co, controls; AT, Achilles tendinopathy. Significance levels are from the Mann-Whitney U-test summarised in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123114#pone.0123114.t001\" target=\"_blank\">Table 1</a>: *P<0.05, <sup>NS</sup>P>0.05.</p>", "links"=>[], "tags"=>["Blood serum", "HODE", "acid", "roc", "Achilles tendinopathy samples", "Achilles tendinopathy", "oxylipin"], "article_id"=>1377877, "categories"=>["Uncategorised"], "users"=>["Sandra Gouveia-Figueira", "Malin L. Nording", "Jamie E. Gaida", "Sture Forsgren", "Håkan Alfredson", "Christopher J. Fowler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123114.g002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Scatterplots_for_the_epoxy_5Z_8Z_14Z_eicosatrienoic_acid_oxylipins_/1377877", "title"=>"Scatterplots for the epoxy-5Z,8Z,14Z- eicosatrienoic acid oxylipins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-13 05:50:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/2018077"], "description"=>"<p>Co, controls; AT, Achilles tendinopathy. Significance levels are from the Mann-Whitney U-test summarised in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123114#pone.0123114.t001\" target=\"_blank\">Table 1</a>: ***P<0.001, **P<0.01, <sup>NS</sup>P>0.05.</p>", "links"=>[], "tags"=>["Blood serum", "HODE", "acid", "roc", "Achilles tendinopathy samples", "Achilles tendinopathy", "oxylipin"], "article_id"=>1377876, "categories"=>["Uncategorised"], "users"=>["Sandra Gouveia-Figueira", "Malin L. Nording", "Jamie E. Gaida", "Sture Forsgren", "Håkan Alfredson", "Christopher J. Fowler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123114.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Scatterplots_for_the_oxylipins_derived_from_linoleic_acid_/1377876", "title"=>"Scatterplots for the oxylipins derived from linoleic acid.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-13 05:50:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/2018085", "https://ndownloader.figshare.com/files/2018086"], "description"=>"<div><p>Background</p><p>Linoleic acid-derived oxidation products are found in experimental pain models. However, little is known about the levels of such oxylipins in human pain. In consequence, in the present study, we have undertaken a lipidomic profiling of oxylipins in blood serum from patients with Achilles tendinopathy and controls.</p><p>Methodology/Principal findings</p><p>A total of 34 oxylipins were analysed in the serum samples. At a significance level of P<0.00147 (<0.05/34), two linoleic acid-derived oxylipins, 13-hydroxy-10E,12Z-octadecadienoic (13-HODE) and 12(13)-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) were present at significantly higher levels in the Achilles tendinopathy samples. This difference remained significant when the dataset was controlled for age, gender and body-mass index. In contrast, 0/21 of the arachidonic acid- and 0/4 of the dihomo-γ-linolenic acid, eicosapentaenoic acid or docosahenaenoic acid-derived oxylipins were higher in the patient samples at this level of significance. The area under the Receiver-Operator Characteristic (ROC) curve for 12,13-DiHOME was 0.91 (P<0.0001). Levels of four N-acylethanolamines were also analysed and found not to be significantly different between the controls and the patients at the level of P<0.0125 (<0.05/4).</p><p>Conclusions/Significance</p><p>It is concluded from this exploratory study that abnormal levels of linoleic acid-derived oxylipins are seen in blood serum from patients with Achilles tendinopathy. Given the ability of two of these, 9- and 13-HODE to activate transient receptor potential vanilloid 1, it is possible that these changes may contribute to the symptoms seen in Achilles tendinopathy.</p></div>", "links"=>[], "tags"=>["Blood serum", "HODE", "acid", "roc", "Achilles tendinopathy samples", "Achilles tendinopathy", "oxylipin"], "article_id"=>1377884, "categories"=>["Uncategorised"], "users"=>["Sandra Gouveia-Figueira", "Malin L. Nording", "Jamie E. Gaida", "Sture Forsgren", "Håkan Alfredson", "Christopher J. Fowler"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0123114.s001", "https://dx.doi.org/10.1371/journal.pone.0123114.s002"], "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_Levels_of_Oxylipins_in_Achilles_Tendinopathy_An_Exploratory_Study_/1377884", "title"=>"Serum Levels of Oxylipins in Achilles Tendinopathy: An Exploratory Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-04-13 05:50:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/2018082"], "description"=>"<p>Abbreviations: tMets, physical activity, estimated in metabolic equivalent hours per week; PaD-A, pain duration for the patients with Achilles tendinopathy; BMI, body mass index; Chol, serum cholesterol; TG, serum triglycerides; HDL and LDL, serum high and low density lipoprotein; BDNF and sTNFRI, serum levels of brain-derived neurotrophic factor (BDNF) and soluble tumour necrosis factor receptor I, respectively. Significance levels are: *P<0.05, **P<0.01, ***P<0.001. For OEA, the sample sizes, with the exception of PaD-A are one smaller than those shown at the top of the Table due to one missing value.</p><p>.</p>", "links"=>[], "tags"=>["Blood serum", "HODE", "acid", "roc", "Achilles tendinopathy samples", "Achilles tendinopathy", "oxylipin"], "article_id"=>1377881, "categories"=>["Uncategorised"], "users"=>["Sandra Gouveia-Figueira", "Malin L. Nording", "Jamie E. Gaida", "Sture Forsgren", "Håkan Alfredson", "Christopher J. Fowler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123114.t002", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Non_parametric_bivariate_correlation_coefficients_between_serum_oxylipin_or_N_acylethanolamine_levels_and_the_age_physical_activity_pain_duration_Achilles_tendinopathy_patients_BMI_blood_lipid_status_BDNF_and_sTNFR1_levels_in_the_dataset_/1377881", "title"=>"Non-parametric bivariate correlation coefficients between serum oxylipin or <i>N</i>-acylethanolamine levels and the age, physical activity, pain duration (Achilles tendinopathy patients), BMI, blood lipid status, BDNF and sTNFR1 levels in the dataset", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-13 05:50:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/2018080"], "description"=>"<p>Co, controls; AT, Achilles tendinosis. Significance levels are from the two-tailed Mann-Whitney U-tests, *P = 0.040; <sup>NS</sup>P>0.5.</p>", "links"=>[], "tags"=>["Blood serum", "HODE", "acid", "roc", "Achilles tendinopathy samples", "Achilles tendinopathy", "oxylipin"], "article_id"=>1377879, "categories"=>["Uncategorised"], "users"=>["Sandra Gouveia-Figueira", "Malin L. Nording", "Jamie E. Gaida", "Sture Forsgren", "Håkan Alfredson", "Christopher J. Fowler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123114.g004", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_N_acylethanolamine_levels_in_control_and_Achilles_tendinopathy_serum_samples_/1377879", "title"=>"Comparison of <i>N</i>-acylethanolamine levels in control and Achilles tendinopathy serum samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-13 05:50:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/2018081"], "description"=>"<p>Abbreviation: tMET, physical activity, estimated in metabolic equivalent hours per week. Unless otherwise indicated, values are given as means with ranges in brackets, and statistical significance was assessed using a two-tailed t-test.</p><p><sup>#</sup>One or both of the groups did not pass the D’Agostino & Pearson omnibus normality test, and so the values are given as medians and ranges, with statistical significance being assessed using a two-tailed Mann-Whitney U test.</p><p><sup>##</sup>Fishers exact test. Control, N = 16 except for tMet (N = 11) and LDL (N = 15). Achilles tendinopathy, N = 15 except for waist, hip and tMet (N = 14), cholesterol, TG, HDL and LDL (N = 13).</p><p>Description of the study population.</p>", "links"=>[], "tags"=>["Blood serum", "HODE", "acid", "roc", "Achilles tendinopathy samples", "Achilles tendinopathy", "oxylipin"], "article_id"=>1377880, "categories"=>["Uncategorised"], "users"=>["Sandra Gouveia-Figueira", "Malin L. Nording", "Jamie E. Gaida", "Sture Forsgren", "Håkan Alfredson", "Christopher J. Fowler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123114.t001", "stats"=>{"downloads"=>6, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Description_of_the_study_population_/1377880", "title"=>"Description of the study population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-13 05:50:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/2018079"], "description"=>"<p>In Panel A, two individual examples are shown for 12,13-DiHOME (red line) and 11-HETE (purple line). The area under the ROC curves for these lipids were 0.91 (95% CI 0.80–1.02, P = 0.0001) and 0.52 (95% CI 0.29–0.74, P = 0.87), respectively. The dotted line is for an area under the ROC curve of 0.5, i.e. no predictive value. The turquoise circle in the ROC curve for 12,13-DiHOME shows the optimum cut-off value (the Youden score). In Panel B, the area under the ROC curves (means ± SE) are plotted against the P values from the ROC analyses for all the oxylipins, colour-coded upon the basis of the fatty acid group to which they belong. The vertical lines delineate P values of 0.00147 (= 0.05/34) and 0.01. The three oxylipins with the highest P value and area under the ROC curves are (left to right) 12,13-DiHOME, 13-HODE and 9,10,13-TriHOME.</p>", "links"=>[], "tags"=>["Blood serum", "HODE", "acid", "roc", "Achilles tendinopathy samples", "Achilles tendinopathy", "oxylipin"], "article_id"=>1377878, "categories"=>["Uncategorised"], "users"=>["Sandra Gouveia-Figueira", "Malin L. Nording", "Jamie E. Gaida", "Sture Forsgren", "Håkan Alfredson", "Christopher J. Fowler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123114.g003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Receiver_operated_curves_ROC_for_the_oxylipins_/1377878", "title"=>"Receiver operated curves (ROC) for the oxylipins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-13 05:50:07"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"43", "full-text"=>"44", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"25", "full-text"=>"39", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"13", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"227", "full-text"=>"322", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
Loading … Spinner
There are currently no alerts