Molecular Signatures of Nicotinoid-Pathogen Synergy in the Termite Gut
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Molecular signatures of nicotinoid-pathogen synergy in the termite gut", "type"=>"journal", "authors"=>[{"first_name"=>"Ruchira", "last_name"=>"Sen", "scopus_author_id"=>"35173538700"}, {"first_name"=>"Rhitoban", "last_name"=>"Raychoudhury", "scopus_author_id"=>"24923991400"}, {"first_name"=>"Yunpeng", "last_name"=>"Cai", "scopus_author_id"=>"8234801000"}, {"first_name"=>"Yijun", "last_name"=>"Sun", "scopus_author_id"=>"7408370398"}, {"first_name"=>"Verena Ulrike", "last_name"=>"Lietze", "scopus_author_id"=>"22958570300"}, {"first_name"=>"Brittany F.", "last_name"=>"Peterson", "scopus_author_id"=>"56548078800"}, {"first_name"=>"Michael E.", "last_name"=>"Scharf", "scopus_author_id"=>"7101609231"}, {"first_name"=>"Drion G.", "last_name"=>"Boucias", "scopus_author_id"=>"7003900629"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84927124603", "pmid"=>"25837376", "sgr"=>"84927124603", "doi"=>"10.1371/journal.pone.0123391", "issn"=>"19326203", "pui"=>"603600258"}, "id"=>"378d05ea-c2eb-3f23-9111-fb9f8cf6a94d", "abstract"=>"Previous studies in lower termites revealed unexpected synergies between nicotinoid insecticides and fungal entomopathogens. The present study investigated molecular mechanisms of nicotinoid-pathogen synergy in the lower termite Reticulitermes flavipes, using the nicotinoid, imidacloprid, in combination with fungal and bacterial entomopathogens. Particular focus was placed on metatranscriptome composition and microbial dynamics in the symbiont-rich termite gut, which houses diverse mixes of protists and bacteria. cDNA microarrays containing a mix of host and protist symbiont oligonucleotides were used to simultaneously assess termite and protist gene expression. Five treatments were compared that included single challenges with sublethal doses of fungi (Metharizium anisopliae), bacteria (Serratia marcescens) or imidacloprid, and dual challenges with fungi + imidacloprid or bacteria + imidacloprid. Our findings point towards protist dysbiosis and compromised social behavior, rather than suppression of stereotypical immune defense mechanisms, as the dominant factors underlying nicotinoid-pathogen synergy in termites. Also, greater impacts observed for the fungal pathogen than for the bacterial pathogen suggest that the rich bacterial symbiont community in the R. flavipes gut (>5000 species-level phylotypes) exists in an ecological balance that effectively excludes exogenous bacterial pathogens. These findings significantly advance our understanding of antimicrobial defenses in this important eusocial insect group, as well as provide novel insights into how nicotinoids can exert deleterious effects on social insect colonies.", "link"=>"http://www.mendeley.com/research/molecular-signatures-nicotinoidpathogen-synergy-termite-gut", "reader_count"=>28, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>5, "Student > Bachelor"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>5, "Student > Bachelor"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Environmental Science"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>23}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>23}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Environmental Science"=>{"Environmental Science"=>4}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>1, "Norway"=>1, "Brazil"=>1, "United Kingdom"=>1, "France"=>1, "Switzerland"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84927124603"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84927124603?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84927124603&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84927124603&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84927124603", "dc:identifier"=>"SCOPUS_ID:84927124603", "eid"=>"2-s2.0-84927124603", "dc:title"=>"Molecular signatures of nicotinoid-pathogen synergy in the termite gut", "dc:creator"=>"Sen R.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"10", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-04-02", "prism:coverDisplayDate"=>"2 April 2015", "prism:doi"=>"10.1371/journal.pone.0123391", "citedby-count"=>"10", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"D.A.V. College, Chandigarh", "affiliation-city"=>"Chandigarh", "affiliation-country"=>"India"}, {"@_fa"=>"true", "affilname"=>"Purdue University", "affiliation-city"=>"West Lafayette", "affiliation-country"=>"United States"}], "pubmed-id"=>"25837376", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0123391", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0123391", "share_count"=>2, "like_count"=>2, "comment_count"=>0, "click_count"=>0, "total_count"=>4}

Counter

  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"140", "xml_views"=>"47", "html_views"=>"1286"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"47", "xml_views"=>"1", "html_views"=>"234"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"156"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"84"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"75"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"106"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"3"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"4"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2003545"], "description"=>"<p>Reported analyses consisted of five pairwise comparisons to a common control, as denoted by the numbers 1–5.</p>", "links"=>[], "tags"=>["Termite Gut", "mix", "metatranscriptome composition", "findings point", "antimicrobial defenses", "insect colonies", "eusocial insect group", "imidacloprid", "gut", "sublethal doses", "symbiont community", "synergy", "Particular focus", "bacteria", "termites", "novel insights", "entomopathogen", "nicotinoid insecticides", "defense mechanisms", "protist dysbiosis", "pathogen", "protist symbiont oligonucleotides", "Serratia marcescens", "cDNA microarrays", "challenge", "protist gene expression", "termite Reticulitermes flavipes", "fungi", "Molecular Signatures"], "article_id"=>1366069, "categories"=>["Biological Sciences"], "users"=>["Ruchira Sen", "Rhitoban Raychoudhury", "Yunpeng Cai", "Yijun Sun", "Verena-Ulrike Lietze", "Brittany F. Peterson", "Michael E. Scharf", "Drion G. Boucias"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0123391.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microarray_treatment_summary_F_fungi_I_imidacloprid_B_bacteria_F_I_fungus_imidacloprid_B_I_bacteria_imidacloprid_and_SC_solvent_control_treatments_/1366069", "title"=>"Microarray treatment summary: F (fungi), I (imidacloprid), B (bacteria), F+I (fungus + imidacloprid), B+I (bacteria + imidacloprid), and SC (solvent control) treatments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-02 15:03:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003546"], "description"=>"<p>(A,B) Control termites displaying normal behaviors and (C,D) imidacloprid treated termites displaying mild intoxication effects. (E,F) Termites treated with sublethal fungal dose showing no effects, and (G,H) termites displaying mycosis after treatment with fungi + imidacloprid. (I) Termites treated with bacteria + imidacloprid showing varying degrees of Serratia infection.</p>", "links"=>[], "tags"=>["Termite Gut", "mix", "metatranscriptome composition", "findings point", "antimicrobial defenses", "insect colonies", "eusocial insect group", "imidacloprid", "gut", "sublethal doses", "symbiont community", "synergy", "Particular focus", "bacteria", "termites", "novel insights", "entomopathogen", "nicotinoid insecticides", "defense mechanisms", "protist dysbiosis", "pathogen", "protist symbiont oligonucleotides", "Serratia marcescens", "cDNA microarrays", "challenge", "protist gene expression", "termite Reticulitermes flavipes", "fungi", "Molecular Signatures"], "article_id"=>1366070, "categories"=>["Biological Sciences"], "users"=>["Ruchira Sen", "Rhitoban Raychoudhury", "Yunpeng Cai", "Yijun Sun", "Verena-Ulrike Lietze", "Brittany F. Peterson", "Michael E. Scharf", "Drion G. Boucias"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0123391.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_examples_of_normal_and_infected_termites_/1366070", "title"=>"Representative examples of normal and infected termites.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-02 15:03:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003547"], "description"=>"<p>Highest mortality occurred in combination treatments of fungi + imidacloprid and bacteria + imidacloprid (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123391#pone.0123391.g001\" target=\"_blank\">Fig. 1</a> for treatment abbreviations). Kruskal-Wallis (K-W) test statistics are shown indicating significance of the whole model. Bars with the same letters (a,b,c) are not different by Mann-Whitney U-tests (p<0.05).</p>", "links"=>[], "tags"=>["Termite Gut", "mix", "metatranscriptome composition", "findings point", "antimicrobial defenses", "insect colonies", "eusocial insect group", "imidacloprid", "gut", "sublethal doses", "symbiont community", "synergy", "Particular focus", "bacteria", "termites", "novel insights", "entomopathogen", "nicotinoid insecticides", "defense mechanisms", "protist dysbiosis", "pathogen", "protist symbiont oligonucleotides", "Serratia marcescens", "cDNA microarrays", "challenge", "protist gene expression", "termite Reticulitermes flavipes", "fungi", "Molecular Signatures"], "article_id"=>1366071, "categories"=>["Biological Sciences"], "users"=>["Ruchira Sen", "Rhitoban Raychoudhury", "Yunpeng Cai", "Yijun Sun", "Verena-Ulrike Lietze", "Brittany F. Peterson", "Michael E. Scharf", "Drion G. Boucias"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0123391.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bioassay_mortality_after_7_day_exposures_to_six_treatments_/1366071", "title"=>"Bioassay mortality after 7 day exposures to six treatments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-02 15:03:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003548"], "description"=>"<p>Red and blue spots indicate significant upregulated and downregulated array positions with +/- 2-fold change (FC) upregulation and downregulation, respectively.</p>", "links"=>[], "tags"=>["Termite Gut", "mix", "metatranscriptome composition", "findings point", "antimicrobial defenses", "insect colonies", "eusocial insect group", "imidacloprid", "gut", "sublethal doses", "symbiont community", "synergy", "Particular focus", "bacteria", "termites", "novel insights", "entomopathogen", "nicotinoid insecticides", "defense mechanisms", "protist dysbiosis", "pathogen", "protist symbiont oligonucleotides", "Serratia marcescens", "cDNA microarrays", "challenge", "protist gene expression", "termite Reticulitermes flavipes", "fungi", "Molecular Signatures"], "article_id"=>1366072, "categories"=>["Biological Sciences"], "users"=>["Ruchira Sen", "Rhitoban Raychoudhury", "Yunpeng Cai", "Yijun Sun", "Verena-Ulrike Lietze", "Brittany F. Peterson", "Michael E. Scharf", "Drion G. Boucias"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0123391.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microarray_volcano_plots_showing_differing_numbers_of_passing_array_positions_in_F_fungi_I_imidacloprid_B_bacteria_F_I_fungus_imidacloprid_B_I_bacteria_imidacloprid_treatments_/1366072", "title"=>"Microarray volcano plots showing differing numbers of passing array positions in F (fungi), I (imidacloprid), B (bacteria), F+I (fungus + imidacloprid), B+I (bacteria + imidacloprid) treatments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-02 15:03:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003549"], "description"=>"<p>Overall, greater numbers of host genes were upregulated and symbiont genes were downregulated by the various treatments. “Mixed” refers to genes that were sampled from both host and symbiont libraries.</p><p>Summary table showing up- and downregulated contigs and “singletons” from host and symbiont in each treatment category (F, B, I, F+I and B+I).</p>", "links"=>[], "tags"=>["Termite Gut", "mix", "metatranscriptome composition", "findings point", "antimicrobial defenses", "insect colonies", "eusocial insect group", "imidacloprid", "gut", "sublethal doses", "symbiont community", "synergy", "Particular focus", "bacteria", "termites", "novel insights", "entomopathogen", "nicotinoid insecticides", "defense mechanisms", "protist dysbiosis", "pathogen", "protist symbiont oligonucleotides", "Serratia marcescens", "cDNA microarrays", "challenge", "protist gene expression", "termite Reticulitermes flavipes", "fungi", "Molecular Signatures"], "article_id"=>1366073, "categories"=>["Biological Sciences"], "users"=>["Ruchira Sen", "Rhitoban Raychoudhury", "Yunpeng Cai", "Yijun Sun", "Verena-Ulrike Lietze", "Brittany F. Peterson", "Michael E. Scharf", "Drion G. Boucias"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0123391.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_table_showing_up_and_downregulated_contigs_and_8220_singletons_8221_from_host_and_symbiont_in_each_treatment_category_F_B_I_F_I_and_B_I_/1366073", "title"=>"Summary table showing up- and downregulated contigs and “singletons” from host and symbiont in each treatment category (F, B, I, F+I and B+I).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-02 15:03:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/2003555", "https://ndownloader.figshare.com/files/2003556", "https://ndownloader.figshare.com/files/2003557", "https://ndownloader.figshare.com/files/2003558", "https://ndownloader.figshare.com/files/2003559", "https://ndownloader.figshare.com/files/2003560", "https://ndownloader.figshare.com/files/2003561", "https://ndownloader.figshare.com/files/2003562", "https://ndownloader.figshare.com/files/2003563", "https://ndownloader.figshare.com/files/2003564", "https://ndownloader.figshare.com/files/2003565", "https://ndownloader.figshare.com/files/2003566", "https://ndownloader.figshare.com/files/2003567", "https://ndownloader.figshare.com/files/2003568", "https://ndownloader.figshare.com/files/2003569", "https://ndownloader.figshare.com/files/2003570", "https://ndownloader.figshare.com/files/2003571", "https://ndownloader.figshare.com/files/2003572", "https://ndownloader.figshare.com/files/2003573", "https://ndownloader.figshare.com/files/2003574", "https://ndownloader.figshare.com/files/2003575", "https://ndownloader.figshare.com/files/2003576", "https://ndownloader.figshare.com/files/2003577", "https://ndownloader.figshare.com/files/2003578", "https://ndownloader.figshare.com/files/2003579", "https://ndownloader.figshare.com/files/2003580", "https://ndownloader.figshare.com/files/2003581", "https://ndownloader.figshare.com/files/2003582"], "description"=>"<div><p>Previous studies in lower termites revealed unexpected synergies between nicotinoid insecticides and fungal entomopathogens. The present study investigated molecular mechanisms of nicotinoid-pathogen synergy in the lower termite <i>Reticulitermes flavipes</i>, using the nicotinoid, imidacloprid, in combination with fungal and bacterial entomopathogens. Particular focus was placed on metatranscriptome composition and microbial dynamics in the symbiont-rich termite gut, which houses diverse mixes of protists and bacteria. cDNA microarrays containing a mix of host and protist symbiont oligonucleotides were used to simultaneously assess termite and protist gene expression. Five treatments were compared that included single challenges with sublethal doses of fungi (<i>Metharizium anisopliae</i>), bacteria (<i>Serratia marcescens</i>) or imidacloprid, and dual challenges with fungi + imidacloprid or bacteria + imidacloprid. Our findings point towards protist dysbiosis and compromised social behavior, rather than suppression of stereotypical immune defense mechanisms, as the dominant factors underlying nicotinoid-pathogen synergy in termites. Also, greater impacts observed for the fungal pathogen than for the bacterial pathogen suggest that the rich bacterial symbiont community in the <i>R</i>. <i>flavipes</i> gut (>5000 species-level phylotypes) exists in an ecological balance that effectively excludes exogenous bacterial pathogens. These findings significantly advance our understanding of antimicrobial defenses in this important eusocial insect group, as well as provide novel insights into how nicotinoids can exert deleterious effects on social insect colonies.</p></div>", "links"=>[], "tags"=>["Termite Gut", "mix", "metatranscriptome composition", "findings point", "antimicrobial defenses", "insect colonies", "eusocial insect group", "imidacloprid", "gut", "sublethal doses", "symbiont community", "synergy", "Particular focus", "bacteria", "termites", "novel insights", "entomopathogen", "nicotinoid insecticides", "defense mechanisms", "protist dysbiosis", "pathogen", "protist symbiont oligonucleotides", "Serratia marcescens", "cDNA microarrays", "challenge", "protist gene expression", "termite Reticulitermes flavipes", "fungi", "Molecular Signatures"], "article_id"=>1366079, "categories"=>["Biological Sciences"], "users"=>["Ruchira Sen", "Rhitoban Raychoudhury", "Yunpeng Cai", "Yijun Sun", "Verena-Ulrike Lietze", "Brittany F. Peterson", "Michael E. Scharf", "Drion G. Boucias"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0123391.s001", "https://dx.doi.org/10.1371/journal.pone.0123391.s002", "https://dx.doi.org/10.1371/journal.pone.0123391.s003", "https://dx.doi.org/10.1371/journal.pone.0123391.s004", "https://dx.doi.org/10.1371/journal.pone.0123391.s005", "https://dx.doi.org/10.1371/journal.pone.0123391.s006", "https://dx.doi.org/10.1371/journal.pone.0123391.s007", "https://dx.doi.org/10.1371/journal.pone.0123391.s008", "https://dx.doi.org/10.1371/journal.pone.0123391.s009", "https://dx.doi.org/10.1371/journal.pone.0123391.s010", "https://dx.doi.org/10.1371/journal.pone.0123391.s011", "https://dx.doi.org/10.1371/journal.pone.0123391.s012", "https://dx.doi.org/10.1371/journal.pone.0123391.s013", "https://dx.doi.org/10.1371/journal.pone.0123391.s014", "https://dx.doi.org/10.1371/journal.pone.0123391.s015", "https://dx.doi.org/10.1371/journal.pone.0123391.s016", "https://dx.doi.org/10.1371/journal.pone.0123391.s017", "https://dx.doi.org/10.1371/journal.pone.0123391.s018", "https://dx.doi.org/10.1371/journal.pone.0123391.s019", "https://dx.doi.org/10.1371/journal.pone.0123391.s020", "https://dx.doi.org/10.1371/journal.pone.0123391.s021", "https://dx.doi.org/10.1371/journal.pone.0123391.s022", "https://dx.doi.org/10.1371/journal.pone.0123391.s023", "https://dx.doi.org/10.1371/journal.pone.0123391.s024", "https://dx.doi.org/10.1371/journal.pone.0123391.s025", "https://dx.doi.org/10.1371/journal.pone.0123391.s026", "https://dx.doi.org/10.1371/journal.pone.0123391.s027", "https://dx.doi.org/10.1371/journal.pone.0123391.s028"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Molecular_Signatures_of_Nicotinoid_Pathogen_Synergy_in_the_Termite_Gut_/1366079", "title"=>"Molecular Signatures of Nicotinoid-Pathogen Synergy in the Termite Gut", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-04-02 15:03:25"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"27", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"34", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"28", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
Loading … Spinner
There are currently no alerts