An Exploratory Study on 99mTc-RGD-BBN Peptide Scintimammography in the Assessment of Breast Malignant Lesions Compared to 99mTc-3P4-RGD2
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{"title"=>"An exploratory study on<sup>99m</sup>Tc-RGD-BBN peptide scintimammography in the assessment of breast malignant lesions compared to<sup>99m</sup>Tc-3P4-RGD2", "type"=>"journal", "authors"=>[{"first_name"=>"Qianqian", "last_name"=>"Chen", "scopus_author_id"=>"56590837500"}, {"first_name"=>"Qingjie", "last_name"=>"Ma", "scopus_author_id"=>"7402815829"}, {"first_name"=>"Minglong", "last_name"=>"Chen", "scopus_author_id"=>"56590759300"}, {"first_name"=>"Bin", "last_name"=>"Chen", "scopus_author_id"=>"55807231900"}, {"first_name"=>"Qiang", "last_name"=>"Wen", "scopus_author_id"=>"36549558600"}, {"first_name"=>"Bing", "last_name"=>"Jia", "scopus_author_id"=>"25947472400"}, {"first_name"=>"Fan", "last_name"=>"Wang", "scopus_author_id"=>"55569060100"}, {"first_name"=>"Butong", "last_name"=>"Sun", "scopus_author_id"=>"56591114900"}, {"first_name"=>"Shi", "last_name"=>"Gao", "scopus_author_id"=>"35215158300"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"603666445", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0123401", "scopus"=>"2-s2.0-84927590158", "sgr"=>"84927590158"}, "id"=>"8089bb66-818e-3a63-99b2-c42ccd89041f", "abstract"=>"Purpose: This study aimed to explore the diagnostic performance of single photon emission computed tomography / computerized tomography (SPECT/CT) using a new radiotracer <sup>99m</sup>Tc-RGD-BBN for breast malignant tumor compared with <sup>99m</sup>Tc-3P4-RGD<inf>2</inf>. Methods: 6 female patients with breastmalignant tumors diagnosed by fine needle aspiration cytology biopsy (FNAB) who were scheduled to undergo surgery were included in the study. <sup>99m</sup>Tc-3P4-RGD<inf>2</inf> and <sup>99m</sup>Tc-RGD-BBN were performed with single photon emission computed tomography (SPECT) at 1 hour after intravenous injection of 299 ± 30 MBq and 293 ± 32 MBq of radiotracers respectively at separate day. The results were evaluated by the Tumor to non-Tumor ratios (T/NT). <sup>99m</sup>Tc-RGD-BBN and <sup>99m</sup>Tc-3P4-RGD<inf>2</inf> SPECT/CT images were interpreted independently by 3 experienced nuclear medicine physicians using a 3-point scale system. All of the samples were analyzed immunohistochemically to evaluate the integrin αvβ3 and gastrin-releasing peptide receptor (GRPR) expression. The safety, biodistribution and radiation dosimetry of <sup>99m</sup>Tc-RGD-BBN were also evaluated in the healthy volunteers. Results: No serious adverse events were reported in any of the patients during the study. The effective radiation dose entirely conformed to the relevant standards. A total of 6 palpable malignant lesions were detected using <sup>99m</sup>Tc-RGD-BBN SPECT/CT with clear uptake. All malignant lesions were also detected using <sup>99m</sup>Tc-3P4-RGD<inf>2</inf> SPECT/CT. The results showed that five malignant lesions were with clear uptake and the other one with barely an uptake. 4 malignant cases were found with both αvβ3 and GRPR expression, 1 case with only GRPR positive expression (integrin αvβ3 negative) and 1 case with only integrin αvβ3 positive expression (GRPR negative). Conclusion: <sup>99m</sup>Tc-RGD-BBN is a safe agent for detecting breast cancer. <sup>99m</sup>Tc-RGD-BBN may have the potential to make up for the deficiency of <sup>99m</sup>Tc-3P4-RGD<inf>2</inf> in the detection of breast cancer with only GRPR positive expression (integrin α<inf>v</inf>β<inf>3</inf> negative). The preliminary application of <sup>99m</sup>Tc-RGD-BBN has demonstrated its powerful potential in breast cancer diagnosis and therapy.", "link"=>"http://www.mendeley.com/research/exploratory-study-onsup99msuptcrgdbbn-peptide-scintimammography-assessment-breast-malignant-lesions", "reader_count"=>2, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}}, "group_count"=>0}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/2008386"], "description"=>"<p>(b) CT scan demonstrates a mass in the right breast. (c) <sup>99m</sup>Tc-RGD-BN SMM demonstrates high uptake observed in the lesion. (d) Histopathology staining indicated a ductal carcinoma in situ. ×40 (e) Immunohistochemistry demonstrates barely α<sub>v</sub>β<sub>3</sub> expression in tumor vessels and tumor cells. ×400. (f) Immunohistochemistry demonstrates intense GRPR expression in tumor vessels and tumor cells. ×400.</p>", "links"=>[], "tags"=>["uptake", "photon emission", "breast cancer diagnosis", "needle aspiration cytology biopsy", "1 case", "expression", "mtc", "integrin", "fnab", "breast cancer", "Breast Malignant Lesions", "tomography", "lesion", "grpr", "spect"], "article_id"=>1370034, "categories"=>["Biological Sciences"], "users"=>["Qianqian Chen", "Qingjie Ma", "Minglong Chen", "Bin Chen", "Qiang Wen", "Bing Jia", "Fan Wang", "Butong Sun", "Shi Gao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123401.g006", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_51_y_old_patient_with_a_breast_malignant_tumor_in_the_right_side_as_Patient_1_in_Table_3_a_99m_Tc_3P4_RGD_2_SMM_demonstrates_no_tracer_uptake_observed_in_the_lesion_/1370034", "title"=>"A 51-y-old patient with a breast malignant tumor in the right side as Patient 1 in Table 3; (a) <sup>99m</sup>Tc-3P4-RGD<sub>2</sub> SMM demonstrates no tracer uptake observed in the lesion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-07 04:36:44"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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