Theta, Mental Flexibility, and Post-Traumatic Stress Disorder: Connecting in the Parietal Cortex
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{"title"=>"Theta, mental flexibility, and post-traumatic stress disorder: Connecting in the parietal cortex", "type"=>"journal", "authors"=>[{"first_name"=>"Benjamin T.", "last_name"=>"Dunkley", "scopus_author_id"=>"54399987600"}, {"first_name"=>"Paul A.", "last_name"=>"Sedge", "scopus_author_id"=>"56367526000"}, {"first_name"=>"Sam M.", "last_name"=>"Doesburg", "scopus_author_id"=>"8721433400"}, {"first_name"=>"Richard J.", "last_name"=>"Grodecki", "scopus_author_id"=>"56367713500"}, {"first_name"=>"Rakesh", "last_name"=>"Jetly", "scopus_author_id"=>"36164177000"}, {"first_name"=>"Pang N.", "last_name"=>"Shek", "scopus_author_id"=>"7006158686"}, {"first_name"=>"Margot J.", "last_name"=>"Taylor", "scopus_author_id"=>"7406239195"}, {"first_name"=>"Elizabeth W.", "last_name"=>"Pang", "scopus_author_id"=>"7005496578"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"604371937", "sgr"=>"84929380126", "issn"=>"19326203", "pmid"=>"25909654", "scopus"=>"2-s2.0-84929380126", "doi"=>"10.1371/journal.pone.0123541", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"2b1631c0-18d6-3f50-ba0e-c6c22d43ab5b", "abstract"=>"Post-traumatic stress disorder (PTSD) is a mental health injury characterised by re-experiencing, avoidance, numbing and hyperarousal. Whilst the aetiology of the disorder is relatively well understood, there is debate about the prevalence of cognitive sequelae that manifest in PTSD. In particular, there are conflicting reports about deficits in executive function and mental flexibility. Even less is known about the neural changes that underlie such deficits. Here, we used magnetoencephalography to study differences in functional connectivity during a mental flexibility task in combat-related PTSD (all males, mean age = 37.4, n = 18) versus a military control (all males, mean age = 33.05, n = 19) group. We observed large-scale increases in theta connectivity in the PTSD group compared to controls. The PTSD group performance was compromised in the more attentionally-demanding task and this was characterised by 'late-stage' theta hyperconnectivity, concentrated in network connections involving right parietal cortex. Furthermore, we observed significant correlations with the connectivity strength in this region with a number of cognitive-behavioural outcomes, including measures of attention, depression and anxiety. These findings suggest atypical coordination of neural synchronisation in large scale networks contributes to deficits in mental flexibility for PTSD populations in timed, attentionally-demanding tasks, and this propensity toward network hyperconnectivity may play a more general role in the cognitive sequelae evident in this disorder.", "link"=>"http://www.mendeley.com/research/theta-mental-flexibility-posttraumatic-stress-disorder-connecting-parietal-cortex", "reader_count"=>38, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>2, "Student > Master"=>9, "Other"=>5, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>2, "Student > Master"=>9, "Other"=>5, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>2, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>4, "Neuroscience"=>7, "Philosophy"=>1, "Sports and Recreations"=>1, "Psychology"=>7, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>7}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Unspecified"=>{"Unspecified"=>5}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Denmark"=>1, "Australia"=>2, "France"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2039089"], "description"=>"<p>There were no differences between-groups for reaction time, although RT was longer for the Extra compared to Intra-dimensional shifts. No significant differences were observed between the groups for accuracy in the Intra-dimensional shifts; however, the PTSD group had significantly poorer performance in the Extra-dimensional set-shifting task (*<i>p</i><0.05).</p>", "links"=>[], "tags"=>["scale networks", "PTSD populations", "theta connectivity", "network hyperconnectivity", "disorder", "network connections", "right parietal cortex", "PTSD group", "flexibility task", "connectivity strength", "theta hyperconnectivity", "PTSD group performance", "health injury characterised", "study differences", "executive function", "Mental Flexibility"], "article_id"=>1393865, "categories"=>["Biological Sciences"], "users"=>["Benjamin T. Dunkley", "Paul A. Sedge", "Sam M. Doesburg", "Richard J. Grodecki", "Rakesh Jetly", "Pang N. Shek", "Margot J. Taylor", "Elizabeth W. Pang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123541.g001", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_behavioural_results_reaction_time_and_accuracy_in_the_Intra_and_Extra_Dimensional_set_shifting_tasks_for_PTSD_and_control_soldiers_with_177_1_SE_bars_/1393865", "title"=>"Mean behavioural results (reaction time and accuracy) in the Intra and Extra-Dimensional set-shifting tasks for PTSD and control soldiers, with ±1 SE bars.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-24 03:15:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2039090"], "description"=>"<p>ADHD Index subscores on the Conners test correlates with Extra-dimensional set-shifting task accuracy for the PTSD group (<i>p</i><0.05), but not for the Control group (<i>p</i>>0.05).</p>", "links"=>[], "tags"=>["scale networks", "PTSD populations", "theta connectivity", "network hyperconnectivity", "disorder", "network connections", "right parietal cortex", "PTSD group", "flexibility task", "connectivity strength", "theta hyperconnectivity", "PTSD group performance", "health injury characterised", "study differences", "executive function", "Mental Flexibility"], "article_id"=>1393866, "categories"=>["Biological Sciences"], "users"=>["Benjamin T. Dunkley", "Paul A. Sedge", "Sam M. Doesburg", "Richard J. Grodecki", "Rakesh Jetly", "Pang N. Shek", "Margot J. Taylor", "Elizabeth W. Pang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123541.g002", "stats"=>{"downloads"=>2, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ADHD_Index_subscores_on_the_Conners_test_correlates_with_Extra_dimensional_set_shifting_task_accuracy_for_the_PTSD_group_p_p_0_05_/1393866", "title"=>"ADHD Index subscores on the Conners test correlates with Extra-dimensional set-shifting task accuracy for the PTSD group (<i>p</i><0.05), but not for the Control group (<i>p</i>>0.05).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-24 03:15:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2039091"], "description"=>"<p><b>(A)</b> The PTSD group show elevated whole-brain theta coherence during the Intra-dimensional task (<i>top left panel</i>), particularly in the 100–300ms time window, which is evident in the regional connectivity maps below (<b>B;</b> all maps PTSD > control). In the Extra-dimensional set shifting task, the groups do not differ until the 300–400 ms time-window, when the PTSD show high-degree node differences, particularly in the right superior parietal lobule connecting to the right temporal and left frontal regions.</p>", "links"=>[], "tags"=>["scale networks", "PTSD populations", "theta connectivity", "network hyperconnectivity", "disorder", "network connections", "right parietal cortex", "PTSD group", "flexibility task", "connectivity strength", "theta hyperconnectivity", "PTSD group performance", "health injury characterised", "study differences", "executive function", "Mental Flexibility"], "article_id"=>1393867, "categories"=>["Biological Sciences"], "users"=>["Benjamin T. Dunkley", "Paul A. Sedge", "Sam M. Doesburg", "Richard J. Grodecki", "Rakesh Jetly", "Pang N. Shek", "Margot J. Taylor", "Elizabeth W. Pang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123541.g003", "stats"=>{"downloads"=>3, "page_views"=>39, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Whole_brain_theta_connectivity_time_series_and_the_temporal_evolution_of_functional_network_differences_between_PTSD_and_control_groups_/1393867", "title"=>"Whole-brain theta connectivity time-series and the temporal evolution of functional network differences between PTSD and control groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-24 03:15:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2039092"], "description"=>"<p>The PTSD group show no significant correlation of theta strength with reaction time (<i>bottom left panel</i>) in the 100–300 ms time-window, whilst there is a strong significant correlation in the control group (<i>bottom right panel</i>). Connectivity time-series were baselined against the -200–0 ms time window and smoothed using a 50 ms moving-average for visualisation purposes; all further analyses were conducted on unsmoothed connectivity time-series.</p>", "links"=>[], "tags"=>["scale networks", "PTSD populations", "theta connectivity", "network hyperconnectivity", "disorder", "network connections", "right parietal cortex", "PTSD group", "flexibility task", "connectivity strength", "theta hyperconnectivity", "PTSD group performance", "health injury characterised", "study differences", "executive function", "Mental Flexibility"], "article_id"=>1393868, "categories"=>["Biological Sciences"], "users"=>["Benjamin T. Dunkley", "Paul A. Sedge", "Sam M. Doesburg", "Richard J. Grodecki", "Rakesh Jetly", "Pang N. Shek", "Margot J. Taylor", "Elizabeth W. Pang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123541.g004", "stats"=>{"downloads"=>2, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Atypical_network_theta_connectivity_in_the_right_superior_parietal_cortex_seed_A_B_and_reaction_time_correlations_in_the_Extra_Dimensional_task_C_/1393868", "title"=>"Atypical network theta connectivity in the right superior parietal cortex seed (A, B), and reaction time correlations in the Extra-Dimensional task (C).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-24 03:15:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2039093"], "description"=>"<p><b>(A)</b> Scatterplot showing a significant positive correlation between right superior parietal lobule theta connectivity strength <i>within</i> the hyperconnected network component during the more difficult Extra-dimensional set-shifting task in the 100–300 ms time window versus Conners ADHD test score, at the combined group level. <b>(B)</b> Same as before, but for the GAD7, <b>(C)</b> and for the PHQ9.</p>", "links"=>[], "tags"=>["scale networks", "PTSD populations", "theta connectivity", "network hyperconnectivity", "disorder", "network connections", "right parietal cortex", "PTSD group", "flexibility task", "connectivity strength", "theta hyperconnectivity", "PTSD group performance", "health injury characterised", "study differences", "executive function", "Mental Flexibility"], "article_id"=>1393869, "categories"=>["Biological Sciences"], "users"=>["Benjamin T. Dunkley", "Paul A. Sedge", "Sam M. Doesburg", "Richard J. Grodecki", "Rakesh Jetly", "Pang N. Shek", "Margot J. Taylor", "Elizabeth W. Pang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123541.g005", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Right_parietal_theta_in_the_Extra_dimensional_task_correlates_with_combined_group_cognitive_assessment_in_the_Conners_ADHD_GAD7_and_PHQ9_test_scores_/1393869", "title"=>"Right parietal theta in the Extra-dimensional task correlates with combined group cognitive assessment in the Conners ADHD, GAD7 and PHQ9 test scores.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-04-24 03:15:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2039094"], "description"=>"<p>WASI, <i>Wechsler Abbreviated Scale of Intelligence</i>; AUDIT, <i>Alcohol Use Disorders Identification Test;</i> Conners, <i>Attention-Deficit Hyperactivity Disorder Test;</i> GAD-7, <i>Generalized Anxiety Disorder 7;</i> PHQ9, <i>Patient Health Questionnaire;</i> PCL, <i>Post Traumatic Stress Disorder Check List</i>.</p><p>Cognitive-behavioural test measures for PTSD and Control groups, with SD in parentheses, and inferential tests, with <i>df</i> in parentheses.</p>", "links"=>[], "tags"=>["scale networks", "PTSD populations", "theta connectivity", "network hyperconnectivity", "disorder", "network connections", "right parietal cortex", "PTSD group", "flexibility task", "connectivity strength", "theta hyperconnectivity", "PTSD group performance", "health injury characterised", "study differences", "executive function", "Mental Flexibility"], "article_id"=>1393870, "categories"=>["Biological Sciences"], "users"=>["Benjamin T. Dunkley", "Paul A. Sedge", "Sam M. Doesburg", "Richard J. Grodecki", "Rakesh Jetly", "Pang N. Shek", "Margot J. Taylor", "Elizabeth W. Pang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0123541.t001", "stats"=>{"downloads"=>5, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cognitive_behavioural_test_measures_for_PTSD_and_Control_groups_with_SD_in_parentheses_and_inferential_tests_with_df_in_parentheses_/1393870", "title"=>"Cognitive-behavioural test measures for PTSD and Control groups, with SD in parentheses, and inferential tests, with <i>df</i> in parentheses.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-24 03:15:39"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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