Effect of Mesenchymal Precursor Cells on the Systemic Inflammatory Response and Endothelial Dysfunction in an Ovine Model of Collagen-Induced Arthritis
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{"title"=>"Effect of mesenchymal precursor cells on the systemic inflammatory response and endothelial dysfunction in an ovine model of collagen-induced arthritis", "type"=>"journal", "authors"=>[{"first_name"=>"Laura M.", "last_name"=>"Dooley", "scopus_author_id"=>"56059199900"}, {"first_name"=>"Anwar", "last_name"=>"Abdalmula", "scopus_author_id"=>"56059331200"}, {"first_name"=>"Elizabeth A.", "last_name"=>"Washington", "scopus_author_id"=>"7004161544"}, {"first_name"=>"Claire", "last_name"=>"Kaufman", "scopus_author_id"=>"56637929400"}, {"first_name"=>"Elizabeth M.", "last_name"=>"Tudor", "scopus_author_id"=>"8559393200"}, {"first_name"=>"Peter", "last_name"=>"Ghosh", "scopus_author_id"=>"7402072756"}, {"first_name"=>"Silviu", "last_name"=>"Itescu", "scopus_author_id"=>"55694378800"}, {"first_name"=>"Wayne G.", "last_name"=>"Kimpton", "scopus_author_id"=>"7003751419"}, {"first_name"=>"Simon R.", "last_name"=>"Bailey", "scopus_author_id"=>"7401729812"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84929120202", "pui"=>"604276396", "doi"=>"10.1371/journal.pone.0124144", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84929120202", "pmid"=>"25950840"}, "id"=>"5db6d49f-5b10-33c6-8116-f8c57a18a458", "abstract"=>"BACKGROUND AND AIM: Mesenchymal precursor cells (MPC) are reported to possess immunomodulatory properties that may prove beneficial in autoimmune and other inflammatory conditions. However, their mechanism of action is poorly understood. A collagen-induced arthritis model has been previously developed which demonstrates local joint inflammation and systemic inflammatory changes. These include not only increased levels of inflammatory markers, but also vascular endothelial cell dysfunction, characterised by reduced endothelium-dependent vasodilation. This study aimed to characterise the changes in systemic inflammatory markers and endothelial function following the intravenous administration of MPC, in the ovine model.\\n\\nMETHODS: Arthritis was induced in sixteen adult sheep by administration of bovine type II collagen into the hock joint following initial sensitisation. After 24h, sheep were administered either 150 million allogeneic ovine MPCs intravenously, or saline only. Fibrinogen and serum amyloid-A were measured in plasma to assess systemic inflammation, along with pro-inflammatory and anti-inflammatory cytokines. Animals were necropsied two weeks following arthritis induction. Coronary and digital arterial segments were mounted in a Mulvaney-Halpern wire myograph. The relaxant response to endothelium-dependent and endothelium-independent vasodilators was used to assess endothelial dysfunction.\\n\\nRESULTS AND CONCLUSION: Arthritic sheep treated with MPC demonstrated a marked spike in plasma IL-10, 24h following MPC administration. They also showed significantly reduced plasma levels of the inflammatory markers, fibrinogen and serum amyloid A, and increased HDL. Coronary arteries from RA sheep treated with MPCs demonstrated a significantly greater maximal relaxation to bradykinin when compared to untreated RA sheep (253.6 ± 17.1% of pre-contracted tone vs. 182.3 ± 27.3% in controls), and digital arteries also demonstrated greater endothelium-dependent vasodilation. This study demonstrated that MPCs given intravenously are able to attenuate systemic inflammatory changes associated with a monoarthritis, including the development of endothelial dysfunction.", "link"=>"http://www.mendeley.com/research/effect-mesenchymal-precursor-cells-systemic-inflammatory-response-endothelial-dysfunction-ovine-mode-1", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Other"=>2, "Student > Master"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Other"=>2, "Student > Master"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>7, "Veterinary Science and Veterinary Medicine"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Turkey"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2059086"], "description"=>"<p>Arterial rings were contracted with endothelin-1, and relaxation responses to cumulatively increasing concentrations of (A) Bradykinin (BK), (B) Sodium nitroprusside (SNP), were expressed as a percentage relaxation of pre-contracted tone. Each point represents the mean ±SEM from 8 animals. * Indicates statistically significant difference (p < 0.05) in the maximum response for the dilation to bradykinin between treated and untreated animals (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124144#pone.0124144.t001\" target=\"_blank\">Table 1</a>).</p>", "links"=>[], "tags"=>["allogeneic ovine MPCs", "AimMesenchymal precursor cells", "ovine model.MethodsArthritis", "ovine model", "RA sheep", "Coronary Arteries", "type II collagen", "arthritis induction", "mesenchymal precursor cells", "marker", "adult sheep", "ConclusionArthritic sheep", "relaxant response", "MPC administration", "serum amyloid", "hdl", "immunomodulatory properties", "24 h", "cell dysfunction", "Endothelial Dysfunction", "il", "plasma levels"], "article_id"=>1407888, "categories"=>["Biological Sciences"], "users"=>["Laura M. Dooley", "Anwar Abdalmula", "Elizabeth A. Washington", "Claire Kaufman", "Elizabeth M. Tudor", "Peter Ghosh", "Silviu Itescu", "Wayne G. Kimpton", "Simon R. Bailey"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124144.g003", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_vasorelaxation_in_ovine_coronary_arteries_in_arthritic_sheep_treated_and_untreated_with_mesenchymal_precursor_cells_MPC_/1407888", "title"=>"Comparison of vasorelaxation in ovine coronary arteries in arthritic sheep treated and untreated with mesenchymal precursor cells (MPC).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-07 03:15:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/2059088"], "description"=>"<p>Arterial rings were contracted with 5-hydroxytryptamine (5-HT), and relaxation responses to cumulatively increasing concentrations of (A) Carbachol and (B) Sodium Nitroprusside (SNP) were expressed as a percentage relaxation of pre-contracted tone. Each point represents the mean ±SEM from 7–8 animals. * Indicates statistically significant difference (p < 0.05) in the maximum response for the dilation to carbachol between treated and untreated animals (See <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124144#pone.0124144.t002\" target=\"_blank\">Table 2</a>).</p>", "links"=>[], "tags"=>["allogeneic ovine MPCs", "AimMesenchymal precursor cells", "ovine model.MethodsArthritis", "ovine model", "RA sheep", "Coronary Arteries", "type II collagen", "arthritis induction", "mesenchymal precursor cells", "marker", "adult sheep", "ConclusionArthritic sheep", "relaxant response", "MPC administration", "serum amyloid", "hdl", "immunomodulatory properties", "24 h", "cell dysfunction", "Endothelial Dysfunction", "il", "plasma levels"], "article_id"=>1407890, "categories"=>["Biological Sciences"], "users"=>["Laura M. Dooley", "Anwar Abdalmula", "Elizabeth A. Washington", "Claire Kaufman", "Elizabeth M. Tudor", "Peter Ghosh", "Silviu Itescu", "Wayne G. Kimpton", "Simon R. Bailey"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124144.g004", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_vasorelaxation_in_ovine_digital_arteries_in_arthritic_sheep_treated_and_untreated_with_mesenchymal_precursor_cells_MPC_/1407890", "title"=>"Comparison of vasorelaxation in ovine digital arteries in arthritic sheep treated and untreated with mesenchymal precursor cells (MPC).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-07 03:15:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/2059089"], "description"=>"<p>* Indicates significant difference between groups; unpaired <i>t</i>-test. SNP, sodium nitroprusside.</p><p>EC<sub>50</sub> values and maximum responses derived from arthritic sheep coronary artery responses, showing the effect of mesenchymal precursor cell treatment on dilation caused by endothelium-dependent and-independent vasodilators.</p>", "links"=>[], "tags"=>["allogeneic ovine MPCs", "AimMesenchymal precursor cells", "ovine model.MethodsArthritis", "ovine model", "RA sheep", "Coronary Arteries", "type II collagen", "arthritis induction", "mesenchymal precursor cells", "marker", "adult sheep", "ConclusionArthritic sheep", "relaxant response", "MPC administration", "serum amyloid", "hdl", "immunomodulatory properties", "24 h", "cell dysfunction", "Endothelial Dysfunction", "il", "plasma levels"], "article_id"=>1407891, "categories"=>["Biological Sciences"], "users"=>["Laura M. Dooley", "Anwar Abdalmula", "Elizabeth A. Washington", "Claire Kaufman", "Elizabeth M. Tudor", "Peter Ghosh", "Silviu Itescu", "Wayne G. Kimpton", "Simon R. Bailey"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124144.t001", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_EC_50_values_and_maximum_responses_derived_from_arthritic_sheep_coronary_artery_responses_showing_the_effect_of_mesenchymal_precursor_cell_treatment_on_dilation_caused_by_endothelium_dependent_and_independent_vasodilators_/1407891", "title"=>"EC<sub>50</sub> values and maximum responses derived from arthritic sheep coronary artery responses, showing the effect of mesenchymal precursor cell treatment on dilation caused by endothelium-dependent and-independent vasodilators.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-07 03:15:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/2059090"], "description"=>"<p>* Indicates significant difference between groups; unpaired <i>t</i>-test. SNP, sodium nitroprusside.</p><p>EC<sub>50</sub> values and maximum responses derived from arthritic sheep digital artery responses, showing the effect of mesenchymal precursor cell treatment on dilation caused by endothelium-dependent and-independent vasodilators.</p>", "links"=>[], "tags"=>["allogeneic ovine MPCs", "AimMesenchymal precursor cells", "ovine model.MethodsArthritis", "ovine model", "RA sheep", "Coronary Arteries", "type II collagen", "arthritis induction", "mesenchymal precursor cells", "marker", "adult sheep", "ConclusionArthritic sheep", "relaxant response", "MPC administration", "serum amyloid", "hdl", "immunomodulatory properties", "24 h", "cell dysfunction", "Endothelial Dysfunction", "il", "plasma levels"], "article_id"=>1407892, "categories"=>["Biological Sciences"], "users"=>["Laura M. Dooley", "Anwar Abdalmula", "Elizabeth A. Washington", "Claire Kaufman", "Elizabeth M. Tudor", "Peter Ghosh", "Silviu Itescu", "Wayne G. Kimpton", "Simon R. Bailey"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124144.t002", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_EC_50_values_and_maximum_responses_derived_from_arthritic_sheep_digital_artery_responses_showing_the_effect_of_mesenchymal_precursor_cell_treatment_on_dilation_caused_by_endothelium_dependent_and_independent_vasodilators_/1407892", "title"=>"EC<sub>50</sub> values and maximum responses derived from arthritic sheep digital artery responses, showing the effect of mesenchymal precursor cell treatment on dilation caused by endothelium-dependent and-independent vasodilators.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-07 03:15:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/2059083"], "description"=>"<p>Each point represents the mean ± SEM of 7–8 sheep.**** Indicates a statistically significant difference between groups at that time point, p ≤ 0.0001.</p>", "links"=>[], "tags"=>["allogeneic ovine MPCs", "AimMesenchymal precursor cells", "ovine model.MethodsArthritis", "ovine model", "RA sheep", "Coronary Arteries", "type II collagen", "arthritis induction", "mesenchymal precursor cells", "marker", "adult sheep", "ConclusionArthritic sheep", "relaxant response", "MPC administration", "serum amyloid", "hdl", "immunomodulatory properties", "24 h", "cell dysfunction", "Endothelial Dysfunction", "il", "plasma levels"], "article_id"=>1407885, "categories"=>["Biological Sciences"], "users"=>["Laura M. Dooley", "Anwar Abdalmula", "Elizabeth A. Washington", "Claire Kaufman", "Elizabeth M. Tudor", "Peter Ghosh", "Silviu Itescu", "Wayne G. Kimpton", "Simon R. Bailey"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124144.g001", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_plasma_concentrations_of_A_IL_10_and_B_IL_6_measured_over_time_in_arthritic_sheep_treated_and_untreated_with_mesenchymal_precursor_cells_MPC_/1407885", "title"=>"Comparison of plasma concentrations of (A) IL-10 and (B) IL-6 measured over time in arthritic sheep treated and untreated with mesenchymal precursor cells (MPC).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-07 03:15:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/2059085"], "description"=>"<p>Each point represents the mean ±SEM from 8 animals. * Indicates a statistically significant difference between groups at that time point, p< 0.05, ** indicates a statistically significant difference between groups at that time point, p< 0.01.</p>", "links"=>[], "tags"=>["allogeneic ovine MPCs", "AimMesenchymal precursor cells", "ovine model.MethodsArthritis", "ovine model", "RA sheep", "Coronary Arteries", "type II collagen", "arthritis induction", "mesenchymal precursor cells", "marker", "adult sheep", "ConclusionArthritic sheep", "relaxant response", "MPC administration", "serum amyloid", "hdl", "immunomodulatory properties", "24 h", "cell dysfunction", "Endothelial Dysfunction", "il", "plasma levels"], "article_id"=>1407887, "categories"=>["Biological Sciences"], "users"=>["Laura M. Dooley", "Anwar Abdalmula", "Elizabeth A. Washington", "Claire Kaufman", "Elizabeth M. Tudor", "Peter Ghosh", "Silviu Itescu", "Wayne G. Kimpton", "Simon R. Bailey"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124144.g002", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_plasma_concentrations_of_A_Fibrinogen_B_Serum_amyloid_A_SAA_C_High_density_lipoprotein_HDL_measured_over_time_in_arthritic_sheep_treated_and_untreated_with_mesenchymal_precursor_cells_MPC_/1407887", "title"=>"Comparison of plasma concentrations of (A) Fibrinogen, (B) Serum amyloid-A (SAA), (C) High density lipoprotein (HDL) measured over time in arthritic sheep treated and untreated with mesenchymal precursor cells (MPC).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-07 03:15:47"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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