Strategic Lesions in the Anterior Thalamic Radiation and Apathy in Early Alzheimer's Disease
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Strategic lesions in the anterior thalamic radiation and apathy in early Alzheimer's disease", "type"=>"journal", "authors"=>[{"first_name"=>"Mario", "last_name"=>"Torso", "scopus_author_id"=>"55588141800"}, {"first_name"=>"Laura", "last_name"=>"Serra", "scopus_author_id"=>"8266381200"}, {"first_name"=>"Giovanni", "last_name"=>"Giulietti", "scopus_author_id"=>"7801428522"}, {"first_name"=>"Barbara", "last_name"=>"Spanò", "scopus_author_id"=>"36971977400"}, {"first_name"=>"Elisa", "last_name"=>"Tuzzi", "scopus_author_id"=>"56638582700"}, {"first_name"=>"Giacomo", "last_name"=>"Koch", "scopus_author_id"=>"36866518200"}, {"first_name"=>"Carlo", "last_name"=>"Caltagirone", "scopus_author_id"=>"35228717800"}, {"first_name"=>"Mara", "last_name"=>"Cercignani", "scopus_author_id"=>"6603813790"}, {"first_name"=>"Marco", "last_name"=>"Bozzali", "scopus_author_id"=>"6701548417"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84929119245", "doi"=>"10.1371/journal.pone.0124998", "issn"=>"19326203", "pui"=>"604276402", "isbn"=>"1932-6203", "pmid"=>"25932637", "scopus"=>"2-s2.0-84929119245"}, "id"=>"828bd2e6-fd5c-39c7-8311-a4caac183a52", "abstract"=>"BACKGROUND: Behavioural disorders and psychological symptoms of Dementia (BPSD) are commonly observed in Alzheimer's disease (AD), and strongly contribute to increasing patients' disability. Using voxel-lesion-symptom mapping (VLSM), we investigated the impact of white matter lesions (WMLs) on the severity of BPSD in patients with amnestic mild cognitive impairment (a-MCI).\\n\\nMETHODS: Thirty-one a-MCI patients (with a conversion rate to AD of 32% at 2 year follow-up) and 26 healthy controls underwent magnetic resonance imaging (MRI) examination at 3T, including T2-weighted and fluid-attenuated-inversion-recovery images, and T1-weighted volumes. In the patient group, BPSD was assessed using the Neuropsychiatric Inventory-12. After quantitative definition of WMLs, their distribution was investigated, without an a priori anatomical hypothesis, against patients' behavioural symptoms. Unbiased regional grey matter volumetrics was also used to assess the contribution of grey matter atrophy to BPSD.\\n\\nRESULTS: Apathy, irritability, depression/dysphoria, anxiety and agitation were shown to be the most common symptoms in the patient sample. Despite a more widespread anatomical distribution, a-MCI patients did not differ from controls in WML volumes. VLSM revealed a strict association between the presence of lesions in the anterior thalamic radiations (ATRs) and the severity of apathy. Regional grey matter atrophy did not account for any BPSD.\\n\\nCONCLUSIONS: This study indicates that damage to the ATRs is strategic for the occurrence of apathy in patients with a-MCI. Disconnection between the prefrontal cortex and the mediodorsal and anterior thalamic nuclei might represent the pathophysiological substrate for apathy, which is one of the most common psychopathological symptoms observed in dementia.", "link"=>"http://www.mendeley.com/research/strategic-lesions-anterior-thalamic-radiation-apathy-early-alzheimers-disease", "reader_count"=>41, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>11, "Psychology"=>13, "Decision Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Neuroscience"=>{"Neuroscience"=>11}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Psychology"=>{"Psychology"=>13}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>6}}, "reader_count_by_country"=>{"Netherlands"=>1, "United Kingdom"=>1, "Italy"=>1, "Germany"=>1}, "group_count"=>2}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84929119245"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84929119245?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84929119245&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84929119245&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84929119245", "dc:identifier"=>"SCOPUS_ID:84929119245", "eid"=>"2-s2.0-84929119245", "dc:title"=>"Strategic lesions in the anterior thalamic radiation and apathy in early Alzheimer's disease", "dc:creator"=>"Torso M.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"10", "prism:issueIdentifier"=>"5", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-05-01", "prism:coverDisplayDate"=>"1 May 2015", "prism:doi"=>"10.1371/journal.pone.0124998", "citedby-count"=>"24", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"IRCCS Fondazione Santa Lucia", "affiliation-city"=>"Rome", "affiliation-country"=>"Italy"}], "pubmed-id"=>"25932637", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0124998", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0124998", "share_count"=>1, "like_count"=>1, "comment_count"=>2, "click_count"=>0, "total_count"=>4}

Journal Comments | Further Information

Twitter

Counter

  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"49", "xml_views"=>"5", "html_views"=>"372"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"118"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"113"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"63"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"116"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"32", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"97"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"4", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"5", "html_views"=>"17"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"8", "html_views"=>"11"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"4", "html_views"=>"11"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"18"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2048616"], "description"=>"<p>Colours represent number of subjects with a lesion to a specific voxel. Warmer areas indicate areas of greater lesion overlap. The anatomical distribution of T2-hyperintense white matter lesions was similar between amnestic mild cognitive impairment (a-MCI) patients (panel A) and controls (panel B). The between-group difference in T2-lesion volumes was not statistically significant, although it was on average slightly larger in the patient group (see also <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124998#pone.0124998.t001\" target=\"_blank\">Table 1</a>).</p>", "links"=>[], "tags"=>["wml", "Anterior Thalamic Radiation", "bpsd", "VLSM", "atr", "matter atrophy", "symptom", "ad", "apathy", "Disease BackgroundBehavioural disorders", "mri"], "article_id"=>1401251, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Mario Torso", "Laura Serra", "Giovanni Giulietti", "Barbara Spanò", "Elisa Tuzzi", "Giacomo Koch", "Carlo Caltagirone", "Mara Cercignani", "Marco Bozzali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124998.g002", "stats"=>{"downloads"=>3, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lesions_frequency_distribution_map_in_patients_A_and_controls_B_/1401251", "title"=>"Lesions frequency distribution map in patients (A) and controls (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-01 03:36:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2048618"], "description"=>"<p>A significant association was found between the anatomical localization of white matter lesion in the anterior thalamic radiation (areas in red) and the presence/severity of apathy in between amnestic mild cognitive impairment (a-MCI) patients (panel A). Voxels in green show the lesion distribution in patients used for the voxel lesion-symptom mapping (VSLM) analysis, i.e., only including areas where at least 4 subjects presented a lesion. The lesion distribution in healthy controls (panel B, in blue), does not overlap with the area found to be significant for apathy in patients. Note that the lesion distribution is thresholded to show only voxels where at least 4 participants had a lesion, in order to match those included in the VLSM analysis.</p>", "links"=>[], "tags"=>["wml", "Anterior Thalamic Radiation", "bpsd", "VLSM", "atr", "matter atrophy", "symptom", "ad", "apathy", "Disease BackgroundBehavioural disorders", "mri"], "article_id"=>1401253, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Mario Torso", "Laura Serra", "Giovanni Giulietti", "Barbara Spanò", "Elisa Tuzzi", "Giacomo Koch", "Carlo Caltagirone", "Mara Cercignani", "Marco Bozzali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124998.g003", "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_voxel_lesion_symptom_mapping_analyses_/1401253", "title"=>"Results of voxel lesion-symptom mapping analyses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-01 03:36:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2048606"], "description"=>"<p>Histograms represent the percentage of amnestic mild cognitive impairment (a-MCI) patients exhibiting each symptom assessed by the Neuropsychiatric Inventory 12 (NPI-12). Abbreviation: Mot. Ab. Behav. = motor aberrant behavior.</p>", "links"=>[], "tags"=>["wml", "Anterior Thalamic Radiation", "bpsd", "VLSM", "atr", "matter atrophy", "symptom", "ad", "apathy", "Disease BackgroundBehavioural disorders", "mri"], "article_id"=>1401241, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Mario Torso", "Laura Serra", "Giovanni Giulietti", "Barbara Spanò", "Elisa Tuzzi", "Giacomo Koch", "Carlo Caltagirone", "Mara Cercignani", "Marco Bozzali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124998.g001", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Behavioural_disorders_and_psychological_symptoms_in_amnestic_mild_cognitive_impairment_patients_/1401241", "title"=>"Behavioural disorders and psychological symptoms in amnestic mild cognitive impairment patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-01 03:36:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2048621"], "description"=>"<p>There is shown here the pattern of regional grey matter loss in all a-MCI patients compared to controls. Consistent to previous literature, atrophy was predominantly distributed to the medial temporal lobes. Statistical threshold: p values family wise error corrected at cluster level < 0.05.</p>", "links"=>[], "tags"=>["wml", "Anterior Thalamic Radiation", "bpsd", "VLSM", "atr", "matter atrophy", "symptom", "ad", "apathy", "Disease BackgroundBehavioural disorders", "mri"], "article_id"=>1401256, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Mario Torso", "Laura Serra", "Giovanni Giulietti", "Barbara Spanò", "Elisa Tuzzi", "Giacomo Koch", "Carlo Caltagirone", "Mara Cercignani", "Marco Bozzali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124998.g004", "stats"=>{"downloads"=>4, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pattern_of_regional_grey_matter_atrophy_in_all_a_MCI_patients_compared_to_controls_/1401256", "title"=>"Pattern of regional grey matter atrophy in all a-MCI patients compared to controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-01 03:36:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2048622"], "description"=>"<p>Abbreviations: a-MCI = amnestic Mild Cognitive Impairment; HS = healthy subjects; MMSE = Mini Mental State Examination.</p><p>*a-MCI <i>vs</i>. HS p-value≤ 0.05.</p><p>Principal characteristics of studied subjects.</p>", "links"=>[], "tags"=>["wml", "Anterior Thalamic Radiation", "bpsd", "VLSM", "atr", "matter atrophy", "symptom", "ad", "apathy", "Disease BackgroundBehavioural disorders", "mri"], "article_id"=>1401257, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Mario Torso", "Laura Serra", "Giovanni Giulietti", "Barbara Spanò", "Elisa Tuzzi", "Giacomo Koch", "Carlo Caltagirone", "Mara Cercignani", "Marco Bozzali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124998.t001", "stats"=>{"downloads"=>7, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Principal_characteristics_of_studied_subjects_/1401257", "title"=>"Principal characteristics of studied subjects.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-01 03:36:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2048623"], "description"=>"<p><b>(*)</b> One-way ANOVA p-values Bonferroni’s corrected <0.003 (0.05/16)</p><p>Abbreviations: a-MCI = amnestic Mild Cognitive Impairment; HS = healthy subjects; Mod. = modified, errs. = errors</p><p>Neuropsychological assessment.</p>", "links"=>[], "tags"=>["wml", "Anterior Thalamic Radiation", "bpsd", "VLSM", "atr", "matter atrophy", "symptom", "ad", "apathy", "Disease BackgroundBehavioural disorders", "mri"], "article_id"=>1401258, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Mario Torso", "Laura Serra", "Giovanni Giulietti", "Barbara Spanò", "Elisa Tuzzi", "Giacomo Koch", "Carlo Caltagirone", "Mara Cercignani", "Marco Bozzali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124998.t002", "stats"=>{"downloads"=>7, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neuropsychological_assessment_/1401258", "title"=>"Neuropsychological assessment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-01 03:36:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2048624"], "description"=>"<p>Abbreviations: R = right; L = left; max = relative maximum.</p><p>Relationship between apathy and WMLs in the a-MCI group as assessed by VLSM.</p>", "links"=>[], "tags"=>["wml", "Anterior Thalamic Radiation", "bpsd", "VLSM", "atr", "matter atrophy", "symptom", "ad", "apathy", "Disease BackgroundBehavioural disorders", "mri"], "article_id"=>1401259, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Mario Torso", "Laura Serra", "Giovanni Giulietti", "Barbara Spanò", "Elisa Tuzzi", "Giacomo Koch", "Carlo Caltagirone", "Mara Cercignani", "Marco Bozzali"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0124998.t003", "stats"=>{"downloads"=>6, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_apathy_and_WMLs_in_the_a_MCI_group_as_assessed_by_VLSM_/1401259", "title"=>"Relationship between apathy and WMLs in the a-MCI group as assessed by VLSM.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-01 03:36:11"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"45", "full-text"=>"44", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"31", "full-text"=>"29", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"25", "full-text"=>"19", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"9", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"24", "full-text"=>"23", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
Loading … Spinner
There are currently no alerts