Metabolic Heat Stress Adaption in Transition Cows: Differences in Macronutrient Oxidation between Late-Gestating and Early-Lactating German Holstein Dairy Cows
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{"title"=>"Metabolic heat stress adaption in transition cows: Differences in macronutrient oxidation between late-gestating and early-lactating German Holstein dairy cows", "type"=>"journal", "authors"=>[{"first_name"=>"Ole", "last_name"=>"Lamp", "scopus_author_id"=>"56582179900"}, {"first_name"=>"Michael", "last_name"=>"Derno", "scopus_author_id"=>"55973313100"}, {"first_name"=>"Winfried", "last_name"=>"Otten", "scopus_author_id"=>"56219157100"}, {"first_name"=>"Manfred", "last_name"=>"Mielenz", "scopus_author_id"=>"11838865600"}, {"first_name"=>"Gerd", "last_name"=>"Nürnberg", "scopus_author_id"=>"35616440500"}, {"first_name"=>"Björn", "last_name"=>"Kuhla", "scopus_author_id"=>"6602656371"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25938406", "doi"=>"10.1371/journal.pone.0125264", "sgr"=>"84929121230", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84929121230", "issn"=>"19326203", "pui"=>"604276389"}, "id"=>"bec1c9ca-e5ee-3519-94c5-ce3576ff8e30", "abstract"=>"High ambient temperatures have severe adverse effects on biological functions of high-yielding dairy cows. The metabolic adaption to heat stress was examined in 14 German Holsteins transition cows assigned to two groups, one heat-stressed (HS) and one pair-fed (PF) at the level of HS. After 6 days of thermoneutrality and ad libitum feeding (P1), cows were challenged for 6 days (P2) by heat stress (temperature humidity index (THI) = 76) or thermoneutral pair-feeding in climatic chambers 3 weeks ante partum and again 3 weeks post-partum. On the sixth day of each period P1 or P2, oxidative metabolism was analyzed for 24 hours in open circuit respiration chambers. Water and feed intake, vital parameters and milk yield were recorded. Daily blood samples were analyzed for glucose, β-hydroxybutyric acid, non-esterified fatty acids, urea, creatinine, methyl histidine, adrenaline and noradrenaline. In general, heat stress caused marked effects on water homeorhesis with impairments of renal function and a strong adrenergic response accompanied with a prevalence of carbohydrate oxidation over fat catabolism. Heat-stressed cows extensively degraded tissue protein as reflected by the increase of plasma urea, creatinine and methyl histidine concentrations. However, the acute metabolic heat stress response in dry cows differed from early-lactating cows as the prepartal adipose tissue was not refractory to lipolytic, adrenergic stimuli, and the rate of amino acid oxidation was lower than in the postpartal stage. Together with the lower endogenous metabolic heat load, metabolic adaption in dry cows is indicative for a higher heat tolerance and the prioritization of the nutritional requirements of the fast-growing near-term fetus. These findings indicate that the development of future nutritional strategies for attenuating impairments of health and performance due to ambient heat requires the consideration of the physiological stage of dairy cows.", "link"=>"http://www.mendeley.com/research/metabolic-heat-stress-adaption-transition-cows-differences-macronutrient-oxidation-between-lategesta", "reader_count"=>27, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>9, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>3, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>9, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>3, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>2, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>3, "Psychology"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "reader_count_by_country"=>{"Poland"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2050491"], "description"=>"<p>(A) Temperature humidity index (THI, solid or dashed lines), and dry matter intake (DMI; dotted lines; given as mean of both heat-stressed (HS, red) and pair-fed groups (PF, blue), respectively) during the six days of P1 and P2 and the transition day (TD). Effects of HS and PF on (B) daily milk yield, (C) rectal temperatures, (D) respiratory rate, (E) heart rate and (F) Water intake/DMI. In experimental period 1 (P1) all animals were kept at thermoneutral conditions (THI = 59.7) with ad-libitum feeding for six days. During period 2 (P2), HS cows (red lines) were heat-stressed (THI = 76.1), whereas PF cows (blue lines) were pair-fed in thermoneutrality (THI = 60.0) for six days, once ante partum (ap, dashed lines) and again post-partum (pp, solid lines). All data given as mean ± SEM; for P1 the mean of the last days of period 1 is given in Fig 1B-F as used for baseline correction; numbers of animals analyzed per group: HSap n = 7, PFap n = 6, HSpp n = 6, PFpp n = 6.</p>", "links"=>[], "tags"=>["heat stress response", "thi", "temperature humidity index", "hs", "Metabolic Heat Stress Adaption", "acid", "period P 1", "pf", "methyl histidine concentrations", "prepartal adipose tissue", "Daily blood samples", "chambers 3 weeks ante partum", "heat stress", "6 days", "circuit respiration chambers", "Holsteins transition cows", "Holstein Dairy Cows High ambient temperatures", "dairy cows"], "article_id"=>1402863, "categories"=>["Biological Sciences"], "users"=>["Ole Lamp", "Michael Derno", "Winfried Otten", "Manfred Mielenz", "Gerd Nürnberg", "Björn Kuhla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125264.g001", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nutritional_and_Vital_Data_/1402863", "title"=>"Nutritional and Vital Data.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-04 03:18:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/2050492"], "description"=>"<p>Effect of heat stress (HS) and pair-feeding (PF) on (A) hematocrit, (B) plasma glucose, (C) plasma β-hydroxybutyric acid (BHBA), (D) plasma non-esterified fatty acids. In experimental period 1 (P1) all animals were kept at thermoneutral conditions (THI = 59.7) with ad-libitum feeding for six days. During period 2 (P2), HS cows (red lines) were heat-stressed (THI = 76.1), whereas PF cows (blue lines) were pair-fed in thermoneutrality (THI = 60.0) for six days, once ante partum (ap, dashed lines) and again post-partum (pp, solid lines). All data given as mean ± SEM; for P1 the mean of the last days of period 1 is given as used for baseline correction. BHBA: β-hydroxybutyric acid; NEFA: non-esterified fatty acids. Numbers of animals analyzed per group: HSap n = 7, PFap n = 6, HSpp n = 6, PFpp n = 6.</p>", "links"=>[], "tags"=>["heat stress response", "thi", "temperature humidity index", "hs", "Metabolic Heat Stress Adaption", "acid", "period P 1", "pf", "methyl histidine concentrations", "prepartal adipose tissue", "Daily blood samples", "chambers 3 weeks ante partum", "heat stress", "6 days", "circuit respiration chambers", "Holsteins transition cows", "Holstein Dairy Cows High ambient temperatures", "dairy cows"], "article_id"=>1402864, "categories"=>["Biological Sciences"], "users"=>["Ole Lamp", "Michael Derno", "Winfried Otten", "Manfred Mielenz", "Gerd Nürnberg", "Björn Kuhla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125264.g002", "stats"=>{"downloads"=>0, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hematocrit_and_Plasma_Metabolites_/1402864", "title"=>"Hematocrit and Plasma Metabolites.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-04 03:18:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/2050493"], "description"=>"<p>Effect of heat stress (HS) and pair-feeding (PF) on (A) plasma urea, (B) plasma creatinine, (C) urea/creatinine ratio. In experimental period 1 (P1) all animals were kept at thermoneutral conditions (THI = 59.7) with ad-libitum feeding for six days. During period 2 (P2), HS cows (red lines) were heat-stressed (THI = 76.1), whereas PF cows (blue lines) were pair-fed in thermoneutrality (THI = 60.0) for six days, once ante partum (ap, dashed lines) and again post-partum (pp, solid lines). All data given as mean ± SEM; for P1 the mean of the last days of period 1 is given as used for baseline correction. Numbers of animals analyzed per group: HSap n = 7, PFap n = 6, HSpp n = 6, PFpp n = 6.</p>", "links"=>[], "tags"=>["heat stress response", "thi", "temperature humidity index", "hs", "Metabolic Heat Stress Adaption", "acid", "period P 1", "pf", "methyl histidine concentrations", "prepartal adipose tissue", "Daily blood samples", "chambers 3 weeks ante partum", "heat stress", "6 days", "circuit respiration chambers", "Holsteins transition cows", "Holstein Dairy Cows High ambient temperatures", "dairy cows"], "article_id"=>1402865, "categories"=>["Biological Sciences"], "users"=>["Ole Lamp", "Michael Derno", "Winfried Otten", "Manfred Mielenz", "Gerd Nürnberg", "Björn Kuhla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125264.g003", "stats"=>{"downloads"=>1, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plasma_Urea_and_Creatinine_/1402865", "title"=>"Plasma Urea and Creatinine.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-04 03:18:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/2050495"], "description"=>"<p>Effect of heat stress (HS) and pair-feeding (PF) on (A) heat production per metabolic weight (HP/mBW), (B) net carbohydrate oxidation per metabolic weight (COX/mBW), (C) net fat oxidation per metabolic weight (FOX/mBW), (D) COX/FOX ratio. In experimental period 1 (P1, black) all animals were kept at thermoneutral conditions (TN, THI = 59.7) with ad-libitum feeding (AL) for six days. During period 2 (P2), HS cows (red) were heat-stressed (THI = 76.1), whereas PF cows (blue) were pair-fed in thermoneutrality (THI = 60.0) for six days, once ante partum (ap) and again post-partum (pp). Cows underwent a 24-hours indirect calorimetry analysis on day 5 of each period. Numbers of animals analyzed per group: HSap n = 7, PFap n = 6, HSpp n = 6, PFpp n = 6; all data given as sums of continuous measurements over 24 hours on day 6 of each period; <sup><b>+</b></sup>P < 0.05 in Wilcoxon signed rank sum test for paired samples of the same group; there were no group differences between independent samples of the same reproductive stage and period according to the exact Wilcoxon-Mann-Whitney test (P > 0.05).</p>", "links"=>[], "tags"=>["heat stress response", "thi", "temperature humidity index", "hs", "Metabolic Heat Stress Adaption", "acid", "period P 1", "pf", "methyl histidine concentrations", "prepartal adipose tissue", "Daily blood samples", "chambers 3 weeks ante partum", "heat stress", "6 days", "circuit respiration chambers", "Holsteins transition cows", "Holstein Dairy Cows High ambient temperatures", "dairy cows"], "article_id"=>1402867, "categories"=>["Biological Sciences"], "users"=>["Ole Lamp", "Michael Derno", "Winfried Otten", "Manfred Mielenz", "Gerd Nürnberg", "Björn Kuhla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125264.g004", "stats"=>{"downloads"=>5, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Indirect_Calorimetry_/1402867", "title"=>"Indirect Calorimetry.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-04 03:18:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/2050498"], "description"=>"<p>Effect of heat stress (HS) and pair-feeding (PF) on (A) conductance and (B) water condensate. In experimental period 1 (P1, black) all animals were kept at thermoneutral conditions (TN, THI = 59.7) with ad-libitum feeding (AL) for six days. During period 2 (P2), HS cows (red) were heat-stressed (THI = 76.1), whereas PF cows (blue) were pair-fed in thermoneutrality (THI = 60.0) for six days, once ante partum (ap) and again post-partum (pp). Data acquired during the 24-hour indirect calorimetry analysis on day 5 of each period. (A) For conductance analysis, numbers of animals analyzed per group: HSap n = 7, PFap n = 6, HSpp n = 6, PFpp n = 6; (B) For water condensate measurement, numbers of animals analyzed per group: HSap n =, 6 PFap n = 6, HSpp n = 4, PFpp n = 4; <sup><b>+</b></sup>P < 0.05 in Wilcoxon signed rank sum test for paired samples of the same group; there were no differences in groups of the same reproductive stage in P1 (P > 0.05) according to the exact Wilcoxon-Mann-Whitney test; <sup><b>*</b></sup>P < 0.05 in the exact Wilcoxon-Mann-Whitney test for group differences of the same reproductive stage in P2.</p>", "links"=>[], "tags"=>["heat stress response", "thi", "temperature humidity index", "hs", "Metabolic Heat Stress Adaption", "acid", "period P 1", "pf", "methyl histidine concentrations", "prepartal adipose tissue", "Daily blood samples", "chambers 3 weeks ante partum", "heat stress", "6 days", "circuit respiration chambers", "Holsteins transition cows", "Holstein Dairy Cows High ambient temperatures", "dairy cows"], "article_id"=>1402870, "categories"=>["Biological Sciences"], "users"=>["Ole Lamp", "Michael Derno", "Winfried Otten", "Manfred Mielenz", "Gerd Nürnberg", "Björn Kuhla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125264.g005", "stats"=>{"downloads"=>1, "page_views"=>29, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Conductance_and_Water_Condensate_/1402870", "title"=>"Conductance and Water Condensate.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-04 03:18:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/2050499"], "description"=>"<p>Effect of heat stress (HS) and pair-feeding (PF) on (A) plasma noradrenaline and (B) adrenaline. In experimental period 1 (P1) all animals were kept at thermoneutral conditions (THI = 59.7) with ad-libitum feeding for six days. During period 2 (P2), HS cows (red lines) were heat-stressed (THI = 76.1), whereas PF cows (blue lines) were pair-fed in thermoneutrality (THI = 60.0) for six days, once ante partum (ap, dashed lines) and again post-partum (pp, solid lines). All data given as mean ± SEM; for P1 the mean of the last days of period 1 is given as used for baseline correction. Numbers of animals analyzed per group: HSap n = 7, PFap n = 6, HSpp n = 6, PFpp n = 6.</p>", "links"=>[], "tags"=>["heat stress response", "thi", "temperature humidity index", "hs", "Metabolic Heat Stress Adaption", "acid", "period P 1", "pf", "methyl histidine concentrations", "prepartal adipose tissue", "Daily blood samples", "chambers 3 weeks ante partum", "heat stress", "6 days", "circuit respiration chambers", "Holsteins transition cows", "Holstein Dairy Cows High ambient temperatures", "dairy cows"], "article_id"=>1402871, "categories"=>["Biological Sciences"], "users"=>["Ole Lamp", "Michael Derno", "Winfried Otten", "Manfred Mielenz", "Gerd Nürnberg", "Björn Kuhla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125264.g006", "stats"=>{"downloads"=>1, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Catecholamines_/1402871", "title"=>"Catecholamines.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-04 03:18:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/2050500"], "description"=>"<p>TMR total mixed ration; DM dry matter</p><p>Components and chemical analysis of TMR diets ante and post-partum.</p>", "links"=>[], "tags"=>["heat stress response", "thi", "temperature humidity index", "hs", "Metabolic Heat Stress Adaption", "acid", "period P 1", "pf", "methyl histidine concentrations", "prepartal adipose tissue", "Daily blood samples", "chambers 3 weeks ante partum", "heat stress", "6 days", "circuit respiration chambers", "Holsteins transition cows", "Holstein Dairy Cows High ambient temperatures", "dairy cows"], "article_id"=>1402872, "categories"=>["Biological Sciences"], "users"=>["Ole Lamp", "Michael Derno", "Winfried Otten", "Manfred Mielenz", "Gerd Nürnberg", "Björn Kuhla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125264.t002", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Components_and_chemical_analysis_of_TMR_diets_ante_and_post_partum_/1402872", "title"=>"Components and chemical analysis of TMR diets ante and post-partum.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-04 03:18:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/2050509", "https://ndownloader.figshare.com/files/2050510", "https://ndownloader.figshare.com/files/2050511", "https://ndownloader.figshare.com/files/2050512", "https://ndownloader.figshare.com/files/2050513", "https://ndownloader.figshare.com/files/2050514", "https://ndownloader.figshare.com/files/2050515"], "description"=>"<div><p>High ambient temperatures have severe adverse effects on biological functions of high-yielding dairy cows. The metabolic adaption to heat stress was examined in 14 German Holsteins transition cows assigned to two groups, one heat-stressed (HS) and one pair-fed (PF) at the level of HS. After 6 days of thermoneutrality and ad libitum feeding (P1), cows were challenged for 6 days (P2) by heat stress (temperature humidity index (THI) = 76) or thermoneutral pair-feeding in climatic chambers 3 weeks ante partum and again 3 weeks post-partum. On the sixth day of each period P1 or P2, oxidative metabolism was analyzed for 24 hours in open circuit respiration chambers. Water and feed intake, vital parameters and milk yield were recorded. Daily blood samples were analyzed for glucose, β-hydroxybutyric acid, non-esterified fatty acids, urea, creatinine, methyl histidine, adrenaline and noradrenaline. In general, heat stress caused marked effects on water homeorhesis with impairments of renal function and a strong adrenergic response accompanied with a prevalence of carbohydrate oxidation over fat catabolism. Heat-stressed cows extensively degraded tissue protein as reflected by the increase of plasma urea, creatinine and methyl histidine concentrations. However, the acute metabolic heat stress response in dry cows differed from early-lactating cows as the prepartal adipose tissue was not refractory to lipolytic, adrenergic stimuli, and the rate of amino acid oxidation was lower than in the postpartal stage. Together with the lower endogenous metabolic heat load, metabolic adaption in dry cows is indicative for a higher heat tolerance and the prioritization of the nutritional requirements of the fast-growing near-term fetus. These findings indicate that the development of future nutritional strategies for attenuating impairments of health and performance due to ambient heat requires the consideration of the physiological stage of dairy cows.</p></div>", "links"=>[], "tags"=>["heat stress response", "thi", "temperature humidity index", "hs", "Metabolic Heat Stress Adaption", "acid", "period P 1", "pf", "methyl histidine concentrations", "prepartal adipose tissue", "Daily blood samples", "chambers 3 weeks ante partum", "heat stress", "6 days", "circuit respiration chambers", "Holsteins transition cows", "Holstein Dairy Cows High ambient temperatures", "dairy cows"], "article_id"=>1402875, "categories"=>["Biological Sciences"], "users"=>["Ole Lamp", "Michael Derno", "Winfried Otten", "Manfred Mielenz", "Gerd Nürnberg", "Björn Kuhla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0125264.s001", "https://dx.doi.org/10.1371/journal.pone.0125264.s002", "https://dx.doi.org/10.1371/journal.pone.0125264.s003", "https://dx.doi.org/10.1371/journal.pone.0125264.s004", "https://dx.doi.org/10.1371/journal.pone.0125264.s005", "https://dx.doi.org/10.1371/journal.pone.0125264.s006", "https://dx.doi.org/10.1371/journal.pone.0125264.s007"], "stats"=>{"downloads"=>6, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Metabolic_Heat_Stress_Adaption_in_Transition_Cows_Differences_in_Macronutrient_Oxidation_between_Late_Gestating_and_Early_Lactating_German_Holstein_Dairy_Cows_/1402875", "title"=>"Metabolic Heat Stress Adaption in Transition Cows: Differences in Macronutrient Oxidation between Late-Gestating and Early-Lactating German Holstein Dairy Cows", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-05-04 03:18:01"}

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  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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