Association of the Lipoprotein Receptor SCARB1 Common Missense Variant rs4238001 with Incident Coronary Heart Disease
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{"title"=>"Association of the lipoprotein receptor SCARB1 common missense variant rs4238001 with incident coronary heart disease", "type"=>"journal", "authors"=>[{"first_name"=>"Ani", "last_name"=>"Manichaikul", "scopus_author_id"=>"14626609600"}, {"first_name"=>"Xin Qun", "last_name"=>"Wang", "scopus_author_id"=>"7501856820"}, {"first_name"=>"Solomon K.", "last_name"=>"Musani", "scopus_author_id"=>"57195617242"}, {"first_name"=>"David M.", "last_name"=>"Herrington", "scopus_author_id"=>"7005853829"}, {"first_name"=>"Wendy S.", "last_name"=>"Post", "scopus_author_id"=>"7005941996"}, {"first_name"=>"James G.", "last_name"=>"Wilson", "scopus_author_id"=>"7406645019"}, {"first_name"=>"Stephen S.", "last_name"=>"Rich", "scopus_author_id"=>"7201384816"}, {"first_name"=>"Annabelle", "last_name"=>"Rodriguez", "scopus_author_id"=>"7403543664"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25993026", "doi"=>"10.1371/journal.pone.0125497", "sgr"=>"84930673107", "scopus"=>"2-s2.0-84930673107", "issn"=>"19326203", "pui"=>"604612756"}, "id"=>"ad0866af-c68e-334e-af46-314fb7d17282", "abstract"=>"BACKGROUND: Previous studies in mice and humans have implicated the lipoprotein receptor SCARB1 in association with atherosclerosis and lipid levels. In the current study, we sought to examine association of SCARB1 missense single nucleotide polymorphism (SNP) rs4238001 with incident coronary heart disease (CHD).\\n\\nMETHODS AND RESULTS: Genotypes for rs4238001 were imputed for 2,319 White, 1,570 African American, and 1,292 Hispanic-American MESA participants using the 1,000 Genomes reference set. Cox proportional hazards models were used to determine association of rs4238001 with incident CHD, with adjustments for age, sex, study site, principal components of ancestry, body mass index, diabetes status, serum creatinine, lipid levels, hypertension status, education and smoking exposure. Meta-analysis across race/ethnic groups within MESA showed statistically significant association of the T allele with higher risk of CHD under a consistent and formally adjudicated definition of CHD events in this contemporary cohort study (hazard ratio [HR] = 1.49, 95% CI [1.04, 2.14], P = 0.028). Analyses combining MESA with additional population-based cohorts expanded our samples in Whites (total n = 11,957 with 871 CHD events) and African Americans (total n = 5,962 with 355 CHD events) and confirmed an increased risk of CHD overall (HR of 1.19 with 95% CI [1.04, 1.37], P = 0.013), in African Americans (HR of 1.49 with 95% CI [1.07, 2.06], P = 0.019), in males (HR of 1.29 with 95% CI [1.08, 1.54], P = 4.91 x 10(-3)) and in White males (HR of 1.24 with 95% CI [1.03, 1.51], P = 0.026).\\n\\nCONCLUSION: SCARB1 missense rs4238001 is statistically significantly associated with incident CHD across a large population of multiple race/ethnic groups.", "link"=>"http://www.mendeley.com/research/association-lipoprotein-receptor-scarb1-common-missense-variant-rs4238001-incident-coronary-heart-di", "reader_count"=>17, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>2, "Mathematics"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>5, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2077287"], "description"=>"<p>Analyses were conducted stratified by race/ethnic group and combined by meta-analysis, for all participants as well as stratified by sex (males or female).</p>", "links"=>[], "tags"=>["lipid levels", "African Americans", "association", "body mass index", "snp", "hr", "Lipoprotein Receptor SCARB 1 Common Missense Variant rs 4238001", "871 CHD events", "rs 4238001", "Incident Coronary Heart Disease BackgroundPrevious studies", "ci", "SCARB 1 missense", "355 CHD events", "mesa", "lipoprotein receptor SCARB 1", "incident CHD"], "article_id"=>1421880, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Ani Manichaikul", "Xin-Qun Wang", "Solomon K. Musani", "David M. Herrington", "Wendy S. Post", "James G. Wilson", "Stephen S. Rich", "Annabelle Rodriguez"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125497.g002", "stats"=>{"downloads"=>6, "page_views"=>46, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_estimated_genetic_additive_effects_of_rs4238001_allele_T_on_LDL_C_mg_dL_LDL_particle_number_nmol_L_and_LDL_particle_size_log_nm_under_a_basic_regression_model_Model_1_/1421880", "title"=>"Summary of estimated genetic additive effects of rs4238001 allele T on LDL-C (mg/dL), LDL particle number (nmol/L) and LDL particle size (log nm) under a basic regression model (Model 1).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 04:45:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/2077288"], "description"=>"<p>Analyses were conducted stratified by race/ethnic group and combined by meta-analysis, for all participants as well as stratified by sex (males or female).</p>", "links"=>[], "tags"=>["lipid levels", "African Americans", "association", "body mass index", "snp", "hr", "Lipoprotein Receptor SCARB 1 Common Missense Variant rs 4238001", "871 CHD events", "rs 4238001", "Incident Coronary Heart Disease BackgroundPrevious studies", "ci", "SCARB 1 missense", "355 CHD events", "mesa", "lipoprotein receptor SCARB 1", "incident CHD"], "article_id"=>1421881, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Ani Manichaikul", "Xin-Qun Wang", "Solomon K. Musani", "David M. Herrington", "Wendy S. Post", "James G. Wilson", "Stephen S. Rich", "Annabelle Rodriguez"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125497.g003", "stats"=>{"downloads"=>6, "page_views"=>40, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_genetic_additive_effects_of_rs4238001_allele_T_on_HDL_C_log_mg_dL_HDL_particle_number_nmol_L_and_HDL_particle_size_log_nm_under_a_basic_model_Model_1_/1421881", "title"=>"Summary of genetic additive effects of rs4238001 allele T on HDL-C (log mg/dL), HDL particle number (nmol/L) and HDL particle size (log nm) under a basic model (Model 1).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 04:45:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/2077289"], "description"=>"<p>Data are presented as N (%) for binary measures or median [IQR] for continuous measure.</p><p>*Summary statistics are reported for the subset of individuals with data available for at least one of the clinical events.</p><p>†P-values are presented for statistical significance of the difference in values across race/ethnic groups according to a likelihood ratio test with 2 degrees of freedom.</p><p>Characteristics of MESA participants across three ethnic groups.</p>", "links"=>[], "tags"=>["lipid levels", "African Americans", "association", "body mass index", "snp", "hr", "Lipoprotein Receptor SCARB 1 Common Missense Variant rs 4238001", "871 CHD events", "rs 4238001", "Incident Coronary Heart Disease BackgroundPrevious studies", "ci", "SCARB 1 missense", "355 CHD events", "mesa", "lipoprotein receptor SCARB 1", "incident CHD"], "article_id"=>1421882, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Ani Manichaikul", "Xin-Qun Wang", "Solomon K. Musani", "David M. Herrington", "Wendy S. Post", "James G. Wilson", "Stephen S. Rich", "Annabelle Rodriguez"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125497.t001", "stats"=>{"downloads"=>9, "page_views"=>49, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_MESA_participants_across_three_ethnic_groups_/1421882", "title"=>"Characteristics of MESA participants across three ethnic groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-20 04:45:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/2077291", "https://ndownloader.figshare.com/files/2077292", "https://ndownloader.figshare.com/files/2077293", "https://ndownloader.figshare.com/files/2077294", "https://ndownloader.figshare.com/files/2077295", "https://ndownloader.figshare.com/files/2077296", "https://ndownloader.figshare.com/files/2077297", "https://ndownloader.figshare.com/files/2077298"], "description"=>"<div><p>Background</p><p>Previous studies in mice and humans have implicated the lipoprotein receptor <i>SCARB1</i> in association with atherosclerosis and lipid levels. In the current study, we sought to examine association of <i>SCARB1</i> missense single nucleotide polymorphism (SNP) rs4238001 with incident coronary heart disease (CHD).</p><p>Methods and Results</p><p>Genotypes for rs4238001 were imputed for 2,319 White, 1,570 African American, and 1,292 Hispanic-American MESA participants using the 1,000 Genomes reference set. Cox proportional hazards models were used to determine association of rs4238001 with incident CHD, with adjustments for age, sex, study site, principal components of ancestry, body mass index, diabetes status, serum creatinine, lipid levels, hypertension status, education and smoking exposure. Meta-analysis across race/ethnic groups within MESA showed statistically significant association of the T allele with higher risk of CHD under a consistent and formally adjudicated definition of CHD events in this contemporary cohort study (hazard ratio [HR]=1.49, 95% CI [1.04, 2.14], <i>P</i> = 0.028). Analyses combining MESA with additional population-based cohorts expanded our samples in Whites (total n = 11,957 with 871 CHD events) and African Americans (total n = 5,962 with 355 CHD events) and confirmed an increased risk of CHD overall (HR of 1.19 with 95% CI [1.04, 1.37], <i>P</i> = 0.013), in African Americans (HR of 1.49 with 95% CI [1.07, 2.06], <i>P</i> = 0.019), in males (HR of 1.29 with 95% CI [1.08, 1.54], <i>P</i> = 4.91x10<sup>-3</sup>) and in White males (HR of 1.24 with 95% CI [1.03, 1.51], <i>P</i> = 0.026).</p><p>Conclusion</p><p><i>SCARB1</i> missense rs4238001 is statistically significantly associated with incident CHD across a large population of multiple race/ethnic groups.</p></div>", "links"=>[], "tags"=>["lipid levels", "African Americans", "association", "body mass index", "snp", "hr", "Lipoprotein Receptor SCARB 1 Common Missense Variant rs 4238001", "871 CHD events", "rs 4238001", "Incident Coronary Heart Disease BackgroundPrevious studies", "ci", "SCARB 1 missense", "355 CHD events", "mesa", "lipoprotein receptor SCARB 1", "incident CHD"], "article_id"=>1421884, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Ani Manichaikul", "Xin-Qun Wang", "Solomon K. Musani", "David M. Herrington", "Wendy S. Post", "James G. Wilson", "Stephen S. Rich", "Annabelle Rodriguez"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0125497.s001", "https://dx.doi.org/10.1371/journal.pone.0125497.s002", "https://dx.doi.org/10.1371/journal.pone.0125497.s003", "https://dx.doi.org/10.1371/journal.pone.0125497.s004", "https://dx.doi.org/10.1371/journal.pone.0125497.s005", "https://dx.doi.org/10.1371/journal.pone.0125497.s006", "https://dx.doi.org/10.1371/journal.pone.0125497.s007", "https://dx.doi.org/10.1371/journal.pone.0125497.s008"], "stats"=>{"downloads"=>37, "page_views"=>34, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Association_of_the_Lipoprotein_Receptor_SCARB1_Common_Missense_Variant_rs4238001_with_Incident_Coronary_Heart_Disease/1421884", "title"=>"Association of the Lipoprotein Receptor <i>SCARB1</i> Common Missense Variant rs4238001 with Incident Coronary Heart Disease", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-05-20 04:45:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/2077286"], "description"=>"<p>Analyses were conducted stratified by race/ethnic group and combined by meta- analysis, for all participants as well as stratified by sex (males or female).</p>", "links"=>[], "tags"=>["lipid levels", "African Americans", "association", "body mass index", "snp", "hr", "Lipoprotein Receptor SCARB 1 Common Missense Variant rs 4238001", "871 CHD events", "rs 4238001", "Incident Coronary Heart Disease BackgroundPrevious studies", "ci", "SCARB 1 missense", "355 CHD events", "mesa", "lipoprotein receptor SCARB 1", "incident CHD"], "article_id"=>1421879, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Ani Manichaikul", "Xin-Qun Wang", "Solomon K. Musani", "David M. Herrington", "Wendy S. Post", "James G. Wilson", "Stephen S. Rich", "Annabelle Rodriguez"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0125497.g001", "stats"=>{"downloads"=>4, "page_views"=>61, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_estimates_log_hazard_ratio_of_CHD_for_rs4238001_effect_allele_T_and_corresponding_95_confidence_intervals_shown_for_Model_1_basic_Model_2_extended_Model_3_Model_2_lipid_medication_and_Model_4_NMR_lipids_/1421879", "title"=>"Effect estimates (log hazard ratio of CHD for rs4238001 effect allele T) and corresponding 95% confidence intervals shown for Model 1 (basic), Model 2 (extended), Model 3 (Model 2 + lipid medication) and Model 4 (NMR lipids).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-20 04:45:34"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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