Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission
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{"title"=>"Roux-en-Y gastric bypass surgery induces early plasma metabolomic and lipidomic alterations in humans associated with diabetes remission", "type"=>"journal", "authors"=>[{"first_name"=>"Tulika", "last_name"=>"Arora", "scopus_author_id"=>"36930128200"}, {"first_name"=>"Vidya", "last_name"=>"Velagapudi", "scopus_author_id"=>"14523689500"}, {"first_name"=>"Dimitri J.", "last_name"=>"Pournaras", "scopus_author_id"=>"26641323700"}, {"first_name"=>"Richard", "last_name"=>"Welbourn", "scopus_author_id"=>"56524200400"}, {"first_name"=>"Carel W.", "last_name"=>"Le Roux", "scopus_author_id"=>"56962726600"}, {"first_name"=>"Matej", "last_name"=>"Orešič", "scopus_author_id"=>"6603416304"}, {"first_name"=>"Fredrik", "last_name"=>"Bäckhed", "scopus_author_id"=>"57193396141"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"604276454", "sgr"=>"84929147898", "issn"=>"19326203", "pmid"=>"25946120", "scopus"=>"2-s2.0-84929147898", "doi"=>"10.1371/journal.pone.0126401", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"a4bdf08c-6a57-3101-af7e-2cd363379c93", "abstract"=>"Roux-en-Y gastric bypass (RYGB) is an effectivemethod to attain sustained weight loss and diabetes remission.We aimed to elucidate early changes in the plasmametabolome and lipidome after RYGB. Plasma samples from 16 insulin-resistant morbidly obese sub- jects, of whom 14 had diabetes, were subjected to global metabolomics and lipidomics anal- ysis at pre-surgery and 4 and 42 days after RYGB. Metabolites and lipid species were compared between time points and between subjects who were in remission and not in re- mission from diabetes 2 years after surgery. We found that the variables that were most dis- criminatory between time points were decanoic acid and octanoic acid, which were elevated 42 days after surgery, and sphingomyelins (18:1/21:0 and 18:1/23:3), which were at their lowest level 42 days after surgery. Insulin levels were lower at 4 and 42 days after surgery compared with pre-surgery levels. At 4 days after surgery, insulin levels correlated positively with metabolites of branched chain and aromatic amino acid metabolism and neg- atively with triglycerides with long-chain fatty acids. Of the 14 subjects with diabetes prior to surgery, 7 were in remission 2 years after surgery. The subjects in remission displayed higher pre-surgery levels of tricarboxylic acid cycle intermediates and triglycerides with long-chain fatty acids compared with subjects not in remission. Thus, metabolic alterations are induced soon after surgery and subjects with diabetes remission differ in the metabolic profiles at pre- and early post-surgery time points compared to patients not in remission.", "link"=>"http://www.mendeley.com/research/rouxeny-gastric-bypass-surgery-induces-early-plasma-metabolomic-lipidomic-alterations-humans-associa", "reader_count"=>52, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>19, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>19, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>2, "Nursing and Health Professions"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>19, "Neuroscience"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>2, "Social Sciences"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"United States"=>1, "Ireland"=>1, "Finland"=>1, "Germany"=>2}, "group_count"=>4}

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Figshare

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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