Decreased Expression of Innate Immunity-Related Genes in Peripheral Blood Mononuclear Cells from Patients with IgG4-Related Disease
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Decreased expression of innate immunity-related genes in peripheral blood mononuclear cells from patients with IgG4-related disease", "type"=>"journal", "authors"=>[{"first_name"=>"Akio", "last_name"=>"Nakajima", "scopus_author_id"=>"35068513600"}, {"first_name"=>"Yasufumi", "last_name"=>"Masaki", "scopus_author_id"=>"35378276100"}, {"first_name"=>"Takuji", "last_name"=>"Nakamura", "scopus_author_id"=>"55741610300"}, {"first_name"=>"Takafumi", "last_name"=>"Kawanami", "scopus_author_id"=>"8693308200"}, {"first_name"=>"Yasuhito", "last_name"=>"Ishigaki", "scopus_author_id"=>"7006613226"}, {"first_name"=>"Tsutomu", "last_name"=>"Takegami", "scopus_author_id"=>"7006845596"}, {"first_name"=>"Mitsuhiro", "last_name"=>"Kawano", "scopus_author_id"=>"7201851932"}, {"first_name"=>"Kazunori", "last_name"=>"Yamada", "scopus_author_id"=>"55732853600"}, {"first_name"=>"Norifumi", "last_name"=>"Tsukamoto", "scopus_author_id"=>"7102243355"}, {"first_name"=>"Shoko", "last_name"=>"Matsui", "scopus_author_id"=>"7401854055"}, {"first_name"=>"Takako", "last_name"=>"Saeki", "scopus_author_id"=>"12769978700"}, {"first_name"=>"Kazuichi", "last_name"=>"Okazaki", "scopus_author_id"=>"7401720860"}, {"first_name"=>"Terumi", "last_name"=>"Kamisawa", "scopus_author_id"=>"7006533567"}, {"first_name"=>"Taiichiro", "last_name"=>"Miyashita", "scopus_author_id"=>"7201920729"}, {"first_name"=>"Yoshihiro", "last_name"=>"Yakushijin", "scopus_author_id"=>"6603976330"}, {"first_name"=>"Keita", "last_name"=>"Fujikawa", "scopus_author_id"=>"17034616800"}, {"first_name"=>"Motohisa", "last_name"=>"Yamamoto", "scopus_author_id"=>"55710738400"}, {"first_name"=>"Hideaki", "last_name"=>"Hamano", "scopus_author_id"=>"7101830613"}, {"first_name"=>"Tomoki", "last_name"=>"Origuchi", "scopus_author_id"=>"7003431327"}, {"first_name"=>"Shintaro", "last_name"=>"Hirata", "scopus_author_id"=>"49663141300"}, {"first_name"=>"Hiroto", "last_name"=>"Tsuboi", "scopus_author_id"=>"56644193200"}, {"first_name"=>"Takayuki", "last_name"=>"Sumida", "scopus_author_id"=>"7103166990"}, {"first_name"=>"Hisanori", "last_name"=>"Morimoto", "scopus_author_id"=>"56644087100"}, {"first_name"=>"Tomomi", "last_name"=>"Sato", "scopus_author_id"=>"53983121800"}, {"first_name"=>"Haruka", "last_name"=>"Iwao", "scopus_author_id"=>"26429397000"}, {"first_name"=>"Miyuki", "last_name"=>"Miki", "scopus_author_id"=>"7202002497"}, {"first_name"=>"Tomoyuki", "last_name"=>"Sakai", "scopus_author_id"=>"57189025023"}, {"first_name"=>"Yoshimasa", "last_name"=>"Fujita", "scopus_author_id"=>"36607908400"}, {"first_name"=>"Masao", "last_name"=>"Tanaka", "scopus_author_id"=>"36049619200"}, {"first_name"=>"Toshihiro", "last_name"=>"Fukushima", "scopus_author_id"=>"7402813630"}, {"first_name"=>"Toshiro", "last_name"=>"Okazaki", "scopus_author_id"=>"35407457600"}, {"first_name"=>"Hisanori", "last_name"=>"Umehara", "scopus_author_id"=>"16148019400"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84929346832", "doi"=>"10.1371/journal.pone.0126582", "sgr"=>"84929346832", "pmid"=>"25973893", "issn"=>"19326203", "pui"=>"604377825"}, "id"=>"772decf9-9e5b-3c9d-b3fb-f909aa8cb9de", "abstract"=>"BACKGROUND IgG4-related disease (IgG4-RD) is a new clinical entity of unknown etiology characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Although aberrancies in acquired immune system functions, including increases in Th2 and Treg cytokines observed in patients with IgG4-RD, its true etiology remains unclear. To investigate the pathogenesis of IgG4-RD, this study compared the expression of genes related to innate immunity in patients with IgG4-RD and healthy controls. MATERIALS AND METHODS Peripheral blood mononuclear cells (PBMCs) were obtained from patients with IgG4-RD before and after steroid therapy and from healthy controls. Total RNA was extracted and DNA microarray analysis was performed in two IgG4-RD patients to screen for genes showing changes in expression. Candidate genes were validated by real-time RT-PCR in 27 patients with IgG4-RD and 13 healthy controls. RESULTS DNA microarray analysis identified 21 genes that showed a greater than 3-fold difference in expression between IgG4-RD patients and healthy controls and 30 genes that showed a greater than 3-fold change in IgG4-RD patients following steroid therapy. Candidate genes related to innate immunity, including those encoding Charcot-Leyden crystal protein (CLC), membrane-spanning 4-domain subfamily A member 3 (MS4A3), defensin alpha (DEFA) 3 and 4, and interleukin-8 receptors (IL8R), were validated by real-time RT-PCR. Expression of all genes was significantly lower in IgG4-RD patients than in healthy controls. Steroid therapy significantly increased the expression of DEFA3, DEFA4 and MS4A3, but had no effect on the expression of CLC, IL8RA and IL8RB. CONCLUSIONS The expression of genes related to allergy or innate immunity, including CLC, MS4A3, DEFA3, DEFA4, IL8RA and IL8RB, was lower in PBMCs from patients with IgG4-RD than from healthy controls. Although there is the limitation in the number of patients applied in DNA microarray, impaired expression of genes related to innate immunity may be involved in the pathogenesis of IgG4-RD as well as in abnormalities of acquired immunity.", "link"=>"http://www.mendeley.com/research/decreased-expression-innate-immunityrelated-genes-peripheral-blood-mononuclear-cells-patients-igg4re", "reader_count"=>7, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84929346832"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84929346832?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84929346832&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84929346832&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84929346832", "dc:identifier"=>"SCOPUS_ID:84929346832", "eid"=>"2-s2.0-84929346832", "dc:title"=>"Decreased expression of innate immunity-related genes in peripheral blood mononuclear cells from patients with IgG4-related disease", "dc:creator"=>"Nakajima A.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"10", "prism:issueIdentifier"=>"5", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-05-14", "prism:coverDisplayDate"=>"14 May 2015", "prism:doi"=>"10.1371/journal.pone.0126582", "citedby-count"=>"6", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Kanazawa Medical University", "affiliation-city"=>"Kahoku District", "affiliation-country"=>"Japan"}], "pubmed-id"=>"25973893", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0126582", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0126582", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"66", "xml_views"=>"12", "html_views"=>"319"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"15"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"99"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"7", "html_views"=>"9"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2068429"], "description"=>"<div><p>Background</p><p>IgG4-related disease (IgG4-RD) is a new clinical entity of unknown etiology characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Although aberrancies in acquired immune system functions, including increases in Th2 and Treg cytokines observed in patients with IgG4-RD, its true etiology remains unclear. To investigate the pathogenesis of IgG4-RD, this study compared the expression of genes related to innate immunity in patients with IgG4-RD and healthy controls.</p><p>Materials and Methods</p><p>Peripheral blood mononuclear cells (PBMCs) were obtained from patients with IgG4-RD before and after steroid therapy and from healthy controls. Total RNA was extracted and DNA microarray analysis was performed in two IgG4-RD patients to screen for genes showing changes in expression. Candidate genes were validated by real-time RT-PCR in 27 patients with IgG4-RD and 13 healthy controls.</p><p>Results</p><p>DNA microarray analysis identified 21 genes that showed a greater than 3-fold difference in expression between IgG4-RD patients and healthy controls and 30 genes that showed a greater than 3-fold change in IgG4-RD patients following steroid therapy. Candidate genes related to innate immunity, including those encoding Charcot–Leyden crystal protein (CLC), membrane-spanning 4-domain subfamily A member 3 (MS4A3), defensin alpha (DEFA) 3 and 4, and interleukin-8 receptors (IL8R), were validated by real-time RT-PCR. Expression of all genes was significantly lower in IgG4-RD patients than in healthy controls. Steroid therapy significantly increased the expression of DEFA3, DEFA4 and MS4A3, but had no effect on the expression of CLC, IL8RA and IL8RB.</p><p>Conclusions</p><p>The expression of genes related to allergy or innate immunity, including CLC, MS4A3, DEFA3, DEFA4, IL8RA and IL8RB, was lower in PBMCs from patients with IgG4-RD than from healthy controls. Although there is the limitation in the number of patients applied in DNA microarray, impaired expression of genes related to innate immunity may be involved in the pathogenesis of IgG4-RD as well as in abnormalities of acquired immunity.</p></div>", "links"=>[], "tags"=>["MS 4A defensin", "rna", "serum IgG 4", "pbmc", "controls.ResultsDNA microarray analysis", "8RA", "candidate genes", "clc", "DEFA", "DNA microarray analysis", "IL 8RB expression", "Peripheral Blood Mononuclear Cells"], "article_id"=>1415330, "categories"=>["Biological Sciences"], "users"=>["Akio Nakajima", "Yasufumi Masaki", "Takuji Nakamura", "Takafumi Kawanami", "Yasuhito Ishigaki", "Tsutomu Takegami", "Mitsuhiro Kawano", "Kazunori Yamada", "Norifumi Tsukamoto", "Shoko Matsui", "Takako Saeki", "Kazuichi Okazaki", "Terumi Kamisawa", "Taiichiro Miyashita", "Yoshihiro Yakushijin", "Keita Fujikawa", "Motohisa Yamamoto", "Hideaki Hamano", "Tomoki Origuchi", "Shintaro Hirata", "Hiroto Tsuboi", "Takayuki Sumida", "Hisanori Morimoto", "Tomomi Sato", "Haruka Iwao", "Miyuki Miki", "Tomoyuki Sakai", "Yoshimasa Fujita", "Masao Tanaka", "Toshihiro Fukushima", "Toshiro Okazaki", "Hisanori Umehara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0126582", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Decreased_Expression_of_Innate_Immunity_Related_Genes_in_Peripheral_Blood_Mononuclear_Cells_from_Patients_with_IgG4_Related_Disease_/1415330", "title"=>"Decreased Expression of Innate Immunity-Related Genes in Peripheral Blood Mononuclear Cells from Patients with IgG4-Related Disease", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-14 03:30:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2068416"], "description"=>"<p>Relative expression of genes in PBMCs from 27 patients with IgG4-RD and 20 healthy controls. (A) CLC; Charcot—Leyden crystal protein. (B) IL8RA; interleukin 8 receptor alpha. (C) IL8RB; interleukin 8 receptor beta. (D) MS4A3; membrane-spanning 4-domain subfamily A member 3. (E) DEFA3; defensin alpha 3. (F) DEFA4; defensin alpha 4. Expression of all genes was significantly lower in PBMCs from untreated IgG4-RD patients than from healthy controls (p< 0.01).</p>", "links"=>[], "tags"=>["MS 4A defensin", "rna", "serum IgG 4", "pbmc", "controls.ResultsDNA microarray analysis", "8RA", "candidate genes", "clc", "DEFA", "DNA microarray analysis", "IL 8RB expression", "Peripheral Blood Mononuclear Cells"], "article_id"=>1415317, "categories"=>["Biological Sciences"], "users"=>["Akio Nakajima", "Yasufumi Masaki", "Takuji Nakamura", "Takafumi Kawanami", "Yasuhito Ishigaki", "Tsutomu Takegami", "Mitsuhiro Kawano", "Kazunori Yamada", "Norifumi Tsukamoto", "Shoko Matsui", "Takako Saeki", "Kazuichi Okazaki", "Terumi Kamisawa", "Taiichiro Miyashita", "Yoshihiro Yakushijin", "Keita Fujikawa", "Motohisa Yamamoto", "Hideaki Hamano", "Tomoki Origuchi", "Shintaro Hirata", "Hiroto Tsuboi", "Takayuki Sumida", "Hisanori Morimoto", "Tomomi Sato", "Haruka Iwao", "Miyuki Miki", "Tomoyuki Sakai", "Yoshimasa Fujita", "Masao Tanaka", "Toshihiro Fukushima", "Toshiro Okazaki", "Hisanori Umehara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0126582.g001", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_gene_expression_between_patients_with_IgG4_RD_and_healthy_controls_/1415317", "title"=>"Comparison of gene expression between patients with IgG4-RD and healthy controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-14 03:30:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2068419"], "description"=>"<p>(A) CLC; Charcot—Leyden crystal protein. (B) IL8RA; interleukin 8 receptor alpha. (C) IL8RB; interleukin 8 receptor beta. (D) MS4A3; membrane-spanning 4-domain subfamily A member 3. (E) DEFA3; defensin alpha 3. (F) DEFA4; defensin alpha 4. Levels of CLC, IL8RA and IL8RB mRNA were not altered in IgG4-RD patients by steroid therapy (A-C), whereas those of MS4A3, DEFA3 and DEFA4 were significantly increased following steroid therapy (D-F, p<0.01).</p>", "links"=>[], "tags"=>["MS 4A defensin", "rna", "serum IgG 4", "pbmc", "controls.ResultsDNA microarray analysis", "8RA", "candidate genes", "clc", "DEFA", "DNA microarray analysis", "IL 8RB expression", "Peripheral Blood Mononuclear Cells"], "article_id"=>1415320, "categories"=>["Biological Sciences"], "users"=>["Akio Nakajima", "Yasufumi Masaki", "Takuji Nakamura", "Takafumi Kawanami", "Yasuhito Ishigaki", "Tsutomu Takegami", "Mitsuhiro Kawano", "Kazunori Yamada", "Norifumi Tsukamoto", "Shoko Matsui", "Takako Saeki", "Kazuichi Okazaki", "Terumi Kamisawa", "Taiichiro Miyashita", "Yoshihiro Yakushijin", "Keita Fujikawa", "Motohisa Yamamoto", "Hideaki Hamano", "Tomoki Origuchi", "Shintaro Hirata", "Hiroto Tsuboi", "Takayuki Sumida", "Hisanori Morimoto", "Tomomi Sato", "Haruka Iwao", "Miyuki Miki", "Tomoyuki Sakai", "Yoshimasa Fujita", "Masao Tanaka", "Toshihiro Fukushima", "Toshiro Okazaki", "Hisanori Umehara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0126582.g002", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_expression_in_PBMCs_from_20_patients_with_IgG4_RD_before_and_after_steroid_treatment_/1415320", "title"=>"Gene expression in PBMCs from 20 patients with IgG4-RD, before and after steroid treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-14 03:30:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2068420"], "description"=>"<p>Patients were diagnosed according to the comprehensive diagnostic criteria for IgG4-RD [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0126582#pone.0126582.ref006\" target=\"_blank\">6</a>] and were subsequently treated with steroids. IgG(mg/dL), IgG4(mg/dL), IgE(IU/mL). Abbreviations: SG, salivary gland; DD, duodenum; LN, lymph node; BD, bile duct; PC, pancreas; PS, prostate.</p><p>Profiles of IgG4-RD patients analyzed by DNA microarrays.</p>", "links"=>[], "tags"=>["MS 4A defensin", "rna", "serum IgG 4", "pbmc", "controls.ResultsDNA microarray analysis", "8RA", "candidate genes", "clc", "DEFA", "DNA microarray analysis", "IL 8RB expression", "Peripheral Blood Mononuclear Cells"], "article_id"=>1415321, "categories"=>["Biological Sciences"], "users"=>["Akio Nakajima", "Yasufumi Masaki", "Takuji Nakamura", "Takafumi Kawanami", "Yasuhito Ishigaki", "Tsutomu Takegami", "Mitsuhiro Kawano", "Kazunori Yamada", "Norifumi Tsukamoto", "Shoko Matsui", "Takako Saeki", "Kazuichi Okazaki", "Terumi Kamisawa", "Taiichiro Miyashita", "Yoshihiro Yakushijin", "Keita Fujikawa", "Motohisa Yamamoto", "Hideaki Hamano", "Tomoki Origuchi", "Shintaro Hirata", "Hiroto Tsuboi", "Takayuki Sumida", "Hisanori Morimoto", "Tomomi Sato", "Haruka Iwao", "Miyuki Miki", "Tomoyuki Sakai", "Yoshimasa Fujita", "Masao Tanaka", "Toshihiro Fukushima", "Toshiro Okazaki", "Hisanori Umehara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0126582.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Profiles_of_IgG4_RD_patients_analyzed_by_DNA_microarrays_/1415321", "title"=>"Profiles of IgG4-RD patients analyzed by DNA microarrays.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-14 03:30:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2068421"], "description"=>"<p>Real time RT-PCR was performed on mRNA samples isolated from the PBMCs of 27 patients (19 men, 8 women; median age 66 years) with IgG4-RD. Case 1* and 2* are the same patients in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0126582#pone.0126582.t001\" target=\"_blank\">Table 1</a>. Patients with steroid treatment are Case1 to Case 20, and IgG4 (post Tx) means the value of serum IgG4 after steroid treatment. Abbreviations: SG, salivary gland; DD, duodenum; LN, lymph node; BD, bile duct; PC, pancreas; PS, prostate; AA, aorta abdominalis; IP, interstitial pneumonia; LG, lacrimal gland; RF, retroperitoneal fibrosis; KN, kidney; UR, ureter; PL, pleura; PG, pituitary gland.</p><p>Profiles of IgG4-RD patients assayed by Real time RT-PCR.</p>", "links"=>[], "tags"=>["MS 4A defensin", "rna", "serum IgG 4", "pbmc", "controls.ResultsDNA microarray analysis", "8RA", "candidate genes", "clc", "DEFA", "DNA microarray analysis", "IL 8RB expression", "Peripheral Blood Mononuclear Cells"], "article_id"=>1415322, "categories"=>["Biological Sciences"], "users"=>["Akio Nakajima", "Yasufumi Masaki", "Takuji Nakamura", "Takafumi Kawanami", "Yasuhito Ishigaki", "Tsutomu Takegami", "Mitsuhiro Kawano", "Kazunori Yamada", "Norifumi Tsukamoto", "Shoko Matsui", "Takako Saeki", "Kazuichi Okazaki", "Terumi Kamisawa", "Taiichiro Miyashita", "Yoshihiro Yakushijin", "Keita Fujikawa", "Motohisa Yamamoto", "Hideaki Hamano", "Tomoki Origuchi", "Shintaro Hirata", "Hiroto Tsuboi", "Takayuki Sumida", "Hisanori Morimoto", "Tomomi Sato", "Haruka Iwao", "Miyuki Miki", "Tomoyuki Sakai", "Yoshimasa Fujita", "Masao Tanaka", "Toshihiro Fukushima", "Toshiro Okazaki", "Hisanori Umehara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0126582.t002", "stats"=>{"downloads"=>1, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Profiles_of_IgG4_RD_patients_assayed_by_Real_time_RT_PCR_/1415322", "title"=>"Profiles of IgG4-RD patients assayed by Real time RT-PCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-14 03:30:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2068422"], "description"=>"<p>We identified 21 genes showing a ≥3-fold increase (16 genes) or decrease (5genes) in expression level among 4 samples from 4 healthy controls and 2 IgG4-RD patients before and after therapy.</p><p>*processed to the validation.</p><p>Genes showing ≥3-fold differences in expression level in IgG4-RD patients and healthy controls.</p>", "links"=>[], "tags"=>["MS 4A defensin", "rna", "serum IgG 4", "pbmc", "controls.ResultsDNA microarray analysis", "8RA", "candidate genes", "clc", "DEFA", "DNA microarray analysis", "IL 8RB expression", "Peripheral Blood Mononuclear Cells"], "article_id"=>1415323, "categories"=>["Biological Sciences"], "users"=>["Akio Nakajima", "Yasufumi Masaki", "Takuji Nakamura", "Takafumi Kawanami", "Yasuhito Ishigaki", "Tsutomu Takegami", "Mitsuhiro Kawano", "Kazunori Yamada", "Norifumi Tsukamoto", "Shoko Matsui", "Takako Saeki", "Kazuichi Okazaki", "Terumi Kamisawa", "Taiichiro Miyashita", "Yoshihiro Yakushijin", "Keita Fujikawa", "Motohisa Yamamoto", "Hideaki Hamano", "Tomoki Origuchi", "Shintaro Hirata", "Hiroto Tsuboi", "Takayuki Sumida", "Hisanori Morimoto", "Tomomi Sato", "Haruka Iwao", "Miyuki Miki", "Tomoyuki Sakai", "Yoshimasa Fujita", "Masao Tanaka", "Toshihiro Fukushima", "Toshiro Okazaki", "Hisanori Umehara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0126582.t003", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genes_showing_8805_3_fold_differences_in_expression_level_in_IgG4_RD_patients_and_healthy_controls_/1415323", "title"=>"Genes showing ≥3-fold differences in expression level in IgG4-RD patients and healthy controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-14 03:30:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2068423"], "description"=>"<p>We identified 36 genes showing ≥3-fold increase or decrease in expression in IgG4-RD patients in response to steroid therapy. IFI44L, SNORA42 and HIST1H2BB had decreased expression by steroid therapy, and the other genes increased. Abbreviations: FC, fold changes.</p><p>*processed to the validation.</p><p>Genes showing ≥3-fold changes in expression in IgG4-RD patients in response to steroid therapy.</p>", "links"=>[], "tags"=>["MS 4A defensin", "rna", "serum IgG 4", "pbmc", "controls.ResultsDNA microarray analysis", "8RA", "candidate genes", "clc", "DEFA", "DNA microarray analysis", "IL 8RB expression", "Peripheral Blood Mononuclear Cells"], "article_id"=>1415324, "categories"=>["Biological Sciences"], "users"=>["Akio Nakajima", "Yasufumi Masaki", "Takuji Nakamura", "Takafumi Kawanami", "Yasuhito Ishigaki", "Tsutomu Takegami", "Mitsuhiro Kawano", "Kazunori Yamada", "Norifumi Tsukamoto", "Shoko Matsui", "Takako Saeki", "Kazuichi Okazaki", "Terumi Kamisawa", "Taiichiro Miyashita", "Yoshihiro Yakushijin", "Keita Fujikawa", "Motohisa Yamamoto", "Hideaki Hamano", "Tomoki Origuchi", "Shintaro Hirata", "Hiroto Tsuboi", "Takayuki Sumida", "Hisanori Morimoto", "Tomomi Sato", "Haruka Iwao", "Miyuki Miki", "Tomoyuki Sakai", "Yoshimasa Fujita", "Masao Tanaka", "Toshihiro Fukushima", "Toshiro Okazaki", "Hisanori Umehara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0126582.t004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genes_showing_8805_3_fold_changes_in_expression_in_IgG4_RD_patients_in_response_to_steroid_therapy_/1415324", "title"=>"Genes showing ≥3-fold changes in expression in IgG4-RD patients in response to steroid therapy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-14 03:30:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2068424"], "description"=>"<p>K-means clustering was used for statistical processing of disease-associated genes, we identified 30 genes. All genes had increased expression level by steroid therapy.</p><p>*processed to the validation.</p><p>The list of disease-associated genes using K-means clustering.</p>", "links"=>[], "tags"=>["MS 4A defensin", "rna", "serum IgG 4", "pbmc", "controls.ResultsDNA microarray analysis", "8RA", "candidate genes", "clc", "DEFA", "DNA microarray analysis", "IL 8RB expression", "Peripheral Blood Mononuclear Cells"], "article_id"=>1415325, "categories"=>["Biological Sciences"], "users"=>["Akio Nakajima", "Yasufumi Masaki", "Takuji Nakamura", "Takafumi Kawanami", "Yasuhito Ishigaki", "Tsutomu Takegami", "Mitsuhiro Kawano", "Kazunori Yamada", "Norifumi Tsukamoto", "Shoko Matsui", "Takako Saeki", "Kazuichi Okazaki", "Terumi Kamisawa", "Taiichiro Miyashita", "Yoshihiro Yakushijin", "Keita Fujikawa", "Motohisa Yamamoto", "Hideaki Hamano", "Tomoki Origuchi", "Shintaro Hirata", "Hiroto Tsuboi", "Takayuki Sumida", "Hisanori Morimoto", "Tomomi Sato", "Haruka Iwao", "Miyuki Miki", "Tomoyuki Sakai", "Yoshimasa Fujita", "Masao Tanaka", "Toshihiro Fukushima", "Toshiro Okazaki", "Hisanori Umehara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0126582.t005", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_list_of_disease_associated_genes_using_K_means_clustering_/1415325", "title"=>"The list of disease-associated genes using K-means clustering.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-14 03:30:51"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"30", "full-text"=>"27", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"31", "full-text"=>"35", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"26", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"15", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime | Further Information

Loading … Spinner
There are currently no alerts