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{"title"=>"Hyperbaric oxygen therapy can diminish fibromyalgia syndrome - Prospective clinical trial", "type"=>"journal", "authors"=>[{"first_name"=>"Shai", "last_name"=>"Efrati", "scopus_author_id"=>"55974869700"}, {"first_name"=>"Haim", "last_name"=>"Golan", "scopus_author_id"=>"16143186800"}, {"first_name"=>"Yair", "last_name"=>"Bechor", "scopus_author_id"=>"11239898700"}, {"first_name"=>"Yifat", "last_name"=>"Faran", "scopus_author_id"=>"13907249700"}, {"first_name"=>"Shir", "last_name"=>"Daphna-Tekoah", "scopus_author_id"=>"25951355300"}, {"first_name"=>"Gal", "last_name"=>"Sekler", "scopus_author_id"=>"57144557300"}, {"first_name"=>"Gregori", "last_name"=>"Fishlev", "scopus_author_id"=>"23469232500"}, {"first_name"=>"Jacob N.", "last_name"=>"Ablin", "scopus_author_id"=>"6603625176"}, {"first_name"=>"Jacob", "last_name"=>"Bergan", "scopus_author_id"=>"15750159900"}, {"first_name"=>"Olga", "last_name"=>"Volkov", "scopus_author_id"=>"11639874700"}, {"first_name"=>"Mony", "last_name"=>"Friedman", "scopus_author_id"=>"55557513500"}, {"first_name"=>"Eshel", "last_name"=>"Ben-Jacob", "scopus_author_id"=>"7005078550"}, {"first_name"=>"Dan", "last_name"=>"Buskila", "scopus_author_id"=>"7102172926"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"608635430", "sgr"=>"84959271759", "issn"=>"19326203", "pmid"=>"26010952", "scopus"=>"2-s2.0-84959271759", "doi"=>"10.1371/journal.pone.0127012", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"a6b440d2-334f-37e8-a20a-f31f2b0f2a5b", "abstract"=>"BACKGROUND: Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS.\\n\\nMETHODS AND FINDINGS: A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including tender point count and pain threshold, extensive evaluation of quality of life, and single photon emission computed tomography (SPECT) imaging for evaluation of brain activity. The HBOT protocol comprised 40 sessions, 5 days/week, 90 minutes, 100% oxygen at 2ATA. Sixty female patients were included, aged 21-67 years and diagnosed with FMS at least 2 years earlier. HBOT in both groups led to significant amelioration of all FMS symptoms, with significant improvement in life quality. Analysis of SPECT imaging revealed rectification of the abnormal brain activity: decrease of the hyperactivity mainly in the posterior region and elevation of the reduced activity mainly in frontal areas. No improvement in any of the parameters was observed following the control period.\\n\\nCONCLUSIONS: The study provides evidence that HBOT can improve the symptoms and life quality of FMS patients. Moreover, it shows that HBOT can induce neuroplasticity and significantly rectify abnormal brain activity in pain related areas of FMS patients.\\n\\nTRIAL REGISTRATION: ClinicalTrials.gov NCT01827683.", "link"=>"http://www.mendeley.com/research/hyperbaric-oxygen-therapy-diminish-fibromyalgia-syndrome-prospective-clinical-trial-4", "reader_count"=>52, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>13, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Other"=>6, "Student > Master"=>5, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>13, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Other"=>6, "Student > Master"=>5, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>31, "Neuroscience"=>2, "Sports and Recreations"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Psychology"=>1, "Chemistry"=>1, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>31}, "Neuroscience"=>{"Neuroscience"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Colombia"=>1, "United States"=>1, "Brazil"=>1, "Spain"=>2}, "group_count"=>2}

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CrossRef

• http://doi.org/10.5812/amh.59684
• http://doi.org/10.1186/s42358-019-0101-9
• http://doi.org/10.2217/pmt-2016-0006
• http://doi.org/10.1016/j.biopha.2018.10.157
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• http://doi.org/10.1016/j.pop.2018.02.008
• http://doi.org/10.1155/2016/3458371
• http://doi.org/10.1016/j.brainres.2018.08.002
• http://doi.org/10.1016/j.brainres.2019.01.009
• http://doi.org/10.1016/j.medmal.2019.01.002
• http://doi.org/10.3389/fpsyg.2018.02495
• http://doi.org/10.1186/s12890-019-0893-8
• http://doi.org/10.1097/FBP.0000000000000497
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• http://doi.org/10.3233/RNN-190959
• http://doi.org/10.1186/s12883-016-0605-4
• http://doi.org/10.3389/fpsyg.2018.00848

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Journal Comments | Further Information

• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/224b13b9-7aae-4788-8eae-374895b8d709", "title"=>"Thank you Dr Efrati for apprising me of this study, it certainly didn't disapppoint!", "body"=>"It is worthy of note that Linda Watkins' work with Prof Mark Hutchinson on naloxone's suppressing glial activation has been furthered by Prof Jared Younger trialing lowdose naltrexone for fibromyalgia.", "isRemoved"=>false, "created"=>"2015-05-27T06:12:18Z", "lastModified"=>"2015-05-27T06:12:18Z", "creator"=>{"userId"=>"470398"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"Patient advocacy FnMyalgia.com"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0127012", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-05-27T06:12:18Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/0c6d317e-ac8f-4736-a4df-7a8527a3d4c0", "title"=>"Some comments on this quite interesting paper", "body"=>"I understand this is a first proof of concept paper, nevertheless it would be nice if the authors could comment on some topics:\n- there is certainly a placebo effect just for entering the chamber and \"doing something\" for a chronic painful condition; are we observing real neuronal plasticity, a placebo effect, a combination of both?\n- what is expected to be the effect of performing the chamber protocol, but without O2? Do you have an additional group of patients that was subjected to this protocol?\n- which are the characteristics of patients with worsening of their pain (almost a third of the patients)?\n- after completing the hyperbaric chamber treatment per protocol, for how long did the authors observe patients were still reporting no or less pain, well being, etc?", "isRemoved"=>false, "created"=>"2015-06-04T20:44:16Z", "lastModified"=>"2015-06-04T20:44:16Z", "creator"=>{"userId"=>"509714"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0127012", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>3, "mostRecentActivity"=>"2015-06-25T04:07:07Z", "replies"=>[{"type"=>"REPLY", "parentID"=>86393, "annotationUri"=>"info:doi/10.1371/reply/ce4090f2-fa67-4fa5-82a4-e656fb934095", "title"=>"RE: Some comments on this quite interesting paper", "body"=>"-\tThe placebo effect and cross over design was discus in the article. Here is citation regarding the cross over approach:\n\" There is a persisting dilemma regarding the adequate sham control for testing the effects of HBOT. The standard requirement for proper sham control is: “Medically ineffectual treatment for medical conditions intended to deceive the recipient from knowing which treatment is given.” Naively, one could assume that placing the patients in the HBO2 chamber at normal air (21% oxygen) and normal pressure (1.0Atm) can serve as proper control. However, in order to have them sense elevated pressure, as required by sham control, the chamber pressure must be increased to 1.3 Atm or higher. The problem is that breathing normal air at 1.3 Atm can elevate the dissolved tissue oxygen by 50% or more, leading to significant physiological effects. Hence, room air at 1.3 Atm is not “ineffectual treatment” and cannot serve as proper sham control as required by the placebo definition. We decided to adopt the crossover approach which we had successfully used to test the effect of HBOT in post-stroke patients and in victims of mTBI at late chronic stage [18, 19]. In this approach, the participants are randomly divided into two groups. One, the trial group, receives two months of daily HBO2 treatments while the other, the control group, goes without treatments during that time. The latter is then given the same treatments two months later. The study endpoints include, in addition to the physiological evaluations, also blinded detailed computerized clinical evaluations with SPECT scans that were blindly compared for all patients. The advantage of the crossover approach [18, 19] is three-fold, as it allows comparison between treatments of two groups, between treatment and no treatment of the same group, and between treatment and no treatment in different groups. This is further reflected upon in the discussion section.\" \nRegarding the lack of double blinding: While the division into two sub-groups was done randomly and so were the physiological evaluations and the SPECT assessments, the patients were not blinded because of the above mentioned placebo considerations. The non- blinded identity of the patients to the examiners may have an effect on the self assessment questionnaires (FIQ, SCL and SF-36). The agreement between the improvements as reflected in self assessment questionnaires and in pain thresholds and brain SPECT analyses, which was done in a blinded fashion, further substantiates the clinical findings. Moreover, the association between the anatomical locations of the changes in the brain metabolism, as demonstrated by the SPECT, and the clinical findings provides important validation of the evaluation.\n\n\n-\tPatients that had history of traumatic brain injury (TBI) as possible trigger to their fibromyalgia did not had worsening of symptoms at the beginning of the study. Regarding the rest we need to further investigate it.\n-\tThe post TBI patients also did not had relapse of the symptoms. Regarding the rest we are still evaluating it and there is wide variability between the patients ranging from 1 month to no relapse. Even if there is a relapse it is still much easier that it was before the treatment but this important issue should be further investigated.\n\n\n\n", "isRemoved"=>false, "created"=>"2015-06-06T14:15:56Z", "lastModified"=>"2015-06-06T14:15:56Z", "creator"=>{"userId"=>"303227"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0127012", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>2, "mostRecentActivity"=>"2015-06-25T04:07:07Z", "replies"=>[{"type"=>"REPLY", "parentID"=>86397, "annotationUri"=>"info:doi/10.1371/reply/a9210df4-eed5-4b22-8ceb-0e50bc12772b", "title"=>"RE: RE: Some comments on this quite interesting paper", "body"=>"The promise of further evaluations would be even more useful if there was a breakout of the pain subscale from the total SF-36 score, which you've provided in aggregate only.", "isRemoved"=>false, "created"=>"2015-06-24T20:28:07Z", "lastModified"=>"2015-06-24T20:28:07Z", "creator"=>{"userId"=>"470398"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"I wish to update the Systematic Review and meta-analysis of HBOT for neuralgia draft at https://www.researchgate.net/publication/267155962_Hyperbaric_Oxygen_for_Chronic_Neuropathic_Pain__Fibromyalgia to provide comparisons with previous studies."}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0127012", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>1, "mostRecentActivity"=>"2015-06-25T04:07:07Z", "replies"=>[{"type"=>"REPLY", "parentID"=>86537, "annotationUri"=>"info:doi/10.1371/reply/37a39b36-fd3e-4683-ae01-96f5e82150b2", "title"=>"RE: RE: RE: Some comments on this quite interesting paper", "body"=>"OK", "isRemoved"=>false, "created"=>"2015-06-25T04:07:07Z", "lastModified"=>"2015-06-25T04:07:07Z", "creator"=>{"userId"=>"303227"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0127012", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2015-06-25T04:07:07Z", "replies"=>[]}]}]}]}

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Reddit | Further Information

• {"domain"=>"self.Fibromyalgia", "banned_by"=>nil, "media_embed"=>{}, "subreddit"=>"Fibromyalgia", "selftext_html"=>"<!-- SC_OFF --><div class=\"md\"><p>Hello! I don't know if you're aware of the couple of recent research classifying fibromyalgia as a central and peripheral nervous system disorder, but here's some updated info:</p>\n\n<ul>\n<li><p><a href=\"http://www.med.umich.edu/opm/newspage/2002/fibromyalgia.htm\">Research from 2002 in University of Michigan showing distortion of pain signals in the brain of fibromyalgia patients</a></p></li>\n<li><p><a href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769083/\">Study from 2009 showing a prevalence of neurological symptoms in fibromyalgia patients</a></p></li>\n<li><p><a href=\"http://www.ncbi.nlm.nih.gov/pubmed/11872181\">Abstract from a 2002 review of medical literature on fibromyalgia concluding that fibromyalgia is a nervous system disorder</a></p></li>\n<li><p><a href=\"http://www.intidyn.com/news-events/news/20-researchers-discover-a-rational-biological-source-of-pain-in-the-skin-of-patients-with-fibromyalgia-press-relase\">2013 study finding a higher than normal number of nerve endings in blood vessels of the hands of fibromyalgia sufferers</a></p></li>\n</ul>\n\n<p>Two recent studies have tried HBOT, in countries where it is frequently used to treat fibromyalgia, among other neurological conditions.</p>\n\n<ul>\n<li><p><a href=\"http://www.ncbi.nlm.nih.gov/pubmed/15174219\">2004 study showing significant improvement in pain threshold and trigger point count</a></p></li>\n<li><p><a href=\"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012\">2015 study completed with a symptom evaluation, brain scan and quality of life/psychological well-being assessment, concluding that most patients could be considered cured</a></p></li>\n</ul>\n\n<p>I'm getting to try it because I happen to be very very lucky. I am in Canada, and here HBOT is still not recognized as a treatment option for FM. So I can't find many first-hand experiences with the treatment, but I'm still reaching out here, just in case anyone has personal experience to share. I will be beginning treatment in 3 months because there's a waiting line and my doctor has to get authorization to make me have it.</p>\n</div><!-- SC_ON -->", "selftext"=>"Hello! I don't know if you're aware of the couple of recent research classifying fibromyalgia as a central and peripheral nervous system disorder, but here's some updated info:\n\n* [Research from 2002 in University of Michigan showing distortion of pain signals in the brain of fibromyalgia patients](http://www.med.umich.edu/opm/newspage/2002/fibromyalgia.htm)\n\n* [Study from 2009 showing a prevalence of neurological symptoms in fibromyalgia patients](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769083/)\n\n* [Abstract from a 2002 review of medical literature on fibromyalgia concluding that fibromyalgia is a nervous system disorder](http://www.ncbi.nlm.nih.gov/pubmed/11872181)\n\n* [2013 study finding a higher than normal number of nerve endings in blood vessels of the hands of fibromyalgia sufferers](http://www.intidyn.com/news-events/news/20-researchers-discover-a-rational-biological-source-of-pain-in-the-skin-of-patients-with-fibromyalgia-press-relase)\n\nTwo recent studies have tried HBOT, in countries where it is frequently used to treat fibromyalgia, among other neurological conditions.\n\n* [2004 study showing significant improvement in pain threshold and trigger point count](http://www.ncbi.nlm.nih.gov/pubmed/15174219)\n\n* [2015 study completed with a symptom evaluation, brain scan and quality of life/psychological well-being assessment, concluding that most patients could be considered cured](http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012)\n\nI'm getting to try it because I happen to be very very lucky. I am in Canada, and here HBOT is still not recognized as a treatment option for FM. So I can't find many first-hand experiences with the treatment, but I'm still reaching out here, just in case anyone has personal experience to share. I will be beginning treatment in 3 months because there's a waiting line and my doctor has to get authorization to make me have it.", "likes"=>nil, "suggested_sort"=>nil, "user_reports"=>[], "secure_media"=>nil, "link_flair_text"=>"Discussion", "id"=>"3uht3y", "from_kind"=>nil, "gilded"=>0, "archived"=>false, "clicked"=>false, "report_reasons"=>nil, "author"=>"spacenb", "media"=>nil, "score"=>6, "approved_by"=>nil, "over_18"=>false, "hidden"=>false, "preview"=>{"images"=>[{"source"=>{"url"=>"https://i.redditmedia.com/lV-sETUURvrcT7EUnQDydzH87p1SE-VeDcmahlv0A94.jpg?s=e23749b6a177693783c8dbf548e54a8b", "width"=>130, "height"=>135}, "resolutions"=>[{"url"=>"https://i.redditmedia.com/lV-sETUURvrcT7EUnQDydzH87p1SE-VeDcmahlv0A94.jpg?fit=crop&crop=faces%2Centropy&arh=2&w=108&s=dd00664f87e7d14990280816d4fbad18", "width"=>108, "height"=>112}], "variants"=>{}, "id"=>"N3aut3TPL3s5LEuKM6QHdtjW9k-qVAKCyPYoTNt60tc"}]}, "num_comments"=>7, "thumbnail"=>"self", "subreddit_id"=>"t5_2qwut", "hide_score"=>false, "edited"=>false, "link_flair_css_class"=>"THREE", "author_flair_css_class"=>"", "downs"=>0, "secure_media_embed"=>{}, "saved"=>false, "removal_reason"=>nil, "post_hint"=>"self", "stickied"=>false, "from"=>nil, "is_self"=>true, "from_id"=>nil, "permalink"=>"/r/Fibromyalgia/comments/3uht3y/i_am_getting_to_try_hbot_for_fibromyalgia_anyone/?ref=search_posts", "locked"=>false, "name"=>"t3_3uht3y", "created"=>1448679275.0, "url"=>"https://www.reddit.com:80/r/Fibromyalgia/comments/3uht3y/i_am_getting_to_try_hbot_for_fibromyalgia_anyone/", "author_flair_text"=>"sick since 03/15", "quarantine"=>false, "title"=>"I am getting to try HBOT for fibromyalgia, anyone here got to do it before? (x-post from r/ChronicPain)", "created_utc"=>1448650475.0, "distinguished"=>nil, "mod_reports"=>[], "visited"=>false, "num_reports"=>nil, "ups"=>6}
• {"domain"=>"self.ChronicPain", "banned_by"=>nil, "media_embed"=>{}, "subreddit"=>"ChronicPain", "selftext_html"=>"<!-- SC_OFF --><div class=\"md\"><p>Hello! I don't know if you're aware of the couple of recent research classifying fibromyalgia as a central and peripheral nervous system disorder, but here's some updated info:</p>\n\n<ul>\n<li><p><a href=\"http://www.med.umich.edu/opm/newspage/2002/fibromyalgia.htm\">Research from 2002 in University of Michigan showing distortion of pain signals in the brain of fibromyalgia patients</a></p></li>\n<li><p><a href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769083/\">Study from 2009 showing a prevalence of neurological symptoms in fibromyalgia patients</a></p></li>\n<li><p><a href=\"http://www.ncbi.nlm.nih.gov/pubmed/11872181\">Abstract from a 2002 review of medical literature on fibromyalgia concluding that fibromyalgia is a nervous system disorder</a></p></li>\n<li><p><a href=\"http://www.intidyn.com/news-events/news/20-researchers-discover-a-rational-biological-source-of-pain-in-the-skin-of-patients-with-fibromyalgia-press-relase\">2013 study finding a higher than normal number of nerve endings in blood vessels of the hands of fibromyalgia sufferers</a></p></li>\n</ul>\n\n<p>Two recent studies have tried HBOT, in countries where it is frequently used to treat fibromyalgia, among other neurological conditions.</p>\n\n<ul>\n<li><p><a href=\"http://www.ncbi.nlm.nih.gov/pubmed/15174219\">2004 study showing significant improvement in pain threshold and trigger point count</a></p></li>\n<li><p><a href=\"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012\">2015 study completed with a symptom evaluation, brain scan and quality of life/psychological well-being assessment, concluding that most patients could be considered cured</a></p></li>\n</ul>\n\n<p>I'm getting to try it because I happen to be very very lucky. I am in Canada, and here HBOT is still not recognized as a treatment option for FM. So I can't find many first-hand experiences with the treatment, but I'm still reaching out here, just in case anyone has personal experience to share. I will be beginning treatment in 3 months because there's a waiting line and my doctor has to get authorization to make me have it.</p>\n</div><!-- SC_ON -->", "selftext"=>"Hello! I don't know if you're aware of the couple of recent research classifying fibromyalgia as a central and peripheral nervous system disorder, but here's some updated info:\n\n* [Research from 2002 in University of Michigan showing distortion of pain signals in the brain of fibromyalgia patients](http://www.med.umich.edu/opm/newspage/2002/fibromyalgia.htm)\n\n* [Study from 2009 showing a prevalence of neurological symptoms in fibromyalgia patients](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769083/)\n\n* [Abstract from a 2002 review of medical literature on fibromyalgia concluding that fibromyalgia is a nervous system disorder](http://www.ncbi.nlm.nih.gov/pubmed/11872181)\n\n* [2013 study finding a higher than normal number of nerve endings in blood vessels of the hands of fibromyalgia sufferers](http://www.intidyn.com/news-events/news/20-researchers-discover-a-rational-biological-source-of-pain-in-the-skin-of-patients-with-fibromyalgia-press-relase)\n\nTwo recent studies have tried HBOT, in countries where it is frequently used to treat fibromyalgia, among other neurological conditions.\n\n* [2004 study showing significant improvement in pain threshold and trigger point count](http://www.ncbi.nlm.nih.gov/pubmed/15174219)\n\n* [2015 study completed with a symptom evaluation, brain scan and quality of life/psychological well-being assessment, concluding that most patients could be considered cured](http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012)\n\nI'm getting to try it because I happen to be very very lucky. I am in Canada, and here HBOT is still not recognized as a treatment option for FM. So I can't find many first-hand experiences with the treatment, but I'm still reaching out here, just in case anyone has personal experience to share. I will be beginning treatment in 3 months because there's a waiting line and my doctor has to get authorization to make me have it.", "likes"=>nil, "suggested_sort"=>nil, "user_reports"=>[], "secure_media"=>nil, "link_flair_text"=>nil, "id"=>"3ue00r", "from_kind"=>nil, "gilded"=>0, "archived"=>false, "clicked"=>false, "report_reasons"=>nil, "author"=>"spacenb", "media"=>nil, "score"=>6, "approved_by"=>nil, "over_18"=>false, "hidden"=>false, "preview"=>{"images"=>[{"source"=>{"url"=>"https://i.redditmedia.com/lV-sETUURvrcT7EUnQDydzH87p1SE-VeDcmahlv0A94.jpg?s=e23749b6a177693783c8dbf548e54a8b", "width"=>130, "height"=>135}, "resolutions"=>[{"url"=>"https://i.redditmedia.com/lV-sETUURvrcT7EUnQDydzH87p1SE-VeDcmahlv0A94.jpg?fit=crop&crop=faces%2Centropy&arh=2&w=108&s=dd00664f87e7d14990280816d4fbad18", "width"=>108, "height"=>112}], "variants"=>{}, "id"=>"N3aut3TPL3s5LEuKM6QHdtjW9k-qVAKCyPYoTNt60tc"}]}, "num_comments"=>2, "thumbnail"=>"self", "subreddit_id"=>"t5_2rdpj", "hide_score"=>false, "edited"=>false, "link_flair_css_class"=>nil, "author_flair_css_class"=>"6", "downs"=>0, "secure_media_embed"=>{}, "saved"=>false, "removal_reason"=>nil, "post_hint"=>"self", "stickied"=>false, "from"=>nil, "is_self"=>true, "from_id"=>nil, "permalink"=>"/r/ChronicPain/comments/3ue00r/i_am_getting_to_try_hbot_for_fibromyalgia_anyone/?ref=search_posts", "locked"=>false, "name"=>"t3_3ue00r", "created"=>1448599375.0, "url"=>"https://www.reddit.com:80/r/ChronicPain/comments/3ue00r/i_am_getting_to_try_hbot_for_fibromyalgia_anyone/", "author_flair_text"=>"6/fibromyalgia", "quarantine"=>false, "title"=>"I am getting to try HBOT for fibromyalgia, anyone here got to do it before?", "created_utc"=>1448570575.0, "distinguished"=>nil, "mod_reports"=>[], "visited"=>false, "num_reports"=>nil, "ups"=>6}
• {"domain"=>"self.ChronicPain", "banned_by"=>nil, "media_embed"=>{}, "subreddit"=>"ChronicPain", "selftext_html"=>"<!-- SC_OFF --><div class=\"md\"><p>has anyone tried hyperbaric chamber therapy for chronic pain? If so what kinds of results did you get? It looks like it's showing some promise for pain disorders but it's a very expensive treatment. <a href=\"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012\">http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012</a> </p>\n</div><!-- SC_ON -->", "selftext"=>"has anyone tried hyperbaric chamber therapy for chronic pain? If so what kinds of results did you get? It looks like it's showing some promise for pain disorders but it's a very expensive treatment. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012 ", "likes"=>nil, "suggested_sort"=>nil, "user_reports"=>[], "secure_media"=>nil, "link_flair_text"=>nil, "id"=>"3q1lhc", "from_kind"=>nil, "gilded"=>0, "archived"=>false, "clicked"=>false, "report_reasons"=>nil, "author"=>"stephanyah09", "media"=>nil, "score"=>1, "approved_by"=>nil, "over_18"=>false, "hidden"=>false, "num_comments"=>3, "thumbnail"=>"self", "subreddit_id"=>"t5_2rdpj", "hide_score"=>false, "edited"=>false, "link_flair_css_class"=>nil, "author_flair_css_class"=>"2", "downs"=>0, "secure_media_embed"=>{}, "saved"=>false, "removal_reason"=>nil, "stickied"=>false, "from"=>nil, "is_self"=>true, "from_id"=>nil, "permalink"=>"/r/ChronicPain/comments/3q1lhc/hyperbaric_for_fibromyofascial_pain_disorder/?ref=search_posts", "locked"=>false, "name"=>"t3_3q1lhc", "created"=>1445732373.0, "url"=>"https://www.reddit.com:80/r/ChronicPain/comments/3q1lhc/hyperbaric_for_fibromyofascial_pain_disorder/", "author_flair_text"=>"2", "quarantine"=>false, "title"=>"Hyperbaric for fibro/myofascial pain disorder?", "created_utc"=>1445703573.0, "distinguished"=>nil, "mod_reports"=>[], "visited"=>false, "num_reports"=>nil, "ups"=>1}

Twitter

• {"id"=>"1007320883604537346", "text"=>"Hyperbaric Oxygen Therapy and Fibromyalgia - Study from 2015\n\nhttps://t.co/f5aFtM7Pu3 https://t.co/f5aFtM7Pu3", "created_at"=>"2018-06-14T17:56:28Z", "user"=>"nvhyperbarics", "user_name"=>"Nevada Hyperbarics", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1298132689/AllHBOTStaff_normal.jpg"}
• {"id"=>"1007583867987988480", "text"=>"RT @nvhyperbarics: Hyperbaric Oxygen Therapy and Fibromyalgia - Study from 2015\n\nhttps://t.co/f5aFtM7Pu3 https://t.co/f5aFtM7Pu3", "created_at"=>"2018-06-15T11:21:28Z", "user"=>"shoriente", "user_name"=>"shoriente", "user_profile_image"=>"http://pbs.twimg.com/profile_images/576417424330874880/WuR8aJ6P_normal.jpeg"}
• {"id"=>"1198123369092337670", "text"=>"#PLOSONE: #HyperbaricOxygenTherapy Can Diminish #Fibromyalgia Syndrome – #Prospective #ClinicalTrial https://t.co/cpTRJ0ONvU", "created_at"=>"2019-11-23T06:17:25Z", "user"=>"scrufton73", "user_name"=>"Carole Sian", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1169961850685001728/4h9a_ZtN_normal.jpg"}
• {"id"=>"603541931252121601", "text"=>"Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome Prospective Clinical Trial http://t.co/VTnsuC05aT Trial https://t.co/fUs9K52hwg", "created_at"=>"2015-05-27T12:43:04Z", "user"=>"PaulWhiteleyPhD", "user_name"=>"Paul Whiteley", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000344449848/35f9d576889f4cf18b0bcf1f367afa4f_normal.jpeg"}
• {"id"=>"603565869759881216", "text"=>"RT @PaulWhiteleyPhD: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome Prospective Clinical Trial http://t.co/VTnsuC05aT Trial h…", "created_at"=>"2015-05-27T14:18:11Z", "user"=>"AutismFreeBrain", "user_name"=>"AutismFreeBrain", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3657853133/53f537b4cc0cb396b8e26b072c64d282_normal.jpeg"}
• {"id"=>"604019320201437184", "text"=>"Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial http://t.co/lssj5ABbB9", "created_at"=>"2015-05-28T20:20:02Z", "user"=>"FullSpectrumPT", "user_name"=>"Damien Cross", "user_profile_image"=>"http://pbs.twimg.com/profile_images/510082386441170944/fd50G4Ro_normal.jpeg"}
• {"id"=>"607987409620320257", "text"=>"Study: Hyperbaric Oxygen Improves Fibromyalgia http://t.co/IJnnZu9gAa More: http://t.co/iCZUieMfMx #health #medicine", "created_at"=>"2015-06-08T19:07:48Z", "user"=>"HealthyFellow", "user_name"=>"J P Fanton", "user_profile_image"=>"http://pbs.twimg.com/profile_images/480798063091392513/5Zz0mSUG_normal.jpeg"}
• {"id"=>"609453368319320064", "text"=>"#PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial http://t.co/6v1ZeW9HJk", "created_at"=>"2015-06-12T20:13:00Z", "user"=>"seittsa", "user_name"=>"Saara Seittenranta", "user_profile_image"=>"http://pbs.twimg.com/profile_images/548245446980677634/ujPeaypw_normal.jpeg"}
• {"id"=>"609854335950958592", "text"=>"@FibroAndPain have you heard about this study? Is it as promising as it sounds? Thoughts? http://t.co/NX2QbM0w6Y", "created_at"=>"2015-06-13T22:46:18Z", "user"=>"ilonadougherty", "user_name"=>"Ilona Dougherty ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1282642135/ilona-0124_normal.jpg"}
• {"id"=>"609854408902451201", "text"=>"@PainBC @FibroAndPain have you heard about this study? Is it as promising as it sounds? Thoughts? http://t.co/NX2QbM0w6Y", "created_at"=>"2015-06-13T22:46:36Z", "user"=>"ilonadougherty", "user_name"=>"Ilona Dougherty ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1282642135/ilona-0124_normal.jpg"}
• {"id"=>"609854554851688448", "text"=>"@May12th @FibroAndPain have you heard about this study? Is it as promising as it sounds? Thoughts? http://t.co/NX2QbM0w6Y", "created_at"=>"2015-06-13T22:47:11Z", "user"=>"ilonadougherty", "user_name"=>"Ilona Dougherty ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1282642135/ilona-0124_normal.jpg"}
• {"id"=>"610154168565821440", "text"=>"#PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial http://t.co/6v1ZeW9HJk", "created_at"=>"2015-06-14T18:37:44Z", "user"=>"seittsa", "user_name"=>"Saara Seittenranta", "user_profile_image"=>"http://pbs.twimg.com/profile_images/548245446980677634/ujPeaypw_normal.jpeg"}
• {"id"=>"611835505496473600", "text"=>"Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome http://t.co/bna7k4irWB #Fibromyalgia", "created_at"=>"2015-06-19T09:58:46Z", "user"=>"MetTherapy", "user_name"=>"Metablic Therapy", "user_profile_image"=>"http://pbs.twimg.com/profile_images/611569179804729346/xfiwPGlr_normal.png"}
• {"id"=>"611836625052651520", "text"=>"RT @MetTherapy: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome http://t.co/bna7k4irWB #Fibromyalgia", "created_at"=>"2015-06-19T10:03:13Z", "user"=>"ascarbs", "user_name"=>"Andrew Scarborough", "user_profile_image"=>"http://pbs.twimg.com/profile_images/585170260422168577/9na8PvcB_normal.jpg"}
• {"id"=>"613996999650754560", "text"=>"***Hyperbaric Oxygen Therapy and Fibromyalgia*** see here - http://t.co/68ugwU7SjE Also see Dr Myhill's page​ here - http://t.co/6tZ3WJg4kS", "created_at"=>"2015-06-25T09:07:46Z", "user"=>"MyhillNews", "user_name"=>"Craig Robinson", "user_profile_image"=>"http://pbs.twimg.com/profile_images/580781643742445569/-BtgXh_l_normal.jpg"}
• {"id"=>"613998547957104640", "text"=>"RT @MyhillNews: ***Hyperbaric Oxygen Therapy and Fibromyalgia*** see here - http://t.co/68ugwU7SjE Also see Dr Myhill's page​ here - http:…", "created_at"=>"2015-06-25T09:13:56Z", "user"=>"leedsMEnetwork", "user_name"=>"Leeds ME Network", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2772217003/ca67671eafd14c892a942383cd7a8b8d_normal.jpeg"}
• {"id"=>"614423256372805632", "text"=>"RT @MyhillNews: ***Hyperbaric Oxygen Therapy and Fibromyalgia*** see here - http://t.co/68ugwU7SjE Also see Dr Myhill's page​ here - http:…", "created_at"=>"2015-06-26T13:21:34Z", "user"=>"tigerosey", "user_name"=>"Katie Lloyd", "user_profile_image"=>"http://pbs.twimg.com/profile_images/595860747172913153/jS5rAC1n_normal.jpg"}
• {"id"=>"615427855414116352", "text"=>"#fibromyalgie http://t.co/Nn2q9qMUrs", "created_at"=>"2015-06-29T07:53:29Z", "user"=>"El_Guapo1969", "user_name"=>"El-Guapo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/552588293209337856/gXGhbU-7_normal.jpeg"}
• {"id"=>"618849864122654720", "text"=>"http://t.co/5UMBtBqqjD", "created_at"=>"2015-07-08T18:31:19Z", "user"=>"YMaliniak", "user_name"=>"Yael Maliniak", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000523943059/e3d143abfc624b864140cd653737f22e_normal.jpeg"}
• {"id"=>"621037272994050052", "text"=>"Hyperbaric Oxygen Therapy Can Diminish #Fibromyalgia by disrupting how brain processes pain http://t.co/hD9wV0AKJc #painrelief #bodywork", "created_at"=>"2015-07-14T19:23:18Z", "user"=>"Fascianator", "user_name"=>"Joe", "user_profile_image"=>"http://pbs.twimg.com/profile_images/614018077001289728/UZFGiJBO_normal.jpg"}
• {"id"=>"621377087878885376", "text"=>"#HBOT for #Fibro, come see us today! 847-236-9310 http://t.co/3MPL8Q9P0X #chronicpain #spoonies", "created_at"=>"2015-07-15T17:53:37Z", "user"=>"SteveDevoreBest", "user_name"=>"Dr Steve Devore Best", "user_profile_image"=>"http://pbs.twimg.com/profile_images/500030243051040769/xrFMM6IQ_normal.png"}
• {"id"=>"621377182204579841", "text"=>"RT @SteveDevoreBest: #HBOT for #Fibro, come see us today! 847-236-9310 http://t.co/3MPL8Q9P0X #chronicpain #spoonies", "created_at"=>"2015-07-15T17:53:59Z", "user"=>"GracieBagosy", "user_name"=>"Gracie Bagosy", "user_profile_image"=>"http://pbs.twimg.com/profile_images/498645169835479040/hGTGbQdN_normal.jpeg"}
• {"id"=>"631730625163173888", "text"=>"La #fibromyalgie vaincue par le caisson hyperbare? http://t.co/9IPnPZUeQX\n@PierrikFaure @MahlerNord @siliconwadi_fr", "created_at"=>"2015-08-13T07:34:52Z", "user"=>"Fraslin", "user_name"=>"Jean-Jacques Fraslin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3348796032/d2d00275d03553d41e952b11e47cd8f3_normal.jpeg"}
• {"id"=>"636826698286174209", "text"=>"#PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial http://t.co/WBzZi3URjZ", "created_at"=>"2015-08-27T09:04:51Z", "user"=>"melwel5", "user_name"=>"Melissa Wells", "user_profile_image"=>"http://pbs.twimg.com/profile_images/624072475215663104/slYw_te6_normal.jpg"}
• {"id"=>"636893996808146944", "text"=>"RT @MyhillNews: ***Hyperbaric Oxygen Therapy and Fibromyalgia*** see here - http://t.co/68ugwU7SjE Also see Dr Myhill's page​ here - http:…", "created_at"=>"2015-08-27T13:32:16Z", "user"=>"empwrdwholelife", "user_name"=>"Michelle L.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/610553187100037121/v9mE9EoO_normal.jpg"}
• {"id"=>"672100647618142211", "text"=>"Now I want to find a hyperbaric chamber to see if this helps with my pain. https://t.co/fVAEwWc8sC", "created_at"=>"2015-12-02T17:10:56Z", "user"=>"cabezalana", "user_name"=>"Mel Vassey", "user_profile_image"=>"http://pbs.twimg.com/profile_images/756267155/Ch_Tuck_normal.jpg"}
• {"id"=>"673200902463950852", "text"=>"@PaulWhiteleyPhD have you see this paper on hyperbaric and Fibre? Wondered what you think? https://t.co/2eEwMMKozD", "created_at"=>"2015-12-05T18:02:57Z", "user"=>"cyberjennifer", "user_name"=>"Jennifer Skillen", "user_profile_image"=>"http://pbs.twimg.com/profile_images/485147908195360768/lb_XuvSs_normal.jpeg"}
• {"id"=>"674926565822750720", "text"=>"@AnaFisioUsal #PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/IGnV48hr1W", "created_at"=>"2015-12-10T12:20:07Z", "user"=>"pcgarcias", "user_name"=>"PCGarciaSanchez", "user_profile_image"=>"http://pbs.twimg.com/profile_images/602964034946768896/9HtPFnx1_normal.jpg"}
• {"id"=>"677705464814153730", "text"=>"#PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/pNdckiuL5o", "created_at"=>"2015-12-18T04:22:28Z", "user"=>"bearabledeals", "user_name"=>"Renee Simmons", "user_profile_image"=>"http://pbs.twimg.com/profile_images/671959887455252480/bcjyTUih_normal.jpg"}
• {"id"=>"677745228573376512", "text"=>"RT @bearabledeals: #PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/pNdckiu…", "created_at"=>"2015-12-18T07:00:29Z", "user"=>"Kareem2229", "user_name"=>"Kareem Caldwell", "user_profile_image"=>"http://pbs.twimg.com/profile_images/637582123637993472/DyZdiXi5_normal.jpg"}
• {"id"=>"677756450538557441", "text"=>"RT @bearabledeals: #PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/pNdckiu…", "created_at"=>"2015-12-18T07:45:04Z", "user"=>"WinterGeri", "user_name"=>"Geri Winter", "user_profile_image"=>"http://pbs.twimg.com/profile_images/600223702429470721/Pav4HxOG_normal.jpg"}
• {"id"=>"677906254241669120", "text"=>"RT @bearabledeals: #PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/pNdckiu…", "created_at"=>"2015-12-18T17:40:20Z", "user"=>"Shana818", "user_name"=>"Shana Scheuermann", "user_profile_image"=>"http://pbs.twimg.com/profile_images/626311682394972168/VZ90sfnD_normal.jpg"}
• {"id"=>"677907209578283008", "text"=>"RT @bearabledeals: #PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/pNdckiu…", "created_at"=>"2015-12-18T17:44:08Z", "user"=>"Krystle452022", "user_name"=>"Krystle Balas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/632451450535178240/QRKk3iri_normal.jpg"}
• {"id"=>"677908562467688448", "text"=>"RT @bearabledeals: #PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/pNdckiu…", "created_at"=>"2015-12-18T17:49:30Z", "user"=>"Sal3976", "user_name"=>"Sal Godina", "user_profile_image"=>"http://pbs.twimg.com/profile_images/640124068251832320/ss8DG9Al_normal.jpg"}
• {"id"=>"678679232843808768", "text"=>"RT @bearabledeals: #PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/pNdckiu…", "created_at"=>"2015-12-20T20:51:53Z", "user"=>"Oleta914", "user_name"=>"Oleta Penton", "user_profile_image"=>"http://pbs.twimg.com/profile_images/667214159369605120/hHDm81sn_normal.jpg"}
• {"id"=>"682141674605277184", "text"=>"Dd https://t.co/OWbC1frmiH", "created_at"=>"2015-12-30T10:10:23Z", "user"=>"Klodath", "user_name"=>"Klod", "user_profile_image"=>"http://pbs.twimg.com/profile_images/514863257556099073/1HjaHe0g_normal.jpeg"}
• {"id"=>"682144777807212544", "text"=>"@alesitoide ya viste esto? https://t.co/OWbC1frmiH", "created_at"=>"2015-12-30T10:22:43Z", "user"=>"Klodath", "user_name"=>"Klod", "user_profile_image"=>"http://pbs.twimg.com/profile_images/514863257556099073/1HjaHe0g_normal.jpeg"}
• {"id"=>"684387516061880320", "text"=>"It looks like @CharlesGaba's 2017 predictions are (slightly) less uncertain: https://t.co/7DdC3xHGHK", "created_at"=>"2016-01-05T14:54:33Z", "user"=>"icowrich", "user_name"=>"suᴉʞdɯᴉS pɹɐɥɔᴉR", "user_profile_image"=>"http://pbs.twimg.com/profile_images/58689487/Rico_at_conference_-_square_normal.JPG"}
• {"id"=>"696285182379343873", "text"=>"#HyperbaricOxygenTherapy #Fibromyalgia. Improve symptoms, induce #Neuroplasticity & rectify abnormal brain activity. https://t.co/h1TnD9kNHZ", "created_at"=>"2016-02-07T10:51:38Z", "user"=>"MShelpcambs", "user_name"=>"Cambs MS Centre, UK", "user_profile_image"=>"http://pbs.twimg.com/profile_images/603852334880399361/Bc2PSf2G_normal.png"}
• {"id"=>"696285621921435648", "text"=>"#HBOT #Fibromyalgia. May improve symptoms, induce #Neuroplasticity & rectify abnormal brain activity. https://t.co/h1TnD9kNHZ #Huntingdon", "created_at"=>"2016-02-07T10:53:23Z", "user"=>"MShelpcambs", "user_name"=>"Cambs MS Centre, UK", "user_profile_image"=>"http://pbs.twimg.com/profile_images/603852334880399361/Bc2PSf2G_normal.png"}
• {"id"=>"696293530600394752", "text"=>"RT @MShelpcambs: #HBOT #Fibromyalgia. May improve symptoms, induce #Neuroplasticity & rectify abnormal brain activity. https://t.co/h1TnD9k…", "created_at"=>"2016-02-07T11:24:48Z", "user"=>"shoriente", "user_name"=>"shoriente", "user_profile_image"=>"http://pbs.twimg.com/profile_images/576417424330874880/WuR8aJ6P_normal.jpeg"}
• {"id"=>"696293561998950400", "text"=>"RT @MShelpcambs: #HyperbaricOxygenTherapy #Fibromyalgia. Improve symptoms, induce #Neuroplasticity & rectify abnormal brain activity. https…", "created_at"=>"2016-02-07T11:24:56Z", "user"=>"shoriente", "user_name"=>"shoriente", "user_profile_image"=>"http://pbs.twimg.com/profile_images/576417424330874880/WuR8aJ6P_normal.jpeg"}
• {"id"=>"696309110007074816", "text"=>"Fibromyalgie Fribromyalgia\nhttps://t.co/gwM1VF2CR0", "created_at"=>"2016-02-07T12:26:43Z", "user"=>"ACROPOLITESSE", "user_name"=>"CARTOPOL", "user_profile_image"=>"http://pbs.twimg.com/profile_images/520105174673526784/yc-0Sq3A_normal.jpeg"}
• {"id"=>"700002923175084033", "text"=>"#HBOT #Fibromyalgia. May improve symptoms, induce #Neuroplasticity & rectify abnormal brain activity. https://t.co/h1TnD9kNHZ #Huntingdon", "created_at"=>"2016-02-17T17:04:36Z", "user"=>"MShelpcambs", "user_name"=>"Cambs MS Centre, UK", "user_profile_image"=>"http://pbs.twimg.com/profile_images/603852334880399361/Bc2PSf2G_normal.png"}
• {"id"=>"701758335146729472", "text"=>"#HBOT #Fibromyalgia. May #ImproveSymptoms, induce #Neuroplasticity & rectify #AbnormalBrainActivity. https://t.co/h1TnD9kNHZ #Huntingdon #MS", "created_at"=>"2016-02-22T13:19:59Z", "user"=>"MShelpcambs", "user_name"=>"Cambs MS Centre, UK", "user_profile_image"=>"http://pbs.twimg.com/profile_images/603852334880399361/Bc2PSf2G_normal.png"}
• {"id"=>"701758509961101312", "text"=>"#HBOT #Fibromyalgia May improve symptoms, induce #Neuroplasticity & rectify abnormal brain activity https://t.co/h1TnD9kNHZ #Huntingdon #MS", "created_at"=>"2016-02-22T13:20:41Z", "user"=>"MShelpcambs", "user_name"=>"Cambs MS Centre, UK", "user_profile_image"=>"http://pbs.twimg.com/profile_images/603852334880399361/Bc2PSf2G_normal.png"}
• {"id"=>"701759070211088384", "text"=>"#HBOT #Fibromyalgia May #ImproveSymptoms , induce #Neuroplasticity & rectify #AbnormalBrainActivity https://t.co/h1TnD9kNHZ #Huntingdon #MS", "created_at"=>"2016-02-22T13:22:55Z", "user"=>"MShelpcambs", "user_name"=>"Cambs MS Centre, UK", "user_profile_image"=>"http://pbs.twimg.com/profile_images/603852334880399361/Bc2PSf2G_normal.png"}
• {"id"=>"703627247622684672", "text"=>"#HBOT #Fibromyalgia May #ImproveSymptoms , induce #Neuroplasticity & rectify #AbnormalBrainActivity https://t.co/h1TnD9kNHZ #Huntingdon #MS", "created_at"=>"2016-02-27T17:06:23Z", "user"=>"MShelpcambs", "user_name"=>"Cambs MS Centre, UK", "user_profile_image"=>"http://pbs.twimg.com/profile_images/603852334880399361/Bc2PSf2G_normal.png"}
• {"id"=>"703627325670354944", "text"=>"RT @MShelpcambs: #HBOT #Fibromyalgia May #ImproveSymptoms , induce #Neuroplasticity & rectify #AbnormalBrainActivity https://t.co/h1TnD9kNH…", "created_at"=>"2016-02-27T17:06:41Z", "user"=>"Jonno1701a", "user_name"=>"Mark Johnson", "user_profile_image"=>"http://pbs.twimg.com/profile_images/615183171831877634/yEeXWZW5_normal.jpg"}
• {"id"=>"709132548778160128", "text"=>"PLOS ONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/uGIzy7qZVw", "created_at"=>"2016-03-13T21:42:29Z", "user"=>"SpinePainCentre", "user_name"=>"Spine & Pain Centre", "user_profile_image"=>"http://pbs.twimg.com/profile_images/705104604980191232/lIfM0hws_normal.jpg"}
• {"id"=>"728615487635132417", "text"=>"Fibromyalgia? This study is very promising. https://t.co/s8iHixzA5Y \nAlso see: https://t.co/aEs3WZbdpz \n#FrederickMD #massage #fibromyalgia", "created_at"=>"2016-05-06T16:00:43Z", "user"=>"FrederickMassag", "user_name"=>"Frederick Massage MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000825888546/5026bfeda4a1afa569dc9bb3d198fe16_normal.png"}
• {"id"=>"730825611816632320", "text"=>"Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/3xcDPEcebR", "created_at"=>"2016-05-12T18:22:58Z", "user"=>"YordankaIvanov3", "user_name"=>"Yordanka Ivanova", "user_profile_image"=>"http://pbs.twimg.com/profile_images/678984021590847488/GswfbPSi_normal.jpg"}
• {"id"=>"745113890682396672", "text"=>"So I pulled this reference today after the news report floating around in the the feed (thanks Yoav Nagar!). With... https://t.co/dSb8oJuGxg", "created_at"=>"2016-06-21T04:39:29Z", "user"=>"drphillipsnell", "user_name"=>"Phillip Snell", "user_profile_image"=>"http://pbs.twimg.com/profile_images/556173228893155328/MNvp1oRo_normal.jpeg"}
• {"id"=>"745795203156455425", "text"=>"#PLOSONE: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial https://t.co/ou9hEF8FtR", "created_at"=>"2016-06-23T01:46:47Z", "user"=>"JaysonSipress", "user_name"=>"Jayson Sipress", "user_profile_image"=>"http://pbs.twimg.com/profile_images/735875237045096449/3dg7xuCq_normal.jpg"}
• {"id"=>"765176867209015296", "text"=>"Fibromialgia relief by hyperbaric oxygen https://t.co/jjqf4JNET8", "created_at"=>"2016-08-15T13:22:36Z", "user"=>"howardjunca", "user_name"=>"Howard Junca", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2531855984/1yqbps3oe87uz1fbaizz_normal.jpeg"}
• {"id"=>"765185609321312256", "text"=>"FRIBROMIALGIA interesante articulo solucion a esta patologia? publicado revista PLOS ONE https://t.co/OkjzH1AMNd https://t.co/Q7J0iaYkxG", "created_at"=>"2016-08-15T13:57:20Z", "user"=>"drhenryflores", "user_name"=>"dr henry flores", "user_profile_image"=>"http://pbs.twimg.com/profile_images/759756022881787904/bb6cOfSu_normal.jpg"}
• {"id"=>"772687925024813056", "text"=>"The supporting evidence\n\nhttps://t.co/IuIeyTSUM2", "created_at"=>"2016-09-05T06:48:51Z", "user"=>"Lindybud", "user_name"=>"Linda Henderson", "user_profile_image"=>"http://pbs.twimg.com/profile_images/772137340798197768/gVH4KFhM_normal.jpg"}
• {"id"=>"775688237755006976", "text"=>"RT @Lindybud: The supporting evidence\n\nhttps://t.co/IuIeyTSUM2", "created_at"=>"2016-09-13T13:31:02Z", "user"=>"Lindybud", "user_name"=>"Linda Henderson", "user_profile_image"=>"http://pbs.twimg.com/profile_images/772137340798197768/gVH4KFhM_normal.jpg"}
• {"id"=>"816647414199255040", "text"=>"\"La terapia de ox?geno hiperb?rico puede disminuir el s?ndrome de fibromialgia\"\nhttps://t.co/3sAjFGMxqR", "created_at"=>"2017-01-04T14:08:10Z", "user"=>"LorenArdilaV", "user_name"=>"Lorena Ardila", "user_profile_image"=>"http://pbs.twimg.com/profile_images/804817591562805250/sm9sJ4e7_normal.jpg"}
• {"id"=>"833079246033649668", "text"=>"Hyperbaric Oxygen for #Fibromyalgia - looking forward to seeing some long-term followup on this one! #meded #FOAMed https://t.co/OBl3epr0VB", "created_at"=>"2017-02-18T22:22:24Z", "user"=>"AmyPearsonMD", "user_name"=>"Amy Pearson, MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/667769170675806208/As877_WQ_normal.jpg"}
• {"id"=>"862748794554863616", "text"=>"For #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #FibromyalgiaAwareness #Fibromyalgia", "created_at"=>"2017-05-11T19:18:36Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"862749517845811201", "text"=>"Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromyalgia", "created_at"=>"2017-05-11T19:21:28Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"862851433108054016", "text"=>"RT @HyperbaricSwf: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromy…", "created_at"=>"2017-05-12T02:06:27Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"862885746289627136", "text"=>"RT @HyperbaricSwf: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromy…", "created_at"=>"2017-05-12T04:22:48Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"863001988036009984", "text"=>"RT @HyperbaricSwf: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromy…", "created_at"=>"2017-05-12T12:04:42Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"863415087553433600", "text"=>"RT @HyperbaricSwf: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromy…", "created_at"=>"2017-05-13T15:26:13Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"864814247016095746", "text"=>"RT @HyperbaricSwf: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromy…", "created_at"=>"2017-05-17T12:05:58Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"864821666748260353", "text"=>"RT @HyperbaricSwf: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromy…", "created_at"=>"2017-05-17T12:35:27Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"864891746840346624", "text"=>"RT @HyperbaricSwf: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromy…", "created_at"=>"2017-05-17T17:13:56Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"864899460329074689", "text"=>"RT @HyperbaricSwf: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromy…", "created_at"=>"2017-05-17T17:44:35Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}
• {"id"=>"874289329417449472", "text"=>"RT @HyperbaricSwf: Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome. 4 #hbot call 941-379-4280 https://t.co/U3PmT1TmbP #Fibromy…", "created_at"=>"2017-06-12T15:36:34Z", "user"=>"HyperbaricSwf", "user_name"=>"HyperbaricSWF", "user_profile_image"=>"http://pbs.twimg.com/profile_images/842476687900123136/R2DachZI_normal.jpg"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/2083709", "https://ndownloader.figshare.com/files/2083710", "https://ndownloader.figshare.com/files/2083711", "https://ndownloader.figshare.com/files/2083712", "https://ndownloader.figshare.com/files/2083713"], "description"=>"<div><p>Background</p><p>Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2–4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS.</p><p>Methods and Findings</p><p>A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including tender point count and pain threshold, extensive evaluation of quality of life, and single photon emission computed tomography (SPECT) imaging for evaluation of brain activity. The HBOT protocol comprised 40 sessions, 5 days/week, 90 minutes, 100% oxygen at 2ATA. Sixty female patients were included, aged 21–67 years and diagnosed with FMS at least 2 years earlier. HBOT in both groups led to significant amelioration of all FMS symptoms, with significant improvement in life quality. Analysis of SPECT imaging revealed rectification of the abnormal brain activity: decrease of the hyperactivity mainly in the posterior region and elevation of the reduced activity mainly in frontal areas. No improvement in any of the parameters was observed following the control period.</p><p>Conclusions</p><p>The study provides evidence that HBOT can improve the symptoms and life quality of FMS patients. Moreover, it shows that HBOT can induce neuroplasticity and significantly rectify abnormal brain activity in pain related areas of FMS patients.</p><p>Trial Registration</p><p>ClinicalTrials.gov <a href=\"https://clinicaltrials.gov/ct2/show/NCT01827683\" target=\"_blank\">NCT01827683</a></p></div>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427181, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0127012.s001", "https://dx.doi.org/10.1371/journal.pone.0127012.s002", "https://dx.doi.org/10.1371/journal.pone.0127012.s003", "https://dx.doi.org/10.1371/journal.pone.0127012.s004", "https://dx.doi.org/10.1371/journal.pone.0127012.s005"], "stats"=>{"downloads"=>9, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hyperbaric_Oxygen_Therapy_Can_Diminish_Fibromyalgia_Syndrome_8211_Prospective_Clinical_Trial_/1427181", "title"=>"Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-05-26 17:00:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2083708"], "description"=>"<p>P₁- p values for comparison before and after HBOT in the treated group (paired t test).</p><p>P₂- p values for comparison before and after the control period in the crossover group (paired t test).</p><p>P₃- p values for comparison after the control period before and after HBOT in the crossover group (paired t test).</p><p>P₄- p values for comparison of the treated group after HBOT and the crossover after the control period (independent sample t test).</p><p>* Data is presented as mean± standard deviation</p><p>Summary of the results of the tender points evaluation, physical function assessment, symptoms and quality of life questionnaires.</p>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427180, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127012.t002", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_the_results_of_the_tender_points_evaluation_physical_function_assessment_symptoms_and_quality_of_life_questionnaires_/1427180", "title"=>"Summary of the results of the tender points evaluation, physical function assessment, symptoms and quality of life questionnaires.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-05-26 17:00:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2083705"], "description"=>"<p>The figure shows the histogram as is explained in the text. The Y-axis shows the mean relative change change>(n) for the Brodmann area indicated in the X-axis. The results for the patients of the response group after the HBOT period are colored from light blue (BA with the strongest activity reduction) to light red (BA with the highest activity elevation). The green bars correspond to the mean relative changes in the patients of the crossover group following the control period.</p>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427177, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127012.g006", "stats"=>{"downloads"=>2, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BA_histogram_of_mean_relative_changes_/1427177", "title"=>"BA histogram of mean relative changes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-26 17:00:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2083703"], "description"=>"<p>The figure shows the relative change in all patients (y-axis in unit change) as a function of the baseline value. For the treated group, each patient is represented by a single red dot. The relative change is the change during HBOT and the baseline value is the value before treatment. For the crossover group, each patient is represented by two dots: a green dot represents the relative change during the control period, with the baseline being the value before the control. A blue dot represents the relative change during treatment, with the baseline value being the value before treatment (which is also the value at the end of the control period). The green line represents the mean relative change in the crossover group following the control period and the green dashed lines represent the ±1std from the mean.</p>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427175, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127012.g004", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Scatter_plot_of_the_individual_relative_changes_in_the_dolorimeter_threshold_/1427175", "title"=>"Scatter plot of the individual relative changes in the dolorimeter threshold.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-26 17:00:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2083704"], "description"=>"<p>The figures show the mean relative changes and standard errors in the three measures for the crossover group following the control period (green) and following HBOT (blue), and for the treated group following HBOT (red). A) Mean relative changes and standard errors in physical function assessed by the FIQ score. B) Mean relative changes in and standard errors in the psychological distress assessed by the SCL-90 score. c) Mean relative changes and standard errors in the quality of life assessed by the SF-36 score.</p>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427176, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127012.g005", "stats"=>{"downloads"=>4, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Assessments_of_the_mean_relative_changes_in_the_FIQ_SCL_90_and_the_SF_36_scores_/1427176", "title"=>"Assessments of the mean relative changes in the FIQ, SCL-90 and the SF-36 scores.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-26 17:00:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2083699"], "description"=>"<p>A) The effect on dolorimeter threshold. For both groups, the threshold level tripled after treatment (about 1.5, red bars, vs. about 0.5, blue bars). B) The effect on the number of tender points. The treatment led to significant reduction in the number of tender points in both groups: by a factor of 2 in the treated group and by a factor of 3 in the crossover group.</p>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427171, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127012.g002", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_HBOT_effects_on_tender_points_/1427171", "title"=>"The HBOT effects on tender points.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-26 17:00:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2083707"], "description"=>"<p>The figure shows the results of the normalized mean changes as projected on the brain maps, left BAs (A) and right BAs (B). We colored the BAs that show significant changes in activity using the same color code as in Figs <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127012#pone.0127012.g006\" target=\"_blank\">6</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127012#pone.0127012.g007\" target=\"_blank\">7</a> - from light blue (BA with the strongest activity reduction) to light red (BA with the highest activity elevation).</p>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427179, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127012.g008", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Projection_of_the_significant_changes_on_the_brain_maps_/1427179", "title"=>"Projection of the significant changes on the brain maps.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-26 17:00:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2083706"], "description"=>"<p>A) Normalized BA histogram of mean relative changes. The figure is similar to <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127012#pone.0127012.g006\" target=\"_blank\">Fig 6</a> but the Y-axis is for the normalized values, that is for I_σ(n)* change>(n) and not for change>(n) that are used in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127012#pone.0127012.g006\" target=\"_blank\">Fig 6</a>. The BAs within the rectangles are the ones with normalized mean relative changes smaller than -0.6 or larger than +0.6. B) The two dimensional scatter plot I_σ(n) vs. I_σ(n)* change>(n) for the patients of the response group following the HBOT period. C) Similar scatter plot for the patients in the crossover group following the control period. The color code in (B) and (C) is the same as in (A). The funnel shaped black curve is a fit of the results in (B) to a reciprocal Lorentzian curve: f(x) = {X_max- γ*[π*(γ²+x²)]^-1} with X_max = 0.95, γ = 0.335.</p>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427178, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127012.g007", "stats"=>{"downloads"=>3, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effect_of_significance_index_normalization_/1427178", "title"=>"The effect of significance index normalization.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-26 17:00:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2083702"], "description"=>"<p>A) The mean relative change and standard errors in the dolorimeter thresholds for the crossover group following the control period (green) and following HBOT (blue), and for the treated group following HBOT (red). B) The mean relative changes and standard errors in the number of tender points for the crossover group following the control period (green) and following HBOT (blue), and for the treated group following HBOT (red).</p>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427173, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127012.g003", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Assessments_of_the_mean_relative_changes_in_the_pain_level_/1427173", "title"=>"Assessments of the mean relative changes in the pain level.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-26 17:00:51"}
• {"files"=>["https://ndownloader.figshare.com/files/2083697"], "description"=>"<p>Flow chart of the patients in the study.</p>", "links"=>[], "tags"=>["hyperbaric oxygen therapy", "ata", "hbot", "Clinical Trial BackgroundFibromyalgia Syndrome", "symptom", "control period.ConclusionsThe study", "brain activity", "tender point count", "fms", "nct", "spect", "life quality"], "article_id"=>1427169, "categories"=>["Biological Sciences"], "users"=>["Shai Efrati", "Haim Golan", "Yair Bechor", "Yifat Faran", "Shir Daphna-Tekoah", "Gal Sekler", "Gregori Fishlev", "Jacob N. Ablin", "Jacob Bergan", "Olga Volkov", "Mony Friedman", "Eshel Ben-Jacob", "Dan Buskila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127012.g001", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_of_the_patients_in_the_study_/1427169", "title"=>"Flow chart of the patients in the study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-05-26 17:00:51"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime | Further Information

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